Search Results (217)

The Yizhuan constructs a temporal ethics centered on “time” (shi 時), bridging the Will of Heaven and human affairs. This ethical paradigm is primarily manifested in the tripartite conceptual framework: First, as the transcendent source of temporal ethics, “The Will of Heaven” (tianming 天命) endows the ever-changing processes of cosmic existence with a moral teleological dimension. Secondly, “Heaven’s Timing” (tianshi 天時) manifests as the Will of Heaven within specific time and spatial contexts, guiding actors to discern the operational principles of fortune and opportunity. Finally, “the Timely Mean” (shizhong 時中), as the fundamental principle of practical life, refers to the practice of acting in harmony with the times, based on the agent’s insight into the Will of Heaven and grasp of Heaven’s Timing. Its essence lies in adapting to the times to achieve the supreme realm of morality, as outlined in the Way of the Mean (zhongdao 中道). The core purpose of the temporal ethics in the Yizhuan is to emphasize understanding moral practice within the dimension of time, opposing the abstract application of moral principles divorced from specific contexts. It requires the agent to make choices aligned with the Will of Heaven at the appropriate moment, cultivating moral character and addressing complex practical matters within the flow of time. Full article

The doctrine of theosis, or deification, is a distinctive feature of Eastern Orthodoxy. In recent centuries, it has also become a pursuit across various Christian traditions. Although theosis was historically associated with humanity, modern theology has not adequately explored its cosmic dimension, which concerns both human and non-human beings as well as the cosmos as a whole. This article draws on elements of the Orthodox tradition, including the Logos–logoi theory of St. Maximus the Confessor and the Essence–Energies distinction of St. Gregory Palamas. It also engages with insights from contemporary Orthodox thinkers relevant to the discussion. The aim is to outline the theological foundations for a more inclusive and holistic understanding of theosis, particularly in light of the current climate crisis and issues of animal welfare. Full article

This article explores Rudolf Steiner’s Christology within the framework of cosmic evolution, focusing on the Second Coming of Christ as a pivotal metaphysical event. Identifying a scholarly lacuna regarding Steiner’s developmental cosmology and the work of Yeshayahu Ben-Aharon, the study adopts an immanent–synthetic methodology to demonstrate a sacramental, participatory epistemology. The first part unfolds Steiner’s vision of the ‘Mystery of Golgotha’ as a cosmic turning point where a macrocosmic death process is reversed into a resurrection life stream. The second part examines Ben-Aharon’s esoteric development of these ideas into a contemporary ‘knowledge drama of the Second Coming.’ Through the spiritualization of consciousness, Ben-Aharon describes an individual ‘essence-exchange’ with the Christ impulse within the ‘abyss of nothingness’ of our age. Finally, the article discusses the social–metaphysical implications of this drama through the ‘Reversed Cultus.’ Here, the indwelling Christ is recognized as humanity’s ‘Higher Self,’ grounding a new community and ‘school of love’ capable of responding to the technoscientific challenges of mechanization of intelligence and life. By positioning the human being as a co-creative agent in cosmic becoming, the article argues for a renewed understanding of the Second Coming as a new step in humanity’s spiritual evolution. Full article

Human physiology is among the most complex systems in nature, characterized by intricate structural and functional networks and rich temporal dynamics. Electrophysiological signals produced by different tissues/organs reflect physiological activity, and are inherently non-stationary, non-linear, and noisy. This work focuses on fractal analysis, a framework that captures the self-similar and scale-free properties of electrophysiological signals, which is considered to act as an output of complex physiological structures that generate complex processes. Central to this approach is the principle of ‘decomplexification’, whereby aging and disease are associated with a loss of physiological complexity. We discuss key algorithms, particularly Higuchi’s fractal dimension, which is often combined with other nonlinear measures and machine-learning models for real-time analysis of electrophysiological signals. Evidence shows that fractal metrics enable the early detection and monitoring of neurological and psychiatric disorders, outperforming traditional spectral measures. In movement disorders and mood disorders, fractal and nonlinear features show high diagnostic accuracy. Beyond diagnostics, we discuss therapeutic applications, including the prediction of responsiveness to non-invasive brain stimulation. Here, we envisage the evolution of one fractal or nonlinear measure use, to several measures applied, then use it as a feature for machine learning, and then realize that a whole cluster of biomarkers must be used to reflect the state of autonomic profile, which then can be used for ontology-based application profiles that can be machine-actionable. In addition, we discuss the fractal and fractional description of transport processes, which offer innovative improvement for a much more accurate description of physiological reality as a prerequisite for further modeling: for example, this is needed for digital twins to support the clinical translation of fractal analysis for personalized medicine. In essence, if one is trying to mathematically describe or quantify structures or processes in human physiology, fractal and fractional are the supreme and adequate approach to accurately model that reality. Full article

