Search Results (2,276)

As an important zoonotic parasite, Capillaria hepatica poses a threat to human health that cannot be ignored due to its association with high mortality and serious damage to the liver, although there are relatively few human infections. The infection rate of Capillaria hepatica in rodents is very high, which poses a great threat to the health of rodents, and Rattus norvegicus has been found to be the main group carrying Capillaria hepatica. Capillaria hepatica’s unique biological characteristics, including its morphological features and complex life history, determine the specificity of its infection and pathogenicity. In terms of epidemiology, Capillaria hepatica has a worldwide distribution, a wide variety of hosts (mainly rodents), and various transmission routes, all of which increase the difficulty of its prevention and control. Children are more likely to be infected by it, and there is little gender difference among the infected population. Although there are a variety of diagnostic methods for hepatic capillariasis, all of them have certain limitations. In addition, due to its non-specific clinical manifestations, early accurate diagnosis of hepatic capillariasis is still a challenge. This article reviews the biological characteristics and pathogenic mechanism of Capillaria hepatica, the epidemiology of human infection, the epidemiology of animal infection, and the diagnosis and treatment of hepatic capillariasis, so as to provide a useful reference for related research and clinical practice. Full article

Background: Female patients undergoing radical cystectomy (RC) for bladder cancer have historically presented with more advanced disease and poorer survival outcomes than males. These disparities have been attributed to biological differences, delayed diagnosis, and variations in treatment delivery. Recent data suggest, however, that outcomes may converge when patients are managed in standardized, multidisciplinary, high-volume centers. This study evaluated the influence of gender on perioperative features and oncological outcomes such as disease-free survival (DFS), disease-specific survival (DSS), and overall survival (OS) at a tertiary uro-oncology center. Methods: We retrospectively reviewed a prospectively maintained database of patients who underwent open or robotic-assisted RC for histologically confirmed urothelial carcinoma between 2014 and 2023 at Guy’s and St. Thomas’ NHS Foundation Trust. Demographic, perioperative, and pathological variables were stratified by gender to assess their association with DFS, DSS, and OS. Results: A total of 887 patients were included: 640 men (72.2%) and 247 women (27.8%), with similar mean age (68.5 vs. 68.1 years) and tumour histology (pure urothelial carcinoma 85% vs. 83%). Men had a higher prevalence of diabetes and chronic kidney disease, but no significant differences were observed in time from referral to surgery (0.93 vs. 1.03 months, p = 0.93), use of neoadjuvant therapy (21.6% vs. 17.3%, p = 0.25), or surgical approach (p = 0.55). Pathological stage distribution was comparable between sexes (pT0–1: 44% vs. 50%; pT2–4: 56% vs. 50%; p = 0.13). Kaplan–Meier analysis revealed no significant gender-related differences in 12-month DFS (77.3% vs. 75.4%, p = 0.20), DSS (85.6% vs. 86.9%, p = 0.56), or OS (81.2% vs. 85.2%, p = 0.70). Conclusion: In this high-volume tertiary center, gender did not independently influence perioperative or survival outcomes following radical cystectomy. These findings suggest that standardized, multidisciplinary management within specialized bladder cancer pathways may mitigate the pathological and survival disparities historically associated with gender. Full article

Women have made substantial gains in representation in some STEM fields (e.g., biology, chemistry, math) but not others (e.g., physics, computer science, engineering). Researchers have called for a STEM field-specific approach to investigate the persistent gender gap. While some studies indicate that males report higher self-efficacy than females, which may contribute to the persistent gender gap, other studies do not. The current research used Hunter–Schmidt meta-analysis to clarify the relationship between gender and self-efficacy in STEM fields where women are underrepresented compared to fields where representation has improved. A meta-analysis of 145 effects found gender differences in self-efficacy in all but one field (biology), but the magnitude of the difference was field-specific. In computer science and physics, two fields in which underrepresentation most strongly persists, there were greater gender differences in self-efficacy compared to the other fields. Findings also highlight participant educational stage as a potentially important factor in explaining heterogeneity of gender differences in self-efficacy within STEM fields and as an area for continued research. Full article

