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Keywords = functionalized implants

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18 pages, 763 KB  
Review
Implant-Assisted Removable Partial Dentures with Surveyed Crowns: A Narrative Review of Treatment Concepts, Material Considerations, and Clinical Outcomes
by Isaraporn Phusadeekunpaisan, Pimduen Rungsiyakull and Pisaisit Chaijareenont
Dent. J. 2026, 14(9), 591; https://doi.org/10.3390/dj14090591 (registering DOI) - 13 Sep 2026
Abstract
Background: Tooth loss remains a major clinical challenge, affecting mastication, speech, facial aesthetics, and oral health-related quality of life. Prosthetic rehabilitation must therefore balance functional demands, biological limitations, patient preferences, maintenance capacity, and cost. Implant-assisted removable partial dentures (IARPDs) have emerged as a [...] Read more.
Background: Tooth loss remains a major clinical challenge, affecting mastication, speech, facial aesthetics, and oral health-related quality of life. Prosthetic rehabilitation must therefore balance functional demands, biological limitations, patient preferences, maintenance capacity, and cost. Implant-assisted removable partial dentures (IARPDs) have emerged as a practical alternative to conventional removable partial dentures (RPDs) and full-arch fixed implant prostheses, particularly in distal-extension cases where conventional RPDs often demonstrate greater displacement and unfavorable stress distribution. Objectives: This narrative review summarizes current concepts in IARPDs treatment, with an emphasis on attachment-retained designs and implant-surveyed crown removable partial dentures (ISCRPDs). Methods: A narrative literature review was conducted using PubMed and Scopus. English-language articles related to IARPDs, surveyed crowns, attachment systems, material considerations, biomechanics, clinical outcomes, and complications were identified and narratively synthesized. Results: Available evidence suggests that IARPDs provide superior patient-reported outcomes compared with conventional RPDs, largely through improved retention, stability, comfort, and reduced prosthesis movement. Attachment systems offer versatile retention and aesthetic advantages but may require regular maintenance because of component wear and progressive loss of retention. In contrast, surveyed crowns provide a space-efficient and potentially more cost-effective design, with favorable implant survival and prosthetic outcomes reported in retrospective studies. However, complications such as clasp loosening, sore spots, crown dislodgement, and crown or framework fracture remain clinically relevant. Material selection for frameworks and implant crowns further influences aesthetics, durability, hygiene, and long-term maintenance. Conclusions: IARPDs treatment should be individualized according to the available prosthetic space, residual ridge anatomy, implant position, oral hygiene ability, aesthetic expectations, financial limitations, and access to follow-up care. Prospective comparative studies are needed. Full article
(This article belongs to the Special Issue Critical Issues on Long-Term Clinical Performance of Dental Implants)
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11 pages, 360 KB  
Article
Long-Term Clinical and Radiological Outcomes of Cementless Total Knee Arthroplasty in Patients with Rheumatoid Arthritis
by Filippo Calanna, Silvia De Martinis, Leonardo Clausetti, Alessia Invernizzi, Luca Tanel, Roberto Viganò, Alessandra Menon, Alessio Maione, Riccardo Compagnoni, Paolo Ferrua and Pietro S. Randelli
J. Clin. Med. 2026, 15(18), 7091; https://doi.org/10.3390/jcm15187091 (registering DOI) - 12 Sep 2026
Abstract
Background: Total knee arthroplasty (TKA) is an established treatment for end-stage rheumatoid arthritis (RA). Although cemented fixation has traditionally been preferred because of concerns regarding poor bone quality, advances in implant design and osseointegration have renewed interest in cementless fixation. This study evaluated [...] Read more.
