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Article

1 Citations

1,701 Views

24 Pages

Biophysical Analysis of a Minimalistic Kidney Model Expressing SGLT1 Reveals Crosstalk between Luminal and Lateral Membranes and a Plausible Mechanism of Isosmotic Transport

Erik Hviid Larsen and
Jens Nørkær Sørensen

Biomolecules2024, 14(8), 889;https://doi.org/10.3390/biom14080889

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23 July 2024

We extended our model of the S1 tubular segment to address the mechanisms by which SGLT1 interacts with lateral Na/K pumps and tight junctional complexes to generate isosmotic fluid reabsorption via tubular segment S3. The strategy applied allowed fo...

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Review

36 Citations

10,842 Views

22 Pages

AMP-Activated Protein Kinase (AMPK)-Dependent Regulation of Renal Transport

Philipp Glosse and
Michael Föller

Int. J. Mol. Sci.2018, 19(11), 3481;https://doi.org/10.3390/ijms19113481

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6 November 2018

AMP-activated kinase (AMPK) is a serine/threonine kinase that is expressed in most cells and activated by a high cellular AMP/ATP ratio (indicating energy deficiency) or by Ca2+. In general, AMPK turns on energy-generating pathways (e.g., glucose upt...

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Commentary

6 Citations

2,003 Views

5 Pages

Gliflozins, Erythropoietin, and Erythrocytosis: Is It Renal Normoxia- or Hypoxia-Driven?

Samuel N. Heyman and
Zaid Abassi

J. Clin. Med.2023, 12(14), 4871;https://doi.org/10.3390/jcm12144871

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24 July 2023

The introduction of gliflozins in the management of type 2 diabetes mellitus leads to a better control of hyperglycemia, obesity, hypertension, dyslipidemia, and fluid retention. Most importantly, it also improves renal survival and reduces major car...

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