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19 pages, 4324 KB  
Article
Numerical Simulation of Natural Convection in Freezing Water Droplets Using OpenFOAM
by Paria Khosravifar, Anna-Lena Ljung and T. Staffan Lundström
Water 2026, 18(8), 949; https://doi.org/10.3390/w18080949 - 16 Apr 2026
Abstract
Droplet freezing on cold surfaces plays a critical role in icing phenomena and thermal management systems. In this study, a numerical model is developed to investigate the freezing of a single water droplet, with emphasis on the influence of natural convection on internal [...] Read more.
Droplet freezing on cold surfaces plays a critical role in icing phenomena and thermal management systems. In this study, a numerical model is developed to investigate the freezing of a single water droplet, with emphasis on the influence of natural convection on internal flow dynamics. A two-phase (water–ice) solver is implemented in OpenFOAM by incorporating an enthalpy–porosity solidification model and a buoyancy model into an existing framework. The solver is verified against the analytical solution of the one-dimensional Stefan problem and validated using benchmark cases of natural convection and solidification in a cavity. Using the validated model, we examine the effects of natural convection and water density inversion on the internal flow behavior during droplet freezing. Simulations are performed for a rigid axisymmetric droplet configuration. By accounting for density inversion in the buoyancy source term, the model successfully captures the experimentally observed reversal of internal flow during freezing. The results indicate that the flow reversal occurs when the maximum droplet temperature approaches the density inversion temperature of water. While early-stage freezing follows the classical Stefan solution, comparisons with experimental data indicate that incorporating droplet impact and heat transfer to the surroundings would further enhance the model’s predictive capability. Full article
(This article belongs to the Section Hydraulics and Hydrodynamics)
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18 pages, 2903 KB  
Article
Solid Foams from Geopolymerization of Lunar Regolith Simulants Slurries
by Michela Elena Pedretti, Libero Liggieri, Luca Valentini, Giovanna Canu, Alberto Lagazzo, Francesca Ravera and Eva Santini
Colloids Interfaces 2026, 10(2), 29; https://doi.org/10.3390/colloids10020029 - 16 Apr 2026
Abstract
Robust, lightweight, and thermally insulating building materials, developed according to the In Situ Resource Utilization (ISRU) paradigm, are essential for enabling Moon settlements. With this aim, we have investigated the formulation and characterization of porous geopolymeric materials based on a lunar regolith simulant, [...] Read more.
Robust, lightweight, and thermally insulating building materials, developed according to the In Situ Resource Utilization (ISRU) paradigm, are essential for enabling Moon settlements. With this aim, we have investigated the formulation and characterization of porous geopolymeric materials based on a lunar regolith simulant, focusing on the influence of surfactants and rheology-modifying additives on pore structure and final material performance. As an optimized procedure, a pre-formed TTAB foam was, in fact, incorporated into the geopolymeric precursor slurries to achieve a suitable porosity. Then, the effects of three thickeners (xanthan gum, bentonite, and Actigel-208) were evaluated in view of the possible utilization for the production of building blocks by 3D printing. Observations of the pore structure after the geopolymeric consolidation of the slurries showed predominantly closed-cell networks across all formulations, with a pore morphology strongly dependent on the thickener used. Xanthan gum promoted high porosity but reduced mechanical integrity, whereas bentonite produced denser structures with higher thermal conductivity. Actigel-208 provided the most balanced performance, combining adequate porosity with improved strength. These findings demonstrate the potential of producing thermally insulating, structurally stable solid foams from lunar regolith simulants via a geopolymerization route. Full article
(This article belongs to the Special Issue Advances in Soft Matter Interfaces and Structures)
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22 pages, 8791 KB  
Article
Machine Learning-Based Modeling and Multi-Objective Optimization of Direct Urea–Hydrogen Peroxide Fuel Cell
by Phan Khanh Thinh Nguyen, Thi Thu Ha Tran and Tamirat Redae Gebreselassie
Electrochem 2026, 7(2), 9; https://doi.org/10.3390/electrochem7020009 - 15 Apr 2026
Abstract
Direct urea–hydrogen peroxide fuel cells (DUHPFCs) are promising for sustainable power generation, but their performance is governed by highly nonlinear material and operating interactions. This study develops a machine-learning framework employing a multi-output artificial neural network (ANN) to predict cell voltage, power density [...] Read more.