Background: Total knee arthroplasty (TKA) is an established treatment for end-stage rheumatoid arthritis (RA). Although cemented fixation has traditionally been preferred because of concerns regarding poor bone quality, advances in implant design and osseointegration have renewed interest in cementless fixation. This study evaluated the long-term clinical and radiological outcomes of cementless TKA in patients with RA. Methods: A retrospective single-center study included adult patients with RA who underwent primary cementless TKA between 2004 and 2021 using the same cruciate retaining implant. Clinical outcomes were assessed using range of motion (ROM), Visual Analog Scale (VAS), Oxford Knee Score (OKS), and patient satisfaction. Radiographic evaluation assessed implant fixation, while implant survivorship was analyzed using bilateral clustering via a Marginal Cox model analysis. Results: Seventy-five cementless TKAs performed in 52 patients were analyzed after a mean clinical follow-up of 10.8 ± 3.8 years. Mean ROM was 101° ± 26.5°, mean VAS score was 0.88 ± 1.84, and mean OKS was 40.3 ± 7.1. Overall, patients were satisfied or very satisfied in 89.6% of implants. Radiographic assessment showed no evidence of progressive radiolucent lines, osteolysis, implant subsidence, aseptic loosening, or malalignment. Only one revision was required because of periprosthetic joint infection, resulting in an implant survivorship of 98.3% at long-term follow-up. Conclusions: Cementless TKA demonstrated excellent long-term implant survival, durable radiographic fixation, and favorable clinical and functional outcomes in patients with rheumatoid arthritis. These findings support modern cementless fixation as a reliable and effective alternative to cemented TKA in carefully selected RA patients. Full article
(This article belongs to the Special Issue Knee Arthroplasty: Recent Advances and Future Challenges)
34 pages, 10872 KB  
Systematic Review
Time-Zero Kidney Biopsy and Deceased-Donor Transplant Outcomes: A Systematic Review and Meta-Analysis of Prognostic Value, Prediction, and Clinical Utility
by Livier Sainz-Bravo, Benjamín Gómez-Navarro, Diana Laura Figueroa-Gamiño, Jenniffer Topacio Tapia-Báez, José David González-Barajas, Manuel Luis Prieto-Magallanes, José Ángel Solís-Rojas, Edgar Bautista-Reyes, Juan Alberto Gómez-Fregoso, Judith Carolina De Arcos-Jiménez, Ramón Medina-González, Violeta Aidee Camarena-Arteaga, Manuel Arizaga-Napoles and Jaime Briseno-Ramirez
Med. Sci. 2026, 14(5), 566; https://doi.org/10.3390/medsci14050566 (registering DOI) - 12 Sep 2026
Abstract
Background/Objectives: Time-zero biopsy informs deceased-donor kidney implantation or discard, but its prognostic value is contested. We systematically reviewed pre-reperfusion morphological biopsy evidence in adult deceased-donor kidney transplantation, keeping four questions separate: prognostic association, incremental prediction, clinical utility and measurement reproducibility. Methods: We searched [...] Read more.
Background/Objectives: Time-zero biopsy informs deceased-donor kidney implantation or discard, but its prognostic value is contested. We systematically reviewed pre-reperfusion morphological biopsy evidence in adult deceased-donor kidney transplantation, keeping four questions separate: prognostic association, incremental prediction, clinical utility and measurement reproducibility. Methods: We searched PubMed/MEDLINE, Embase, Scopus, Web of Science, CENTRAL and three trial registries through 25 July 2026 without date or language restriction. One estimate per non-overlapping cohort was selected under a prespecified hierarchy; random-effects models used restricted maximum likelihood with Hartung–Knapp inference; GRADE assessed certainty. Results: Of 45,676 records, 25,746 were screened; 203 eligible reports (159 study investigations and 154 cohort families) and 22 contextual reports were included. Vascular injury was associated with delayed graft function (odds ratio: 1.85, 95% CI 1.11–3.06), glomerulosclerosis with graft failure (hazard ratio: 2.03, 1.22–3.39) and vascular injury with graft failure (hazard ratio: 1.48, 1.07–2.04); glomerulosclerosis with delayed graft function was inconclusive (odds ratio: 1.13, 0.59–2.17). All 12 pooled bodies were of very low certainty. Conclusions: Current evidence does not support time-zero histology as a stand-alone rule for accepting or discarding a deceased-donor kidney. Whether standardized histology adds predictive information beyond established clinical variables remains open and should be addressed in linked registry analyses before biopsy findings guide management. Full article
(This article belongs to the Section Nephrology and Urology)
30 pages, 24263 KB  
Article
Multi-Material Joints of Biocompatible Ti15Ta, Ti10Ta2Nb2Zr, and Ti13Nb13Zr5Cu Titanium Alloys Fabricated by Laser Powder Bed Fusion for Functionally Graded Orthopedic Implants
by Igor Polozov, Victoria Nefyodova and Anton Zolotarev
Metals 2026, 16(9), 1015; https://doi.org/10.3390/met16091015 (registering DOI) - 12 Sep 2026
Abstract
In this work, multi-material joints of three biocompatible low-modulus titanium alloys—Ti15Ta, Ti10Ta2Nb2Zr, and Ti13Nb13Zr5Cu—were produced and systematically investigated by laser powder bed fusion (LPBF) for the development of functionally graded orthopedic implants. Three pairwise joints were examined (Ti10Ta2Nb2Zr/Ti15Ta, Ti15Ta/Ti13Nb13Zr5Cu, and Ti13Nb13Zr5Cu/Ti10Ta2Nb2Zr). The process [...] Read more.
