Search Results (197)

Early printed books, particularly incunabula, are invaluable archives of the beginnings of modern educational systems. However, their complex layouts, antique typefaces, and page degradation caused by bleed-through and ink fading pose significant challenges for automatic transcription. In this work, we present a modular pipeline that addresses these problems by combining modern layout analysis and language modeling techniques. The pipeline begins with historical layout-aware text segmentation using Kraken, a neural network-based tool tailored for early typographic structures. Initial optical character recognition (OCR) is then performed with Kraken’s recognition engine, followed by post-correction using a fine-tuned ByT5 transformer model trained on manually aligned line-level data. By learning to map noisy OCR outputs to verified transcriptions, the model substantially improves recognition quality. The pipeline also integrates a preprocessing stage based on our previous work on bleed-through removal using robust statistical filters, including non-local means, Gaussian mixtures, biweight estimation, and Gaussian blur. This step enhances the legibility of degraded pages prior to OCR. The entire solution is open, modular, and scalable, supporting long-term preservation and improved accessibility of cultural heritage materials. Experimental results on 15th-century incunabula show a reduction in the Character Error Rate (CER) from around 38% to around 15% and an increase in the Bilingual Evaluation Understudy (BLEU) score from 22 to 44, confirming the effectiveness of our approach. This work demonstrates the potential of integrating transformer-based correction with layout-aware segmentation to enhance OCR accuracy in digital humanities applications. Full article

This study provides a comprehensive philological analysis of ten Old Uyghur manuscript fragments of the Saddharmapuṇḍarīka-sūtra (Lotus Sutra) in the Berlin Turfan Collection, while systematically examining all extant Old Uyghur Lotus Sutra manuscripts to establish a complete corpus for comparative analysis. By collating this complete corpus with Kumārajīva’s Chinese translation, this research demonstrates a typology of Old Uyghur Lotus Sutra fragments. It identifies at least two distinct translation lineages: (1) early translations (pre-10th century) exhibiting lexical and structural divergences indicative of Sogdian mediation or hybrid source traditions, and (2) late translations (11th–14th centuries) directly derived from the Chinese version, characterized by syntactic fidelity and a standardized terminology. Through comparative textual analysis, orthographic scrutiny, and terminological cross-referencing, this paper aims to reconstruct the historical trajectory of the Lotus Sutra’s transmission. In addition, it discusses some facts indicating linguistic and cultural contact between the Sogdians and the progressive alignment of Uyghur Buddhist texts with Chinese Buddhist traditions. Full article

The shear strength of rock discontinuities is a critical parameter in rock engineering projects for assessing the safety conditions of rock slopes or concrete dam foundations. It is primarily controlled by the frictional contribution of rock texture (basic friction angle), the roughness of discontinuities, and the applied normal stress. While proper testing is essential for accurately quantifying shear strength, engineering geologists and engineers often rely on published historical databases during early design stages or when test results show significant variability. This paper serves two main objectives. First, it intends to provide a comprehensive overview of the basic friction angle concept from early years until its emergence in the Barton criterion, along with insights into distinctions and misunderstandings between basic and residual friction angles. The other, given the influence of the basic friction angle for the entire rock joint shear strength, the manuscript offers an extended database of basic friction angle values. Full article

Checkpoint inhibitor therapy revolutionized the treatment of patients with melanoma. However, in patients where melanoma exhibits resistance to checkpoint inhibitor therapy, the treatment options are limited. Oncolytic viruses are a unique form of immunotherapy that uses live viruses to infect and lyse tumor cells to release the elusive neoantigen picked up by the antigen-presenting cells, thus increasing the chances of an immune response against cancer. Coupled with checkpoint inhibitors, intratumoral injections of the oncolytic virus can help an enhanced immune response, especially in a tumor that displays resistance to checkpoint inhibitors. However, oncolytic viruses are not bereft of challenges and face several obstacles in the tumor microenvironment. From the historical use of wild viruses to the sophisticated use of genetically modified viruses in the current era, oncolytic virus therapy has evolved tremendously in the last two decades. Increasing the ability of the virus to select the malignant cells over the non-malignant ones, circumventing the antiviral immune response from the body, and enhancing the oncolytic properties of the viral platform by attaching various ligands are some of the several improvements made in the last three decades. In this manuscript, we trace the journey of the development of oncolytic virus therapy, especially in the context of melanoma. We review the clinical trials of talimogene laherparepvec in patients with melanoma. We also review the data available from the clinical trials of vusolimogene oderparepvec in patients with melanoma. Finally, we review the use of various oncolytic viruses and their challenges in clinical development. This manuscript aims to create a comprehensive literature review for clinicians to understand and implement oncolytic virus therapy in patients diagnosed with melanoma. Full article