In the Amyloid Cascade Hypothesis (ACH2.0) paradigm, Alzheimer’s disease (AD) is defined as a disorder triggered by a sustained neuronal integrated stress response (ISR) and driven by the C99 fragment of amyloid-beta protein precursor (AβPP) generated in the autonomous AβPP-independent pathway. This implies that AD can be initiated by any stressor capable of activating one or more of the four eIF2α kinases and accumulated intraneuronally to sufficient levels. In most instances of AD, such a stressor is intraneuronal Aβ (iAβ) accumulated to a PKR- and/or HRI-activating concentration and designated, in terms of the ACH2.0, as a “conventional stressor”. The ensuing disease is referred to, accordingly, as “conventional AD”. Any stressor other than iAβ, which is capable of activating one or more eIF2α kinases in neuronal cells, is designated as an “unconventional stressor”. At a sufficient concentration, it triggers elicitation of the neuronal ISR and initiates the disease, referred to in terms of the ACH2.0 as “unconventional AD”, at levels of iAβ below those required for activation of PKR and/or HRI. In both forms of AD, the neuronal ISR activates production of components essential for, and, consequently, enables operation of, the RNA-dependent mRNA amplification pathway. Human AβPP mRNA is eligible for this process, and its asymmetric amplification yields 5′-truncated mRNA molecules that are translated into C99 at rates that are orders of magnitude greater than those seen in AβPP proteolysis. The resulting C99 drives AD pathology; it also propagates the ISR state and perpetuates both its own production and the progression of the disease. Thus, the neuronal ISR-enabled amplification of AβPP mRNA constitutes the active core of AD. It follows that the essence of any effective therapy for AD, in both conventional and unconventional forms, is to either prevent activation or suppress the operation of the AβPP mRNA amplification process. The present perspective considers therapeutic options capable of accomplishing these objectives. They include inhibition of the neuronal ISR, targeted degradation of iAβ and C99, anti-antisense oligonucleotides (AASO) for AβPP RNA, and the restructuring of the 5′ terminus of AβPP mRNA. Collectively, these therapeutic approaches constitute the state of the art in the ACH2.0 paradigm; if successful, they would render both AD and aging-associated cognitive decline (AACD) obsolete. This study also describes transgenic animal and human neuronal cell-based models of both conventional and unconventional forms of AD that are suitable for testing the proposed therapeutic strategies. Full article

Internal Boxing (neijiaquan 內家拳) is an advanced form of the Daoist gymnastic exercise of daoyin (導引). However, how it achieves a paradigmatic shift from qi/blood regulation to deep-level transmutation of sexual energy still requires further exploration. Therefore, it is of great significance to look into how Internal Boxing inheres and integrates various techniques of “desire transmutation” (zhuanyu 轉欲) from internal alchemy (neidan 內丹), thereby transcending traditional daoyin, bringing about a significant systematic reconfiguration in the model of body cultivation practices in Daoist medicine. The traditional daoyin (i.e., “guiding and stretching”) practice emphasizes the regulation of qi/blood, but it remains limited in accounting for and producing the self-conscious transmutation of sexual energy. In contrast, Internal alchemy provides a different system of theory and techniques, which is centered on the concept of “transmutation of desires”, converting human desires into high-level life energy through a process of interaction between one’s internal spirit (xinshen 心神) and internal breathing (neixi 內息). This study thus examines the ways in which Internal Boxing integrates and reconfigures these techniques within its bodily training regimen. In the core of all these styles is the goal to refine the primordial essence (yuanjing 元精) by transitioning the method to induce the flow of vital energy from breathing to somatic movements. As a result, this study shows that the innovations of Internal Boxing reconfigure the qi/blood regulation model in the traditional daoyin practice, causing a systematic reconfiguration in the transmutation of sexual energy and, further, bridging the gap between daoyin and internal alchemy in both theory and practice. Furthermore, such innovations also develop a holistic view of the human body as marked by an emphasis on the “unity of pre-heaven (xiantian 先天) and post-heaven (houtian 後天) states”, which expands in both depth and breadth the theories of body cultivation practices in Daoist medicine. Full article

