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Article

2 Citations

1,926 Views

20 Pages

RTL4, a Retrovirus-Derived Gene Implicated in Autism Spectrum Disorder, Is a Microglial Gene That Responds to Noradrenaline in the Postnatal Brain

Fumitoshi Ishino,
Johbu Itoh,
Ayumi Matsuzawa,
Masahito Irie,
Toru Suzuki,
Yuichi Hiraoka,
Masanobu Yoshikawa and
Tomoko Kaneko-Ishino

Int. J. Mol. Sci.2024, 25(24), 13738;https://doi.org/10.3390/ijms252413738

23 December 2024

Retrotransposon Gag-like 4 (RTL4), a gene acquired from a retrovirus, is a causative gene in autism spectrum disorder. Its knockout mice exhibit increased impulsivity, impaired short-term spatial memory, failure to adapt to novel environments, and de...

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Article

7 Citations

3,326 Views

16 Pages

Retrovirus-Derived RTL9 Plays an Important Role in Innate Antifungal Immunity in the Eutherian Brain

Fumitoshi Ishino,
Johbu Itoh,
Masahito Irie,
Ayumi Matsuzawa,
Mie Naruse,
Toru Suzuki,
Yuichi Hiraoka and
Tomoko Kaneko-Ishino

Int. J. Mol. Sci.2023, 24(19), 14884;https://doi.org/10.3390/ijms241914884

4 October 2023

Retrotransposon Gag-like (RTL) genes play a variety of essential and important roles in the eutherian placenta and brain. It has recently been demonstrated that RTL5 and RTL6 (also known as sushi-ichi retrotransposon homolog 8 (SIRH8) and SIRH3) are...

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Review

10 Citations

3,734 Views

20 Pages

Retrovirus-Derived RTL/SIRH: Their Diverse Roles in the Current Eutherian Developmental System and Contribution to Eutherian Evolution

Tomoko Kaneko-Ishino and
Fumitoshi Ishino

Biomolecules2023, 13(10), 1436;https://doi.org/10.3390/biom13101436

22 September 2023

Eutherians have 11 retrotransposon Gag-like (RTL)/sushi-ichi retrotransposon homolog (SIRH) genes presumably derived from a certain retrovirus. Accumulating evidence indicates that the RTL/SIRH genes play a variety of roles in the current mammalian d...

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Review

25 Citations

5,024 Views

12 Pages

Short Histone H2A Variants: Small in Stature but not in Function

Xuanzhao Jiang,
Tatiana A. Soboleva and
David J. Tremethick

Cells2020, 9(4), 867;https://doi.org/10.3390/cells9040867

2 April 2020

The dynamic packaging of DNA into chromatin regulates all aspects of genome function by altering the accessibility of DNA and by providing docking pads to proteins that copy, repair and express the genome. Different epigenetic-based mechanisms have b...

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