Background: Papillary thyroid cancer (PTC) incidence is rising, particularly among Adolescents and Young Adults (AYA, 15–39 years). However, data on PTC characteristics in the AYA population, especially from the Middle East, remain limited. This study aims to describe the clinicopathological features of PTC in AYA patients treated at a large tertiary center in Qatar. Methods: A retrospective chart review was conducted for AYA patients diagnosed with PTC between May 2015 and December 2020 at Hamad General Hospital, Qatar. Data on demographics, tumor characteristics, histopathology, staging, risk stratification, and treatment were extracted and analyzed. We stratified the cohort based on sex. Results: We studied 326 AYA patients (mean age 33.0 ± 5.2 years); the majority were females (72.7%) and were mostly of Asian origin (51.5%). Most patients underwent total thyroidectomy (77.6%), while 22.4% underwent partial thyroidectomy. Histologically, classic PTC was most common (83.38%), followed by the follicular variant (16.00%). Capsule invasion occurred in 21.04%, vascular invasion in 11.76%, and lymphatic invasion in 14.38%. Most patients were at low ATA risk (68.61%), with intermediate (20.06%) and high risk (11.33%) less common. Distant metastases were rare (0.3%), and 59.1% received Radioactive iodine (RAI). Compared to females, males had larger tumors (mean 2.65 cm vs. 2.01 cm, p = 0.0009), higher rates of vascular invasion (22.4% vs. 7.7%, p < 0.001), affected lymph nodes (mean 4.2 vs. 2.4, p = 0.0223), and ATA high-risk proportions (23.5% vs. 7.0%, p < 0.001). Conclusions: This study provides the first detailed characterization of PTC in AYA patients from Qatar. While confirming female predominance, males exhibited more aggressive features (larger tumors, higher LN involvement, and ATA risk). These findings emphasize the need to consider gender-specific differences in managing PTC within the AYA population. Full article

Background: Emotions—including joy, sadness, fear, and anger—are fundamental expressions of human experience. For children and adults who are deaf or hard-of-hearing, emotional experiences and communication can differ due to linguistic and communication-related factors. Methods: This scoping review identifies instruments that are suitable for assessing emotional intelligence in the context of the lived and cultural experiences of individuals who are deaf or hard-of-hearing. A comprehensive search was conducted in April 2024 following the JBI methodology. Results: Out of 3091 articles, 21 studies were included. Two adapted methods were identified: the Meadow/Kendall Social–Emotional Assessment Inventory and ISEAR-D. Assessments supported by sign language revealed no significant differences in age or gender. Conclusions: The authors recommend further development of screening instruments that reflect the specific experiences of the population who are deaf or hard-of-hearing. Full article

Background: Adolescence is a developmental phase characterised by profound biological, emotional and social changes and these changes make adolescents particularly vulnerable to the emergence of psychiatric disorders. In this context, gender differences in mental health disorders are of increasing clinical interest. Method: We conducted a scoping review of the literature regarding gender differences in psychiatric disorders during adolescence. Three databases, PubMed, Web of Science and EBSCO, were used to identify articles published in English from 2015 until 2025. Twenty-one studies fulfilled the inclusion criteria. Results: Ten studies deal with mood disorders, with a focus on gender differences in depression and anxiety during adolescence. Two articles analyse eating disorders, highlighting that girls show higher levels of food restriction and body dissatisfaction. Two studies focus on externalising and neurobehavioural disorders, showing a higher prevalence in boys than in girls. Four articles examine self-harm and suicidal behaviour, where girls report higher rates of suicidal ideation and self-harm. Finally, two studies address personality disorders in adolescence, noting a higher incidence of borderline traits and impulsive behaviour among girls. Conclusions: Research has revealed gender differences in the onset, frequency and factors associated with psychiatric disorders in adolescence. Understanding these differences is essential for developing prevention strategies, early diagnosis and specific interventions. Full article