Direct urea–hydrogen peroxide fuel cells (DUHPFCs) are promising for sustainable power generation, but their performance is governed by highly nonlinear material and operating interactions. This study develops a machine-learning framework employing a multi-output artificial neural network (ANN) to predict cell voltage, power density (PD), and substrate-based energy efficiency (SEE) of DUHPFCs. The ANN exhibits excellent predictive accuracy, achieving coefficients of determination (R2) above 0.995 and normalized root mean square errors (NRMSE) below 1.75 × 10−2 for all outputs. Model interpretability is enhanced by using Shapley additive explanations and partial dependence plots, which identify current density as the dominant factor affecting DUHPFC performance, followed by temperature and anolyte composition. The ANN is coupled with a multi-objective Pareto-search algorithm optimization (PAO) to resolve the trade-offs among competing performance metrics. Under different optimization objectives, a DUHPFC with an Ni0.2Co0.8/Ni-foam anode is predicted to achieve a maximum PD of 45.6 mW/cm2 with a low SEE of 2.6% or a maximum SEE of 15.2% with a moderate PD of 40.9 mW/cm2. Additionally, a balanced operating regime is identified, achieving a PD of 43.1 mW/cm2 and an SEE of 13.9%. Overall, the proposed framework provides an effective decision-support tool for optimizing DUHPFC performance under competing objectives. Full article
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20 pages, 1340 KB  
Article
Acute Effects of Muscle Flexibility and Myofascial Release of the Posterior Lower-Leg Muscles on Ankle Function in Individuals with Active Ankle Dorsiflexion Range of Motion Deficits
by Maria Giannioti, Konstantinos Fousekis, Eleftherios Paraskevopoulos and Dimitris Mandalidis
Sports 2026, 14(4), 154; https://doi.org/10.3390/sports14040154 - 15 Apr 2026
Abstract
Ankle dorsiflexion range of motion (ADF-ROM) deficits has been linked to impaired function, altered gait, and injury risk. This study’s objective was to examine the acute effects of static self-stretching (SSS), foam rolling (FR), and instrument-assisted soft tissue mobilization (IASTM) of the posterior [...] Read more.
Ankle dorsiflexion range of motion (ADF-ROM) deficits has been linked to impaired function, altered gait, and injury risk. This study’s objective was to examine the acute effects of static self-stretching (SSS), foam rolling (FR), and instrument-assisted soft tissue mobilization (IASTM) of the posterior lower-leg on ADF-ROM and functional ankle outcomes in individuals with ADF-ROM deficits. Thirteen healthy, physically active college students with active ADF-ROM ≤ 13°, assessed in a non-weight-bearing position, completed all three interventions in a randomized, within-subject repeated-measures design. Pre- and post-intervention assessments included ADF-ROM, ankle plantar flexor isometric strength (APF-IS), single-leg countermovement vertical jump (SLCVJ), anterior reach distance in the Y-Balance Test (A-YBT), and gait parameters (contact time and plantar pressure). A two-way repeated-measures ANOVA with Bonferroni post hoc tests was used. Effect sizes reported as partial eta squared (ηp2) and Cohen dz. All interventions significantly improved ADF-ROM (p < 0.001; ηp2 = 0.885), with IASTM showing the largest increase (50.7%, dz = 2.15), followed by FR (35.4%, dz = 2.20) and SSS (21.5%, dz = 1.82). Differences between IASTM and FR (p > 0.05, dz = 0.40) and between FR and SSS (p > 0.05, dz = 0.69) were nonsignificant, while IASTM was significantly greater than SSS (p < 0.05, dz = 0.92). Significant gains were also seen in A-YBT (p < 0.05; ηp2 = 0.302) and rearfoot plantar pressure (p < 0.01; ηp2 = 0.482), although pairwise comparisons were nonsignificant and demonstrated small-to-moderate effect sizes (dz = 0.35–0.52). No significant changes occurred in APF-IS, SLCVJ, or contact time and mid- and forefoot plantar pressures during roll-off. In conclusion, all interventions improved ADF-ROM, with IASTM and FR being comparably effective. However, only slight improvements in dynamic balance and certain gait parameters were noted, with no effect on strength or power. Full article