In 1900, Francis Herbert Jennison’s book The Manufacture of Lake Pigments from Artificial Colours was published in London. In the early 20th century, the technical literature focussing on synthetic dyes mainly dealt with their use for dyeing. Conversely, the literature on lake pigment manufacture is less comprehensive, and Jennison’s publication was the first monograph on this topic. His book comprises descriptions of the dyes, substrates, and various methods for lake making. Practical examples complete the work: sixteen colour plates with original samples of lake pigments showcase the practical effect on colour of the different dyes and preparation methods. Herein, we present an overview of the context of Jennison’s research and delve into a selection of formulations. Green lake pigment plates were sampled and analysed by liquid chromatography coupled with spectroscopic and spectrometric detectors and by X-ray fluorescence spectroscopy to correlate the chemical composition with the recipes reported in the book. Seldom or no longer used and unexplored historical dyes were detected, along with polyphenolic compounds possibly used as precipitating agents in lake pigment formulations. Moreover, the examination of two different editions of the Jennison manuscript (i.e., the English and German books) revealed different chemical profiles corresponding to the same lake pigment formulation. This emphasizes the significance of Jennison’s book, confirming how understanding of early formulations is needed to elucidate the later ones. Full article

Romantic poetry is known to have engendered a potent discursive space in 19th-century Europe, wherein national aspirations, personal tragedies, and mythic narratives coalesced. This study examines the recurring images of the “galloping horse” and the “self-sacrificing cavalryman” in 19th-century Romantic poetry in the context of a common poetic myth shaped around the themes of national identity, spiritual transcendence, and historical destiny. The present study focuses on Adam Mickiewicz’s “Faris” and Nikoloz Baratashvili’s “Merani”, employing a comparative literary and philosophical approach to analyze these two works. This study reveals that “Faris” presents a messianic call around the ideal of freedom of the Polish nation, while “Merani” is structured as an individual tragedy and inner journey. Both poems are positioned within a broader poetic paradigm that can be called the “Faris” Cycle, and they can be compared thematically and imaginatively with the works of Goethe, Petőfi, Sully Prudhomme, and Vazha-Pshavela. This study explores the aesthetic and intellectual dimensions of intercultural interaction by analyzing the poetic transitions between the two poles of the Romantic paradigm: collective hope and individual melancholy, action, and inner intuition. By tracing the interplay between national poetics and universal archetypes, this manuscript investigates how such interaction facilitates the symbolic transformation of historical traumas. Full article

Identifying the scriptwriter in historical manuscripts is crucial for historians, providing valuable insights into historical contexts and aiding in solving historical mysteries. This research presents a robust deep learning system designed for classifying historical manuscripts by writer, employing intelligent feature selection and vision transformers. Our methodology meticulously investigates the efficacy of both handcrafted techniques for feature identification and deep learning architectures for classification tasks in writer identification. The initial preprocessing phase involves thorough document refinement using bilateral filtering for denoising and Otsu thresholding for binarization, ensuring document clarity and consistency for subsequent feature detection. We utilize the FAST detector for feature detection, extracting keypoints representing handwriting styles, followed by clustering with the k-means algorithm to obtain meaningful patches of uniform size. This strategic clustering minimizes redundancy and creates a comprehensive dataset ideal for deep learning classification tasks. Leveraging vision transformer models, our methodology effectively learns complex patterns and features from extracted patches, enabling precise identification of writers across historical manuscripts. This study pioneers the application of vision transformers in historical document analysis, showcasing superior performance on the “ICDAR 2017” dataset compared to state-of-the-art methods and affirming our approach as a robust tool for historical manuscript analysis. Full article