Heavy metals (HMs) were originally formed in the universe long before human evolution and are now ubiquitous in the environment, where some HMs are good as essential elements for human health while others are not. The purpose of this analytical review is to provide an updated clinical overview on health risks attributable to drinking water containing specific HMs and to discuss new aspects of molecular steps leading to disrupted diseases. This approach was favored because the study cohorts were homogeneous, since exposed individuals lived in households where all members had access to the same drinking water of constant quality. Among the HMs under consideration, aluminum, arsenic, cadmium, chromium, copper, iron, lead, manganese, and mercury were detected in drinking water and represented a health risk if levels were above thresholds recommended by national and international regulatory authorities. For example, (1) aluminum increased the risk of dementia and Alzheimer’s disease; (2) arsenic was associated with the development of bladder cancer; (3) cadmium increased the no-carcinogenic, as well as the carcinogenic, health risk; (4) chromium was considered as a risk factor for liver and kidney injury, as well cancer development; (5) copper contributed to cognitive impairment in the aging population and Alzheimer’s disease; (6) iron increased the non-carcinogenic health risk; (7) lead impaired neurodevelopmental functions in children; (8) manganese increased the risk of attention-deficit hyperactivity disorder (ADHD); and (9) mercury was causally related to chronic kidney disease. In contrast, for nickel and zinc, no overt health risks have been reported, likely due to low levels in the drinking water, attributable to their low water solubility. Of note is the good news that some HMs represent essential elements for human health. In essence, many HMs were detected in drinking water and exerted non-carcinogenic or carcinogenetic health risks, requiring proactive management of national and international regulatory authorities. Full article

This article introduces the Olfactory Attribution Circle (OAC), a conceptual tool for integrating olfaction, color and semantic attributes in the design of sensory atmospheres. Developed through a multi-method strategy, the research combined a literature review, semi-structured interviews with academic and industry sources, a case study of Every Human (Algorithmic Perfumery), and AI-assisted exploration. The review revealed a lack of tools operationalizing olfactory design within the built environment. Interviews provided practice-based insights on inclusion, intensity calibration, and feasibility, while the case study demonstrated the potential and limitations of AI-driven personalization. AI was employed to generate mappings between 60 essences, semantic attributes, and chromatic codes, refined through authorial curation. Results highlight systematic crossmodal correspondences between scents, linguistic attributes, and chromatic values, underscoring the importance of crossmodal congruence in designing coherent sensory experiences. The OAC enables congruent, human-centered olfactory design, though cultural variability and semantic ambiguity limit universal application. The study positions the OAC as both a methodological contribution and a foundation for future empirical testing across diverse cultural contexts. Full article

As a form of living cultural heritage, local residential landscapes manifest the essence of long-term, resilient human–land interactions. The Wuling Corridor, a vital ethnic and cultural passage connecting the Central Plains with Southwest China in Chinese history, serves as a crucial region for the mixed residence and cultural exchange of Tujia, Miao, Dong, Han, and other ethnic groups. Within this region, Ganlan stands as both the most representative vernacular architectural heritage and a residential form that is still extensively used, constituting a continuous and unique residential landscape. The spatial distribution patterns of Ganlan are the physical witness of the history of ethnic groups adapting to the complex topographic and cultural conditions. Current research focuses on the case description of single Ganlan forms, failing to systematically investigate the spatial formation mechanisms of Ganlan as a residential landscape from a geographical continuum perspective. Therefore, this study establishes a geographical database encompassing 9425 Ganlan samples from the Wuling Corridor. It integrates the geographic information system (GIS) with clustering algorithms to systematically identify the distribution patterns of Ganlan within specific geographic–cultural units and their coupling relationships with natural environments. It conducts quantitative analysis on the key driving factors concerning the emergence and evolution of Ganlan in the study area; the findings reveal the following: (1) Ganlan buildings exhibit a spatially aggregated distribution pattern along major water systems, demonstrating characteristics of multi-ethnic sharing and spatial interweaving. (2) Their distribution is constrained by natural geographical factors and influenced by the transmission pathways of construction techniques during ancient ethnic migrations to the southwest China. (3) Within multi-ethnic settlement structures, inter-ethnic cultural interactions (particularly with Central Plains culture) serve as a key driving force for the typological evolution of Ganlan. (4) The evolutionary lineage of “full-Ganlan,” “semi-Ganlan,” and “courtyard-style Ganlan” systematically demonstrates the dynamic adaptive capacity of local residential systems. Additionally, by integrating massive Ganlan heritage data with multiple spatial analysis methods, the study serves as a typical case study illuminating the adaptive strategies and resilience mechanisms of Ganlan as a local residential landscape formed in response to the environmental conditions and social changes. Also, it provides a scientific basis for the holistic conservation of architectural heritages shared by multiple ethnic groups and the integrated development of local cultural tourism industries. Full article