(This article belongs to the Special Issue Innovative Approaches to Sports Injury Prevention and Recovery)
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17 pages, 1524 KB  
Article
Comparative Characterization of Pumpkin Seed Protein Isolates Obtained by Alkaline, Ultrasound-Assisted, and Microwave-Assisted Extraction: Functionality, Particle Size, and Structural Integrity
by Walid Zenasni, Ismail Hakkı Tekiner, Hanaa Abdelmoumen, Rachid Nejjari, Abdelhak Chergui, Said Ennahli and El Amine Ajal
Processes 2026, 14(8), 1250; https://doi.org/10.3390/pr14081250 - 14 Apr 2026
Abstract
As demand for sustainable plant protein rises, pumpkin seeds emerge as a promising but underutilized source. Conventional alkaline extraction (ALK) often impairs protein functionality, prompting interest in non-thermal alternatives. This study systematically compared the functional, colloidal, and structural properties of pumpkin seed protein [...] Read more.
As demand for sustainable plant protein rises, pumpkin seeds emerge as a promising but underutilized source. Conventional alkaline extraction (ALK) often impairs protein functionality, prompting interest in non-thermal alternatives. This study systematically compared the functional, colloidal, and structural properties of pumpkin seed protein isolates obtained via ALK (conducted at 50 °C), ultrasound-assisted (UAE), and microwave-assisted extraction (MAE). UAE produced the highest extraction yield (50.07%), superior overall solubility, greatest water and fat absorption capacities, and lowest least gelation concentration (12%). Furthermore, UAE best preserved native protein secondary structure (retaining 43.45% alpha-helix), as quantified by FTIR peak deconvolution, and maintained an intact, flake-like morphology under scanning electron microscopy (SEM), yielding the most uniform particle size distribution. Conversely, MAE achieved the highest protein content (73.53%) and the most negative zeta potential, leading to the highest emulsifying and foaming capacities despite inducing a bimodal particle size and irregular, porous surface morphology. ALK performed the poorest across structural and functional metrics, severely denaturing the proteins due to combined alkaline and thermal stress. UAE is recommended for applications requiring optimal solubility and gelation, whereas MAE is highly effective for emulsion- and foam-based food systems, reinforcing pumpkin seeds as a viable sustainable protein ingredient. Full article
(This article belongs to the Special Issue Resource Utilization of Food Industry Byproducts)
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23 pages, 3812 KB  
Article
DSMC Analysis of DiskSat in Very Low Earth Orbits
by Máximo Castillo Rivas, Diego Vera Sepúlveda and Rodrigo Cassineli Palharini
Aerospace 2026, 13(4), 362; https://doi.org/10.3390/aerospace13040362 - 14 Apr 2026
Viewed by 57
Abstract
Satellite containerization is a key factor in the expansion of the aerospace sector. In addition, the container provides a highly simplified launch interface, reducing the launch provider’s integration costs. In this scenario, DiskSats have been proposed as a new standard for a high-power-to-mass-ratio [...] Read more.
