Search Results (33)

Dromedary camels possess unique anatomical, physiological, and metabolic adaptations that enable survival in arid environments; however, these same adaptations make them highly sensitive to nutritional imbalance under modern feeding conditions. This review synthesizes current knowledge on nutritional pathologies and metabolic disorders in camels, emphasizing the links between diet composition, foregut fermentation, mineral status, and systemic health. Imbalances in energy and carbohydrates predispose camels to subacute and acute acidosis, negative energy balance, and ketosis-like syndromes, particularly when rapidly fermentable feeds are introduced without adequate fiber or water. Protein and nitrogen disorders, including ammonia toxicity and impaired urea recycling, arise from mismatches between degradable protein, fermentable energy, hydration, and mineral availability. Widespread deficiencies of phosphorus, copper, cobalt, zinc, selenium, and vitamins A and E remain major constraints, leading to pica, poor microbial fermentation, oxidative stress, immunosuppression, reproductive failure, and skeletal disorders. Nutritional disturbances frequently extend beyond the gastrointestinal tract, forming a gut–liver–kidney metabolic axis characterized by hepatic dysfunction, renal compromise, and systemic oxidative stress. The review also addresses gastrointestinal impaction, foreign-body ingestion, toxic plant consumption, and feeding on human food waste as emerging nutritional challenges, particularly in peri-urban systems. Advances in diagnostic ultrasonography, feed evaluation techniques, probiotics, mineral–vitamin supplementation, and omics-based approaches are discussed as tools for improving early diagnosis and precision nutrition. Despite growing research interest, the lack of camel-specific feeding standards and reliance on cattle-based recommendations remain critical gaps. This review highlights the need for species-specific nutrient requirement models, sustainable rangeland management, and integrative research to support the health, resilience, and productivity of camels under changing environmental and production systems. Full article

Using a method inspired by quantum principles, this study estimates the composition of various types of tax contributions expected from foreign trade operations. The estimation approach is proposed considering the superposition of expectations and disturbances—fundamental elements of quantum methods—that add complexity to the forecasts of tax collections. For instance, the contributions of international trade-related taxes may be determined not only by the country’s degree of regional integration but also by the composition of tax revenue that depends on the kind and use of merchandise. Using the case of Mexico’s imports, the methodology illustrates how the expectations of collecting certain taxes—like the General Import Tariff (GIT) and the Value Added Tax (VAT)—would be impacted by fluctuations in others—such as the Special Tax on Production and Services (STPS). The hypothesis of this study is that, through the proposed quantum-inspired methodology, it is possible to establish future scenarios of tax revenue compositions while maintaining fiscal consistency by anticipating potential outcomes in the adjustments of contributions if the recently proposed fiscal reform is approved by the Mexican Government. This work contributes to the academic literature on public finance management by advancing a methodology that can support the strategic formulation of fiscal expectations and policy. Full article

As global copper demand continues to grow, China, being the largest copper consumer, faces increasingly complex challenges in ensuring the security of its supply chain. However, a substantive gap remains: prevailing assessments rely on static index systems and discrete scenario analyses that seldom model uncertainty-driven, continuous-time strategic interactions, leaving the conditions for self-enforcing cooperation and the attendant policy trade-offs insufficiently identified. This study models the interaction between Chinese copper importers and foreign suppliers as a continuous-time stochastic differential game, with feedback Nash equilibria derived from a Hamilton–Jacobi–Bellman system. The supply security utility is specified as a diffusion process perturbed by Brownian shocks, while regulatory intensity and profit-sharing are treated as structural parameters shaping its drift and volatility—thereby delineating the parameter region for self-enforcing cooperation and clarifying how sudden disturbances reconfigure equilibrium security. The research findings reveal the following: (i) the mean and variance of supply security utility progressively strengthen over time under the influence of both parties’ maintenance efforts, while stochastic disturbances causing actual fluctuations remain controllable within the contract period; (ii) spontaneous cooperation can be achieved under scenarios featuring strong regulation of domestic importers, weak regulation of foreign suppliers, and a profit distribution ratio slightly favoring foreign suppliers, thereby reducing regulatory costs; this asymmetry is beneficial because stricter oversight of domestic importers curbs the primary deviation risk, lighter oversight of foreign suppliers avoids cross-border enforcement frictions, and a modest supplier-favored profit-sharing ratio sustains participation—together expanding the self-enforcing cooperation set; (iii) sudden events exert only short-term impacts on supply security with controllable long-term effects; however, an excessively stringent regulatory environment can paradoxically reduce long-term supply security. Security effort levels demonstrate positive correlation with supply security, while regulatory intensity must be maintained within a moderate range to balance incentives and constraints. Full article