In this work, multi-material joints of three biocompatible low-modulus titanium alloys—Ti15Ta, Ti10Ta2Nb2Zr, and Ti13Nb13Zr5Cu—were produced and systematically investigated by laser powder bed fusion (LPBF) for the development of functionally graded orthopedic implants. Three pairwise joints were examined (Ti10Ta2Nb2Zr/Ti15Ta, Ti15Ta/Ti13Nb13Zr5Cu, and Ti13Nb13Zr5Cu/Ti10Ta2Nb2Zr). The process parameters governing the formation of the transition zones were optimized: all nine combinations of alloy pair and regime yielded a relative density of 99.35–99.73% with no macroscopic defects; one-way ANOVA showed that the baseline parameters of the second alloy provided a relative density equal to or significantly higher than that obtained with an increased energy input. EDS mapping and point analysis indicated that the transition zone (10–90% width ≈ 250–320 µm) forms through the intermixing of the melts within a common melt pool; after annealing at 900 °C for 1 h, the interface becomes blurred owing to interdiffusion, and the microstructure evolves into a uniform lamellar (α + β) structure. In the as-built condition, the Ti10Ta2Nb2Zr/Ti15Ta joint exhibited σUTS = 598 ± 9 MPa, δ = 14.2 ± 1.9%, and E = 96 ± 3 GPa, with fracture occurring in the Ti15Ta region. The joints involving Ti13Nb13Zr5Cu are limited by the inherent brittleness of this alloy, which is removed for the Ti15Ta/Ti13Nb13Zr5Cu pair by annealing. The elastic modulus of the dense joints (94–101 GPa) remains well above that of cortical bone, so that a clinically relevant reduction in stiffness has to be provided by a porous architecture rather than by the alloy composition alone. In vitro testing of the monolithic alloys (osteoblasts and gingival fibroblasts, MTT with n = 6 and flow cytometry) revealed no cytotoxic effect in terms of membrane integrity; the metabolic activity of gingival fibroblasts on Ti10Ta2Nb2Zr remained below the 70% level, whereas among the monolithic alloys the most stable osteoblast activity and the most pronounced recovery of fibroblast activity were observed on Ti13Nb13Zr5Cu. The biological response of the transition zones themselves has not yet been evaluated. These results provide a processing and materials-science basis for the further development of functionally graded implants. Full article
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12 pages, 2442 KB  
Article
The Effects of Diagnostic Anatomical Features on Treatment and Recovery in Feline Spinal Trauma
by Mehmet Kılınç and Sadık Yayla
Vet. Sci. 2026, 13(9), 949; https://doi.org/10.3390/vetsci13090949 (registering DOI) - 12 Sep 2026
Abstract
Background: Spinal trauma remains a clinically significant condition in small animal practice. A thorough understanding of spinal anatomy is essential for accurate lesion localization, appropriate implant selection, optimal surgical planning, and improved treatment outcomes in feline spinal trauma. Aim: The aim of [...] Read more.
Background: Spinal trauma remains a clinically significant condition in small animal practice. A thorough understanding of spinal anatomy is essential for accurate lesion localization, appropriate implant selection, optimal surgical planning, and improved treatment outcomes in feline spinal trauma. Aim: The aim of this study is to evaluate treatment strategies and outcomes in cats with spinal trauma by integrating diagnostic anatomical features with surgical planning. Methods: A total of 20 cats were included, and the location, type, and severity of the spinal lesions were determined through comprehensive clinical, radiographic, neurological, and orthopedic examinations. Surgical stabilization was performed using a polyaxial screw–rod system for thoracic vertebral injuries and a String-of-Pearls (SOP) plate for lumbar vertebral lesions. The type and size of implant used during these procedures were determined according to the anatomical characteristics in each case. In cases with spinal cord compression, decompressive procedures, including laminectomy or hemilaminectomy, were carried out as indicated. Results: The results demonstrated that the surgical stabilization and decompression techniques used in this study provided satisfactory spinal stability and significant functional improvement in most cats. Conclusions: This is related to a good understanding of the lesion type and the anatomical features of the affected spine, as these anatomical features determine not only surgical planning but also the method and implant size to be used. Full article
(This article belongs to the Section Anatomy, Histology and Pathology)
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36 pages, 1196 KB  
Review
Changing Paradigms in Implant–Prosthetic Rehabilitation in Free Fibula Flap (FFF) Reconstruction: Tracing the Transition Toward Digital Workflows
by Gerardo Pellegrino, Carlo Barausse, Subhi Tayeb, Martina Sansavini, Alessandro Antonelli, Andrea Oliverio, Claudia Angelino, Achille Tarsitano, Leonardo Ciocca and Pietro Felice
Appl. Sci. 2026, 16(18), 9033; https://doi.org/10.3390/app16189033 - 11 Sep 2026
Abstract
The free fibula flap (FFF) is a reference reconstructive option, particularly for extensive mandibular defects. This narrative review examines the evolution of implant–prosthetic rehabilitation from conventional free-hand reconstruction to prosthetically driven digital workflows. A structured, non-systematic search of PubMed/MEDLINE, Scopus, and Web of [...] Read more.
