5 Results Found

Advanced Search

Select all

Results per page

Select all

Article

5 Citations

2,465 Views

16 Pages

Expression of Glial-Cell-Line-Derived Neurotrophic Factor Family Ligands in Human Intervertebral Discs

Tatsuya Iwasaki,
Koji Akeda,
Koki Kawaguchi,
Junichi Yamada,
Takahiro Hasegawa,
Norihiko Takegami,
Tatsuhiko Fujiwara and
Akihiro Sudo

Int. J. Mol. Sci.2023, 24(21), 15874;https://doi.org/10.3390/ijms242115874

1 November 2023

Glial-cell-line-derived neurotrophic factor (GDNF) family ligands (GFLs) contribute to the sensitization of primary afferents and are involved in the pathogenesis of inflammatory pain. The purpose of this preliminary study was to examine the expressi...

Full Article

Review

17 Citations

6,382 Views

20 Pages

Small Molecules and Peptides Targeting Glial Cell Line-Derived Neurotrophic Factor Receptors for the Treatment of Neurodegeneration

Yulia A. Sidorova and
Mart Saarma

Int. J. Mol. Sci.2020, 21(18), 6575;https://doi.org/10.3390/ijms21186575

8 September 2020

Glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) are able to promote the survival of multiple neuronal populations in the body and, therefore, hold considerable promise for disease-modifying treatments of diseases and conditio...

Full Article

Review

50 Citations

14,288 Views

21 Pages

RET Receptor Tyrosine Kinase: Role in Neurodegeneration, Obesity, and Cancer

Arun Kumar Mahato and
Yulia A. Sidorova

Int. J. Mol. Sci.2020, 21(19), 7108;https://doi.org/10.3390/ijms21197108

26 September 2020

Rearranged during transfection (RET) is the tyrosine kinase receptor that under normal circumstances interacts with ligand at the cell surface and mediates various essential roles in a variety of cellular processes such as proliferation, differentiat...

Full Article

Article

7 Citations

4,555 Views

11 Pages

Characterization of LDD-2633 as a Novel RET Kinase Inhibitor with Anti-Tumor Effects in Thyroid Cancer

Hyo Jeong Lee,
Pyeonghwa Jeong,
Yeongyu Moon,
Jungil Choi,
Jeong Doo Heo,
Yong-Chul Kim and
Sun-Young Han

Pharmaceuticals2021, 14(1), 38;https://doi.org/10.3390/ph14010038

6 January 2021

Rearranged during transfection (RET), a receptor tyrosine kinase, is activated by glial cell line-derived neurotrophic factor family ligands. Chromosomal rearrangement or point mutations in RET are observed in patients with papillary thyroid and medu...

Full Article

Article

22 Citations

5,156 Views

27 Pages

Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent Manners

Lucas B. Doretto,
Arno J. Butzge,
Rafael T. Nakajima,
Emanuel R. M. Martinez,
Beatriz Marques de Souza,
Maira da Silva Rodrigues,
Ivana F. Rosa,
Juliana M. B. Ricci,
Aldo Tovo-Neto and
Daniel F. Costa
+ 3 authors

Cells2022, 11(8), 1295;https://doi.org/10.3390/cells11081295

11 April 2022

Glial cell line-derived neurotrophic factor (GDNF) and its receptor (GDNF Family Receptor α1-GFRα1) are well known to mediate spermatogonial stem cell (SSC) proliferation and survival in mammalian testes. In nonmammalian species, Gdnf and...

Full Article