Search Results (158)

Sweet sensing is a fundamental sensory experience that plays a critical role not only in food preference, reward and dietary behaviour but also in glucose metabolism. Sweet taste receptors (STRs), composed of a heterodimer of taste receptor type 1 member 2 (T1R2) and member 3 (T1R3), are now recognised as being widely distributed throughout the body, including the gastrointestinal tract. Preclinical studies suggest these receptors are central to nutrient and glucose sensing, detecting energy availability and triggering metabolic and behavioural responses to maintain energy balance. Both internal and external factors tightly regulate their signalling pathways, and dysfunction within these systems may contribute to the development of metabolic disorders such as obesity and type 2 diabetes (T2D). Functional magnetic resonance imaging (fMRI) has provided valuable insights into the neural mechanisms underlying sweet sensing by mapping brain responses to both lingual/oral and gastrointestinal sweet stimuli. This review highlights key findings from fMRI studies and explores how these neural responses are modulated by metabolic state and individual characteristics such as body mass index, habitual intake and metabolic health. By integrating current evidence, this review advances our understanding of the complex interplay between sweet sensing, brain responses, and health and identifies key gaps and directions for future research in nutritional neuroscience. Full article

This paper studies the robust $H_{\infty }$ time-varying formation tracking (TVFT) problem for heterogeneous nonlinear multi-agent systems (MASs) with parameter uncertainties, external disturbances, and unknown leader inputs. The objective is to ensure that follower agents track the leader’s trajectory while achieving a desired time-varying formation, even under unmodeled dynamics and disturbances. Unlike existing methods that rely on global topology information or homogeneous system assumptions, an adaptive control protocol is proposed in full distribution, requiring no global topology information, and integrates nonlinear compensation terms to handle unknown leader inputs and parameter uncertainties. Based on the Lyapunov theory and laplacian matrix, a robust $H_{\infty }$ TVFT criterion is developed. Finally, a numerical example is given to verify the theory. Full article

The unarmored dinoflagellate Akashiwo sanguinea is a cosmopolitan harmful algal species known for forming intense blooms leading to mass mortality of fish, shellfish, and seabirds. Globally distributed populations of A. sanguinea have been classified into four ribotypes based on their characteristic sequences in LSU rRNA gene and primary geographic distributions. In this study, we compared the bacterial communities co-existing with the six strains of A. sanguinea from China and the USA (belonging to two ribotypes) using high-throughput sequencing of 16S rRNA gene amplicons. Generally, a bacterial microbiome with high diversity was found to be associated with laboratory-cultured A. sanguinea strains from different geographic origins. Based on ribotype classification, the six samples were divided into two groups (ribotype A: AsCHINA; ribotype C: AsUSA) for subsequent comparative analyses of their bacterial communities. Beta diversity analysis revealed a clear separation between the two groups, reflecting significant differences in bacterial community composition between the two ribotypes. Significantly higher abundance of nitrogen-fixing bacteria was found in the AsUSA group, suggesting that ribotype C may benefit from external nitrogen sources provided by their bacterial associates. If this also holds true in natural environments, this nitrogen-fixing partnership likely confers a competitive advantage to ribotype C in oligotrophic offshore waters, and potentially extends bloom duration when environmental nitrogen is depleted. Our study raised the possibility that different ribotypes of A. sanguinea may harbor distinct prokaryotic microbiomes in their phycospheres under stable cultivation conditions. Further comprehensive comparison among more isolates across all four ribotypes is highly necessary to validate this hypothesis. Full article

This study presents the development of an adaptive control system for aerodynamic flaps of a two-tier vertical-axis Savonius wind rotor to improve performance under variable wind loads. The approach includes detailed kinematic and dynamic modeling of the flap actuation mechanism, accounting for real-world nonlinearities such as backlash, friction, and impact loads. The mechanical transmission system is analyzed to evaluate the influence of design parameters on system dynamics and control accuracy. A mathematical model of an adaptive PID controller is proposed, capable of real-time adjustment of gain parameters based on external wind torque. Numerical simulations under various wind conditions demonstrate that adaptive tuning significantly enhances system stability, reduces overshoot, and ensures faster response compared to fixed-parameter controllers. Sensitivity analysis confirms the importance of mass distribution, mechanical stiffness, and damping in minimizing vibrations and ensuring durability. The developed system provides a reliable solution for efficient wind energy conversion in dynamic environments, including urban and coastal applications. Full article