Satellite containerization is a key factor in the expansion of the aerospace sector. In addition, the container provides a highly simplified launch interface, reducing the launch provider’s integration costs. In this scenario, DiskSats have been proposed as a new standard for a high-power-to-mass-ratio platform that can be easily stacked within a launcher fairing. However, their behavior in Very Low Earth Orbits remains underexplored. The primary research objective of this study is to characterize the macroscopic aerothermodynamic behavior and aerodynamic footprint of a DiskSat platform operating in Very Low Earth Orbit (VLEO) at altitudes of 100, 150, and 200 km. At such altitudes, the continuum hypothesis is no longer valid, and a particle-based method should be used for computations in the rarefied-flow regime. In this way, the Direct Simulation Monte Carlo (DSMC) method was employed to analyze the flowfield structure around a DiskSat at different altitudes. In the present investigation, the Knudsen number associated with each altitude ranged from 0.14 to 240. According to the computational results, a compressed shock layer with higher temperature was observed over the DiskSat at an altitude of 100 km. However, the 200 km case shows a highly diffuse interaction that extends significantly upstream due to the larger mean free path. In addition, a thermally frozen, near-vacuum wake region is observed across all altitudes. These findings characterize the aerodynamic footprint of planar geometries, establishing a critical baseline for future analyses of orbital lifetime and stability in the transition and free-molecular regimes. Full article
(This article belongs to the Section Astronautics & Space Science)
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19 pages, 1205 KB  
Article
Recycled Denim and Polyurethane Foam for Building Insulation and Resource Conservation
by Neelima Madasu, Farnaz Saadat, Nadia Laredj, Mustapha Maliki, Anthony Lamanna, Hamed Khodadadi Tirkolaei and Elham H. Fini
Sustainability 2026, 18(8), 3847; https://doi.org/10.3390/su18083847 - 13 Apr 2026
Viewed by 208
Abstract
Construction industry remains a major driver of global resource use and waste generation, therefore, identifying sustainable material alternatives is increasingly important. Recycled-textile-based insulation presents a promising pathway to support circular economy principles by diverting post-consumer waste from landfills and reducing reliance on virgin [...] Read more.
Construction industry remains a major driver of global resource use and waste generation, therefore, identifying sustainable material alternatives is increasingly important. Recycled-textile-based insulation presents a promising pathway to support circular economy principles by diverting post-consumer waste from landfills and reducing reliance on virgin petrochemical materials. This study conducts a cradle-to-gate life cycle assessment (LCA) using SimaPro to compare polyurethane (PU) foam and recycled denim (cotton fiber) insulation. The system boundary includes raw material extraction, transportation, and manufacturing. A functional unit of 1 m2 of installed insulation with a thermal resistance of RSI = 1 m2·K/W at the factory gate ensures comparability, with mass-based results reported as secondary metrics. The results indicate that recycled denim exhibits higher embodied carbon per unit mass, despite lower production energy and lower cradle-to-gate impacts per installed area, reinforcing the need for a declared-unit-based comparison tied to thermal performance. Air leakage is evaluated separately as a complementary performance indicator influencing in-service energy behavior showing significantly lower air leakage for PU; but is not included in the cradle-to-gate normalization. However, it could be argued that materials with improved airtightness may enable the use of reduced insulation thickness while still achieving equivalent performance, thereby potentially lowering overall material demand. Nevertheless, recycled denim offers environmental advantages by reducing landfill waste and promoting resource conservation through material reuse. A transient coupled heat–moisture model in COMSOL Multiphysics, using climate data from Arizona and Florida, further reveals that denim absorbs more moisture than polyurethane. This leads to larger heat flux fluctuations, highlighting a trade-off between denim’s sustainability advantages and its reduced hygrothermal durability. Overall, these findings demonstrate the limitations of single-metric comparisons and emphasize the need for performance-based, multi-criteria assessments that integrate functional efficiency with circularity. Future research should incorporate occupant health and comfort to enable a more comprehensive evaluation of insulation sustainability. Full article
(This article belongs to the Section Energy Sustainability)
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45 pages, 3780 KB  
Review
A Review of Convective Schemes Used for Detonation Simulations in OpenFOAM After a Decade of Development
by Luis Gutiérrez Marcantoni and Sergio Elaskar
Axioms 2026, 15(4), 282; https://doi.org/10.3390/axioms15040282 - 13 Apr 2026
Viewed by 115
Abstract
Detonation phenomena in reactive flow systems continue to pose significant challenges for accurate simulation, particularly in 3D validation against experiments and achieving community standardization for schemes. Among the primary difficulties is the selection of suitable convective schemes, which are essential for capturing the [...] Read more.