The free fibula flap (FFF) is a reference reconstructive option, particularly for extensive mandibular defects. This narrative review examines the evolution of implant–prosthetic rehabilitation from conventional free-hand reconstruction to prosthetically driven digital workflows. A structured, non-systematic search of PubMed/MEDLINE, Scopus, and Web of Science included English-language publications from 1989 to May 2026. Early approaches were limited by anatomical discrepancies, unfavorable implant positioning, excessive prosthetic space, and difficult peri-implant maintenance. Surgical refinements, including double-barrel reconstruction and soft-tissue procedures, improved rehabilitative conditions in selected cases. Virtual surgical planning, CAD/CAM guides, patient-specific fixation, and guided implant placement subsequently enabled closer coordination of reconstruction, implant positioning, and prosthetic design, supporting immediate protocols such as Jaw-in-a-Day. However, the available evidence remains heterogeneous and predominantly retrospective. Although digital workflows may improve accuracy and operative efficiency, their superiority in terms of long-term biological, prosthetic, functional, and patient-reported outcomes has not been conclusively demonstrated. Emerging technologies, including augmented reality, robotics, artificial intelligence, and digital twins, remain largely preliminary. Full article
16 pages, 2156 KB  
Review
Immunometabolic Dysregulation in Female Obesity: Mechanistic Links to Ovarian Dysfunction, Implantation Failure, and Preeclampsia
by Rodolfo Oliveira Medeiros, Feres Abrão, Laila Abrão, Cintia Gisele de Andrade Pozenato, Camila Abrão Costa Buzeto, Marines Laveso de Brito, Isis Carrero Zequini de Freitas, Vitória Auler do Santo, Gustavo Henrique de Paulo Ribeiro Ponciano, Bianca Marques, Juliana Ferreira Marcandelli, Isabele de Assis Nagahashi Campos, Maria Clara de Castro Ferreira, Gabriela Novaes Garcia, Cynthia de Paula Costa Borba, José Antonio Pizzolato Neto, Ludmila Trambaiolli de Souza, Felipe Ravazzi Guzzo, Amanda Santiago Ribeiro, Pedro Henrique Lima Domingues, Kelly Karine Pasqual and Felipe Neves Brandãoadd Show full author list remove Hide full author list
Biomedicines 2026, 14(9), 2039; https://doi.org/10.3390/biomedicines14092039 - 10 Sep 2026
Viewed by 157
Abstract
Obesity is one of the most pressing public health challenges of our time, with a growing impact on metabolic and reproductive dysfunction in women. The expansion of visceral adipose tissue drives a chronic, low-grade systemic inflammatory state that has been associated with functional [...] Read more.
Obesity is one of the most pressing public health challenges of our time, with a growing impact on metabolic and reproductive dysfunction in women. The expansion of visceral adipose tissue drives a chronic, low-grade systemic inflammatory state that has been associated with functional changes in the ovary, the endometrium, and the placenta across different stages of the reproductive process. This structured narrative review, guided by a PICo-framed research question and literature searches across PubMed/MEDLINE, Scopus, Web of Science, Embase, and ScienceDirect, examined the main immunometabolic mechanisms underlying female obesity and their reported associations with ovarian dysfunction, implantation failure, placental dysfunction, infertility, and preeclampsia. The evidence indicates that chronic low-grade inflammation, insulin resistance (IR), and functional hyperandrogenemia may impair folliculogenesis, oocyte quality, and ovarian reserve, while cytokine and adhesion-molecule dysregulation in the endometrium has been linked to impaired decidualization and a narrower implantation window. At the maternal–fetal interface, this same inflammatory substrate has been associated with deficient trophoblast invasion, inadequate spiral artery remodeling, and angiogenic imbalance, mechanisms widely implicated in the pathophysiology of preeclampsia. Rather than demonstrating a proven longitudinal chain within the same individual, the evidence reviewed here, drawn from heterogeneous populations, study designs, and experimental models, supports a conceptual, hypothesis-generating model in which obesity-related systemic inflammation may contribute to dysfunction across the ovary, endometrium, and placenta. Clinically, these findings support further investigation of reproductive biomarkers and early screening strategies for women with obesity, particularly in the context of assisted reproduction, alongside emerging preconception therapeutic approaches that remain largely investigational. Female obesity should therefore be understood not merely as a metabolic disorder, but as an immunometabolic condition potentially associated with dysfunction across the ovary–endometrium–placenta axis, an integrative framework that may help guide future preventive and therapeutic strategies for reproductive health, pending confirmation in longitudinal studies. Full article
(This article belongs to the Special Issue Immunology in Recurrent Pregnancy Loss, Preeclampsia and Infertility)
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14 pages, 11903 KB  
Article
Modified Multi-Strand Nice Knot Suture Construct Combined with Suture Anchor Fixation Versus Conventional Kirschner Wire Tension Band Fixation for Inferior Patellar Pole Fractures: A Retrospective Comparative Study
by Junfeng Tang, Chenggang Wang, Xianfa Yuan, Qing Gao, Yuchen Hu, Yusheng Sun, Xiaofeng Liu, Wen Jin and Liangye Sun
J. Clin. Med. 2026, 15(18), 7014; https://doi.org/10.3390/jcm15187014 - 10 Sep 2026
Viewed by 115
Abstract
Objectives: To compare the clinical efficacy of the modified multi-strand Nice knot suture construct combined with suture anchor fixation versus conventional Kirschner wire tension band fixation for inferior patellar pole fractures. Methods: This retrospective chart review enrolled 108 consecutive patients with inferior patellar [...] Read more.
