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29 pages, 4993 KB  
Article
GIS-Based Suitability Evaluation and Layout Optimization of Temporary Disaster Waste Storage Sites During Rainstorm Disasters: A Case Study of Mentougou District, Beijing
by Ying Li, Wenhui Fan, Yao Qu, Haoxiang Chen and Ajuan Yuan
Sustainability 2026, 18(12), 6154; https://doi.org/10.3390/su18126154 - 15 Jun 2026
Viewed by 308
Abstract
Frequent heavy rainstorm disasters have led to the need for temporary storage of large quantities of heterogeneous disaster-related solid waste within a short period, making temporary storage an important issue in the construction and optimization of the urban comprehensive urban emergency management systems. [...] Read more.
Frequent heavy rainstorm disasters have led to the need for temporary storage of large quantities of heterogeneous disaster-related solid waste within a short period, making temporary storage an important issue in the construction and optimization of the urban comprehensive urban emergency management systems. This study takes the “23·7” catastrophic rainstorm event in Mentougou District, an area prone to rainstorm disasters in Beijing, as a case study and develops an auxiliary decision-making model for site selection that integrates estimates of construction waste and household goods waste, an “initial selection—screening—optimization” suitability evaluation, and the optimization of spatial layout optimization. By combining the spatial analysis method of the Geographic Information System (GIS), an evaluation index system covering natural geography, ecological environment, and socio-economic factors was constructed. An integrated AHP–EWM model was constructed, merging the expert-driven, subjective weighting of the Analytic Hierarchy Process with the objective, data-derived weighting of the Entropy Weight Method to determine indicator weights. The suitability distribution for site selection was studied by combining the multi-factor weighted overlay model, and the area most suitable for construction of Temporary Disaster Waste Storage Sites (TDWSSs), accounting for 4.51% of the total area, was identified. Subsequently, multiple constraints—including ecological protection redlines and minimum area requirements—were superimposed to exclude non-compliant areas. Ultimately, a combined optimization model integrating the minimum facility location model, maximum coverage model, and minimum impedance model was constructed, and the optimal site selection scheme was determined via ArcGIS. The results show that, when seven TDWSSs are considered, the coverage rate of administrative villages within the 20 km transportation service range reaches 97.38%. The results also indicate that, when the number of TDWSSs exceeds eight, the increase in the coverage rate tends to be moderate and the optimization space is limited, indicating that the layout scheme with seven TDWSSs is close to the regional optimal solution. This framework provides crucial guidance for post-rainstorm TDWSS planning and layout optimization. Full article
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67 pages, 3540 KB  
Review
When Hazard Maps Are Not Predictions: A Critical Assessment of MCDA in Glacier Hazard Susceptibility
by Ricardo Gacitua, Javier Pereira, Hernán Astudillo, Carla Taramasco and Pedro Contreras
ISPRS Int. J. Geo-Inf. 2026, 15(6), 245; https://doi.org/10.3390/ijgi15060245 - 1 Jun 2026
Viewed by 495
Abstract
Background: Multi-criteria decision analysis (MCDA) has become a dominant approach for glacier hazard susceptibility mapping, widely used to support risk management and climate adaptation planning. However, despite its widespread adoption, the role of MCDA outputs remains conceptually ambiguous: hazard classifications are often [...] Read more.
Background: Multi-criteria decision analysis (MCDA) has become a dominant approach for glacier hazard susceptibility mapping, widely used to support risk management and climate adaptation planning. However, despite its widespread adoption, the role of MCDA outputs remains conceptually ambiguous: hazard classifications are often interpreted as predictive representations of risk, even though they are derived from preference-dependent decision models. This raises a critical but underexamined question regarding the reliability of MCDA-based glacier hazard assessments. This issue becomes particularly relevant in the current transition toward data-driven and artificial intelligence (AI)-based approaches for hazard modelling, where similar challenges of interpretability, validation, and reliability arise. Methods: To address this issue, we conducted a systematic literature review following the PRISMA 2020 protocol, analysing peer-reviewed studies published between 2015 and 2025. After screening 571 records, 60 studies were included. Data were extracted using a structured framework and synthesised through quantitative descriptive analysis and qualitative assessment of modelling practices, including method selection, criteria weighting, uncertainty treatment, validation, and geographical distribution. This study conducts a structured methodological audit—not a catalogue—of multi-criteria decision analysis (MCDA) applications in glacier hazard susceptibility mapping. Results: The analysis reveals a consistent methodological pattern. The Analytic Hierarchy Process (AHP) dominates current practice (36/60 studies, 60%), typically implemented through GIS-based weighted overlay with expert-derived weights. Critically, 80% of studies (48/60) derive criteria weights exclusively from expert judgement, with no data-driven calibration or sensitivity testing of subjective inputs. This