The “yellow-skinned” Nanhong agate represents a unique variety of Nanhong agate found in northeastern Yunnan, China, and it is highly valued for its distinctive yellow exterior and clear red–yellow interface. Owing to the limited research on this variety, the present study provides the first comprehensive analysis. Field surveys and various laboratory techniques—including polarizing microscopy, scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectrometry, ultraviolet–visible (UV-VIS) absorption spectrometry, Raman spectroscopy, micro X-ray diffraction (µ-XRD) with Rietveld refinement, electron microprobe analysis (EPMA), and laser ablation–inductively coupled plasma mass spectrometry (LA-ICP-MS)—were utilized to investigate its gemological, microtextural, spectroscopic, and geochemical characteristics. Field surveys identified the occurrence states of the “yellow-skinned” Nanhong agate. The laboratory results indicate that the agate primarily consists of α-quartz, with minor amounts of moganite, goethite, and hematite. The coloring mechanism observed in this study is consistent with the findings of previous studies: the external yellow coloration is due to goethite, while the internal red hue is attributed to hematite. Its unique pseudo-granular silica (Type III) structure provides a foundational basis for the later formation of the “yellow-skinned” agate variety, and geochemical data reveal the distribution patterns of elements. Based on geological surveys and experimental data, the formation of the “yellow-skinned” Nanhong agate in northeastern Yunnan can be divided into two stages: first, hydrothermal fluids filled the vesicles in the Permian Emeishan Basalt Formation (P₂β), leading to the formation of primary Nanhong agate. Subsequently, the Type III primary agate underwent weathering, erosion, transport, and deposition in the red–brown sandy mudstone of the Lower Triassic Feixianguan Formation (T₁f). The sedimentary environment in the second stage facilitated the conversion of outer hematite into goethite, resulting in the distinct “yellow-skinned” appearance with a clear red–yellow boundary. Based on the occurrence and stratigraphic relations, this study constrains the formation age of the “yellow-skinned” Nanhong agate to approximately 261.6 Ma. Full article

This paper proposes a fixed-time formation-tracking control problem for a heterogeneous multi-agent system (MAS) consisting of six unmanned aerial vehicles (UAVs) and three unmanned ground vehicles (UGVs) under actuator attacks, external disturbances, and input saturation. First, a distributed sliding mode estimator and controller tailored for UAV-UGV heterogeneous systems are proposed based on sliding mode techniques. Second, by integrating repulsive potential functions with sliding manifolds, a distributed fixed-time adaptive sliding mode control protocol was designed. This protocol ensures collision avoidance while enabling the MASs to track desired trajectories and achieve a predefined formation configuration within a fixed time. The fixed-time stability of the closed-loop system was rigorously proven via Lyapunov theory. Full article

Background: The primary treatment of schizophrenia is pharmacotherapy with antipsychotic agents, such as risperidone and paliperidone. Population pharmacokinetic (PopPK) modelling plays a crucial role in optimising therapy by predicting of plasma concentrations, therapeutic efficacy, and the risk of adverse effects using model informed precision dosing. Objectives: This systematic review examined the PopPK models of risperidone and paliperidone in patients diagnosed with schizophrenia based on the available scientific evidence. Methods: A systematic review of the health science databases was conducted. The inclusion criteria were original articles published in peer-reviewed journals, studies focusing on the development of original PopPK models of risperidone and paliperidone, and clinical studies. The exclusion criteria were full-text articles that could not be retrieved; studies not including subjects diagnosed with schizophrenia or schizoaffective disorders; and studies that did not investigate risperidone or paliperidone. Results: A total of 19 studies developing PopPK models were analysed, including one- or two-compartment PopPK model structures. Interindividual variability in the pharmacokinetic parameters was shown to be influenced by factors such as CYP2D6 activity, renal function, body mass index, and sex. Parameter estimation revealed high variability in clearance and volume of distribution. Conclusion: Numerous PopPK models for risperidone and paliperidone have been published with a detailed characterisation of absorption, metabolism, and elimination. Therefore, future research should focus on the external validation of these models to facilitate their integration into clinical practice and optimise individualised dosing, ultimately improving treatment efficacy and safety across diverse patient populations. Full article

In deep-space exploration, Pickup Ion Analyzers (PUIAs) operate under varying thermal environments in orbit, where thermally induced stress–deformation coupling may severely degrade their performance and long-term stability. To address temperature field analysis for in-orbit PUIAs, in this study, we propose a coupled simulation framework integrating external heat flux, parallel temperature field calculation, and thermoelastic deformation analysis, establishing a systematic link from thermal inputs to performance analysis. Based on external heat flux results, a parallel LU decomposition algorithm reduced the computational time from 11.8 h to 2.9 h for rapid temperature field solutions. At 38 astronomical units (AUs), the instrument’s temperature distribution ranged from −45 °C to 51.13 °C, with simulation errors compared to COMSOL simulations meeting engineering accuracy requirements. Maximum thermoelastic deformation induced by thermal gradients reached 0.110 mm. Performance degradation due to deformation in key metrics—including ion energy resolution, angular resolution, detection field-of-view, geometric factor, and mass resolution—was below 7.2%. This research improves the computational efficiency of the temperature field and systematically quantifies temperature effects on PUIA performance in deep-space environments, and the proposed methodology could provide technical support for optimizing on-orbit thermal management strategies. Full article

