Search Results (78)

Intergenerational trauma significantly affects the health and mental health of African American families, particularly women whose lives are shaped by systemic inequities and historical oppression. This scoping review examines how trauma and resilience are transmitted across generations in African American communities, with a focus on dyads such as mother–child and mother–daughter relationships and a conceptual grandmother–mother–daughter triad. The review aims to identify mechanisms of trauma transmission and resilience and to inform culturally responsive, multigenerational interventions. Peer-reviewed studies published between 2012 and 2025 were identified that included African American caregivers and children and addressed biological, psychological, social, cultural, and resilience dimensions of intergenerational processes. Data were synthesized using a dimensional conceptual analysis approach. Findings indicate that intergenerational trauma is perpetuated through chronic stress and discrimination, maternal mental health challenges, family structure and caregiving strain, and cultural narratives about strength and self-reliance. At the same time, resilience is transmitted through sensitive caregiving, spirituality and faith, social and kin support, racial socialization, and economic survival strategies that draw on cultural and historical knowledge. These results underscore the importance of addressing intergenerational trauma holistically by integrating dyadic evidence within a broader conceptual triadic framework. Culturally responsive, multigenerational interventions that leverage family and community strengths and make space for emotional vulnerability are essential for interrupting cycles of trauma and fostering healing within African American families. Full article

Mastectomy, while a life-saving intervention for breast cancer, often leads to profound psychological and emotional challenges for affected women. Feelings of loss altered body image, and anxiety about recurrence can significantly impact mental well-being. This study aimed to explore and describe the experiences of women after mastectomy at Mankweng Tertiary Hospital in Limpopo Province, South Africa. In this study, a qualitative phenomenological design was used. Data were collected through semi-structured in-depth interviews with women who had undergone mastectomy. Fifteen participants were purposively sampled, and thematic analysis was used to identify key patterns and meanings in their narratives. The findings revealed that the participants initially described feelings of being ‘disabled’, incomplete, and anxious about cancer recurrence or their ability to perform maternal functions such as breastfeeding. However, over time, many developed resilience and acceptance, seeing surgery as a life-saving measure and an opportunity for renewal. The adjustment of women after mastectomy is a complicated emotional transition from crisis and loss to adjustment and empowerment. The results identify the need for holistic psychosocial support that combines counseling, peer networks, and education for their family members addressing their emotional healing, body image, and social reintegration. Full article

Migrant populations drive Canada’s demographic expansion, making their successful integration a national priority. However, research has consistently shown that refugees and immigrants experience declining mental health and encounter significant barriers to accessing culturally appropriate mental health support. This scoping review examined the breadth of evidence on culturally adapted mental health education (MHE) programs for migrant populations, including those that integrate traditional and complementary healing practices, and their effectiveness. Systematic searches across six databases (Medline, EMBASE, PsycINFO, Global Health, CINAHL, and Scopus) identified 4075 peer-reviewed articles, with 28 studies meeting inclusion criteria. These included mental health education and awareness programs that integrate psychoeducation and skill-building. Inclusion criteria required cultural adaptation of programs through one or more approaches such as language modification, culturally adapted content, community-based delivery, or integration of traditional and complementary healing practices. Thematic analysis of the programs revealed seven key themes characterizing effective MHE programs: cultural adaptation and sensitivity, addressing unique migration-related stressors, integration of traditional and Western approaches, use of theoretical frameworks and evidence-based practices, rigorous evaluation methodologies, application of holistic frameworks, and community-based peer support models. Programs predominantly utilized psychoeducation and culturally adapted interventions, with common theoretical frameworks including cognitive–behavioral therapy and the PRECEDE–PROCEED model. Across the reviewed studies, program evaluations reported positive outcomes including increased mental health literacy, reduced stigma, enhanced coping skills, and decreased depression, anxiety, and PTSD symptoms, suggesting that culturally adapted MHE programs are acceptable and feasible interventions for migrant populations. Full article