The stable control of the main steam flow rate (MSFR) can effectively improve the waste combustion efficiency and energy utilization, reduce environmental pollution, and is crucial for promoting the sustainable development of municipal solid waste incineration (MSWI). Developed countries benefit from stable municipal solid waste (MSW) composition, enabling advanced automated combustion control. However, in developing countries, fluctuating waste composition and calorific value cause frequent disturbances, limiting the use of foreign control methods. Therefore, MSFR control technologies suited to developing countries are crucial. This study proposes a two-layer intelligent control method, consisting of an optimization setting layer and a loop control layer. The optimization layer uses a steam flow prediction model (OPTICS and RBF) and an improved antlion optimizer (IALO) for manipulated variable setpoints. The control layer applies reinforcement learning (actor–critic) to fine-tune PI controller parameters. Experimental results show that the proposed method adaptively adjusts manipulated variables, ensuring MSFR control within the target range and maintaining efficient, stable MSWI operation. Full article

We present the first comprehensive review of 62 migratory shorebird species in Mongolia, covering their ecological status, IUCN assessments at regional or national levels, population trends, threats, and conservation measures. Mongolia hosts a total of 62 shorebird species from twenty-two genera and seven families, with six species classified as globally threatened: the Critically Endangered Sociable Lapwing, the Endangered Siberian Sandplover, the Far Eastern Curlew, the Great Knot, and the Vulnerable Sharp-Tailed Sandpiper. Both national and global IUCN Red List assessments highlight Mongolia’s significance as a breeding and passage migrating site for globally threatened and Near-Threatened shorebirds. Species richness is higher in northern regions compared to the south, with the highest diversity found in areas with complex aquatic ecosystems. Global population trends indicate a decline in 61% of species, with 18% remaining stable, 16% of unknown status, and 5% increasing. At the national level, most species are stable (61%), 34% status is unknown, and 5% are decreasing. Anthropogenic-induced threats, including habitat loss and degradation, pollution, disturbance, and harvesting, pose significant risks to 69% of species, while natural disasters affect 11%. Additionally, 8% of species are impacted by accidental mortality and intrinsic factors, and 5% by changes in native species. Despite these threats, no specific conservation action plans exist for shorebirds in Mongolia. However, general conservation measures are in place, such as environmental and fauna protection laws, regulations on foreign trade in endangered species, and the establishment of protected areas under governmental resolutions. Mongolia also participates in international conventions like the Convention on Biological Diversity (CBD), Ramsar, and Migratory Species (CMS), and has developed national red lists, red books, and publications such as “A Summary Conservation Action Plan for Mongolian Birds”, “Important Bird Areas” to support conservation efforts. Full article

In the area of dental healthcare services, where patients and professionals deal with multiple auditory stimuli, this cross-sectional study reports on the various dynamics of sound preferences, noise obstacles, and the profound impact of music on anxiety reduction within dental office settings. The sample comprises 134 dental patients, primarily females (56.7%), with varying age groups, education levels, and therapy durations in the university clinics of the Department of Dentistry, National and Kapodistrian University of Athens, and four private dental offices at the metropolitan area of Athens, Greece. Notably, 92.5% of the participants reported no hearing loss, and 56.7% exhibited some level of noise sensitivity. This study reveals a moderate to good perceived health status (M = 3.84, SD = 0.95) among participants, with low perceived noise disturbance in university dental clinics. Preferences for instrumental music, foreign pop, and classical music are prominent during waiting times. Potential irritations include impersonal treatment (44%) and staff behavior (41.8%). Correlations and predictors indicate associations between age, gender, educational status, music preferences, and noise disturbances. Findings aim to optimize eco-soundscapes in dental offices, contributing to enhanced patient well-being. The research underscores the potential of music interventions to alleviate dental anxiety and improve the overall dental experience and quality care. Full article