Background: Human care represents the essence of nursing but faces challenges from increasing technological advancement and healthcare system bureaucratization. Objective: To understand how nursing students balance technical demands with human aspects of care during pre-professional practice experiences. Methods: An interpretive phenomenological study was conducted with 17 nursing students (12 women, 5 men) in their eighth and ninth semesters from a public university in northern Ecuador. The data were collected through focused interviews during the first quarter of 2025. Analysis followed a four-stage phenomenological process: epoché, phenomenological reduction, eidetic reduction, and transcendental reduction, culminating in phenomenological interpretation. Data saturation was achieved, and methodological rigor criteria were applied including triangulation with external analysts. Results: Six main strategies emerged that students develop to balance technical demands with humanized care: Time Management and Optimization, Integration of Human and Technical Dimensions, Patient Communication About Time Constraints, Emotional Regulation and Boundary Setting, Resistance to Dehumanization, and Institutional Context Adaptation. Students transform technical procedures into therapeutic opportunities and develop resilient competencies that preserve nursing’s humanistic values. Conclusions: Nursing students develop integrative competencies that balance technical excellence with human sensitivity. Curriculum modifications are needed to include specific competencies in emotional regulation, therapeutic communication, and dehumanization resistance strategies. Full article

Totemic art, as the fundamental medium of the spiritual realm of primordial societies, employs its distinctive symbolic system to communicate and articulate humanity’s spiritual understanding and sacred quest for nature, the cosmos, and the essence of existence. This article centers on totemic art, which, through the three dimensions of sublime beauty, humanistic beauty, and artistic beauty, establishes a spiritual dialogue system between primitive tribes and supernatural forces. The core principle is the aesthetic metamorphosis of the spiritual realm through material carriers. It explores how it functions as a potent medium for articulating both personal and communal spirituality: sublime beauty manifests and materializes the intangible divine force through the “presenting the unpresentable,” thus establishing the spiritual basis of primal reverence; Humanistic beauty, rooted in familial connections, the celebration of life, and community unity, facilitates the awakening and elevation of both individual and collective consciousness, promoting the integration and symbiosis of personal spirituality and communal sanctity; Behind the evolution of styles and the characteristics of anti-aesthetics in the artistic beauty, there remains the fundamental logic of serving spiritual expression. Research indicates that totemic art serves as the fundamental aesthetic practice of primitive societies for comprehending the world, engaging with the divine, and achieving mental tranquility. The three dimensions of its spiritual expression collectively form a spiritual monument of early human civilization. Full article

This study explores the practice of “soundtalking”, a novel method of participant-led sound practice, across the Dee Estuary in the UK. Over the course of twelve months, the Our Dee Estuary Project facilitated monthly meetings where participants engaged in sound workshops, in-depth discussions, and sound-making activities, with the aim of fostering a deeper connection with both their local and sonic environments. This longitudinal practice-based research study created an environment of sonic learning and listening development, documenting how participants’ interactions and narratives both shape and are shaped by the estuarial environment, its soundscape, and their sense of place. Participant-led conversations formed the basis of the methodology, providing rich qualitative data on how individuals perceive, interpret, and interact with their surroundings and the impact that the soundscape has on the individual. The regular and unstructured discussions revealed the intrinsic value of soundscapes in participants’ lives, emphasising themes of memory, reflection, place attachment, environmental awareness, and well-being. The collaborative nature of the project allowed for the co-creation of a film and a radio soundscape, both of which serve as significant outputs, encapsulating the auditory and emotional essence of the estuary. The study’s initial findings indicate that “soundtalking” as a practice not only enhances participants’ auditory perception but also fosters a sense of community and belonging. The regularity of monthly meetings facilitated the development of a shared acoustic vocabulary and experience among participants, which in turn enriched their collective and individual experiences of the estuary. Soundtalking is proposed as an additional tool in the study of soundscapes to complement and extend more commonly implemented methods, such as soundwalking and soundsitting. Soundtalking demonstrates the efficacy of longitudinal, participant-led approaches in capturing the dynamic and lived experiences of soundscapes and their associated environments, over methods that only create fleeting short-term engagements with the soundscape. In conclusion, the Our Dee Estuary Project demonstrates the transformative potential of soundtalking in deepening our understanding of human–environment interactions and, in addition, has shown that there are both health and well-being aspects that arise from the practice. Beyond this, the project has output a film and a radio sound piece, which not only document but also celebrate the intricate and evolving relationship between the participants and the estuarine soundscape, offering valuable insights for future soundscape research and community engagement initiatives. Full article

