Search Results (1,342)

Cancer remains one of the most formidable challenges to human health; hence, developing effective treatments is critical for saving lives. An important strategy involves reactivating tumor suppressor genes, particularly p53, by targeting their negative regulator MDM2, which is essential in promoting cell cycle arrest and apoptosis. Leveraging a drug repurposing approach, we screened over 24,000 clinically tested molecules to identify new MDM2 inhibitors. A key innovation of this work is the development and application of a selective cleaning algorithm that systematically filters assay data to mitigate noise and inconsistencies inherent in large-scale bioactivity datasets. This approach significantly improved the predictive accuracy of our machine learning model for pIC₅₀ values, reducing RMSE by 21.6% and achieving state-of-the-art performance (R² = 0.87)—a substantial improvement over standard data preprocessing pipelines. The optimized model was integrated with structure-based virtual screening via molecular docking to prioritize repurposing candidate compounds. We identified two clinical CB1 antagonists, MePPEP and otenabant, and the statin drug atorvastatin as promising repurposing candidates based on their high predicted potency and binding affinity toward MDM2. Interactions with the related proteins MDM4 and BCL2 suggest these compounds may enhance p53 restoration through multi-target mechanisms. Quantum mechanical (ONIOM) optimizations and molecular dynamics simulations confirmed the stability and favorable interaction profiles of the selected protein–ligand complexes, resembling that of navtemadlin, a known MDM2 inhibitor. This multiscale, accuracy-boosted workflow introduces a novel data-curation strategy that substantially enhances AI model performance and enables efficient drug repurposing against challenging cancer targets. Full article

Beef fat injection technology, used to enhance the perceived quality of lower-grade meat, often results in artificially marbled beef that mimics the visual traits of Wagyu, characterized by dense fat distribution. This practice, driven by the high cost of Wagyu and the affordability of fat-injected beef, has led to the proliferation of mislabeled “Wagyu-grade” products sold at premium prices, posing potential food safety risks such as allergen exposure or consumption of unverified additives, which can adversely affect consumer health. Addressing this, this study introduces a smart sensing system integrated with handheld mobile devices, enabling consumers to capture beef images during purchase for real-time health-focused assessment. The system analyzes surface texture and color, transmitting data to a server for classification to determine if the beef is artificially marbled, thus supporting informed dietary choices and reducing health risks. Images are processed by applying a region of interest (ROI) mask to remove background noise, followed by partitioning into grid blocks. Local binary pattern (LBP) texture features and RGB color features are extracted from these blocks to characterize surface properties of three beef types (Wagyu, regular, and fat-injected). A support vector machine (SVM) model classifies the blocks, with the final image classification determined via majority voting. Experimental results reveal that the system achieves a recall rate of 95.00% for fat-injected beef, a misjudgment rate of 1.67% for non-fat-injected beef, a correct classification rate (CR) of 93.89%, and an F1-score of 95.80%, demonstrating its potential as a human-centered healthcare tool for ensuring food safety and transparency. Full article

We propose a data-efficient framework for automating sowing operations by agricultural robots in densely mixed polyculture environments. This study addresses the challenge of enabling robots to identify suitable sowing positions with minimal labeled data by integrating image-based field sensing with expert agricultural knowledge. We collected 84 RGB-depth images from seven field sites, labeled by synecological farming practitioners of varying proficiency levels, and trained a regression model to estimate optimal sowing positions and seeding quantities. The model’s predictions were comparable to those of intermediate-to-advanced practitioners across diverse field conditions. To implement this estimation in practice, we mounted a Kinect v2 sensor on a robot arm and integrated its 3D spatial data with axis-specific movement control. We then applied a trajectory optimization algorithm based on the traveling salesman problem to generate efficient sowing paths. Simulated trials incorporating both computation and robotic control times showed that our method reduced sowing operation time by 51% compared to random planning. These findings highlight the potential of interpretable, low-data machine learning models for rapid adaptation to complex agroecological systems and demonstrate a practical approach to combining structured human expertise with sensor-based automation in biodiverse farming environments. Full article