This paper explores the evolution and contextual background of an 18th-century dyer’s manuscript originating in Antwerp, covering the period between 1778 and 1802. This manuscript offers a unique glimpse into the operational practices of a small enterprise specializing in red hues for a middle-class clientele. The manuscript includes dye recipes, accounting records, and business correspondence, along with dyed textile samples that provide a tangible connection between written instructions and their visual outcomes. Our study aims to go beyond content analysis to examine the manuscript as a dynamic document in which the dyer’s craft knowledge and experiential learning are visibly embedded. Unlike most available technical treatises, this manuscript appears to be an evolving draft marked by corrections and additions. This fluidity in structure sheds light on the process of knowledge formation and codification in the craft, aligning with devices of precise knowledge transmission and especially with the concept of “codification of error” (Codification of error refers to how early modern artisans and scholars began systematically recording mistakes in their work rather than hiding them. This shift recognized failure as a valuable part of the learning process, helping to refine techniques and support more empirical, experimental approaches to knowledge in the crafts and sciences)—an approach developed within the artisan community to refine practices over time and theorized by Professor Sven Duprè. Through a selection of annotated pages, we highlight the manuscript’s traces of iterative thought and method development. We propose that these elements illustrate the dialectic between transmitted knowledge and individual experimentation, where mistakes, followed by correction, reflection, and refinement, play a central role. Additionally, we discuss the manuscript as evidence of the thin boundaries between practical trade knowledge and the field of scientific inquiry. Through the abovementioned and the comparison with contemporary manuals, this research positions the manuscript as a valuable case study in understanding craft knowledge evolution and its transmission within the historical context of 18th-century European textile dyeing. Full article

Healthcare disparities in cancer care remain pervasive, driven by intersecting socioeconomic, racial, and insurance-related inequities. These disparities manifest in various forms such as limited access to medical resources, underrepresentation in clinical trials, and worse cancer outcomes for marginalized groups, including low-income individuals, racial minorities, and those with inadequate insurance coverage, who face significant barriers in accessing comprehensive cancer care. This manuscript explores the multifaceted nature of these disparities, examining the roles of socioeconomic status, race, ethnicity, and insurance status in influencing cancer care access and outcomes. Historical and contemporary data highlight that minority racial status correlates with reduced clinical trial participation and increased cancer-related mortality. Barriers such as insurance coverage, health literacy, and language further hinder access to cancer treatments. Addressing these disparities requires a systemic approach that includes regulatory reforms, policy changes, educational initiatives, and innovative trial and treatment designs. This manuscript emphasizes the need for comprehensive interventions targeting biomedicine, socio-demographics, and social characteristics to mitigate these inequities. By understanding the underlying causes and implementing targeted strategies, we can work towards a more equitable healthcare system. This involves improving access to high-quality care, increasing participation in research, and addressing social determinants of health. This manuscript concludes with policy recommendations and future directions to achieve health equity in cancer care, ensuring optimal outcomes for all patients. Full article

The manuscript of the Mineralogical lessons for the 1824–1825 course being held at the Royal Cabinet of Natural History had been found in the Archivo General de Palacio (AGP; Madrid, Spain) by the priest Donato García, who replaced Christian Herrgen and held the chair of Mineralogy until 1853. The historic document increases the scant record of this type of documentary source from a period still little known in relation to the state of Mineralogy teaching and allows for a closer understanding of this discipline. This article presents a thorough analysis to identify the collaboration between Professor García and his pupil, José Musso y Valiente, as well as the authorship of the manuscript in connection with the notes of this pupil, due to the absence of any indication in the historical document, with the objective of producing a mineralogy work on mineralogy in the Spanish language. To this end, the manuscript has been examined and compared with the Mineralogy notes of José Musso Pérez-Valiente, Donato García’s pupil, which are preserved in the Lorca Municipal Archive (Murcia, Spain). By comparing Musso’s notes with the manuscript from the Archivo General de Palacio, the idea is reinforced that the former were corrected by Donato García, who eventually left a copy in the Royal Library, corresponding to the one preserved in the AGP, constituting the first record of Donato García’s authorship in relation to Mineralogy. Full article

Traditional studies on Chinese Buddhism have largely relied on printed canons from the Song, Yuan, Ming, and Goryeo dynasties. However, recent discoveries of Dunhuang and Turfan manuscripts, along with growing recognition of Nihon kosha issaikyō (Japanese Ancient Manuscript Canons), have expanded the scope of Buddhist textual research. Despite their significance, Japanese manuscript Buddhist canons remain underexplored, particularly in relation to their textual lineages and connections to Tang-dynasty texts. This study examines Nihon kosha issaikyō through a philological analysis of the Shisong lü (Ten Recitation Vinaya), assessing textual variants, structural patterns, and transmission histories. By situating Nihon kosha issaikyō within the broader East Asian Buddhist tradition, this research clarifies their role in preserving alternative textual lineages beyond standardized printed canons. The findings contribute to a deeper understanding of Buddhist textual transmission, canon formation, and the interplay between manuscript and printed traditions in China, Korea, and Japan. This study highlights the historical processes that shaped East Asian Buddhist canons and offers new insights into their adaptation and preservation across different cultural contexts. Full article