Oral administration of active pharmaceutical ingredients is desirable because it is easy, safe, painless, and can be performed by patients, resulting in good medication adherence. The mucus layer in the gastrointestinal (GI) tract generally acts as a barrier to protect the epithelial membrane from foreign substances; however, in the absorption process after oral administration, it can also disturb effective drug absorption by trapping it in the biological sieve structured by mucin, a major component of mucus, and eliminating it by mucus turnover. Recently, functional nanocarriers (NCs) have attracted much attention due to their immense potential and effectiveness in the field of oral drug delivery. Among them, NCs with mucopenetrating and mucoadhesive properties are promising dosage options for controlling drug absorption from the GI tracts. Mucopenetrating and mucoadhesive NCs can rapidly deliver encapsulated drugs to the absorption site and/or prolong the residence time of NCs close to the absorption membrane, providing better medications than conventional approaches. The surface characteristics of NCs are important factors that determine their functionality, owing to the formation of various kinds of interactions between the particle surface and mucosal components. Thus, a deeper understanding of surface modifications on the biopharmaceutical characteristics of NCs is necessary to develop the appropriate mucosal drug delivery systems (mDDS) for the treatment of target diseases. This review summarizes the basic information and functions of the mucosal layer, highlights the recent progress in designing functional NCs for mDDS, and discusses their performance in the GI tract. Full article

The use of quartz is critical to the electron spin resonance (ESR) dating of sediments and fault gouges. The germanium center (Ge center) in quartz is a commonly used color center employed in ESR signal measurement. Although Ge center signals in quartz can be detected using an ESR spectrometer, they are weak and sometimes undetectable. Impurities in quartz grains can further aggravate these deficiencies and may even invalidate any attempt to repeat ESR ages due to the deficiencies evident in the processes used in sample preparation. Using sieving, carbonate-organic matter removal, water flotation, magnetic separation, heavy liquid separation, and HF solution etching, we separated quartz, feldspar (plagioclase), mica, and the heavy minerals and measured the ESR signal in each of them to examine the impact of impurities within mineral grains on the ESR signals. From the ESR spectra, we observed intense ESR signals in feldspar and the heavy minerals and weak signals in mica at the same positions as the Ge center in the quartz. The ESR signals in the feldspar proved to be the most intense and overrode the peaks exhibited by the Ge center in the quartz. Feldspar is commonly associated with quartz in sediments, but it is difficult to separate it from quartz as their colors, specific gravities, and magnetic properties are similar. Any ESR signal in quartz containing foreign minerals would therefore be likely to be heavily disturbed by the signals from these foreign minerals, particularly from the feldspar and heavy minerals. ESR signals in the feldspar decreased similarly to those in the quartz when exposed to sunlight, declining by 70%–80% after being exposed for 50 h. Such declination was more obvious in high-altitude areas than in low-altitude areas. Our results indicate that highly pure quartz is required when dating; we would therefore strongly suggest that the procedures for the purification of quartz grains should include floating, heavy liquid separation, and HF solution etching to remove the feldspar, heavy minerals, and any remnant magnetite. Such a procedure would guarantee that the signal that is measured comes from the quartz alone, allowing repeatable measurements using the same spectrometer as well as valid comparisons between the spectrometries derived from different spectrometers. Full article