Ketones are metabolites primarily produced by the liver and are utilized by various organs outside of the liver. Recent advances have demonstrated that ketones serve not only as alternative energy sources but also as signaling molecules. Research indicates that ketones can influence cancer development and metastasis, cardiac metabolic and structural remodeling, physical performance, vascular function, inflammation, and the aging process. Emerging evidence from preclinical and early-phase clinical studies suggests that strategies such as ketone salts, ketone esters, and the ketogenic diet may offer therapeutic benefits for conditions like heart failure, acute cardiac injury, diabetic cardiomyopathy, vascular complications, atherosclerosis, hypertension, and aortic aneurysm. This literature review updates the current understanding of ketone metabolism and its contributions to cardiovascular health and diseases. We highlight the underlying molecular mechanism with post-translational modification known as β-hydroxybutyrylation, which affects the fate and function of target proteins. Additionally, we discuss the therapeutic challenges associated with ketone therapy, the potential of using ketone levels as biomarkers for cardiovascular diseases, as well as gender- and age-specific differences in ketone treatment. Finally, we explore future research directions and what is needed to translate these new insights into cardiovascular medicine. Full article

Background: Identifying differences between genders regarding long-term surgical outcomes in bariatric surgeries may be important for optimizing their results. Objective: The current study evaluated mid-term gender-specific differences in patients undergoing laparoscopic sleeve gastrectomy (LSG). Methods: A retrospective cohort study was done in our university-based hospital, including patients who underwent laparoscopic Sleeve Gastrectomy (LSG) between January 2014 and December 2017. We compared demographics and clinical history (including BMI) before and after surgery, as well as the Bariatric Analysis and Reporting Outcome System (BAROS) and complications. Results: We enrolled 217 patients, 86 of whom were males (39.6%), with an average age of 52 ± 0.8 years. We observed no significant differences between males and females in minimal BMI attained (26.35 ± 4.9 vs. 25.9 ± 4.5 respectively, p = 0.56), total complications rate (p = 0.165), early post-op complication rate (p = 0.158), need for re-operation (p = 0.357), and BAROS score (p = 0.42). Conclusions: LSG outcomes were similar for male and female patients, as measured by BAROS, BMI reduction, and complication rates. Further studies are warranted; however, in the meantime, LSG can be offered to the entire population, regardless of gender-specific considerations. Full article

The electronic word of mouth (eWOM) has emerged as a communication tool that significantly influences consumers’ attitudes and purchasing behavior in the online market. Research indicates that the effect of eWOM sources, such as (strong ties, weak ties, and influencers) varies in terms of perceived value components (price, quality, emotional, and social value) and purchase intention, particularly with regard to gender. This study, which is based on the SOR framework; examines the role of eWOM as a stimulus affecting student responses and considers the mediating role of perceived value components and the moderate effect of gender. A sample of 901 students from Westbank universities was analyzed using Smart PLS software. The findings reveal that strong ties and influencer eWOM are positively associated with perceived value components and purchase intention, while weak tie eWOM does not directly correlate with purchase intention. Mediation analyses show that perceived quality and social value act as mediators of purchase intent towards eWOM sources, while emotional value specifically mediates strong relationships and influencers. Notably, price value exerts only a mediating effect on purchase intention when communicated through influencers, highlighting the unique role of the influencer in shaping price perceptions and its broad impact on all components of perceived value. Gender differences were observed in students’ responses to eWOM content; particularly in terms of price, quality, and emotional appeal but not in terms of social factors. The outcomes of this study underscore the significance of considering both the source of the message and the characteristics of the audience when formulating targeted marketing strategies. Full article

Background and Objectives: This study set out to better understand how posture, spinal level, gender and muscle activation influence the biomechanical properties of the lumbar erector spinae (LES) in healthy young adults. We aimed to measure how these factors influence LES tone, stiffness, and damping using a myotonometry device. Materials and Methods: Thirty healthy young adults (14 males, 16 females; aged 20–25 years) were evaluated at bilateral L3–L5 levels in prone, unsupported sitting, and standing positions, both under relaxed conditions and during submaximal isometric lumbar extension. The myotonometer measured LES tone (Hz), stiffness (N/m), and damping (logarithmic decrement). For each outcome, a mixed-model repeated-measures ANOVA was conducted with Gender as a between-subject factor and Posture, Level, and Action (relaxed vs. contracted) as within-subject factors (Bonferroni-adjusted α = 0.0167). Results: Posture produced the most significant and consistent effects on all properties—stiffness, tone, and damping (p < 0.0167)—with sitting and standing generally increasing stiffness and tone compared to prone, and sitting showing the highest values. Gender significantly impacted stiffness and tone (p < 0.0167), with males showing higher values. Spinal level also significantly influenced damping, stiffness, and tone (all p < 0.0167), with differences more apparent in females. Significant interactions included the influence of Posture × Gender on tone and damping (p < 0.0167), and of Posture × Action on stiffness and tone (p < 0.0167), alongside a strong three-way interaction for Level × Action × Posture across all outcomes, suggesting posture-related responses depend on activation state and spinal level. Conclusions: LES biomechanical properties are strongly affected by posture and further modulated by muscle activation, gender, and spinal level. These results support the creation of posture- and gender-specific reference values and underscore the value of dynamic, posture-specific myotonometer-based assessments for paraspinal muscle evaluation and clinical planning. Full article