Proteins are biomolecules characterized by uncommon chemical and physicochemical complexities coupled with extreme responsiveness to even minor chemical modifications or environmental variations. Since the shape that proteins assume is fundamental for their function, understanding the chemical and structural bases that drive their three-dimensional structures represents the central problem for an atomic-level interpretation of biology. Not surprisingly, this question has progressively become the Holy Grail of structural biology (the folding problem). From this perspective, we initially describe and discuss the different formulations of the folding problem. In the present manuscript, the folding problem is framed from a historical perspective, effectively highlighting the progress made in the last lustrum. We chronologically summarize the major contributions that traditional methodologies provide in approaching this multifaceted problem. We then describe the recent advent and evolution of predictive approaches based on machine learning techniques that are revolutionizing the field by pointing out the potentialities and limitations of this approach. In the final part of the perspective, we illustrate the contribution that computational approaches will make in current structural biology to overcome the limitations of the reductionist approach of studying individual molecules to afford the atomic-level characterization of entire cellular compartments. Full article

The Dīpavaṃsa (Dīp), the first historical account of the Buddhist religion that has survived in Pali, is widely known through Oldenberg’s late-19th century edition (designated hereafter O). The editor himself admitted it was faulty due to the quality of his Sri Lankan manuscript sources, all of which he thought were derived from a faulty Burmese exemplar. This problematic edition prompted new printed editions of Dīp in Sri Lanka and Myanmar in the 1920s, but Western scholarship established it as a ‘problem’ text, and it was thus generally neglected in favour of the later Mahāvaṃsa. A new edition of Dīp has long been a desideratum, and in 2004 Frasch pointed out the existence of a Burmese manuscript of a different text of the work, which, for the purposes of the present discussion, we designate B1. The present authors identified two further mss. of this version and have begun editing a new edition based on this in comparison to Oldenberg and other Burmese mss. The Burmese sources reveal an occasionally faulty but widely disseminated text, designated B2, that is not dissimilar to O, plus the rather ‘better’ text of B1. In addition, we have also identified the so-called ‘Dīpavaṃsa-ṭīkā’, properly named the Sāsanajotikā, as a commentary on B1 by the major 19th century Burmese scholar Jāgara. The present article will give details of this analysis. Full article

Copper slag, produced in pyrometallurgical processes, has the potential to generate hydrogen through thermolysis, depending on its composition. This manuscript explores the use of copper slag as a highly abundant and low-cost material for thermochemical water splitting using concentrated solar power. Copper slag can undergo endothermic reactions with water vapor at high temperatures, conditions which are favorable for activating hydrogen evolution reactions which can be a potential resource for metal recovery such as magnetite and hematite in the circular economy. While research on copper slag and its components has primarily focused on the recovery of valuable metals and material reuse, its direct application in hydrogen production remains largely unexplored, partly due to historically low interest in hydrogen as an energy source. The vast deposits of copper slag in the Atacama Desert, combined with the growing demand for renewable energy, present a unique opportunity to develop sustainable and cost-effective hydrogen production technologies. Full article

Many people admire the Japanese language and culture, but mastering the language’s writing system, particularly handwritten kanji, presents a significant challenge. Furthermore, translating historical manuscripts containing archaic or rare kanji requires specialized expertise. To address this, we designed a new model for handwritten kanji recognition based on the concept of cross-language transfer learning using a Preact ResNet-18 architecture. The model was pretrained in a Chinese dataset and subsequently fine-tuned in a Japanese dataset. We also adapted and evaluated two fine-tuning strategies: unfreezing only the last layer and unfreezing all the layers during fine-tuning. During the implementation of our training algorithms, we trained a model with the CASIA-HWDB dataset with handwritten Chinese characters and used its weights to initialize models that were fine-tuned with a Kuzushiji-Kanji dataset that consists of Japanese handwritten kanji. We investigated the effectiveness of the developed model when solving a multiclass classification task for three subsets with the one hundred fifty, two hundred, and three hundred most-sampled classes and showed an improvement in the recognition accuracy and an enhancement in a number of recognizable kanji with the proposed model compared to those of the existing methods. Our best model achieved 97.94% accuracy for 150 kanji, exceeding the previous SOTA result by 1.51%, while our best model for 300 kanji achieved 97.62% accuracy (exceeding the 150-kanji SOTA accuracy by 1.19% while doubling the class count). This confirms the effectiveness of our proposed model and establishes new benchmarks in handwritten kanji recognition, both in terms of accuracy and the number of recognizable kanji. Full article