A prerequisite for sustainable forest management is knowing the total diversity and how management affects forests. Both are poorly studied and relate to canopy diversity and comparison with primary forests. From 2001–2004, we fogged beetles from oaks in primary and disturbed, managed sites in Białowieża (Eastern Poland) and also in distant age-class forests. Using a machine learning (ML) method (elastic net), we identified a beetle signature based on the species abundance distribution to distinguish these forest types. The beetle communities from 2001 served as training data, with 21 signature species correctly assigning the oaks to primary and different managed forests. However, the predictive quality of the signature decreased with each year due to high spatio-temporal heterogeneity and beta diversity. To improve the power of the signature, we combined the data from all years to calculate a more general model. Due to its greater complexity, this model identified 60 species that correctly classified both the studied forests and foreign forests in Central Europe, increasing the possibility of a general classification. Further research is needed to determine whether it is possible to establish a general signature-based index on a large number of samples from different years and forest types. Full article

Aflatoxin B1 (AFB1) and aflatoxin M1 (AFM1) are universally found as environmental pollutants. AFB1 and AFM1 are group 1 human carcinogens. Previous sufficient toxicological data show that they pose a health risk. The intestine is vital for resistance to foreign pollutants. The enterotoxic mechanisms of AFB1 and AFM1 have not been clarified at the metabolism levels. In the present study, cytotoxicity evaluations of AFB1 and AFM1 were conducted in NCM 460 cells by obtaining their half-maximal inhibitory concentration (IC50). The toxic effects of 2.5 μM AFB1 and AFM1 were determined by comprehensive metabolomics and lipidomics analyses on NCM460 cells. A combination of AFB1 and AFM1 induced more extensive metabolic disturbances in NCM460 cells than either aflatoxin alone. AFB1 exerted a greater effect in the combination group. Metabolomics pathway analysis showed that glycerophospholipid metabolism, fatty acid degradation, and propanoate metabolism were dominant pathways that were interfered with by AFB1, AFM1, and AFB1+AFM1. Those results suggest that attention should be paid to lipid metabolism after AFB1 and AFM1 exposure. Further, lipidomics was used to explore the fluctuation of AFB1 and AFM1 in lipid metabolism. The 34 specific lipids that were differentially induced by AFB1 were mainly attributed to 14 species, of which cardiolipin (CL) and triacylglycerol (TAG) accounted for 41%. AFM1 mainly affected CL and phosphatidylglycerol, approximately 70% based on 11 specific lipids, while 30 specific lipids were found in AFB1+AFM1, mainly reflected in TAG up to 77%. This research found for the first time that the lipid metabolism disorder caused by AFB1 and AFM1 was one of the main causes contributing to enterotoxicity, which could provide new insights into the toxic mechanisms of AFB1 and AFM1 in animals and humans. Full article

This review aims to summarize and present different biological health markers in dairy cows during the lactation period. Biochemical health markers provide an indicator of how foreign chemical substances, whether external or internal, affect the animal’s health. To understand the relationship between dairy cow health issues and oxidative stress, various biomarkers of oxidative stress must be investigated. Biochemical and hematological factors play a significant role in determining the biological health markers of animals. A variety of biochemical parameters are dependent on various factors, including the animal’s breed, its age, its development, its pregnancy status, and its production status. When assessing the health of cattle, a blood test is conducted to determine the blood chemistry. To diagnose diseases in dairy animals, the blood biochemistry is necessary to determine the cause of many physiological, metabolic, and pathological problems. Observing blood alterations during pregnancy and at peak lactation may determine what factors lift oxidative stress in cows due to disturbances in feed intake and metabolic processes. Full article

Staphylococcus aureus causes the majority of implant-related infections. These infections present as biofilms, in which bacteria adhere to the surface of foreign materials and form robust communities that are resilient to the human immune system and antibiotic drugs. The heavy use of broad-spectrum antibiotics against these pathogens disturbs the host’s microbiome and contributes to the growing problem of antibiotic-resistant infections. The use of bacteriophages as antibacterial agents is a potential alternative therapy. In this study, bioluminescent strains of S. aureus were grown to form 48-h biofilms on polyether ether ketone (PEEK), a material used to manufacture orthopaedic implants, in either static or dynamic growth conditions. Biofilms were treated with vancomycin, staphylococcal phage, or a combination of the two. We showed that vancomycin and staph phages were able to independently reduce the total bacterial load. Most phage-antibiotic combinations produced greater log reductions in surviving bacteria compared to single-agent treatments, suggesting antimicrobial synergism. In addition to demonstrating the efficacy of combining vancomycin and staph phage, our results demonstrate the importance of growth conditions in phage-antibiotic combination studies. Dynamic biofilms were found to have a substantial impact on apparent treatment efficacy, as they were more resilient to combination treatments than static biofilms. Full article