epistemic reliance on unstructured or semi-structured expert elicitation, presented without robustness analysis, forms a central concern of this review. Moreover, empirical validation is limited: only 21/60 studies (35.0%) report quantitative performance metrics. Uncertainty and robustness analyses are rarely conducted, and most studies rely on single-model configurations without comparative evaluation. Despite these limitations, the resulting hazard maps are frequently presented as objective spatial predictions. The evidence base is also geographically concentrated, with 48/60 studies (80.0%) located in High Mountain Asia. Conclusions: The findings indicate a systematic mismatch between how MCDA-based hazard maps are constructed and how they are interpreted. In most cases, MCDA functions as a decision-structuring framework rather than a validated predictive model, yet its outputs are commonly treated as predictive evidence. This gap has important implications for the use of such models in risk management and climate adaptation, particularly in the emerging context of AI-driven hazard modelling, where issues of model validation, interpretability, and reliability become even more critical. Advancing the field requires explicit validation against observed events, systematic robustness and sensitivity analysis, transparent uncertainty modelling, and comparative evaluation of alternative or hybrid decision frameworks. Full article
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18 pages, 1165 KB  
Article
Characteristics, Risk Stratification, and Outcomes of Upper Gastrointestinal Bleeding in Patients Receiving Antithrombotic Therapy
by Ragaey Ahmad Eid, Michael Nady Naguib, Amr Ahmed Abd El Bary, Mohamed Medhat Mohamed Zaki, Marwa O. Elgendy, Anwar M. Alnakhli, Mohammed Gamal and Mohamed Mohamed Tawfik
Biomedicines 2026, 14(4), 935; https://doi.org/10.3390/biomedicines14040935 - 20 Apr 2026
Viewed by 561
Abstract
Background/Objectives: Non-variceal upper gastrointestinal bleeding (NVUGIB) remains a major clinical emergency, particularly among patients receiving antiplatelet or anticoagulant therapy, whose use has increased substantially in recent years. This study aimed to evaluate the clinical characteristics, endoscopic findings, risk stratification, and [...] Read more.
Background/Objectives: Non-variceal upper gastrointestinal bleeding (NVUGIB) remains a major clinical emergency, particularly among patients receiving antiplatelet or anticoagulant therapy, whose use has increased substantially in recent years. This study aimed to evaluate the clinical characteristics, endoscopic findings, risk stratification, and outcomes of NVUGIB in patients receiving antithrombotic therapy, and to compare the predictive performance of commonly used prognostic scores. Methods: This prospective cohort study included 89 patients receiving antithrombotic therapy who presented with NVUGIB at Beni-Suef University Hospitals between March 2023 and March 2025. Clinical presentation, laboratory findings, and endoscopic characteristics were recorded. Risk stratification was assessed using Glasgow–Blatchford (GBS), Rockall, Baylor, AIMS65, ABC, and PNED scores. The optimal cut-off values for prediction of rebleeding and mortality were determined using receiver operating characteristic (ROC) analysis and the Youden index. Area under the curve (AUC) values were reported with 95% confidence intervals. Results: Endoscopy revealed that peptic ulcers were the most common lesion (41/89, 46%), followed by erosive disease (27/89, 30%), with the stomach being the most frequently involved site (76.5%). Rebleeding occurred in 16 patients (18.0%), while mortality was observed in 2 patients (2.2%). The Glasgow–Blatchford score demonstrated the most consistent performance for predicting rebleeding, with an optimal cutoff value of 5.5 (derived using the Youden index), yielding 92.9% sensitivity and 78.8% specificity. For mortality prediction, AIMS65, ABC, and PNED scores showed very high AUC values, although these findings should be interpreted cautiously due to the small number of mortality events (n = 2). No statistically significant difference in rebleeding or mortality was observed between single and dual antithrombotic therapy, although patients receiving dual therapy required longer hospitalization and more transfusion units. Conclusions: In patients with antithrombotic-related GI bleeding, ulcers and erosions predominate, with minimal differences between single and dual therapy outcomes. Concomitant NSAID use trends toward higher mortality. Glasgow–Blatchford score offers optimal performance for both rebleeding and mortality prediction, with a cutoff of 5.5 providing excellent sensitivity (92.9%) and specificity (78.8%) for rebleeding risk assessment. Full article
(This article belongs to the Section Molecular and Translational Medicine)
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12 pages, 2278 KB  
Article
Continuous Remimazolam Administration by Gastroenterologists for Endoscopic Sedation
by Tanya M. Bisseling, Angela van Zuuk, Michiel Vaneker, Hennie Hukker, Cariline Roosen, Jasmijn Olde, Marjolijn Duijvestein, Geert J. Bulte, Lucas T. van Eijk and Jörgen Bruhn
Medicina 2026, 62(4), 723; https://doi.org/10.3390/medicina62040723 - 10 Apr 2026
Viewed by 693
Abstract
Background and Objectives: Gastrointestinal (GI) endoscopy requires safe and effective sedation. Remimazolam, an ultra-short-acting benzodiazepine, may offer advantages over traditional sedatives like midazolam and propofol, including rapid onset, short half-life, and a favorable safety profile. This study evaluates the feasibility, safety, and patient [...] Read more.