Severe lost circulation frequently occurs in deep and ultra-deep wells under high-temperature/high-pressure (HPHT) conditions and in fracture-cavity composite loss channels. Conventional lost-circulation materials (LCMs) often fail because of premature loss of mobility, insufficient residence in loss paths, and irreversible failure after solidification. Cement-based sealing systems, owing to their ability to plug large leakage channels and their cost-effectiveness, have become the mainstream solution. To improve their performance under extreme downhole conditions, recent studies have focused on base-cement design, reinforcement phases, and property regulation strategies-including the use of granular/fibrous/nanoscale additives for bridging reinforcement, rheology and thickening control to enhance injectability and residence, and chemical/functional modifiers to improve compactness and durability of the hardened matrix. Significant progress has been achieved in terms of HPHT resistance, densification design, regulation of rheological properties and thickening behavior, and self-healing/responsive sealing functions. However, most existing studies still focus on improving individual properties and lack a cross-scale, holistic design and unified mechanistic perspective for fracture-cavity coupled flow and long-term sealing stability. Distinct from previous reviews that mainly catalogue material types or discuss single-performance optimization, this review is framed by fracture-cavity composite loss channels and long-term sealing requirements under HPHT conditions, systematically synthesizes the material design strategies, reinforcement mechanisms and applicability boundaries of cement-based plugging systems, builds cross-scale linkages among these aspects, and proposes future research directions toward sustainable plugging design. Full article

Background: This study reports on a community engagement knowledge-translation world café hosted in British Columbia, built on the research project “Enhancing cancer navigation for newly diagnosed, treated and post-treatment of people living with breast cancer in interior region”. The aim was to co-create a knowledge translation initiative with community stakeholders to enhance interdisciplinary approaches to psychosocial oncology. Methods: This study drew on implementation science and the consolidated framework for implementation research, which emphasize the importance of creating partnerships between researchers and engaging people for whom the research is meant to be of use—knowledge users and service users. Guided world café and purposeful sampling were used to engage a diverse range of stakeholders. Eighty stakeholders participated in this study from April 2023 to April 2024. Thematic analysis was conducted through familiarization, coding, theme development, review, definition, and reporting. Results: Eleven key themes emerged, including compassionate connection, time as a healing gift, empowering health literacy, informed compassion, holistic support ecosystem, empowering patient navigators, shared decision-making, empowering partnerships, digital–physical synergy, person-centered transformation, and accountability and collaboration. Conclusions: The key findings highlighted the need for continuous professional development for primary care providers, integrating patient-reported outcomes in electronic health records, leveraging digital health tools, and establishing community-engaged psychosocial oncology hubs to enhance care in rural communities. Recommendation: Recommendations include ongoing professional learning, embedding patient voices and lived experiences into care planning through digital tools, and empowering rural and diverse communities through inclusive and accessible cancer models of care. Full article

Background/Objectives: Integrating behavioral health and primary care services is a national public health priority in the US, especially in underserved settings like northern Arizona. This healthcare delivery model is crucial to meet the mental and physical health needs of people with SU/SUDs, particularly those belonging to culturally diverse populations. In collaboration with a behavioral health center in northern Arizona, the current study aimed to assess the perspectives of providers and administrative staff on the implementation of integrated primary care (IPC) services for people with SU/SUDs. Methods: In February 2023, twelve healthcare providers and administrative staff from diverse educational backgrounds were recruited using purposive sampling to capture a range of perspectives on IPC implementation at the behavioral health center. Participants completed individual, semi-structured interviews conducted via Zoom, which were audio recorded and lasted approximately 30 min. The interview recordings were transcribed verbatim using Trint Software, and analyzed on Google Docs using applied thematic analysis. Two researchers coded the transcripts, iteratively developing and refining themes through multiple cycles of review and team discussions. Additional team members provided feedback and verified the themes, with consensus reached through collaborative meetings. This rigorous, iterative approach ensured the reliability and validity of the final thematic framework. Results: We found that IPC supports SU/SUDs recovery by providing holistic care that integrates medical, mental health, and addiction services while addressing social and co-occurring needs. It fosters an empathetic environment where clients do not need to repeatedly disclose their SU/SUDs, improves access to preventive care, and offers continuous support and education. Implementation barriers included workforce shortages, limited internal communication, and insufficient interdisciplinary training. Gaps in culturally centered care were identified, including reliance on Western models, limited representation of Native American and sexual and gender minority staff, and inconsistent use of inclusive practices such as pronouns, traditional healing, and trauma-informed approaches. Additionally, community partnerships with multisectoral organizations help clients access supportive resources beyond the facility, including vision care, clothing, and dental services. Conclusions: The implementation of IPC was seen as important to support the behavioral health center in northern Arizona to foster an empathetic environment where clients with SU/SUDs can have their mental, physical, and social needs addressed, either within the facility or through community partnerships, thereby supporting their recovery. However, progress is hindered by barriers such as workforce shortages, limited internal communication, and insufficient interdisciplinary care training. Additionally, despite regular cultural competency training, gaps remain in culturally centered care for underserved populations, particularly Native American and sexual and gender minority clients. Full article