Novel biodegradable metal alloys are increasingly used as implant materials. The implantation can be accompanied by an inflammatory response to a foreign object. For studying inflammation in the implantation area, non-invasive imaging methods are needed. In vivo imaging for the implanted area and its surroundings will provide beneficiary information to understand implant-related inflammation and help to monitor it. Therefore, inflammation-sensitive fluorescent liposomes in rats were tested in the presence of an implant to evaluate their usability in studying inflammation. The sphingomyelin-containing liposomes carrying alpha-melanocyte-stimulating hormone (α-MSH)-peptide were tested in a rat bone implant model. The liposome interaction with implant material (Mg-10Gd) was analyzed with Mg-based implant material (Mg-10Gd) in vitro. The liposome uptake process was studied in the bone-marrow-derived macrophages in vitro. Finally, this liposomal tracer was tested in vivo. It was found that α-MSH coupled sphingomyelin-containing liposomes and the Mg-10Gd implant did not have any disturbing influence on each other. The clearance of liposomes was observed in the presence of an inert and biodegradable implant. The degradable Mg-10Gd was used as an alloy example; however, the presented imaging system offers a new possible use of α-MSH-SM-liposomes as tools for investigating implant responses. Full article

The Galapagos Islands have been declared a World Heritage site due to their unique biodiversity, which makes them a living museum and a natural laboratory for humankind. However, to fulfill the energy needs of its habitants and foreign visitors, the islands have depended on fossil fuel energies that have produced levels of lead and chemical agents that are affecting the islands’ air quality, flora, and fauna. Therefore, zero-carbon initiatives have been created to protect the islands, wherein solar and wind power plants have been studied as reliable alternatives. In this way, Geographical Information Systems based on Multicriteria Decision Methods constitute a methodology that minimizes the destruction and disturbance of nature in order to assess the best location for the implementation of these alternative energy sources. Therefore, by exploring the geographical information along with the Analytical Hierarchical Processes and the Ordered Weighted Average methods, it was possible to identify the potential for solar power plants of 10 MW on each island; likewise, for wind power plants, it was found that the islands possess implementation potential that has been analyzed in the field, showing that the best location is on Baltra Island, but is not limited to it. Full article

With the advent of the “her economy” era, the new energy automobile market has also ushered in the “her era”, and female consumers have gradually become the main force of domestic and foreign vehicle consumption, thus contributing to the sustainable and rapid development of many female new energy automobile market segments. In this context, this study explores the icon cognitive preferences of female drivers based on gender differences in icon cognition by taking the human–machine interface icons in new energy automobiles as a case study. Firstly, we conducted behavioral response experiments and facial electromyography experiments on 20 male and female participants to analyze their cognitive preferences for icons by combining the four dimensions of “semantic dimension, conceptual dimension, contextual dimension and pragmatic dimension”. The results showed that the four−dimensional graphic deconstruction format had a significant effect on the improvement of icon recognition performance. At the same time, we designed 10 formats of icons as experimental stimulus materials and combined them with subjective scales to jointly explore the reasons for the bias of different gender participants towards icons. The results show that there are significant gender differences in icon perception on a four−dimensional basis, with males more likely to be disturbed by icon constituent elements (semantic dimension), while females are more likely to be disturbed by icon metaphors (semantic dimension) and usage environment and interface context (contextual dimension). This study helps to explore the best balance between studying women’s driving experiences in new energy vehicles and the sustainable product life cycle, and then improve the accuracy of women drivers’ decision−making behavior in new energy vehicles to ensure driving safety. Full article