Critical Care of Medically Complex Children: New Studies and Challenges

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Emergency Medicine & Intensive Care Medicine".

Deadline for manuscript submissions: closed (5 December 2025) | Viewed by 239

Special Issue Editor


E-Mail Website
Guest Editor
Department of Pediatrics, Critical Care, CHU Sainte-Justine, University of Montreal, 3175 Chemin de la Cote-Sainte-Catherine, Montreal, QC H3T 1C5, Canada
Interests: clinical epidemiology; safety systems; health services research; pediatric critical care; cohort studies; health administrative data

Special Issue Information

Dear Colleagues,

Children with special healthcare needs (CSHNs) and complex chronic conditions (CCCs) represent a heterogenous population with increased prevalence. These children are particularly at risk of rapid clinical deterioration, increased morbidity from common conditions, extended hospital length of stay, and pediatric intensive care unit admission. Critical care management of children with CCCs involves the comprehensive and multidisciplinary treatment of multisystem chronic conditions, often requiring technological dependence such as mechanical ventilation and enteral feeding. A major clinical challenge lies in the integration of specialized, high-intensity interventions with strategies aimed at minimizing harm and optimizing long-term outcomes, including quality of life. Care coordination requires good communication across various subspecialties and home care teams, in partnership with families. The preparation and transition of youth with medical complexity toward adult care is another challenging period for these children, their caregivers, and medical teams. Additionally, the psychosocial and economic burden on families is significant, requiring the inclusion of support services to address caregiver burnout, ensure adherence to complex medical regimens, and enhance overall continuity and quality of care.

This Special Issue aims to deepen our understanding of the challenges faced by children with complex chronic conditions in critical care settings, to review the current burden on the healthcare infrastructure, and to explore strategies for mitigating these challenges. We are soliciting papers employing a variety of methodological approaches that address topics such as defining this population, understanding its epidemiology and predictive factors, evaluating interventions and their outcomes, examining child and family/caregiver experiences, and identifying strategies to enhance communication, interdisciplinary collaboration, and care transitions.

Dr. Nadia Roumeliotis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • medical complexity
  • special needs
  • disability
  • critical care
  • chronic critical illness
  • technology dependence

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 576 KB  
Article
Electrical Impedance Tomography Monitoring During Extubation in Critically Ill Children
by Waratchaya Kit-Anan, Jarin Vaewpanich and Nattachai Anantasit
Children 2026, 13(2), 190; https://doi.org/10.3390/children13020190 - 29 Jan 2026
Viewed by 65
Abstract
Background: Extubation failure increases morbidity and mortality. Non-invasive ventilation (NIV), including high-flow nasal cannula (HFNC), can reduce reintubation rates. Current practice often involves prophylactic use of NIV post-extubation. Electrical Impedance Tomography (EIT) provides real-time monitoring of pulmonary distribution and ventilation. Recent adult studies [...] Read more.
Background: Extubation failure increases morbidity and mortality. Non-invasive ventilation (NIV), including high-flow nasal cannula (HFNC), can reduce reintubation rates. Current practice often involves prophylactic use of NIV post-extubation. Electrical Impedance Tomography (EIT) provides real-time monitoring of pulmonary distribution and ventilation. Recent adult studies suggest that EIT has potential in extubation failure prediction, but evidence in children is limited. Our objectives were to evaluate peri-extubation regional lung volume/distribution and to explore EIT-derived physiological changes and on post-extubation respiratory support patterns in critically ill children. Methods: A prospective observational study included intubated patients aged 1 month to 18 years in the PICU who were intubated for over 24 h. Vital signs and chest EIT were recorded pre-extubation (H0), immediately post-extubation (H1), at 30 min (H2), and at 4 h (H3). Patients were categorized by chest X-ray findings into abnormal or normal groups. Results: Among 209 ventilated patients, 54 were included. End-expiratory lung impedance (∆EELI), tidal impedance (TID), and the global inhomogeneity index (GI) demonstrated significant changes across predefined peri-extubation time points. Thirty-eight (70.4%) patients received HFNC or NIV immediately after extubation. No extubation failures occurred, precluding evaluation of extubation failure predictors. In the subgroup analyzed based on chest X-ray findings, differences in TID and ODCL were observed between patients with normal and abnormal chest X-rays immediately after extubation. Conclusions: The ∆EELI, TID, and GI demonstrated significant changes across predefined peri-extubation time points. In the absence of extubation failure events, the ability of EIT monitoring to evaluate extubation failure could not be assessed. The frequent use of prophylactic NIV support after extubation may have influenced post-extubation physiology. Full article
Show Figures

Figure 1

Back to TopTop