In recent years, heavy metal contamination in agricultural products has become a growing concern in the field of food safety. Copper (Cu) stress in crops not only leads to significant reductions in both yield and quality but also poses potential health risks to humans. This study proposes an efficient and precise non-destructive detection method for Cu stress in oilseed rape, which is based on hyperspectral false-color image construction using principal component analysis (PCA). By comprehensively capturing the spectral representation of oilseed rape plants, both the one-dimensional (1D) spectral sequence and spatial image data were utilized for multi-class classification. The classification performance of models based on 1D spectral sequences was compared from two perspectives: first, between machine learning and deep learning methods (best accuracy: 93.49% vs. 96.69%); and second, between shallow and deep convolutional neural networks (CNNs) (best accuracy: 95.15% vs. 96.69%). For spatial image data, deep residual networks were employed to evaluate the effectiveness of visible-light and false-color images. The RegNet architecture was chosen for its flexible parameterization and proven effectiveness in extracting multi-scale features from hyperspectral false-color images. This flexibility enabled RegNetX-6.4GF to achieve optimal performance on the dataset constructed from three types of false-color images, with the model reaching a Macro-Precision, Macro-Recall, Macro-F₁, and Accuracy of 98.17%, 98.15%, 98.15%, and 98.15%, respectively. Furthermore, Grad-CAM visualizations revealed that latent physiological changes in plants under heavy metal stress guided feature learning within CNNs, and demonstrated the effectiveness of false-color image construction in extracting discriminative features. Overall, the proposed technique can be integrated into portable hyperspectral imaging devices, enabling real-time and non-destructive detection of heavy metal stress in modern agricultural practices. Full article

Landslide is one of the most damaging natural hazards, causing extensive damage to the infrastructure and threatening human life. Although advances have been made in landslide susceptibility assessment by objective explainable machine learning, the interpretability robustness of traditional single landslide susceptibility model is still low. The proposed interpretable hybrid model in this study overcomes these challenges and aims to enhance the stability of landslide susceptibility interpretability. The model integrates three base machine learning models—LightGBM, XGBoost, and Random Forest—using a heterogeneous category strategy, thereby enhancing the robustness of model interpretability. The hybrid model is interpreted using SHAP (Shapley Additive Explanations) values, which quantify feature contributions. A 10-fold cross-validation with the coefficient of variation (CV) metric reveals that the hybrid model outperforms individual base models in terms of interpretive robustness, yielding a lower CV value of 0.175 compared to 0.208 for LightGBM, 0.240 for XGBoost, and 0.207 for the Random Forest model. Although predictive accuracy remains comparable to the baseline models, the hybrid model provides more stable and reliable interpretability results for landslide susceptibility. It identifies the slope, elevation, and LS factor as the three most important factors for landslide susceptibility in Xi’an city. Furthermore, the quantitative nonlinear relationships between these predisposing factors and susceptibility were identified, providing empowering knowledge for the landslides risk prevention and urban planning in the regions vulnerable to landslides. Full article

Although artificial intelligence technologies have significantly enhanced autonomous robots’ capabilities in perception, decision-making, and planning, their autonomy may still fail when faced with complex, dynamic, or unpredictable environments. Therefore, it is critical to enable users to take over robot control in real-time and efficiently through teleoperation. The lightweight, wearable myoelectric armband, due to its portability and environmental robustness, provides a natural human–robot gesture interaction interface. However, current myoelectric teleoperation gesture control faces two major challenges: (1) poor intuitiveness due to visual-motor misalignment; and (2) low efficiency from discrete, single-degree-of-freedom control modes. To address these challenges, this study proposes an integrated myoelectric teleoperation interface. The interface integrates the following: (1) a novel hybrid reference frame aimed at effectively mitigating visual-motor misalignment; and (2) a finite state machine (FSM)-based control logic designed to enhance control efficiency and smoothness. Four experimental tasks were designed using different end-effectors (gripper/dexterous hand) and camera viewpoints (front/side view). Compared to benchmark methods, the proposed interface demonstrates significant advantages in task completion time, movement path efficiency, and subjective workload. This work demonstrates the potential of the proposed interface to significantly advance the practical application of wearable myoelectric sensors in human–robot interaction. Full article