Background and Objectives: Gastrointestinal (GI) endoscopy requires safe and effective sedation. Remimazolam, an ultra-short-acting benzodiazepine, may offer advantages over traditional sedatives like midazolam and propofol, including rapid onset, short half-life, and a favorable safety profile. This study evaluates the feasibility, safety, and patient satisfaction of continuous remimazolam infusion administered by trained gastroenterologists for GI endoscopy. Materials and Methods: This prospective registry included patients with ASA physical status I and II undergoing standard endoscopic procedures. Continuous remimazolam sedation was administered, with boluses given as needed. Vital signs were monitored, and patient satisfaction was assessed before and after the procedure using standardized questionnaires. Results: A total of 159 procedures were performed in 141 patients. Sedation was successful in all patients, with a mean induction dose of 7.1 mg and total infusion of 15.1 mg. Recovery time averaged 3.3 min. Adverse events, including transient hypotension and hypoxia, occurred in 11.3% of patients but were easily managed. Most patients (97%) reported sufficient comfort, with an average satisfaction score of 8.1/10. Conclusions: Continuous remimazolam infusion administered by trained gastroenterologists is a safe and effective alternative to traditional propofol sedation for GI endoscopy. It offers stable sedation, rapid recovery and high patient satisfaction, potentially reducing anesthesiology workload and improving procedural efficiency. Further studies are needed to confirm these findings in broader patient populations. Full article
(This article belongs to the Special Issue Application of Endoscopy in Gastrointestinal Disease)
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15 pages, 2314 KB  
Case Report
Clinical Evaluation of Fractional Microneedling with Radiofrequency for Inflammatory Acne Vulgaris: Report of 5 Cases
by Ornella Rossi, Giovanna Perrotti, Massimo Del Fabbro and Tiziano Testori
Dermato 2026, 6(2), 13; https://doi.org/10.3390/dermato6020013 - 8 Apr 2026
Viewed by 958
Abstract
Background: Conventional therapies for moderate-to-severe inflammatory acne include topical agents, systemic antibiotics, hormonal treatments, and oral isotretinoin. However, increasing resistance of Cutibacterium acnes to antibiotics and the potential adverse effects of systemic agents have prompted growing interest in non-pharmacological alternatives such as fractional [...] Read more.
Background: Conventional therapies for moderate-to-severe inflammatory acne include topical agents, systemic antibiotics, hormonal treatments, and oral isotretinoin. However, increasing resistance of Cutibacterium acnes to antibiotics and the potential adverse effects of systemic agents have prompted growing interest in non-pharmacological alternatives such as fractional microneedling radiofrequency (RF-MN), recently introduced in the clinical practice. Objective: This report of five cases aims to document the clinical benefits and safety of RF-MN using the Focus Dual® device in the treatment of moderate-to-severe inflammatory acne vulgaris. Methods: Five patients (2 male, 3 female; aged 19–28 years; Fitzpatrick skin types II–III) with moderate-to-severe acne were treated with two RF-MN sessions at 4-week intervals using the Focus Dual® device (Med & Tech, Occhiobello (RO), Italy). Acne severity was assessed using the Face Global Acne Grading System (F-GAGS) and the 5-point Global Improvement Score (GIS), with evaluations performed by two independent blinded raters (G.P and O.R). Standardized photographic documentation and lesion counting were conducted at baseline (T0) and 4 weeks after the second session (T2). All individual F-GAGS scores for each of the five patients showed a reduction from baseline to T2, as consistently assessed by both evaluators. Two patients improved from moderate to mild acne, one improved from severe to moderate, and one remained mild. GISs indicated clinical improvement ranging from Grade 1 to Grade 2 in all cases, with individual improvements between 8.33% and 37.93%. No adverse events were reported during treatment or follow-up. Conclusions: RF-MN appears to be a promising therapeutic option for moderate-to-severe inflammatory acne, providing clinical improvement and reduction in acne severity without adverse effects. Prospective studies with a larger sample are needed to confirm these preliminary results and support the potential role of RF-MN as an adjunctive or standalone treatment in patients with limited tolerance or response to conventional therapies. Full article
(This article belongs to the Special Issue What Is Your Diagnosis?—Case Report Collection)
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22 pages, 2251 KB  
Article
Environmental Changes During the Late Glacial and Early Holocene Transition Revealed by Palaeolimnological Record from Southern Lithuania
by Gražyna Kluczynska, Neringa Gastevičienė and Vaida Šeirienė
Biology 2026, 15(6), 499; https://doi.org/10.3390/biology15060499 - 20 Mar 2026
Viewed by 567
Abstract
This study presents integrated Cladoceran, plant macrofossil and diatom-based environmental reconstruction from the Čepkeliai Bog (Southern Lithuania), covering the Late Glacial–Early Holocene transition. The objective was to assess palaeoenvironmental changes with a focus on trophic state, acidification, and water-level fluctuations and to explore [...] Read more.
