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Article

4 Citations

3,242 Views

19 Pages

HIV-1 Gag Binds the Multi-Aminoacyl-tRNA Synthetase Complex via the EPRS Subunit

Danni Jin,
Yiping Zhu,
Heidi L. Schubert,
Stephen P. Goff and
Karin Musier-Forsyth

Viruses2023, 15(2), 474;https://doi.org/10.3390/v15020474

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8 February 2023

Host factor tRNAs facilitate the replication of retroviruses such as human immunodeficiency virus type 1 (HIV-1). HIV-1 uses human tRNALys3 as the primer for reverse transcription, and the assembly of HIV-1 structural protein Gag at the plasma membra...

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Article

4 Citations

3,140 Views

22 Pages

Cardiomyocyte-Specific Loss of Glutamyl-prolyl-tRNA Synthetase Leads to Disturbed Protein Homeostasis and Dilated Cardiomyopathy

Jiangbin Wu,
Jared Hollinger,
Emily Bonanno,
Feng Jiang and
Peng Yao

Cells2024, 13(1), 35;https://doi.org/10.3390/cells13010035

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22 December 2023

Glutamyl-prolyl-tRNA synthetase (EPRS1), an aminoacyl-tRNA synthetase (ARS) ligating glutamic acid and proline to their corresponding tRNAs, plays an essential role in decoding proline codons during translation elongation. The physiological function...

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Article

8 Citations

3,590 Views

19 Pages

Hypomyelinating Leukodystrophy 15 (HLD15)-Associated Mutation of EPRS1 Leads to Its Polymeric Aggregation in Rab7-Positive Vesicle Structures, Inhibiting Oligodendroglial Cell Morphological Differentiation

Sui Sawaguchi,
Mizuki Goto,
Yukino Kato,
Marina Tanaka,
Kenji Tago,
Hiroaki Oizumi,
Katsuya Ohbuchi,
Kazushige Mizoguchi,
Yuki Miyamoto and
Junji Yamauchi

Polymers2021, 13(7), 1074;https://doi.org/10.3390/polym13071074

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29 March 2021

Pelizaeus–Merzbacher disease (PMD), also known as hypomyelinating leukodystrophy 1 (HLD1), is an X-linked recessive disease affecting in the central nervous system (CNS). The gene responsible for HLD1 encodes proteolipid protein 1 (plp1), which is th...

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