Urban vegetation shows significant spatial differences due to the combined effects of natural and human factors, yet fine-scale evolutionary patterns and their cross-scale feedback mechanisms remain limited. This study focuses on the Yangtze River Delta (YRD), the top economic area in China. By integrating data from multiple Landsat sensors, we built a high—resolution framework to track vegetation dynamics from 1990 to 2020. It generates annual 30-m Enhanced Vegetation Index (EVI) data and uses a new Vegetation Green—Brown Balance Index (VBI) to measure changes between greening and browning. We combined Mann-Kendall trend analysis with machine—learning based attribution analysis to look into vegetation changes across different city types and urban—rural gradients. Over 30 years, the YRD’s annual EVI increased by 0.015/10 a, with greening areas 3.07 times larger than browning. Spatially, urban centers show strong greening, while peri—urban areas experience remarkable browning. Vegetation changes showed a city-size effect: larger cities had higher browning proportions but stronger urban cores’ greening trends. Cluster analysis finds four main evolution types, showing imbalances in grey—green infrastructure allocation. Vegetation baseline in 1990 is the main factor driving the long-term trend of vegetation greenness, while socioeconomic and climate drivers have different impacts depending on city size and position on the urban—rural continuum. In areas with low urbanization levels, climate factors matter more than human factors. These multi-scale patterns challenge traditional urban greening ideas, highlighting the need for vegetation governance that adapts to specific spatial conditions and city—unique evolution paths. Full article

The growing global demand for energy has resulted in a demand for innovative strategies for residential energy management. This study explores a novel framework—MELISSA (Modern Energy LLM-IoE Smart Solution for Automation)—that integrates Internet of Things (IoT) sensor networks with Large Language Models (LLMs) to optimize household energy consumption through intelligent automation and personalized interactions. The system combines real-time monitoring, machine learning algorithms for behavioral analysis, and natural language processing to deliver personalized, actionable recommendations through a conversational interface. A 12-month randomized controlled trial was conducted with 100 households, which were stratified across four socioeconomic quintiles in metropolitan areas. The experimental design included the continuous collection of IoT data. Baseline energy consumption was measured and compared with post-intervention usage to assess system impact. Statistical analyses included k-means clustering, multiple linear regression, and paired t-tests. The system achieved its intended goal, with a statistically significant reduction of 5.66% in energy consumption (95% CI: 5.21–6.11%, $p<0.001$) relative to baseline, alongside high user satisfaction (mean = 7.81, SD = 1.24). Clustering analysis ($k=4$, silhouette = 0.68) revealed four distinct energy-consumption profiles. Multiple regression analysis ($R^2=0.68$, $p<0.001$) identified household size, ambient temperature, and frequency of user engagement as the principal determinants of consumption. This research advances the theoretical understanding of human–AI interaction in energy management and provides robust empirical evidence of the effectiveness of LLM-mediated behavioral interventions. The findings underscore the potential of conversational AI applications in smart homes and have practical implications for optimization of residential energy use. Full article

The Beijing–Tianjin–Hebei (BTH) region is one of China’s most water-scarce yet economically vital areas, facing increasing challenges due to climate change and intensive human activities. This study develops an integrated Water–Food–Energy–Ecology (WFEE) simulation and regulation model to assess the system’s stability under coordinated development scenarios and extreme climate stress. A 500-year precipitation series was reconstructed using historical drought and flood records combined with wavelet analysis and machine learning models (Random Forest and Support Vector Regression). Results show that during the reconstructed historical megadrought (1633–1647), with average precipitation anomalies reaching −20% to −27%, leading to a regional water shortage rate of 16.9%, food self-sufficiency as low as 44.7%, and a critical reduction in ecological river discharge. Under future recommended scenario with enhanced water conservation, reclaimed water reuse, and expanded inter-basin transfers, the region could maintain a water shortage rate of 2.6%, achieve 69.3% food self-sufficiency, and support ecological water demand. However, long-term water resource degradation could still reduce food self-sufficiency to 62.9% and ecological outflows by 20%. The findings provide insights into adaptive water management, highlight the vulnerability of highly coupled systems to prolonged droughts, and support regional policy decisions on resilience-oriented water infrastructure planning. Full article