This study presents integrated Cladoceran, plant macrofossil and diatom-based environmental reconstruction from the Čepkeliai Bog (Southern Lithuania), covering the Late Glacial–Early Holocene transition. The objective was to assess palaeoenvironmental changes with a focus on trophic state, acidification, and water-level fluctuations and to explore the applicability of these assemblages as temperature-sensitive indicators. The findings of our study revealed that sedimentation started at about 13,200–13,000 cal yr BP in a deep, oligotrophic and cold-water palaeobasin. Inferred palaeoenvironment changes correlate with the GI-1b event (Gertsenzee oscillation). A significant ecological shift to a shallow, warm, ecologically diverse environment occurredat about 13,000 cal yr BP and is consistent with the GI-1a (Allerød) period. The Younger Dryas (12,850–11,650 cal yr BP) is characterised by a rise in lake level and oligo-mesotrophic and high-water transparency conditions. At the end of the Younger Dryas (around 12,000 cal yr BP), climate warming and a drop in water levels were recorded. Intensive palaeobasin swamping processes began around 9700 years cal yr BP, during the Boreal period. A short-lived “9.2” cooling event was fixed at about 9200–9000 cal yr BP. The results obtained provide new insights into postglacial palaeoenvironmental dynamics in the southeastern Baltic region. Full article
(This article belongs to the Section Ecology)
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17 pages, 551 KB  
Article
Gastrointestinal Toxicity and Clinical Predictors of Total Neoadjuvant Therapy in Rectal Cancer: A Real-World Retrospective Study
by Lucian Dragoș Bratu, Puiu Olivian Stovicek, Ana-Maria Ciurea, Alina Maria Mehedințeanu, Tradian Ciprian Berisha, Ramona Adriana Schenker, Andrei Mircea Dicianu, Carmen Stamulescu, Ștefan Paitici, Stelian Ștefăniță Mogoantă and Michael Schenker
Life 2026, 16(3), 422; https://doi.org/10.3390/life16030422 - 4 Mar 2026
Cited by 1 | Viewed by 767
Abstract
Background: Total neoadjuvant therapy (TNT) is increasingly administered in rectal cancer, but compared with concurrent chemoradiotherapy (CRT), data regarding the gastrointestinal (GI) toxicity profile and clinical predictors remain limited. Objectives: To evaluate GI toxicity associated with TNT compared with CRT and to explore [...] Read more.
Background: Total neoadjuvant therapy (TNT) is increasingly administered in rectal cancer, but compared with concurrent chemoradiotherapy (CRT), data regarding the gastrointestinal (GI) toxicity profile and clinical predictors remain limited. Objectives: To evaluate GI toxicity associated with TNT compared with CRT and to explore clinical predictors of these adverse events (AEs). Methods: This retrospective study included 201 patients with rectal cancer treated with TNT (n = 157) and CRT (n = 44). GI AEs (nausea, vomiting, diarrhea) were graded according to CTCAE v5.0. In the analysis of factors associated with GI AEs, multiple clinical and pathological variables were included using multivariable logistic regression. Results: The composite endpoint “any GI AEs grade ≥ 1” was more frequent in the TNT group compared with the CRT group (33.1% vs. 15.9%; RR = 2.08; 95% CI 1.02–4.25; p = 0.038). Nausea was significantly more frequent in the TNT group (28.7% vs. 9.1%; RR = 3.15; 95% CI 1.20–8.30; p = 0.012), whereas vomiting (9.6% vs. 2.3%; p = 0.203) and diarrhea (17.8% vs. 9.1%; p = 0.242) did not reach statistical significance. In multivariable logistic regression, TNT (OR = 2.65; 95% CI 1.08–6.53; p = 0.032) and female sex (OR = 2.03; 95% CI 1.05–3.77; p = 0.033) were identified as independent predictors of grade ≥ 1 GI AEs. For nausea, TNT remained significant (OR = 4.37; 95% CI 1.45–13.20; p = 0.0089). Upper rectal tumor location was significantly associated with vomiting (p = 0.0054). No grade 3–4 GI AEs were observed in either treatment group. Conclusions: TNT was associated with a higher incidence of mild GI AEs, predominantly driven by nausea, without an increase in severe toxicities. TNT and female sex were identified as independent clinical predictors of an increased risk of GI AEs, while tumor location in the upper third of the rectum was associated with a higher occurrence of vomiting. Full article
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23 pages, 16576 KB  
Article
A Framework for Designing Green Infrastructure to Maximize Co-Benefits in High-Density Industrial Districts
by Yue Xing, Yu Wen, Zixiang Xu, Pan Zhang, Sijie Zhu and Haishun Xu
Sustainability 2026, 18(4), 2142; https://doi.org/10.3390/su18042142 - 22 Feb 2026
Viewed by 675
Abstract
Green infrastructure (GI) provides essential ecosystem services for urban sustainability in the face of urbanization and climate change, including stormwater management, heat mitigation, and reduction in carbon dioxide (CO2) concentration levels. Existing studies often focus on single-dimensional ecological effects, lacking a [...] Read more.