Background: Chronic skin ulcers are characterized by an impaired and delayed wound healing process, posing a major economic and healthcare burden. These multifactorial conditions are influenced by both biological, clinical and psychosocial factors. The aim of our cross-sectional study was to investigate the influence of psychosocial and lifestyle factors—specifically adherence to the Mediterranean diet, emotional health, sleep quality and demographic characteristics—on physical symptoms and clinical severity in patients with skin ulcers, using a multidisciplinary approach to identify key predictors of disease burden. Methods: A cross-sectional analysis was conducted on patients with skin ulcers, using data from a monocentric pathology registry. Collected variables included gender, age, dietary habits (specifically, adherence to the Mediterranean diet), sleep disturbances, educational level, anxiety and depressive symptoms, Physician Global Assessment (PGA), Patient Global Assessment (PtGA), and Skindex-17 (a dermatology-specific quality of life measure). Hierarchic multivariate linear regression models were applied to identify predictors of physical symptoms and clinical severity, while simultaneously controlling for potential confounders. Results: Older age, poorer adherence to the Mediterranean diet, and elevated anxiety levels emerged as the strongest predictors of worse physical symptoms, as measured by the Skindex-17. Male sex and more severe depressive symptoms were significantly associated with higher PGA scores. Our data also suggest older age and poorer Mediterranean diet adherence to influence clinical severity. Lastly, sleep disturbances were also found to correlate with patient-reported severity. Conclusions: Our study underscores the impact of psychosocial and behavioral/lifestyle factors on the clinical burden of skin ulcers through a comprehensive multidisciplinary approach. In particular, our data indicate that dietary patterns and emotional health appear to shape both symptom perception and clinical evaluation, emphasizing the need for holistic management strategies. Full article

Background: Conventional rehabilitation after anterior cruciate ligament reconstruction often follows a rigid, phase-based model. This structure may overlook individual differences in healing, neuromuscular control, and psychological readiness, leading to low return-to-sport rates and a high risk of reinjury. Methods: This narrative review proposes a flexible rehabilitation framework based on overlapping progression blocks. Inspired by principles of strength and conditioning, motor learning, and cognitive training, this model emphasizes continuous, individualized development instead of fixed timelines. Results: The proposed model integrates essential components—such as joint mobility, muscle activation, motor control, and psychological factors—throughout the entire recovery process. Functional testing is redefined as a dynamic and ongoing diagnostic tool that helps clinicians identify areas needing further development, rather than acting as a simple pass/fail gateway. Progression is guided by demonstrated readiness rather than time or phase completion. Conclusions: Rehabilitation using adaptive, overlapping progression blocks offers a more holistic and responsive approach. It allows for better personalization, supports safer decision-making, and improves the transition back to sport through sustained development of physical and cognitive capacities. Full article

Background/Objectives: Caring–healing modalities (CHMs), i.e., non-pharmacological, nurse-led interventions rooted in caring science, have shown promise in reducing emotional distress, while enhancing resilience. CHMs are heterogeneous, making it challenging to determine how they are formulated to build resilience, mitigate emotional distress, and explore their mechanisms of action. This scoping review mapped the literature on CHMs, including their components, targeted outcomes, and measures. Methods: This review was conceptually driven by Watson’s Theory of Human Caring, followed the JBI methodology, and reported according to the PRISMA-ScR. Experimental studies, systematic reviews, opinion pieces, and the gray literature on CHMs for emotional distress and resilience delivered to persons with cancer, written in English, were considered. No date or setting limits were applied. Eleven databases (e.g., PubMed and CINAHL Full Text), were searched. Two independent reviewers screened, selected, and extracted the data. The results were interpreted using Watson’s theory. Results: We included 16 records (2016–2025), mostly from the United States (n = 4; 25%) and China (n = 6; 37.5%). The CHMs mainly targeted persons with breast cancer. The CHMs were categorized into four groups: mindfulness-based, group-based, expressive, and educational. Common active ingredients included peer support and group discussions. Dedicated healing spaces facilitated CHMs delivery; mode of delivery and dose varied widely. Conclusions: This review provides a foundational understanding of CHMs as a caring-based, holistic approach to cancer survivorship. Findings identify CHMs’ key components, including active ingredients, mode of delivery, and dose. Future studies should ensure diversity in terms of cancer type, as most existing studies focused on breast cancer. Full article