Understanding and mapping forest fire vulnerability is essential for informed landscape management and disaster risk reduction, especially in the context of increasing anthropogenic and climatic pressures. This study aims to model and spatially predict forest fire vulnerability across Romania using two machine learning algorithms: MaxEnt and XGBoost. We integrated forest fire occurrence data from 2006 to 2024 with a suite of climatic, topographic, ecological, and anthropogenic predictors at a 250 m spatial resolution. MaxEnt, based on presence-only data, achieved moderate predictive performance (AUC = 0.758), while XGBoost, trained on presence–absence data, delivered higher classification accuracy (AUC = 0.988). Both models revealed that the impact of environmental variables on forest fire occurrence is complex and heterogeneous, with the most influential predictors being the Fire Weather Index, forest fuel type, elevation, and distance to human proximity features. The resulting vulnerability and uncertainty maps revealed hotspots in Sub-Carpathian and lowland regions, especially in Mehedinți, Gorj, Dolj, and Olt counties. These patterns reflect historical fire data and highlight the role of transitional agro-forested landscapes. This study delivers a replicable, data-driven approach to wildfire risk modelling, supporting proactive management and emphasising the importance of integrating vulnerability assessments into planning and climate adaptation strategies. Full article

Electrospun nanofiber-based triboelectric nanogenerators (TENGs) have emerged as a highly promising class of self-powered sensors for a broad range of applications, particularly in intelligent sensing technologies. By combining the advantages of electrospinning and triboelectric nanogenerators, these sensors offer superior characteristics such as high sensitivity, mechanical flexibility, lightweight structure, and biocompatibility, enabling their integration into wearable electronics and biomedical interfaces. This review presents a comprehensive overview of recent progress in electrospun nanofiber-based TENGs, covering their working principles, operating modes, and material composition. Both pure polymer and composite nanofibers are discussed, along with various electrospinning techniques that enable control over morphology and performance at the nanoscale. We explore their practical implementations in both contact-type and non-contact-type sensing, such as human–machine interaction, physiological signal monitoring, gesture recognition, and voice detection. These applications demonstrate the potential of TENGs to enable intelligent, low-power, and real-time sensing systems. Furthermore, this paper points out critical challenges and future directions, including durability under long-term operation, scalable and cost-effective fabrication, and seamless integration with wireless communication and artificial intelligence technologies. With ongoing advancements in nanomaterials, fabrication techniques, and system-level integration, electrospun nanofiber-based TENGs are expected to play a pivotal role in shaping the next generation of self-powered, intelligent sensing platforms across diverse fields such as healthcare, environmental monitoring, robotics, and smart wearable systems. Full article

As a crucial ecological barrier in China, the Greater Khingan Mountains play a vital role in global ecological security. Investigating the spatiotemporal variations in fractional vegetation cover (FVC) and the driving mechanisms behind its spatial differentiation is essential. This study introduced a KNDVI-XGeoML framework integrating the Kernel NDVI and explainable geospatial machine learning to analyze the FVC dynamics and the mechanisms driving their spatial differentiation in China’s Greater Khingan Mountains, based on which targeted ecological management strategies were proposed. The key findings reveal that (1) from 2001 to 2022, FVC showed an increasing trend, confirming the effectiveness of ecological restoration. (2) The XGeoML model successfully revealed nonlinear relationships and threshold effects between driving factors and FVC. In addition, both single-factor importance and inter-factor interaction analyses consistently showed that landform factors dominated the spatial distribution of FVC. (3) Regional heterogeneity emerged—human activities drove the northern alpine zones, while landform factors governed other areas. (4) The natural-environment-dominated zones and human-activity-dominated zones were established, and management strategies were proposed: restricting tourism in low-altitude zones, optimizing the cold-resistant vegetation at high elevations, and improving the southern soil conditions to support ecological barrier construction. The innovation lies in merging nonlinear vegetation indices with interpretable machine learning, overcoming the traditional limitations in terms of saturation effects and analyses of spatial heterogeneity. This approach enhances our understanding of high-latitude vegetation dynamics, offering a methodological advancement for precision ecological management. The spatial zoning strategy based on dominant drivers provides actionable insights for maintaining this critical ecological barrier, particularly under climate change pressures. The framework demonstrates strong potential for extrapolation to other ecologically sensitive regions requiring data-driven conservation planning. Full article