Green infrastructure (GI) provides essential ecosystem services for urban sustainability in the face of urbanization and climate change, including stormwater management, heat mitigation, and reduction in carbon dioxide (CO2) concentration levels. Existing studies often focus on single-dimensional ecological effects, lacking a systematic investigation of their synergies and trade-offs. This study developed a coupled framework integrating scenario design, model simulation, and multi-indicator evaluation. Fifty-six scenarios, varying by GI combinations, weather conditions, and total annual runoff control rate (RCR), were applied to a high-density industrial district in Nanjing. The results showed that: (1) GI combinations enhanced comprehensive benefits, with the combination including bioretention (BR), permeable pavement (PP), and green roof (GR) performing most effectively. This was followed by the combination of BR and PP, then by BR and GR, while the use of BR alone provided the lowest effectiveness. (2) PP was a key synergistic component, improving heat mitigation and reducing CO2 concentration levels through the beneficial effects of rainfall events. (3) Exceeding the optimal RCR threshold for some GI combinations diminished tree space and three-dimensional green volume, shifting synergies into trade-offs. (4) Three-dimensional green volume was positively correlated with reductions in Physiological Equivalent Temperature (PET) and CO2 concentration, confirming its core role. (5) Rainfall boosted carbon sinks, while a significant cooling enhancement required PP. This study elucidates the water–heat–carbon synergy in small-scale GI, supporting multi-objective optimization in high-density urban renewal. Full article
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18 pages, 1043 KB  
Article
Assessing the Spatiotemporal Impact of ENSO on Coastal Vegetation in Peru Using Random Forest and MODIS Data
by Rosmery Ramos-Sandoval, Ligia García, Luis Huatay-Salcedo, Denisse Chavez-Huaman, Jonathan Alberto Campos-Trigoso and Meliza del Pilar Bustos Chavez
Geographies 2026, 6(1), 22; https://doi.org/10.3390/geographies6010022 - 19 Feb 2026
Viewed by 894
Abstract
The spatial–temporal impact of the El Niño–Southern Oscillation (ENSO) phenomenon in Peru is characterised by marked regional variability, affecting the economy and general well-being. This study focuses on the Piura region, which is highly sensitive to ENSO events, with the aim of determining [...] Read more.
The spatial–temporal impact of the El Niño–Southern Oscillation (ENSO) phenomenon in Peru is characterised by marked regional variability, affecting the economy and general well-being. This study focuses on the Piura region, which is highly sensitive to ENSO events, with the aim of determining the implications for land management and climate adaptation in the Peruvian coastal region, particularly in the context of ENSO events. The objective of the study is to ascertain the correlation between sea surface temperature (SST) anomalies and the Normalised Difference Vegetation Index (NDVI) in the region. The researchers employed a machine learning approach to model and predict monthly NDVI behaviour, incorporating spatial and seasonal variables from the Moderate Resolution Imaging Spectroradiometer (MODIS) during two periods of ENSO occurrence on the Peruvian coast (2017; 2023) and the one-year post-occurrence periods (2018; 2024). The results demonstrated a correlation between NDVI and SST anomalies in coastal provinces such as Sechura and Morropón, indicating sensitivity to oceanic conditions. In contrast, high Andean provinces such as Ayabaca and Huancabamba exhibited more moderate values, indicating a weaker dependence on SST variability. The study also found that the NDVI exhibited a marked monthly variation associated with altitudinal gradients and climatic conditions. This research demonstrates the potential of remote sensing and GIS technologies in capturing climate-sensitive land-use dynamics and provides a framework for operational monitoring and decision support. Full article
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15 pages, 574 KB  
Systematic Review
Proton Beam Therapy in Gynecological Cancers: A Systematic Review of Indications, Complications, and Limitations
by Vito Andrea Capozzi, Giulia Martignon, Elisa Scarpelli, Alessandra De Finis, Stefano Restaino, Giuseppe Vizzielli and Roberto Berretta
Medicina 2026, 62(2), 334; https://doi.org/10.3390/medicina62020334 - 6 Feb 2026
Cited by 1 | Viewed by 1029
Abstract
Background and Objectives: Gynecological cancers frequently require radiation therapy (RT) in primary, adjuvant, or salvage settings. However, photon-based RT is associated with non-negligible toxicity, and treatment of pelvic recurrences after prior irradiation remains challenging. Proton beam therapy (PBT), due to its favorable [...] Read more.