Objectives: To compare the clinical efficacy of the modified multi-strand Nice knot suture construct combined with suture anchor fixation versus conventional Kirschner wire tension band fixation for inferior patellar pole fractures. Methods: This retrospective chart review enrolled 108 consecutive patients with inferior patellar pole fractures treated surgically at our institution between January 2019 and January 2024. Patients were allocated to two groups based on the fixation method used: 52 patients underwent the modified suture construct fixation (modified suture fixation group, MSFG), and 56 received conventional Kirschner wire tension band fixation (conventional tension band fixation group, CTBFG). The primary outcomes included anterior knee pain VAS score, knee ROM, and complication rate; secondary outcomes comprised operative time, Bostman, Lysholm and Kujala scores, elective and symptomatic implant removal rates, time to fracture union, Insall–Salvati index, patellar length, and hospitalization costs. Results: All surgical procedures were completed uneventfully. Baseline demographic and clinical characteristics were comparable between groups (all p > 0.05), with a mean follow-up of 25.5 ± 6.0 months (range, 22–36 months). Operative time did not differ significantly between cohorts (p = 0.230). Although the MSFG exhibited statistically lower anterior knee pain VAS scores (0.82 ± 0.6 vs. 1.26 ± 0.8, p = 0.003) and slightly greater knee ROM (132.7° ± 9.8° vs. 128.8° ± 8.1°, p = 0.027), the magnitude of these differences was below the recognized minimal clinically important difference. At the final follow-up, Bostman, Lysholm and Kujala scores were similar between groups (all p > 0.05). Of critical importance, the MSFG had markedly lower rates of implant-related complications and any secondary surgery (both p < 0.001). In the CTBFG, 40 patients (71.4%) underwent secondary surgery: 10 for symptomatic hardware irritation and 30 as entirely elective asymptomatic removals. By contrast, no patient in the MSFG required any form of reoperation. No revision surgeries for fixation failure were required in either group. Radiographically, fracture union time and patellar length were comparable (all p > 0.05). While the Insall–Salvati index was statistically lower in the MSFG (0.96 ± 0.1 vs. 1.02 ± 0.1, p = 0.006), all values remained within the normal physiological range and no functional impairment was observed. Subgroup analysis of comminuted fractures with osteoporosis demonstrated that the MSFG eliminated the implant failure complications seen in the CTBFG (0% vs. 28.6%). Conclusions: The modified multi-strand Nice knot suture construct combined with suture anchor fixation provides functional outcomes equivalent to conventional Kirschner wire tension band fixation. However, it offers two distinct advantages: the complete absence of hardware-related complications and the elimination of the need for secondary implant removal. These findings suggest that the modified suture construct may offer particular advantages for patients with comminuted or osteoporotic inferior patellar pole fractures, although further prospective studies are warranted to confirm these observations. Full article
(This article belongs to the Section Orthopedics)
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15 pages, 14058 KB  
Case Report
A Stepwise Technique for Retrieval of a Seized and Stripped Dental Implant Cover Screw: A Case Report
by Keisuke Seki, Kenji Ito, Juntaro Sanada, Taiki Akiyama and Yoshiyuki Hagiwara
Reports 2026, 9(3), 304; https://doi.org/10.3390/reports9030304 - 10 Sep 2026
Viewed by 142
Abstract
Background and Clinical Significance: In two-stage implant treatment the cover screw must be removed at second-stage surgery. Removal is occasionally prevented by cold welding or seizure. When the drive slot is damaged by escalating torque, no standard salvage protocol has been established, and [...] Read more.
Background and Clinical Significance: In two-stage implant treatment the cover screw must be removed at second-stage surgery. Removal is occasionally prevented by cold welding or seizure. When the drive slot is damaged by escalating torque, no standard salvage protocol has been established, and the implant body itself may ultimately require removal. Case Presentation: During second-stage surgery for three implants placed in the mandibular right posterior region (#44, #45, #46) of a 68-year-old man, the cover screw at the #46 site was seized and could not be loosened with a manual screwdriver. An attempt at removal with a contra-angle implant driver, set first to 20 Ncm and then to 35 Ncm, stripped the drive slot. The procedure was suspended, and a revision was performed two weeks later. A tungsten carbide bur was used under water irrigation to prepare a straight slot across the damaged screw head, and a crown remover with a narrowed flat-blade tip was engaged in this slot. The screw was retrieved intact and the internal connection of the implant remained serviceable. A healing abutment was connected and the implant was restored with a definitive prosthesis, which was in function at the most recent review. At seven weeks after delivery, the distance from the implant platform to the crestal bone was greater at #46 than at the two adjacent implants. Conclusions: This report describes a salvage technique that preserved the implant body without the use of a system-specific retrieval kit. The peri-implant bone level observed at the treated site indicates that the procedure may have been accompanied by a loss of crestal bone, and whether the technique is reproducible will require further cases. Full article
(This article belongs to the Special Issue Case Reports in Oral Diseases)
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12 pages, 944 KB  
Article
Rotator Cuff and Deltoid Involvement Are Associated with Shoulder Instability After Proximal Humerus Megaprosthetic Reconstruction
by Luigi Cianni, Sara Martellini, Raffaele Vitiello, Alessandro El Motassime, Giulio Maccauro and Maristella Francesca Saccomanno
J. Clin. Med. 2026, 15(18), 7006; https://doi.org/10.3390/jcm15187006 - 10 Sep 2026
Viewed by 129
Abstract
Background: Reconstruction with megaprostheses is an important limb-salvage option in cases of bone tumors and metastases, as it allows extensive bone resection while preserving the limb. However, postoperative shoulder instability remains a frequent complication. Although implant instability is one of the leading causes [...] Read more.