Detonation phenomena in reactive flow systems continue to pose significant challenges for accurate simulation, particularly in 3D validation against experiments and achieving community standardization for schemes. Among the primary difficulties is the selection of suitable convective schemes, which are essential for capturing the complex dynamics of wave propagation and reaction fronts. This study provides a comprehensive historical review of the development and implementation of convective schemes in OpenFOAM, covering the period from 2013 to the present. In addition to documenting the evolution of these methods, we present a detailed technical description of various convective approximation techniques used in detonation simulations within OpenFOAM. This includes an exploration of their underlying principles, advantages, and limitations. Our analysis synthesizes key findings from recent studies and offers practical guidance to researchers when choosing schemes for specific detonation scenarios. It is found that currently, within OpenFOAM, the dominant schemes for convection are the HLLC and KN. Full article
(This article belongs to the Special Issue Recent Developments in Mathematical Fluid Dynamics)
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19 pages, 3626 KB  
Article
Stability Analysis of High-Fill Slopes with EPS–Spoil Composite in Gullies Under Rainfall Conditions: From Scheme to Practice
by Yijun Xiu and Fei Ye
Water 2026, 18(8), 921; https://doi.org/10.3390/w18080921 - 13 Apr 2026
Viewed by 219
Abstract
Utilizing excavated waste soil to level gullies offers significant advantages in terms of engineering economy and construction efficiency. However, the stability and deformation risks of high-fill embankments in mountainous gullies under rainfall conditions have attracted significant attention, particularly when such structures are located [...] Read more.
Utilizing excavated waste soil to level gullies offers significant advantages in terms of engineering economy and construction efficiency. However, the stability and deformation risks of high-fill embankments in mountainous gullies under rainfall conditions have attracted significant attention, particularly when such structures are located adjacent to residential areas. This study compares two design schemes for highway high-fill embankments, Scheme 1: high-fill slope supported by stabilizing piles and prestressed anchors, and Scheme 2: ordinary waste soil as the core, foamed lightweight soil (EPS) as the edge band, and reinforcement by a micro-pile retaining wall system. Finite element analysis was used to evaluate the Factor of Safety (FOS), displacements of retaining structures, and characteristic slope points under three conditions (no rainfall, heavy rainfall, and heavy rainfall with soil strength deterioration). The results show that Scheme 2 reduces total costs by 3.5%, shortens the construction period by 14%, and cuts maintenance costs by 65%, with a minimum FOS of 1.56 under extreme rainfall. Further parametric analysis of Scheme 2 optimized key design parameters, and field monitoring data over 6 months verified the reliability of the numerical simulation. This study provides a transferable design-verification pathway for combining lightweight and conventional fills in high embankments, offering technical support for similar projects in complex mountainous areas. Full article
(This article belongs to the Special Issue Intelligent Analysis, Monitoring and Assessment of Debris Flow)
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33 pages, 1475 KB  
Article
Design and Construction Practices for Full-Depth Reclamation of Asphalt Mixtures with Bituminous and Cementitious Additives
by Swathi Malluru, Ahmed Saidi, Ayman Ali and Yusuf Mehta
Materials 2026, 19(8), 1540; https://doi.org/10.3390/ma19081540 - 12 Apr 2026
Viewed by 215
Abstract
Several highway agencies have implemented full-depth reclamation (FDR) as a sustainable technology for rehabilitating deteriorated asphalt pavements. However, the lack of standardized mix design procedures and limited field assessment, in terms of rutting and cracking resistance, pose challenges to the widespread implementation of [...] Read more.