Background and Objectives: Gynecological cancers frequently require radiation therapy (RT) in primary, adjuvant, or salvage settings. However, photon-based RT is associated with non-negligible toxicity, and treatment of pelvic recurrences after prior irradiation remains challenging. Proton beam therapy (PBT), due to its favorable dose distribution and reduced exposure of organs at risk (OARs), has emerged as a potential alternative, particularly in re-irradiation scenarios. Despite its expanding use in other malignancies, evidence supporting PBT in gynecologic cancers remains limited. This systematic review aims to investigate the use of PBT in gynecological cancers and its associated complications. Materials and Methods: This systematic review was conducted according to PRISMA guidelines and registered in PROSPERO. A comprehensive search (2000–2025) identified studies investigating PBT in gynecologic cancers. Eligible designs included randomized trials and prospective and retrospective series. Reported adverse events were categorized as GI, GU, or other, and only grade ≥3 CT-CAE complications were considered. Results: Of 580 records screened, 9 studies comprising 232 patients met inclusion criteria. Most patients were treated for endometrial (n = 147) or cervical (n = 75) cancer; 90 received chemotherapy. Overall, severe toxicity occurred in 15.2% of patients. GI complications ranged from 0–14% and GU from 0–33%. Complication rates were lowest in adjuvant or de novo treatment series (0–10%), whereas re-irradiation cohorts showed higher rates (up to 33% GU). Comparative studies suggested a possible advantage of PBT over IMRT, particularly for GI toxicity, though data remain limited. Conclusions: Severe GI and GU toxicity after PBT in gynecologic cancers appears infrequent, particularly in primary and adjuvant settings, though re-irradiation remains challenging. Current evidence is restricted to small and heterogeneous studies. Ongoing phase II trials will provide prospective data to clarify feasibility, toxicity, and long-term outcomes. Until then, PBT in gynecologic oncology should be regarded as investigational. Full article
(This article belongs to the Special Issue Gynecological Surgery: Bridging Research and Clinical Practice)
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13 pages, 576 KB  
Article
Electrical Impedance Tomography Monitoring During Extubation in Critically Ill Children
by Waratchaya Kit-Anan, Jarin Vaewpanich and Nattachai Anantasit
Children 2026, 13(2), 190; https://doi.org/10.3390/children13020190 - 29 Jan 2026
Viewed by 1042
Abstract
Background: Extubation failure increases morbidity and mortality. Non-invasive ventilation (NIV), including high-flow nasal cannula (HFNC), can reduce reintubation rates. Current practice often involves prophylactic use of NIV post-extubation. Electrical Impedance Tomography (EIT) provides real-time monitoring of pulmonary distribution and ventilation. Recent adult studies [...] Read more.
Background: Extubation failure increases morbidity and mortality. Non-invasive ventilation (NIV), including high-flow nasal cannula (HFNC), can reduce reintubation rates. Current practice often involves prophylactic use of NIV post-extubation. Electrical Impedance Tomography (EIT) provides real-time monitoring of pulmonary distribution and ventilation. Recent adult studies suggest that EIT has potential in extubation failure prediction, but evidence in children is limited. Our objectives were to evaluate peri-extubation regional lung volume/distribution and to explore EIT-derived physiological changes and on post-extubation respiratory support patterns in critically ill children. Methods: A prospective observational study included intubated patients aged 1 month to 18 years in the PICU who were intubated for over 24 h. Vital signs and chest EIT were recorded pre-extubation (H0), immediately post-extubation (H1), at 30 min (H2), and at 4 h (H3). Patients were categorized by chest X-ray findings into abnormal or normal groups. Results: Among 209 ventilated patients, 54 were included. End-expiratory lung impedance (∆EELI), tidal impedance (TID), and the global inhomogeneity index (GI) demonstrated significant changes across predefined peri-extubation time points. Thirty-eight (70.4%) patients received HFNC or NIV immediately after extubation. No extubation failures occurred, precluding evaluation of extubation failure predictors. In the subgroup analyzed based on chest X-ray findings, differences in TID and ODCL were observed between patients with normal and abnormal chest X-rays immediately after extubation. Conclusions: The ∆EELI, TID, and GI demonstrated significant changes across predefined peri-extubation time points. In the absence of extubation failure events, the ability of EIT monitoring to evaluate extubation failure could not be assessed. The frequent use of prophylactic NIV support after extubation may have influenced post-extubation physiology. Full article
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20 pages, 5947 KB  
Article
A Knowledge Graph-Guided and Multimodal Data Fusion-Driven Rapid Modeling Method for Digital Twin Scenes: A Case Study of Bridge Tower Construction
by Yongtao Zhang, Yongwei Wang, Zhihao Guo, Jun Zhu, Fanxu Huang, Hao Zhu, Yuan Chen and Yajian Kang
ISPRS Int. J. Geo-Inf. 2026, 15(1), 27; https://doi.org/10.3390/ijgi15010027 - 6 Jan 2026
Viewed by 1510
Abstract
Establishing digital twin scenes facilitates the understanding of geospatial phenomena, representing a significant research focus for GIS scientists and engineers. However, current research on digital twin scenes modeling relies on manual intervention or the overlay of static models, resulting in low modeling efficiency [...] Read more.