This paper addresses the urgent need to redefine education strategies for the Net Generation in the context of rapid technological and societal changes. First, the educational challenge is placed within a broader philosophical and cultural framework, focusing on the fluid and evolving nature of knowledge and human experience. Building on the paradigm shift from Web 2.0 to Web 4.0 and the emergence of Education 5.0, this paper investigates the pedagogical implications of these developments. Through conceptual analysis supported by contemporary educational theory, this paper proposes a model of education that integrates personalized learning, real-time feedback, and collaborative, interdisciplinary environments. A special focus is placed on the role of educators as mentors, rather than mere transmitters of information, and on the ethical, social, and emotional dimensions of digital learning. This article highlights the importance of adjusting educational practices to real-life contexts and future challenges of young learners while ensuring that the humanistic essence of education is not lost. Full article

In the evolving digital landscape, the pervasive influence of artificial intelligence (AI) on social media platforms reveals a compelling paradox: the capability to provide personalized experiences juxtaposed with inherent biases reminiscent of human imperfections. Such biases prompt rigorous contemplation on matters of fairness, equity, and societal ramifications, and penetrate the foundational essence of AI. Within this intricate context, the present work ventures into novel domains by examining the potential of quantum computing as a viable remedy for bias in artificial intelligence. The conceptual framework of the quantum sentinel is presented—an innovative approach that employs quantum principles for the detection and scrutiny of biases in AI algorithms. Furthermore, the study poses and investigates the question of whether the integration of advanced quantum computing to address AI bias is seen as an excessive measure or a requisite advancement commensurate with the intricacy of the issue. By intertwining quantum mechanics, AI bias, and the philosophical considerations they induce, this research fosters a discourse on the journey toward ethical AI, thus establishing a foundation for an ethically conscious and balanced digital environment. We also show that the quantum Zeno effect can protect SVM hyperplanes from bias through targeted simulations. Full article

This paper explores the perspectives of Master Taixu (太虛, 1890–1947) and Master Hsing Yun (星雲, 1927–2023) on the practice of the Buddhist Five Vehicles (五乘), particularly focusing on the relationship between the Vehicles of Men and Gods (人天乘) and the Bodhisattva Vehicle (菩薩乘). Master Taixu advocated “Buddhism for Human Life” (人生佛教), emphasizing the improvement of real life as the foundation for Buddhist practice in daily life. He proposed the principle of “following the practice and fruition of the Human Vehicle to cultivate the Mahāyāna path” (依人乘行果，趣修大乘行), suggesting a gradual progression from the human vehicle to the Mahāyāna Bodhisattva path. He introduced the concept of “The perfection of human character leads to Buddhahood” (人圓佛即成) and “Present Bodhisattva Practice” (今菩薩行), highlighting the importance of adapting Buddhist practice to contemporary society and actively engaging in social service. Master Hsing Yun’s advocacy of “Humanistic Buddhism” (人間佛教) emphasizes the diversity of practice, asserting that any action aligned with Buddhist teachings, beneficial to human well-being, and conducive to the welfare of all beings constitutes a form of practice, thereby expanding its definition. He elaborated on the Five Vehicles, viewing the Vehicle of Men and Gods as a preliminary stage, advocating a gradual progression towards the Bodhisattva Vehicle, ultimately culminating in Buddhahood. He proposed the principle of “undertaking worldly affairs with an otherworldly mindset” (以出世的思想，做入世的事業), highlighting the importance of practicing the Bodhisattva path in everyday life. With “Buddha Light Pure Land” (佛光淨土) as the ultimate goal, he sought to integrate the essence of various Pure Lands traditions to achieve earthly peace and purification. Both masters highlight the importance of practicing Humanistic Buddhism, advocating for the application of the Bodhisattva practice in daily life, guiding all beings with compassion and wisdom, and actively engaging in society to address real-world issues, ultimately realizing a Humanistic Pure Land. However, their perspectives also differ: Master Taixu focused more on the theoretical construction and an exposition on the order of practice, whereas Master Hsing Yun placed greater emphasis on the diversity and flexibility of practice and the integration of Buddhist teachings into modern life. Full article