Background: Reconstruction with megaprostheses is an important limb-salvage option in cases of bone tumors and metastases, as it allows extensive bone resection while preserving the limb. However, postoperative shoulder instability remains a frequent complication. Although implant instability is one of the leading causes of treatment failure, the factors contributing to it are still not clearly defined. This study analyzes the correlation between resection length, implant type, and involvement of the deltoid and rotator cuff in relation to postoperative instability and the risk of postoperative dislocation. Methods: Twenty-five patients treated at our institution between 2014 and 2025 who underwent proximal humerus replacement with a megaprosthesis were included. Patients were divided into two groups: those with postoperative dislocation (Group A) and those without (Group B). Functional outcomes were assessed using the MSTS and DASH scores. The mean follow-up was 20.38 ± 11.87 months. Results: Of the twenty-five patients included, six (24%) experienced instability and subsequent dislocation (Group A). Rotator cuff invasion was present in 100% of Group A and 36.8% of Group B (p < 0.001), while deltoid invasion was present in 83.3% of Group A and 21% of Group B (p = 0.001). The mean resection length was 14.4 ± 2.2 cm in Group A and 13.7 ± 3.7 cm in Group B (p = 0.636). No significant differences were found between the groups in DASH and MSTS scores. Conclusions: In this cohort, rotator cuff and deltoid involvement were significantly associated with postoperative shoulder instability following proximal humerus megaprosthetic reconstruction. These findings suggest that careful preoperative assessment of rotator cuff and deltoid involvement may help identify patients at higher risk of postoperative instability and optimize surgical planning. Future studies should focus on preoperative planning and the development of a risk score to identify patients at higher risk of instability, potentially allowing for additional procedures such as latissimus dorsi flap reconstruction. Full article
(This article belongs to the Section Orthopedics)
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16 pages, 5420 KB  
Article
Etiology-Related Differences in Left Ventricular Remodeling and Left Atrial Function in Patients with Heart Failure and Reduced Ejection Fraction Referred for ICD/CRT Implantation
by Martyna Dąbrowska, Magdalena Potapowicz-Krysztofiak, Marek Kiliszek, Zbigniew Orski, Magdalena Smalc-Stasiak, Małgorzata Banak, Małgorzata Maciorowska, Paweł Krzesiński and Beata Uziębło-Życzkowska
J. Clin. Med. 2026, 15(18), 6989; https://doi.org/10.3390/jcm15186989 - 9 Sep 2026
Viewed by 121
Abstract
Background: Heart failure with reduced ejection fraction (HFrEF) may be caused by various factors. The etiology of HFrEF may influence prognosis and further management. Objectives: In this study we aimed to assess differences between ischemic and non-ischemic etiology in the context of clinical [...] Read more.
Background: Heart failure with reduced ejection fraction (HFrEF) may be caused by various factors. The etiology of HFrEF may influence prognosis and further management. Objectives: In this study we aimed to assess differences between ischemic and non-ischemic etiology in the context of clinical features, hemodynamic evaluation, and left ventricular (LV) and left atrial (LA) remodeling in a selected cohort of patients referred for device implantation. Methods: This prospective single-center study included 86 patients with HFrEF in sinus rhythm, without a history of atrial fibrillation, referred for ICD or CRT implantation. All patients underwent comprehensive echocardiography, electrocardiography, impedance cardiography and laboratory testing. This was a cross-sectional analysis without clinical follow-up. The pre-specified question was whether the two etiological groups differed in LV remodeling and LA function. All regression analyses were exploratory. Guideline-directed medical therapy was recorded in all patients. Results: Among 86 patients, 58 had ischemic and 28 had non-ischemic HFrEF. Patients with ischemic etiology were older, had worse renal function, and had higher N-terminal pro–B-type natriuretic peptide levels. They also exhibited lower left ventricular mass index (LVMI), left atrial reservoir strain (LASr), left atrial emptying fraction (LAEF), and higher left atrial stiffness index (LASI). Among myocardial work parameters, only global wasted work (GWW) differed significantly, with higher values in the non-ischemic group. Patients with ischemic HFrEF also had a higher Heather index (HI) in impedance cardiography. The two groups did not differ in guideline-directed medical therapy. In univariable logistic regression, older age, lower LVMI, reduced LASr and LAEF, higher LASI, higher HI, and lower eGFR were associated with ischemic HFrEF etiology. In the multivariable model, older age, lower LVMI, and reduced LASr remained independently associated with ischemic HFrEF (area under the ROC curve 0.82). Conclusions: Patients with ischemic and non-ischemic HFrEF referred for device implantation differ in LV remodeling and LA function. The between-group differences were small in absolute terms, with widely overlapping distributions, and the study was not designed to test whether echocardiography can replace established methods of establishing HFrEF etiology. These exploratory findings are hypothesis-generating and require confirmation in larger, independent cohorts. Full article
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15 pages, 1127 KB  
Article
Magnetocardiographic Rotation Score and Arrhythmic Endpoints in Primary-Prevention ICD Recipients: An Exploratory Substudy of the Magneto-SCD Trial
by Thomas Lachlan, Hejie He, Adam Miller, Nakul Chandan, Taesoon Hwang, Shoaib Siddiqui, Roger Beadle, David Wilson, Sanjiv Petkar, Ven Gee Lim, Peter K. Kimani and Faizel Osman
J. Clin. Med. 2026, 15(18), 6985; https://doi.org/10.3390/jcm15186985 - 9 Sep 2026
Viewed by 165
Abstract
Background/Objectives: Primary-prevention implantable cardioverter-defibrillator (ICD) selection remains dominated by left ventricular ejection fraction and clinical heart failure markers, which incompletely distinguish between patients who will experience ventricular arrhythmia and those whose prognosis is limited by competing non-arrhythmic mortality. The Magneto-SCD trial recently reported [...] Read more.