Offshore cranes are widely used in important fields such as wind power construction and ship replenishment. However, large payloads such as wind turbine blades are hoisted by multiple steel wire ropes, which makes it difficult to directly control their movements; that is, the number of input degrees of freedom is less than that of the output degrees of freedom. In addition, compared with land cranes, offshore cranes are inevitably affected by waves, wind, etc. The transition from a fixed base to a dynamic base brings severe challenges to their oscillation suppression and precise positioning. At the same time, to improve operational efficiency, the hoisting operation of offshore cranes usually adopts velocity input control patterns that fit the habits of manual operation, and most of them are in the form of dual-axis linkage for pitch and hoisting. Therefore, this paper proposes a fast terminal sliding mode control method for double-pendulum offshore cranes with distributed-mass payloads (DMPs). First, a nonlinear dynamic model of offshore cranes considering DMPs is established, and a dynamic model based on acceleration input control patterns is acquired. Based on this, considering the variation in hoisting rope lengths, a novel adaptive control method is proposed. Finally, simulation results verify the effectiveness of the proposed method, and the robustness of the proposed method to DMP mass parameter uncertainty and disturbances is demonstrated. Full article

Gibberellic acid (GA3) may help to synchronize coffee flowering, whilst ethylene (in the form of Ethephon) may assist in advancing coffee berry maturation even when applied in the pre-flowering stage of phenophase. Functional–structural plant modeling (FSPM) can be used to help understand whole-plant responses, such as plant-scale photosynthesis. FSPM has never been used to investigate the response of coffee plants to external plant growth regulator (PGR) applications. We hypothesized that treatment with PGRs at the beginning of berry maturation (BM) during phenophase could (1) influence plant leaf area and plant photosynthesis at the end of BM and (2) assist in the uniformity of the berry maturation of seven-year-old coffee plants. Additionally, we assumed that (3) the distribution of berries over the vertical plant profile could be related to the coffee beans’ chemical quality, and that irrigated plants would have delayed maturation, but a higher yield than non-irrigated (NI) plants. To test these hypotheses, a short sustainable period of irrigation was applied six weeks before harvest. Irrigated plants were treated with GA3 or Ethephon. A combination of field measurements (leaf gas exchanges, berry collection and bean chemical analyses in relation to vertical plant strata) and computer modeling were used. At the beginning or the end of BM, coffee trees were coded using the VPlants modeling platform and reconstructed using CoffePlant3D software to compute the plant leaf area and plant photosynthesis. The greatest number of second-order red berries were found in the upper stratum, S3 (>160 cm), while slightly fewer were found in S2 (80–160 cm) belonging to the third-order axes, and the lowest number was found in S1 (<80 cm). Green berries were more representative in S2, with the greatest number belonging to the third-order axes. The participation of third-order axes in berry yield was up to approximately 37% for red berries and 25% for green berries. The greatest separation between PGRs could be seen in S2, where more berries in the Ethephon-treated plants were found than in the GA3 treated ones, while the dry mass (DM) percentage was higher in GA3 than in the Ethephon treatment. The percentage of DM in fresh mass was 17–28% in the green berries and 28–36% in the red berries. PGRs were important for homogenous berry maturity, especially GA3, which also showed the lowest total chlorogenic acid content. The NI plants showed reduced red and total berry production when compared to irrigated ones, indicating this horticultural measure is important, even during a sustainably reduced six-week period, due to preserved leaf area and plant photosynthesis, and it also increased the lipid and kahweol contents of irrigated plants when compared to NI plants, despite the maturation delay. Full article

Non-contact acoustic detection methods for blades have gained significant attention due to their advantages such as easy installation and immunity to mechanical noise interference. Numerical simulation investigations on the aerodynamic noise mechanism of blade erosion provide a theoretical basis for acoustic detection. However, constructing a three-dimensional erosion model remains a challenge due to the uncertainty in external natural environmental factors. This study investigates a leading-edge erosion calculation model for wind turbine blades subjected to rain erosion. A rain erosion distribution model based on the Weibull distribution of raindrop size is first constructed. Then, the airfoil modification scheme combined with the erosion distribution model is presented to calculate leading-edge erosion mass. Finally, for a sample National Renewable Energy Laboratory 5 MW wind turbine, a three-dimensional erosion model is investigated by analyzing erosion mass related to the parameter of the attack angle. The results indicate that the maximum erosion amount is presented at the pressure surface near the leading edge, and the decrease in erosion on the pressure surface is more rapid than the suction side from the leading edge to the trailing edge. With an increase in the attack angle, the erosion on the pressure side is more severe. Furthermore, a separation vortex appears at the leading edge of the airfoil under computational non-uniform erosion. For aerodynamic noise, a larger sound pressure level with significant fluctuation occurs at 400–1000 Hz. Full article