Establishing digital twin scenes facilitates the understanding of geospatial phenomena, representing a significant research focus for GIS scientists and engineers. However, current research on digital twin scenes modeling relies on manual intervention or the overlay of static models, resulting in low modeling efficiency and poor standardization. To address these challenges, this paper proposes a knowledge graph-guided and multimodal data fusion-driven rapid modeling method for digital twin scenes, using bridge tower construction as an illustrative example. We first constructed a knowledge graph linking the three domains of “event-object-data” in bridge tower construction. Guided by this graph, we designed a knowledge graph-guided multimodal data association and fusion algorithm. Then a rapid modeling method for bridge tower construction scenes based on dynamic data was established. Finally, a prototype system was developed, and a case study area was selected for analysis. Experimental results show that the knowledge graph we built clearly captures all elements and their relationships in bridge tower construction scenes. Our method enables precise fusion of 5 types of multimodal data: BIM, DEM, images, videos, and point clouds. It improves spatial registration accuracy by 21.83%, increases temporal fusion efficiency by 65.6%, and reduces feature fusion error rates by 70.9%. Local updates of the 3D geographic scene take less than 30 ms, supporting millisecond-level digital twin modeling. This provides a practical reference for building geographic digital twin scenes. Full article
(This article belongs to the Special Issue Knowledge-Guided Map Representation and Understanding)
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29 pages, 11546 KB  
Article
Evolutionary Characteristics, Improvement Strategies and Driving Mechanisms of the Human Settlement Environment in Chinese Traditional Villages Based on Historical Hydrological Resilience Assessment
by Haobing Wang, Pengcheng Liu, Yong Shan, Junxue Zhang and Sisi Xia
Buildings 2025, 15(23), 4264; https://doi.org/10.3390/buildings15234264 - 25 Nov 2025
Cited by 1 | Viewed by 901
Abstract
(1) Background: In the context of rapid urbanization and climate change, Chinese traditional villages are facing severe challenges such as deterioration of hydrological environment, weakened social resilience, and degradation of cultural heritage. (2) Methods: This paper took Baoyan Village in Zhenjiang City, Jiangsu [...] Read more.
(1) Background: In the context of rapid urbanization and climate change, Chinese traditional villages are facing severe challenges such as deterioration of hydrological environment, weakened social resilience, and degradation of cultural heritage. (2) Methods: This paper took Baoyan Village in Zhenjiang City, Jiangsu Province as the research object and constructs a research framework of “assessment of historical hydrological resilience–diagnosis of current problems–construction of enhancement strategies”, aiming to explore the paths and driving mechanisms for enhancing the resilience of traditional villages. The spatio-temporal evolution of historical hydrological resilience in Baoyan Village was quantitatively evaluated by establishing a three-dimensional resilience index system of “ecological governance–social adaptation–cultural continuity”, combined with the Analytic Hierarchy Process (AHP) and GIS spatial overlay technology. (3) Results: The study found that ① The hydrological resilience zoning of Baoyan Village presented spatial differentiation characteristics of “core vulnerability-marginal resilience”, and the high-risk area was concentrated in the cultural building density area along the old Tongji River in the historical town area, indicating that this area requires key flood protection and resilience construction; ② this paper constructed a composite evaluation system of “Ecological Governance–cultural inheritance–social adaptation”, and the total score after evaluation was 0.67, indicating that the overall HHRI of Baoyan Village has declined. Specifically, the scores for Ecological Governance Resilience and Cultural Heritage Resilience were 0.48 and 0.46, respectively, reflecting a significant decrease compared to historical scenarios. Conversely, the score for Social Adaptation Resilience was recorded at 1.05, suggesting an improvement in this dimension. This enhancement can be attributed to advancements in water infrastructure and increased levels of community organizational support, which have bolstered the village’s capacity to withstand flooding events. ③ The integrity of weir fields, the transmission of traditional disaster prevention knowledge, and the stability of natural river channels are the main factors hindering the improvement of resilience systems. (4) Conclusions: Based on the assessment results, this study proposed the resilience enhancement path of “ecological space reconstruction-traditional water management wisdom activation–cultural resilience empowerment” for this case, and constructed a four-pronged driving mechanism consisting of government guidance, community participation, technology empowerment, and industrial synergy for implementation. Practice has shown that through specific strategies such as restoring the weir and field system, constructing sponge village units, and developing the rain and flood cultural experience industry, the key obstacle factors of the village can be effectively addressed, and the goals of flood safety and cultural inheritance can be achieved in a coordinated manner. This case provides an empirical reference that combines historical wisdom with modern technology for understanding the evolution of human–water relationships and the enhancement of resilience in traditional villages, and its research framework and methods are also of reference value for similar villages. Full article
(This article belongs to the Section Architectural Design, Urban Science, and Real Estate)
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12 pages, 488 KB  
Article
Effects of Probiotic Short-Term Regiment on Oral Health Parameters in Children: A Pilot Randomized Controlled Trial
by Edouard Starck, Vanessa Machado, João Botelho, Luís Proença, Helena Barroso, Carla Ascenso and Cecília Rozan
Nutrients 2025, 17(22), 3604; https://doi.org/10.3390/nu17223604 - 18 Nov 2025
Cited by 1 | Viewed by 2099
Abstract
Background/Objectives: Streptococcus mutans (S. mutans) is a primary cariogenic bacterium contributing to biofilm acidogenicity and enamel demineralization. Conventional caries prevention relies mainly on mechanical plaque control and dietary modification, but probiotics have emerged as potential adjuncts for oral microbiota modulation. [...] Read more.