Background/Objectives: Primary-prevention implantable cardioverter-defibrillator (ICD) selection remains dominated by left ventricular ejection fraction and clinical heart failure markers, which incompletely distinguish between patients who will experience ventricular arrhythmia and those whose prognosis is limited by competing non-arrhythmic mortality. The Magneto-SCD trial recently reported novel rotation-based magnetocardiography (MCG) indices associated with future appropriate ICD therapies. This substudy explores whether MCG Rotation Score provides incremental information in primary-prevention ICD recipients, particularly beyond NYHA status and MADIT-arrhythmic and non-arrhythmic risk scores. Methods: We included all Magneto-SCD trial participants with a primary-prevention indication with non-missing follow-up/MCG Rotation Score data. The full primary-prevention cohort comprised 54 participants; the post-MI subgroup comprised 28. The primary endpoint was time to first appropriate ICD therapy. Death without prior therapy was used as a pragmatic competing endpoint and not assumed to represent adjudicated non-arrhythmic death. Appropriate shock was a secondary endpoint. Two-year cumulative incidence functions were estimated using Aalen–Johansen methods. Cause-specific Cox models assessed Rotation Score alone and after addition to MADIT-derived scores; nested likelihood-ratio tests evaluated model fit. Results: Of 104 participants, 90 had analysable MCG data and 65 had a primary-prevention ICD indication; after exclusions for missing patients, 54 patients remained (mean age 63.8 ± 13.2 yrs, 45(83.3%) male). Appropriate ICD therapies occurred in 10 (18.5%), including appropriate ICD shock in eight (14.8%); 10 patients (18.5%) died without prior therapy. The median follow-up was 1211.5 days (IQR 793.5–1396.0). Each SD increase in Rotation Score was associated with appropriate ICD therapy with HR 1.64 (95% CI 0.93–2.87; p = 0.086), appropriate ICD shock with HR 2.07 (95% CI 1.15–3.72; p = 0.015), death without prior therapy with HR 1.08 (95% CI 0.54–2.17; p = 0.824), and death without prior ICD shock with HR 0.95 (95% CI 0.48–1.90; p = 0.890). Adding Rotation Score did not significantly improve the primary therapy model beyond MADIT components (LRT p = 0.065) or MADIT benefit score (LRT p = 0.109). Model fit improved for the secondary appropriate ICD shock endpoint when Rotation Score was added to MADIT components (LRT p = 0.016), based on eight shock events. Conclusions: Rotation Score showed an association pattern more closely aligned with arrhythmic endpoints, particularly appropriate ICD shock, than with death without prior therapy. Incremental prognostic value for the primary endpoint was not established. These findings are hypothesis-generating and require confirmation in adequately powered, prospectively designed and externally validated cohorts before any role in clinical risk stratification or ICD decision-making can be determined. Full article
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18 pages, 7023 KB  
Article
Nerve Cell Responses to Biocompatible RGO–Chitosan–CMC Nanofiber Composite Membranes
by Quentin Sins, Giulia Zo, Giuliana Paravizzini, Elena Raluca Sandu, Stefania Raimondo, Wang Meng-Jiy, Federica Fregnan and Yuki Shirosaki
Int. J. Mol. Sci. 2026, 27(18), 8013; https://doi.org/10.3390/ijms27188013 - 9 Sep 2026
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Abstract
Peripheral nerve injuries are common traumas that are difficult to overcome. Although nerve grafting can quickly recover nearly all sensitivity and function, graft availability remains an issue. Research has focused on ways to directly rebuild and promote the healing of damaged nerves using [...] Read more.