Keratinocytes are the primary cells of the epidermis layer in our skin. They play a crucial role in maintaining skin health, responding to injuries, and counteracting disease progression. Understanding their behaviour is essential for advancing wound healing therapies, improving outcomes in regenerative medicine, and developing numerical models that accurately mimic skin deformation. To create physically representative models, it is essential to evaluate the nuanced ways in which keratinocytes deform, interact, and respond to mechanical and biochemical signals. This has prompted researchers to investigate various computational methods that capture these dynamics effectively. This review summarises the main mathematical and biomechanical modelling techniques (with particular focus on the literature published since 2010). It includes reaction–diffusion frameworks, finite element analysis, viscoelastic models, stochastic simulations, and agent-based approaches. We also highlight how machine learning is being integrated to accelerate model calibration, improve image-based analyses, and enhance predictive simulations. While these models have significantly improved our understanding of keratinocyte function, many approaches rely on idealised assumptions. These may be two-dimensional unicellular analysis, simplistic material properties, or uncoupled analyses between mechanical and biochemical factors. We discuss the need for multiscale, integrative modelling frameworks that bridge these computational and experimental approaches. A more holistic representation of keratinocyte behaviour could enhance the development of personalised therapies, improve disease modelling, and refine bioengineered skin substitutes for clinical applications. Full article

Carbon nanotubes (CNTs) have remarkable mechanical, electrical, and thermal properties, making them highly attractive as foundational elements for advanced materials. However, translating their nanoscale potential into macroscale reliability and longevity requires a holistic design approach that integrates precise architectural control with robust damage mitigation strategies. This review presents a synergistic perspective on enhancing the durability of CNT-based systems by critically examining the interplay between molecular assembly, self-repair mechanisms, and the advanced characterization techniques required for their validation. We first establish how foundational architectural control—achieved through strategies like chemical functionalization, field-directed alignment, and dispersion—governs the ultimate performance of CNT materials. A significant focus is placed on advanced functionalization, such as fluorination, and its verification using high-powered spectroscopic tools, including X-ray photoelectron spectroscopy (XPS) and near-edge X-ray absorption fine structure (NEXAFS) spectroscopy. Subsequently, this manuscript delves into the mechanisms of self-repair, systematically analyzing both the intrinsic capacity of the carbon lattice to heal atomic-level defects and the extrinsic strategies that incorporate engineered healing agents into composites. This discussion is uniquely supplemented by an exploration of the experimental techniques, such as electron energy loss spectroscopy (EELS) and Auger electron spectroscopy (AES), that provide crucial evidence for irradiation-induced healing dynamics. Finally, we argue that a “characterization gap” has limited the field’s progress and highlight the critical role of techniques like in situ Raman spectroscopy for quantitatively monitoring healing efficiency at the molecular level. By identifying current challenges and future research frontiers, this review underscores that the creation of truly durable materials depends on an integrated understanding of how to build, repair, and precisely measure CNT-based systems. Full article

Black Canadians are one of the fastest-growing groups in Canada, with 59% of this population comprising immigrants. Ongoing systemic racism and discrimination have serious consequences for the mental health of Black Canadians. While research and policy efforts to address the mental health needs of this population are ongoing, a greater understanding of the healing practices relevant to this diverse population is needed. This scoping review synthesized and discussed key features of culturally inclusive, affirming, and contextually relevant approaches and practices for mental health care and healing with Black Canadians, as well as identified limitations and gaps in the current research. This study followed the PRISMA guidelines for scoping reviews and conducted a search in PsycINFO, MEDLINE, Embase, SocINDEX, CINAHL, Sociological Abstracts, and Global Health in October 2023. A total of 34 articles met the inclusion criteria. The review identified that most studies were conducted in one Canadian province (i.e., Ontario) and involved diverse perspectives, including service users and providers. The thematic review of articles revealed limited research regarding specific interventions, but identified many commonly reported features of culturally and contextually relevant approaches to mental health care and healing for Black Canadians that broaden the scope of mental health care beyond Euro-Western clinical models, including taking a holistic and empowerment-based approach, engaging in culturally affirming care, a social justice approach, community-centred and collaborative healing, and the necessity of practitioner education. Recommendations for practice, policy, education, and research are provided to support more inclusive and responsive mental health care systems for Black Canadians. Full article