Several highway agencies have implemented full-depth reclamation (FDR) as a sustainable technology for rehabilitating deteriorated asphalt pavements. However, the lack of standardized mix design procedures and limited field assessment, in terms of rutting and cracking resistance, pose challenges to the widespread implementation of FDR. This study addresses these challenges by synthesizing current FDR mix design and construction practices and validating highway agency-recommended practices through laboratory performance evaluation. The study objectives were achieved by (1) reviewing current FDR mix design and construction specifications of highway agencies across the US and internationally, (2) conducting surveys with highway agencies and interviews with subject matter experts (SMEs), and (3) evaluating the laboratory performance of FDR mixtures. Based on the findings from the literature, survey responses, and SME interviews, three FDR mixtures were designed in the lab: (i) cement-only, (ii) asphalt emulsion and cement, and (iii) foamed asphalt and cement. Each mix was then evaluated for rutting susceptibility using the Asphalt Pavement Analyzer (APA) and cracking resistance using the indirect tensile (IDT) test to identify optimum dosages of bituminous and cementitious additives. Laboratory results showed that FDR mixtures with 3% asphalt emulsion and 1% cement improved rutting resistance by 46% and cracking performance by 70% compared to cement-only mixtures with 4% cement. In contrast, foamed asphalt did not result in a significant improvement in FDR performance. Survey responses indicated that 89% of respondents reported good field performance of FDR, with Pennsylvania and North Dakota exhibiting excellent performance 10 years after construction. Full article
(This article belongs to the Section Construction and Building Materials)
15 pages, 5305 KB  
Article
Assessment of the AUSM Scheme for Near-Nozzle Flow Field Characterization of Under-Expanded Hydrogen Jets
by Oscar Vento, Carmelo Baronetto and Alessandro Ferrari
Energies 2026, 19(8), 1871; https://doi.org/10.3390/en19081871 - 11 Apr 2026
Viewed by 231
Abstract
Hydrogen is a carbon-free energy carrier that can support decarbonization of the energy and transport systems. Its usage as a fuel in internal combustion engines can abate the pollutants and CO2 emissions but also presents various challenges. Among these, the formation of [...] Read more.
Hydrogen is a carbon-free energy carrier that can support decarbonization of the energy and transport systems. Its usage as a fuel in internal combustion engines can abate the pollutants and CO2 emissions but also presents various challenges. Among these, the formation of under-expanded jets requires proper injector design and accurate control of the injection process. CFD can accelerate the development of hydrogen engine technologies towards market readiness. Low-dissipative density-based schemes are essential to accurately describe the complex flow structures, that affect mixture formation in under-expanded injections. In the present work, the AUSM scheme was implemented in the OpenFOAM library, and successfully used to simulate an experimental hydrogen-into-nitrogen injection. The numerical method, validated against experimental Schlieren images, was compared with the Kurganov–Noelle–Petrova scheme implemented in the current density-based OpenFOAM solver. The numerical results highlighted the reduced dissipation of the AUSM scheme, leading to improved jet penetration and gas mixing. The investigation demonstrated the superior performance of the AUSM scheme, suggesting it as an alternative OpenFOAM solver. Nevertheless, the study identified areas for improvement and critical issues associated with this type of simulations. Full article
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21 pages, 1732 KB  
Article
Modification Effects of High-Pressure Homogenization and Decolorization on Microalgae-Fortified 3D-Printed Foods
by Dalne Sinclair, Armin Mirzapour-Kouhdasht, Juan A. Velasquez, Da Chen, Senay Simsek and Jen-Yi Huang
Processes 2026, 14(8), 1221; https://doi.org/10.3390/pr14081221 - 10 Apr 2026
Viewed by 270
Abstract
The global transition towards sustainable food systems has intensified the search for alternative protein sources that can meet human nutritional demands with reduced environmental impacts. Although microalgae are rich in protein, their applications in food remain limited due to thick cell walls and [...] Read more.