Peripheral nerve injuries are common traumas that are difficult to overcome. Although nerve grafting can quickly recover nearly all sensitivity and function, graft availability remains an issue. Research has focused on ways to directly rebuild and promote the healing of damaged nerves using surgically implanted scaffolds. Nerve regeneration can be further promoted through strategies aimed at enhancing the regenerative microenvironment, such as improving the electrical conductivity of nerve guidance conduits. In this study, composite films of chitosan (Ch) and carboxymethyl cellulose (CMC) nanofibers were prepared. To improve the films’ conductivity, reduced graphene oxide (RGO) was added. Structural analysis indicated interactions between Ch and CMC and showed that incorporation of RGO did not produce additional detectable crystalline phases. ChCMCRGO films showed slightly higher conductivity and greater surface hydrophilicity than ChCMC membranes and supported greater neurite outgrowth. Full article
(This article belongs to the Special Issue Functional Materials for Biomedical Applications and Uses)
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45 pages, 4926 KB  
Review
Biomimetic Coacervate Coatings: From Phase Separation Fundamentals to Advanced Biomedical Applications
by Ki Ha Min, Yi-Rang Jeong, Jong Won Mun, Kyu Ho Jeon and Seung Pil Pack
Biomimetics 2026, 11(9), 647; https://doi.org/10.3390/biomimetics11090647 - 9 Sep 2026
Viewed by 260
Abstract
This review systematically elucidates the rapidly evolving field of biomimetic coacervate coatings, bridging the fundamental thermodynamic principles of liquid–liquid phase separation (LLPS) with advanced biomedical translations. While conventional surface modifications for medical implants frequently fail to maintain structural and functional integrity within dynamic, [...] Read more.
This review systematically elucidates the rapidly evolving field of biomimetic coacervate coatings, bridging the fundamental thermodynamic principles of liquid–liquid phase separation (LLPS) with advanced biomedical translations. While conventional surface modifications for medical implants frequently fail to maintain structural and functional integrity within dynamic, wet physiological environments, biomimetic coacervation inspired by natural underwater adhesive mechanisms offers a highly versatile, conformable, and robust interfacial strategy. Here, we analyze the critical physicochemical driving forces governing coacervate formation, emphasizing the synergistic interplay of electrostatic, hydrophobic, hydrogen-bonding, and cation–π interactions. We comprehensively discuss diverse macromolecular design principles utilizing marine-derived biopolymers, synthetic or recombinant polypeptides, and hybrid organic–inorganic condensates, alongside key architectural orchestration methodologies including direct deposition, in situ triggerable coacervation, and layer-by-layer (LbL) assembly. Furthermore, we evaluate multi-functional clinical translations, highlighting breakthroughs in wet tissue sealing, bone repair, localized stimuli-responsive drug or nucleic acid delivery, anti-biofouling medical device coatings, and regenerative cell–material interfaces. Ultimately, this review underscores the profound potential of biomimetic coacervates as a cornerstone platform for next-generation multifunctional medical devices and personalized regenerative medicine. Full article
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8 pages, 243 KB  
Article
Trapeziometacarpal Dual Mobility Prostheses in Patients with Rheumatoid Disease: A Multicenter Retrospective Cohort Study
by Matteo Guzzini, Lorenzo Alirio Diaz Balzani, Andrea Zampaletta and Alice Patrignani
Surgeries 2026, 7(3), 107; https://doi.org/10.3390/surgeries7030107 - 9 Sep 2026
Viewed by 118
Abstract
Background/Objectives: Trapeziometacarpal (TM) joint involvement is common in inflammatory rheumatic disease and may result in pain, instability, and functional impairment. Although TM arthroplasty is widely performed for primary osteoarthritis, evidence in patients with inflammatory arthropathy remains limited. This multicenter study evaluated clinical outcomes, [...] Read more.
Background/Objectives: Trapeziometacarpal (TM) joint involvement is common in inflammatory rheumatic disease and may result in pain, instability, and functional impairment. Although TM arthroplasty is widely performed for primary osteoarthritis, evidence in patients with inflammatory arthropathy remains limited. This multicenter study evaluated clinical outcomes, complications, and revision rates of TM arthroplasty in patients with inflammatory rheumatic disease. Methods: We conducted a retrospective multicenter cohort study including patients with inflammatory rheumatic disease who underwent primary TM arthroplasty at tertiary referral centers. Demographic, clinical, radiographic, and surgical data were collected. Standard radiographs obtained at 1, 6, and 12 months postoperatively were reviewed to assess implant stability, radiolucent lines, and implant-related complications. Primary outcomes included revision rate and complications; secondary outcomes included functional recovery. Results: Fourteen patients undergoing 15 TM arthroplasties were included; one patient underwent bilateral surgery. The cohort was predominantly female (64%), with a mean age of 63 years. Mean clinical follow-up was 12.8 months (range, 12–18). Functional outcomes improved significantly following surgery, with substantial reductions in QuickDASH disability scores. One complication (1/15 procedures; 6.7%) occurred, consisting of a postoperative hematoma managed nonoperatively. No revision surgeries were required among 15 procedures during the available follow-up, corresponding to a revision rate of 0%. Conclusions: TM arthroplasty in inflammatory rheumatic disease was associated with satisfactory functional outcomes, a low complication rate, and no revision procedures during short-term follow-up, suggesting that TM arthroplasty may represent a potential option in carefully selected patients. Full article
(This article belongs to the Section Hand Surgery and Research)
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