The automation of smart building design processes remains a significant challenge, particularly in translating complex natural language requirements into structured design parameters within Computer-Aided Design (CAD) environments. Traditional design workflows rely heavily on manual input, which can be inefficient, error-prone, and time-consuming, limiting the integration of adaptive, real-time inputs. To address this issue, this study proposes an intelligent Natural Language Processing (NLP)-based workflow for automating the conversion of design briefs into CAD-readable parameters. This study proposes a five-step integration framework that utilizes NLP to extract key design requirements from unstructured inputs such as emails and textual descriptions. The framework then identifies optimal integration points—such as APIs, direct database connections, or plugin-based solutions—to ensure seamless adaptability across various CAD systems. The implementation of this workflow has the potential to enable the automation of routine design tasks, reducing the reliance on manual data entry and enhancing efficiency. The key findings demonstrate that the proposed NLP-based approach may significantly streamline the design process, minimize human intervention while maintaining accuracy and adaptability. By integrating NLP with CAD environments, this study contributes to advancing intelligent design automation, ultimately supporting more efficient, cost-effective, and scalable smart building development. These findings highlight the potential of NLP to bridge the gap between human input and machine-readable data, providing a transformative solution for the architectural and construction industries. Full article

In the context of rapidly evolving industrial ecosystems, the human–machine interaction (HMI) has shifted from basic interface control toward complex, adaptive, and human-centered systems. This review explores the multidisciplinary foundations and technological advancements driving this transformation within Industry 4.0 and the emerging paradigm of Industry 5.0. Through a comprehensive synthesis of the recent literature, we examine the cognitive, physiological, psychological, and organizational factors that shape operator performance, safety, and satisfaction. A particular emphasis is placed on ergonomic interface design, real-time physiological sensing (e.g., EEG, EMG, and eye-tracking), and the integration of collaborative robots, exoskeletons, and extended reality (XR) systems. We further analyze methodological frameworks such as RULA, OWAS, and Human Reliability Analysis (HRA), highlighting their digital extensions and applicability in industrial contexts. This review also discusses challenges related to cognitive overload, trust in automation, and the ethical implications of adaptive systems. Our findings suggest that an effective HMI must go beyond usability and embrace a human-centric philosophy that aligns technological innovation with sustainability, personalization, and resilience. This study provides a roadmap for researchers, designers, and practitioners seeking to enhance interaction quality in smart manufacturing through cognitive ergonomics and intelligent system integration. Full article

Human Factors and Ergonomics (HF/E) play an essential role in the development of sustainable manufacturing systems. By prioritizing worker wellbeing through the mitigation of occupational hazards and the enhancement of workplace health, HF/E contributes significantly to improved system performance. In accordance with the principles of Industry 5.0 and Society 5.0, which emphasize human-centered design and wellbeing, organizations that effectively integrate HF/E principles can achieve a competitive advantage on the market. Based on a globally recognized ranking system utilized by investors in making informed decisions, the study focuses on manufacturing companies ranked by their occupational health and safety (OHS) scores, a key criterion for assessing the social dimension of company performance. This research aims to identify and analyze top-ranked companies that explicitly highlight HF/E-related benefits within their public documents and sustainability reports. The paper investigates aspects related to the integration of AI and digital technologies to enhance safety and health in manufacturing systems, with a specific focus on human presence detection in hazardous zones, improvements in machines and equipment design, occupational risk assessments, and initiatives for enhancing worker wellbeing. The findings are expected to provide compelling evidence for companies to prioritize HF/E consideration during the design and redesign phases of sustainable manufacturing systems. The paper provides significant value to non-indexed companies by offering a dual approach for improving OHS performance, based on an empirical evaluation assessment method and practical strategies for effective OHS implementation in different manufacturing industries and countries. Full article