The global transition towards sustainable food systems has intensified the search for alternative protein sources that can meet human nutritional demands with reduced environmental impacts. Although microalgae are rich in protein, their applications in food remain limited due to thick cell walls and intense green color. The aim of this study is to modify Chlorella vulgaris by high-pressure homogenization (HPH) and decolorization to improve its processability for extrusion-based 3D printing. Microalgal biomass was pretreated by HPH at different pressures (10,000, 15,000, 20,000 psi) for one to three passes, followed by pigment removal using ethanol of different concentrations (70, 85, 100%). Microscopic imaging shows that HPH effectively disrupted microalgal cell walls and caused cell disintegration, resulting in increased foaming stability (22–28%) but lower solubility (up to 24%), with other functional properties largely preserved. Ethanol treatments markedly decolored microalgae and increased their water-holding capacity (10–45%) and solubility (6–11%). The formulation of HPH-treated decolorized microalgae with soy protein isolate and xanthan gum increased the viscosity (66–179%) and elasticity (78–235%) of printing inks. The resulting 3D prints show higher hardness (47–128%), springiness (up to 155%) and chewiness (47–408%). The information obtained from this study provides guidance for modifying the functional and rheological properties of microalgae and contributes to advancing the formulation and manufacturing of microalgae-based foods. Full article
24 pages, 10141 KB  
Review
Recent Advances in the Fabrication of High-Performance Polypropylene Micro-Nano Composites via Supercritical Foaming
by Xin Pan, Gang Wang, Faqi Zhan, Yuehong Zheng, Mengyao Dong, Peiqing La, Kun Li, Xiaoli Zhang and Jingbo Chen
Materials 2026, 19(8), 1527; https://doi.org/10.3390/ma19081527 - 10 Apr 2026
Viewed by 425
Abstract
Against the backdrop of the global trends toward lightweighting, multi-functionalization, and greening of materials, polypropylene (PP) has been extensively applied owing to its advantages of low density and low cost. However, its inferior foaming performance fails to meet high-end application requirements, which is [...] Read more.
Against the backdrop of the global trends toward lightweighting, multi-functionalization, and greening of materials, polypropylene (PP) has been extensively applied owing to its advantages of low density and low cost. However, its inferior foaming performance fails to meet high-end application requirements, which is primarily attributed to its low melt strength and restricted crystallization behavior. In this paper, the five-dimensional selection mechanism and classification of components for PP micro/nanocomposites fabricated via supercritical foaming are systematically summarized. The regulatory effects of micro/nano additives on the crystallization, rheological properties, and foaming behavior of PP are quantitatively analyzed. The parameter optimization windows of three foaming processes, namely batch foaming, extrusion foaming, and injection foaming, are integrated (e.g., a foaming temperature of 150–170 °C and a saturation pressure of 8–20 MPa). Additionally, the application progress of PP micro/nanocomposite foams in fields such as automotive lightweighting (with a weight reduction rate of 64.29%) and building thermal insulation (with a thermal conductivity as low as 29 mW/(m·K)) is outlined. The core novel insight of this work lies in clarifying the unified mechanism of crystal refinement induced by reinforcing agents with different geometric morphologies, which is dominated by the synergy between heterogeneous nucleation and steric hindrance. This finding provides theoretical and technical guidelines for the industrial-scale preparation of high-performance PP foams. Full article
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12 pages, 1117 KB  
Review
Transient Glycocalyx Remodeling by Intravenous Hyaluronidase in Atherosclerosis: A Hypothesis-Generating Review
by Andreas Pfützner, Tobias Gantner, Harald Burgard, Tilman Steinmeier, Eduard Stappler, Julia Jantz and Petra Wiechel
Pathophysiology 2026, 33(2), 26; https://doi.org/10.3390/pathophysiology33020026 - 10 Apr 2026
Viewed by 165
Abstract
Atherosclerosis remains the leading cause of death worldwide and imposes a major healthcare burden. Physiologically, elimination of cholesterol from the arterial wall depends on reverse cholesterol transport (RCT). RCT requires access to HDL and apolipoprotein A-I (ApoA-I) to lesional macrophages/foam cells. The endothelial [...] Read more.