Background/Objectives: Streptococcus mutans (S. mutans) is a primary cariogenic bacterium contributing to biofilm acidogenicity and enamel demineralization. Conventional caries prevention relies mainly on mechanical plaque control and dietary modification, but probiotics have emerged as potential adjuncts for oral microbiota modulation. This pilot randomized controlled trial aimed to evaluate the short-term effects of a multi-strain probiotic containing Lactobacillus and Bifidobacterium on clinical and microbiological parameters associated with dental caries in children. Methods: A double-blind, randomized, placebo-controlled clinical trial was conducted in 40 children aged 6–14 years from a community setting. Participants were randomly allocated (1:1) to receive either probiotic or placebo lozenges for 30 days. Clinical assessments included the Gingival Index (GI), Plaque Index (PI), International Caries Detection and Assessment System (ICDAS), salivary pH, buffering capacity, and salivary S. mutans concentration. The study was preregistered (10.17605/OSF.IO/GKVUW) and ethically approved. Results: The intervention was well tolerated, with no adverse events reported and high participant acceptability. Despite there being no statistically significant differences in any clinical or microbiological parameter (p > 0.05), we found trends toward higher salivary pH, improved buffering capacity, and reduced S. mutans counts in the probiotic group. Conclusions: Short-term probiotic supplementation was safe and well accepted among children but did not produce statistically significant improvements in oral health parameters over 30 days. These findings highlight the feasibility of probiotic use in pediatric populations and support the need for larger, longer-term trials to clarify their potential role as adjuncts in caries prevention. Full article
(This article belongs to the Special Issue Probiotics and Prebiotics for Oral Health Improvement)
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22 pages, 9159 KB  
Article
A Dynamic Urban Waterlogging Risk Assessment Framework Using RAGA-Optimized Projection Pursuit and Scenario Simulation
by Ye Rao, Qiming Cheng, Jiayue Zhu, Linhao Liu, Yixin Mu, Yuanhan Zhou, Dingjiang Su, Zhen Liu and Yao Chen
Sustainability 2025, 17(22), 10305; https://doi.org/10.3390/su172210305 - 18 Nov 2025
Cited by 2 | Viewed by 855
Abstract
In response to escalating urban waterlogging crises exacerbated by global warming and accelerated urbanization, an innovative waterlogging risk assessment framework was advanced in this study to bolster urban resilience and promote sustainable urban development. Current methodologies often suffer from subjective bias in weight [...] Read more.
In response to escalating urban waterlogging crises exacerbated by global warming and accelerated urbanization, an innovative waterlogging risk assessment framework was advanced in this study to bolster urban resilience and promote sustainable urban development. Current methodologies often suffer from subjective bias in weight assignments for evaluation indicators. To overcome this limitation, the projection pursuit (PP) technique was integrated with a real-coded accelerated genetic algorithm (RAGA) to derive objective indicator weights. Focusing on the built-up area of Xiushan County in Chongqing, the InfoWorks ICM was employed to develop a 1D-2D coupled hydrodynamic model for simulating the dynamic spatiotemporal evolution of waterlogging events. Based on three dimensions namely hazard, sensitivity, and vulnerability, an urban waterlogging risk assessment model was developed and ArcGIS was utilized to precisely generate risk distribution maps under rainfall scenarios with return periods of 20 years and 100 years. Additionally, to enhance flood mitigation capabilities in identified high-risk zones, this study proposed implementing stormwater storage tank systems. Simulation results demonstrated that these measures achieve a 50.88% reduction in overflow volumes in critical areas, effectively lowering peak waterlogging depth from 0.74 m to 0.53 m. Key findings revealed that high-risk areas exhibit significant spatial clustering in low-elevation districts characterized by high population density and economic development intensity, where extreme rainfall events amplify water accumulation vulnerabilities, highlighting the importance of sustainable land use planning and climate adaptation strategies. The proposed assessment methodology not only enables objective quantification of urban waterlogging risks but also facilitates evidence-based formulation of targeted mitigation strategies, facilitating the goals of urban sustainability and long-term environmental resilience. Full article
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