With the enactment of the 2013 government mandate, Indian corporations meeting specific criteria no longer have the discretion to forgo CSR expenditures. Previous studies have reported negative capital market reactions to this regulatory intervention. In contrast, our study offers a long-term perspective on the impact of the CSR law on firms’ investment efficiency. Using a difference-in-differences framework, this study examines publicly listed Indian firms from 2011 to 2018, capturing a clean pre- and post-mandate window that isolates the structural impact of the CSR law while excluding confounding and shocks such as the COVID-19 crisis. Thus, the paper focuses on identifying the long-term institutional and structural effects of CSR rather than short-term cyclical fluctuations. We find that the CSR law leads to an increase in the investment efficiency of affected firms, driven primarily by reductions in agency conflicts and information asymmetry. This effect is more pronounced among firms with a strong presence of active monitoring groups, such as Hindu-owned promoters and institutional investors. Improved efficiency is also profound among firms located in areas with a lower Human Development Index (HDI) and Gender Diversity Index (GDI). Our findings demonstrate the positive impact of mandatory CSR law on capitalism and present insights for policymakers for regulators as ESG and CSR mandates are increasingly debated and adopted. Full article

Background/Objectives: Schizophrenia (SCH) and bipolar disorder (BD) share overlapping symptoms and genetic factors, making differential diagnosis challenging and often leading to misdiagnosis. This study aimed to identify potential lipid biomarkers of serum capable of distinguishing BD from SCH. Methods: Lipid profiles of serum from 30 SCH and 31 BD patients were analyzed in triplicates using liquid chromatography–high-resolution mass spectrometry (LC-HRMS). Chemometric analysis was applied, including class and gender identifiers. Orthogonal partial least squares (OPLS) models with 1000 cross-validations were used to validate feature subsets. Results: The chemometric analysis included the most relevant metabolites in the comparison between all samples of SCH and BD patients, identifying five key biomarkers (LPC 16:0, SM 33:1, SM 32:1, compound C30H58O3, and PC 30:0) with VIP scores > 1 for distinguishing BD from SCH. Gender-specific models revealed five biomarkers in males (SM 32:1, SM 33:1, PC 32:1, PC 30:0, and FA 16:1) and two in females (LPC 16:0 and C30H58O3). These biomarkers primarily belonged to glycerophospholipids (GPs) and sphingophospholipids (SPs). Conclusions: Comparative lipid profiling between SCH and BD, including gender-specific subgroups, enabled identification of potential diagnosis-specific biomarkers. Elevated levels of GPs and SPs in SCH patients suggest lipid metabolism differences that may support improved diagnostic accuracy and personalized treatment strategies. Full article