Atherosclerosis remains the leading cause of death worldwide and imposes a major healthcare burden. Physiologically, elimination of cholesterol from the arterial wall depends on reverse cholesterol transport (RCT). RCT requires access to HDL and apolipoprotein A-I (ApoA-I) to lesional macrophages/foam cells. The endothelial glycocalyx is a dynamic and injury-sensitive layer of proteoglycans and glycosaminoglycans (including hyaluronan). It contributes to vascular barrier properties, leukocyte adhesion, mechanotransduction, and macromolecular transport. In atherosclerosis, glycocalyx structure and function are altered; this may facilitate entry/retention of atherogenic lipoproteins and may also alter transport conditions relevant to cholesterol efflux pathways. This article presents a mechanistic hypothesis: short, transient, systemic hyaluronidase exposure could temporarily remodel glycocalyx/extracellular matrix components and thereby facilitate conditions permissive for regulated transport processes relevant to RCT. However, the proposed link between glycocalyx remodeling and improved lesional cholesterol efflux remains theoretical. Direct in vivo evidence that the endothelial glycocalyx is a dominant barrier limiting HDL- or ApoA-I-mediated cholesterol efflux from plaque macrophages is currently limited. Moreover, glycocalyx degradation is widely associated with endothelial dysfunction, increased permeability, inflammation, and thrombosis, all of which could aggravate rather than ameliorate atherosclerosis. Human pharmacokinetic data indicate a very short plasma half-life of circulating hyaluronidase activity, suggesting that any systemic enzymatic effect is brief. Nevertheless, the biological consequences of repeated degradation–regeneration cycles, especially in high-risk states such as diabetes, inflammation, oxidative stress, or chronic kidney disease, remain incompletely understood. Evidence supporting clinical benefit in atherosclerosis is currently limited to heterogeneous animal experiments, historical uncontrolled reports, and a small number of anecdotal case observations, whereas randomized trials have only been performed in other settings such as acute myocardial infarction and do not establish efficacy for plaque regression. We therefore provide a balanced evaluation of knowns, uncertainties, alternative interpretations, potential risks, dosing unknowns, and a translational research agenda including mechanistic preclinical studies, biomarker development, imaging, and carefully designed early-phase clinical investigation. Full article
(This article belongs to the Section Cardiovascular Pathophysiology)
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27 pages, 8224 KB  
Article
Structure and Properties of Foam Concrete and Fiber-Reinforced Foam Concrete Produced Using a Complex Nanomodifier Based on Industrial Waste
by Diana M. Shakhalieva, Evgenii M. Shcherban’, Sergey A. Stel’makh, Levon R. Mailyan, Andrei Chernil’nik, Natalya Shcherban’, Alexandr Evtushenko and Alexey N. Beskopylny
Materials 2026, 19(8), 1517; https://doi.org/10.3390/ma19081517 - 10 Apr 2026
Viewed by 334
Abstract
Foam concrete and fiber-reinforced foam concrete are promising building materials for sustainable and energy-efficient construction. Improving the environmental performance of cellular composites through the use of industrial waste and additives based on them is highly relevant. This study intends to create a novel [...] Read more.
Foam concrete and fiber-reinforced foam concrete are promising building materials for sustainable and energy-efficient construction. Improving the environmental performance of cellular composites through the use of industrial waste and additives based on them is highly relevant. This study intends to create a novel complex nanomodifying additive (CNA) from industrial waste and nanomaterials, alongside new eco-friendly foam concrete (FC) and fiber-reinforced foam concrete (FFC) mixes incorporating CNA and polypropylene fiber (PF). Experimental studies yielded the optimal CNA formulation and described a method for its preparation. The test results indicate that FC’s properties are enhanced by CNA. The properties were best in the FC that was modified with 10% CNA. The FC control composition was surpassed by a 25.5% increase in compressive strength and a 23.1% increase in flexural strength, with a 9.5% reduction in thermal conductivity. Dispersed PF reinforcement also positively impacts the properties of FFCs with CNA, and the combined modification of 10% CNA and 1.2% PF provides maximum increases in compressive and flexural strength, amounting to 43.1% and 102.2%, respectively, and a 16.9% reduction in thermal conductivity. A microstructural analysis of the cellular composites confirms the feasibility of the tested formulation solutions. The FFCs, when modified by CNA and PF, display a homogeneous cellular structure, and the interpore zones contain multiple clusters of calcium silicate hydrate. Using CNA in the production of FC and FFCs will reduce cement consumption and improve their environmental friendliness. Full article
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