To improve the flow mass transfer inside the electrodes and the efficiency of an all-iron redox flow battery, a semi-solid all-iron redox flow battery is presented experimentally. A slurry electrode is designed to replace the traditional porous electrode. Moreover, the effects of an additional external magnetic field are further investigated in the semi-solid battery experiment. The results show that the mass transfer of the slurry in the battery flow channel and the prolonged discharge time are significantly affected by the additional external magnetic fields. In addition, a three-dimensional model of the semi-solid all-iron redox flow battery is presented in detail, and it is verified to be reliable by experimental data. The simulation results show that the ion concentration distributions in the battery become more uniform with the increase in the flow rate and the initial concentration. Furthermore, it is also found that the size of the flow channel influences the mass transfer efficiency of the slurry. After optimizing the flow channel, it is found that when the flow channel length of the slurry inlet and outlet section is 2 cm, the operating efficiency of the semi-solid battery shows an increasing trend. This work provides comprehensive insight into the improvement of the performances of flow batteries, which will be conducive to the practical application of flow batteries. Full article

Magnetic fluids (MF), composed of ferromagnetic nanoparticles, surfactants, and a carrier liquid, exhibit tunable physical properties under external magnetic fields due to the formation of chain-like nanoparticle structures. Using dissipative particle dynamics (DPD), we simulate the structural evolution of these fluids and establish a computational model incorporating magnetic nanoparticles and solvent particles. Our simulations confirm qualitative agreement with the literature results, validating the chosen time integration methods. Through radial distribution function analysis, we further demonstrate how the mass of solvent molecules and magnetic interaction strength govern the fluid’s microstructure. This work provides insights into the design of magnetic fluids for applications such as targeted drug delivery, adaptive dampers, and advanced magneto-rheological devices. Full article

This study focused on T. strauchii in Sayram Lake, Xinjiang. In August 2023, a total of 768 samples were collected to investigate its morphological, age, and growth characteristics. T. strauchii has an elongated body with a slightly raised area behind the head. Its head is flat, the body is slender, the back contour is arc-shaped, the trunk is thick and round, and the tail is short. Principal component analysis (PCA) showed that the cumulative contribution rate of the first three principal components was 53.80%, which reflects the morphological characteristics of the species. Moreover, gender characteristics are not prominently manifested in external morphology. Discriminant analysis showed an accuracy rate of 51.80%, indicating that the accuracy of gender discrimination relying solely on external morphology is limited. The species’ age distribution ranges between 1 and 7 years old, with the dominant age around 3 years old, and age structure showing a unimodal distribution. The relationship between body length and body weight is W = 7.432 × 10⁻⁶L^3.037(R² = 0.995, n = 768). The exponent 3.037 indicates a growth pattern with priority given to body mass growth because it is greater than 3. The von Bertalanffy growth equation was selected to describe the growth of T. strauchii. The body length growth equation is L_t =139.346 [1 − e^{−0.267(t+1.639)}], and the body mass growth equation is W_t = 27.79 [1 − e^{−0.267(t+1.639)}]^3.073. The inflection point age (t_i) is 2.563, the growth coefficient (k) is 0.267, and the growth characteristic index(φ) is 3.715. The growth rate decreases with age, and the growth inflection point ages of males and females differ. The research findings provide basic data for population assessment, resource protection, and rational fishing in fishery resource management. This highlights the ecological adaptability of T. strauchii and emphasizes the importance of comprehensively considering multiple factors in fishery management. Full article

In recent years, the distributed propulsion system has received extensive attention due to its advantages such as high propulsion efficiency, low noise, high safety redundancy, and good flexibility and maneuverability. However, the interaction between the internal and external flow can limit the aerodynamic performance of the ducted fan. To investigate the influence of the internal and external flow interaction on the aerodynamic–propulsion coupling characteristics of the distributed propulsion system, an over-wing symmetric configuration with five distributed ducted fans was constructed, and numerical simulations were performed using a method based on the body force model. Results show that as the flight Mach number increases, the lift obtained by the wing increases, while the stall angle of attack decreases, and the stall angle of attack at a Mach number of 0.5 is reduced by 15° compared with a Mach number of 0.2. At large angles of attack, the edge fans have the strongest ability to resist airflow separation, while the middle fan has the weakest ability to resist airflow separation, and its fan performance index drops the fastest. When the Mach number is 0.4, the mass flow rate and thrust of the middle fan are reduced by 16% and 28%, respectively, compared with those when the Mach number is 0.2. The higher the flight Mach number, the larger the intake distortion degree of the ducted fans. The middle fan is most affected by total pressure distortion and least affected by swirl distortion, whereas the edge fans are least affected by total pressure distortion and most affected by swirl distortion. Full article