Background: Dietary habits established during young adulthood have long-term implications for health, and food choices among university students are strongly shaped by contextual factors. Institutional eating environments represent a relevant setting for promoting healthier dietary behaviors, yet limited evidence integrates students’ engagement with these settings, their food consumption patterns across contexts, and the individual decision-making processes underlying food choice. Methods: This cross-sectional study analyzed survey data from 1519 students enrolled at a large Italian university. Measures included sociodemographic characteristics, self-identified dietary style, engagement with the university canteen, consumption frequency of selected food categories across institutional and non-institutional contexts, and category-specific food-choice motivations. Data were analyzed using descriptive analyses, Borda count rankings, paired comparisons, and multiple linear regression models. Results: Clear contextual differences in food consumption emerged across all food categories, with consistently lower consumption frequencies within the university canteen compared to outside settings (all p < 0.001). The largest contextual gap was observed for fruit consumption (d = 0.94), with similarly pronounced differences for plant-based foods. Taste was the most salient decision-making factor across food categories (overall M ≈ 4.4), while health-related motives were more prominent for healthier foods and gratification for desserts. Across contexts, self-identified dietary style was the most consistent predictor of food consumption, explaining substantial variance for animal-based protein consumption (R² = 0.293 in the canteen; R² = 0.353 outside), whereas age and gender showed smaller, food-specific associations. Conclusions: The findings highlight institutional eating settings as distinct food environments in which individual dietary preferences are only partially expressed. Effective strategies to promote healthier eating among university students should move beyond generic approaches and integrate interventions targeting service-related engagement, category-specific choice architecture, and students’ dietary identities. Full article

Medical students experience fluctuations in their motivation, influenced by various factors, including curricular rigor, mental health, and institutional factors. Based on Self-Determination Theory (SDT) and the Four Pillars of Academic Engagement (HPEE), this study, conducted at a private Mexican university, examined motivational variation according to academic year, curricular impact, gender differences, and its relationship with mental health. Methods: A quantitative, cross-sectional, descriptive study was conducted using qualitative tools for contextualization (n = 1326). Mann–Whitney U tests, Kruskal–Wallis tests, logistic regression, and psychological network analysis were performed. Results: Motivation showed cross-sectional variation: high in preclinical years 1 and 2, decreasing in clinical years 3 and 4 (p < 0.001), and rebounding in year 6. The reformed curriculum (elective subjects, student-centered active learning) resulted in greater motivation (OR = 10.68, p < 0.001). Women tended to have slightly higher motivation (p = 0.050), higher grade point averages (p < 0.001), but also greater stress (p < 0.001). Network analysis revealed that intrinsic achievement (centrality = 1.11) and curiosity about knowledge (predictability = 84.5%) are the main drivers, while demotivation was linked to the later years. The qualitative part of the study showed altruism/curiosity as the main motivators; mistreatment/workload (demotivators). Conclusions: Motivation is context-sensitive, peaks in the preclinical stage, and recovers with autonomy but is vulnerable during clinical immersion. Autonomy in course selection, active student-centered pedagogies, and gender-sensitive support foster sustained participation. The centrality of intrinsic factors in the network highlights that achievement motivation and knowledge are general and independent motivators. Qualitative data reveal systemic barriers. Stage-specific interventions, such as mentoring, student support programs, and reporting mistreatment, can be crucial for strengthening resilience and performance. Longitudinal and multi-institutional studies are needed to validate the causality and generalizability of this study. Full article

(1) Background/Purpose: Talent management research has typically focused on early-career entrants or high-potential employees, leaving mid-career professionals underexplored despite their pivotal role in organisational continuity and leadership pipelines. This study examines whether the principles of Conservation of Resources (COR) theory apply to careers, testing whether career resources predict objective and subjective career success, and whether gender differences emerge. (2) Study Design/Methodology/Approach: A three-wave survey of 543 individuals employed in the United Kingdom (UK) (mean age 39) was analysed using Latent Growth Modelling and hierarchical regression to capture the temporal dynamics of career resources and their links to success. (3) Findings: Subjective career success declined overall, but increased among participants with high human capital, environmental resources, career self-management behaviours, and baseline motivation. Gender differences were found: human capital and self-management were stronger predictors for men, while environmental resources were more important for women. Objective success was predicted by human capital only for women, while private-sector employment and subjective success were the strongest predictors for men. (4) Originality/Value: Our unique contribution advances understanding of mid-career dynamics among women and men, highlighting critical implications for talent management. Some, but not all, predictions of COR theory are supported. Women and men experience the benefits of resources differently. Whilst career resources were critical for career success, caring responsibilities were not, irrespective of gender. Organisations must recognise that subjective career success needs resources to sustain it and move beyond one-size-fits-all approaches by tailoring development, mobility, and support systems to gendered and career-stage-specific needs. Full article