Eczema is the most common skin disease among Hong Kong’s adults and children, affecting an estimated 30% of the total population. Western and Chinese medicinal ointments are the usual treatment for eczema. Conventional Western medicinal ointments are topical corticosteroids and non-steroidal agents. Eczema skin products include “Aveeno Parabens Lotion”, “Cerave Moisturizing Cream”, and “Cetaphil Lotion”. However, these are not a long-term solution for managing significant erythema. Chinese medicinal ointments are based on adjusting the formula, including the ingredients and amount, to address an individual’s skin condition and other factors that may be worsening symptoms. This approach aims to regulate the immune system and make it less reactive to environmental and food allergies. This approach is mainly for local topical use. The ingredients of eczema skin products should include Coptis chinensis Franch, Phellodendron chinense Schneid, Angelica sinensis (Oliv.) Diels, Rehmannia glutinosa Libosch, Curcuma longa L., and sesame oil. Chinese medicinal ointments are natural ingredients, personalized formulas, and concerned with holistic healing, while Western medicinal ointments provide fast-acting relief, targeted action, and a standardized dosage. Methods: Nine electronic databases, such as WanFang Data, PubMed, Science Direct, Scopus, Web of Science, Springer Link, SciFinder, and the China National Knowledge Infrastructure (CNKI), were searched mainly within the past twenty years and without any language restrictions. The inclusion criteria were the keywords “Western medicine and ointment”, “Chinese medicine and ointment”, and “Western and Chinese medicines and ointment”. Differences in effectiveness between Western and Chinese ointments were evaluated to determine if they had functions against eczema. This review included an analysis and summary of all relevant papers. Results: Western medicinal ointments are topical corticosteroids, and they exert their pharmacological activities via many mechanisms, including anti-inflammatory, immunosuppressive, antiproliferative, and vasoconstrictive effects on eczema. Similarly, Chinese medicinal ointments have the same pharmacological functions, but they may focus on the immune system for the treatment of inflammatory and skin conditions, including erythema, edema, dryness, desquamation, and callus exfoliation. Conclusion: Based on the clinical research, the effectiveness rate of integrated Chinese and Western medicines was 88%, which was greater than the 70% rate for using Western medicine alone to treat eczema. Western and Chinese medicinal ointments have different active ingredients with advantages and disadvantages for eczema or when acting as skin care products. The most important thing is knowing “How” to use Western and Chinese medicinal ointments properly, especially for some formulations of Chinese ointments. It may be beneficial to consider the pharmacokinetic studies of herbal ingredients, which offer personalized formulas tailored to individual body constitutions and conditions, as well as to emphasize holistic healing, addressing both symptoms and underlying imbalances in the body. Much more work needs to be carried out, such as safety assessments of these ointments for use as skin care products for eczema. Full article

Intestinal regeneration is essential for maintaining epithelial integrity and repairing mucosal damage caused by inflammation, infections, or injuries. Traditional Chinese Medicine (TCM) has long utilized herbal remedies for gastrointestinal disorders, and accumulating evidence highlights that natural compounds derived from TCM possess significant regenerative potential. This review summarizes the multifaceted mechanisms by which these bioactive compounds promote intestinal healing. Key actions include the stimulation of intestinal stem cell (ISC) proliferation and differentiation, the modulation of inflammatory responses, the reinforcement of epithelial barrier integrity, the attenuation of oxidative stress, and the reshaping of the gut microbiota. Representative compounds such as Astragalus polysaccharides, berberine, curcumin, puerarin, and flavonoids like quercetin exhibit these effects through signaling pathways, including HIF-1, Wnt/β-catenin, NF-κB, Nrf2, and IL-22. Evidence from in vitro organoid models and in vivo studies in colitis, radiation injury, antibiotic-associated diarrhea, and intestinal dysmotility and diarrhea models demonstrates that these compounds enhance crypt villus regeneration, preserve tight junctions, and improve clinical outcomes. The holistic, multi-target actions of Chinese medicine-derived natural products make them promising candidates for therapeutic strategies aimed at intestinal repair. Further clinical validation and mechanistic studies are warranted to facilitate their integration into modern gastrointestinal medicine. Full article

Maximizing hydrocarbon recovery from mature and complex reservoirs is constrained by heterogeneity, sand production, and harsh operational conditions. While polyacrylamide (PAM)-based systems are pivotal in addressing these challenges, a comprehensive synthesis of their transformative evolution and multifunctional capabilities remains overdue. This review critically analyzes advancements in PAM-based materials for enhanced oil recovery (EOR), conformance control, and sand management. We show that nanomaterial integration (e.g., magnetic NPs, nanoclays) significantly augments PAM’s rheological control, thermal and salinity stability, interfacial properties, and wettability alteration. Furthermore, the emergence of supramolecular chemistry has endowed PAM systems with unprecedented resilience, enabling self-healing and adaptive performance under extreme subsurface conditions. The review highlights a crucial paradigm shift towards integrated reservoir management, synergizing these advanced chemical designs with mechanical strategies and leveraging sophisticated monitoring and predictive analytics. Critically, innovations in sustainable and bio-inspired PAM materials offer environmentally responsible solutions with enhanced biodegradability. This synthesis provides a holistic understanding of the state of the art. Despite persistent challenges in scalability and predictability, continually re-engineered PAM systems are positioned as an indispensable and increasingly sustainable cornerstone for future hydrocarbon recovery in the complex energy landscape. Full article