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Search Results (324)

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Keywords = estimated mutual information

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22 pages, 3409 KiB  
Article
Short-Term Prediction Intervals for Photovoltaic Power via Multi-Level Analysis and Dual Dynamic Integration
by Kaiyang Kuang, Jingshan Zhang, Qifan Chen, Yan Zhou, Yan Yan, Litao Dai and Guanghu Wang
Electronics 2025, 14(15), 3068; https://doi.org/10.3390/electronics14153068 - 31 Jul 2025
Viewed by 178
Abstract
There is an obvious correlation between the photovoltaic (PV) output of different physical levels; that is, the overall power change trend of large-scale regional (high-level) stations can provide a reference for the prediction of the output of sub-regional (low-level) stations. The current PV [...] Read more.
There is an obvious correlation between the photovoltaic (PV) output of different physical levels; that is, the overall power change trend of large-scale regional (high-level) stations can provide a reference for the prediction of the output of sub-regional (low-level) stations. The current PV prediction methods have not deeply explored the multi-level PV power generation elements and have not considered the correlation between different levels, resulting in the inability to obtain potential information on PV power generation. Moreover, traditional probabilistic prediction models lack adaptability, which can lead to a decrease in prediction performance under different PV prediction scenarios. Therefore, a probabilistic prediction method for short-term PV power based on multi-level adaptive dynamic integration is proposed in this paper. Firstly, an analysis is conducted on the multi-level PV power stations together with the influence of the trend of high-level PV power generation on the forecast of low-level power generation. Then, the PV data are decomposed into multiple layers using the complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) and analyzed by combining fuzzy entropy (FE) and mutual information (MI). After that, a new multi-level model prediction method, namely, the improved dual dynamic adaptive stacked generalization (I-Stacking) ensemble learning model, is proposed to construct short-term PV power generation prediction models. Finally, an improved dynamic adaptive kernel density estimation (KDE) method for prediction errors is proposed, which optimizes the performance of the prediction intervals (PIs) through variable bandwidth. Through comparative experiments and analysis using traditional methods, the effectiveness of the proposed method is verified. Full article
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24 pages, 1163 KiB  
Article
The Analysis of Cultural Convergence and Maritime Trade Between China and Saudi Arabia: Toda–Yamamoto Granger Causality
by Nashwa Mostafa Ali Mohamed, Jawaher Binsuwadan, Rania Hassan Mohammed Abdelkhalek and Kamilia Abd-Elhaleem Ahmed Frega
Sustainability 2025, 17(14), 6501; https://doi.org/10.3390/su17146501 - 16 Jul 2025
Viewed by 442
Abstract
This study investigates the dynamic relationship between maritime trade and cultural convergence between China and Saudi Arabia, with a particular focus on the roles of creative goods and information and communication technology (ICT) exports as proxies for sociocultural integration. Utilizing quarterly data from [...] Read more.
This study investigates the dynamic relationship between maritime trade and cultural convergence between China and Saudi Arabia, with a particular focus on the roles of creative goods and information and communication technology (ICT) exports as proxies for sociocultural integration. Utilizing quarterly data from 2012 to 2021, the analysis employs the Toda–Yamamoto Granger causality approach within a Vector Autoregression (VAR) framework. This methodology offers a robust means of testing causality without requiring data stationarity or cointegration, thereby reducing estimation bias and enhancing applicability to real-world economic data. The empirical model examines causal interactions among maritime trade, creative goods exports, ICT exports, and population, the latter serving as a control variable to account for demographic scale effects on trade dynamics. The results indicate statistically significant bidirectional causality between maritime trade and both creative goods and ICT exports, suggesting a reciprocal reinforcement between trade and cultural–technological exchange. In contrast, the relationship between maritime trade and population is found to be unidirectional. These findings underscore the strategic importance of cultural and technological flows in shaping maritime trade patterns. Furthermore, the study contextualizes its results within broader policy initiatives, notably China’s Belt and Road Initiative and Saudi Arabia’s Vision 2030, both of which aim to promote mutual economic diversification and regional integration. The study contributes to the literature on international trade and cultural economics by demonstrating how cultural convergence can serve as a catalyst for strengthening bilateral trade relations. Policy implications include the promotion of cultural and technological collaboration, investment in maritime infrastructure, and the incorporation of cultural dimensions into trade policy formulation. Full article
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26 pages, 543 KiB  
Article
Bounds on the Excess Minimum Risk via Generalized Information Divergence Measures
by Ananya Omanwar, Fady Alajaji and Tamás Linder
Entropy 2025, 27(7), 727; https://doi.org/10.3390/e27070727 - 5 Jul 2025
Viewed by 242
Abstract
Given finite-dimensional random vectors Y, X, and Z that form a Markov chain in that order (YXZ), we derive the upper bounds on the excess minimum risk using generalized information divergence measures. Here, Y is [...] Read more.
Given finite-dimensional random vectors Y, X, and Z that form a Markov chain in that order (YXZ), we derive the upper bounds on the excess minimum risk using generalized information divergence measures. Here, Y is a target vector to be estimated from an observed feature vector X or its stochastically degraded version Z. The excess minimum risk is defined as the difference between the minimum expected loss in estimating Y from X and from Z. We present a family of bounds that generalize a prior bound based on mutual information, using the Rényi and α-Jensen–Shannon divergences, as well as Sibson’s mutual information. Our bounds are similar to recently developed bounds for the generalization error of learning algorithms. However, unlike these works, our bounds do not require the sub-Gaussian parameter to be constant, and therefore, apply to a broader class of joint distributions over Y, X, and Z. We also provide numerical examples under both constant and non-constant sub-Gaussianity assumptions, illustrating that our generalized divergence-based bounds can be tighter than the ones based on mutual information for certain regimes of the parameter α. Full article
(This article belongs to the Special Issue Information Theoretic Learning with Its Applications)
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16 pages, 814 KiB  
Article
An Interpretable Method for Anomaly Detection in Multivariate Time Series Predictions
by Shijie Tang, Yong Ding and Huiyong Wang
Appl. Sci. 2025, 15(13), 7479; https://doi.org/10.3390/app15137479 - 3 Jul 2025
Viewed by 348
Abstract
Anomaly detection methods for industrial control networks using multivariate time series usually adopt deep learning-based prediction models. However, most of the existing anomaly detection research only focuses on evaluating detection performance and rarely explains why data is marked as abnormal and which physical [...] Read more.
Anomaly detection methods for industrial control networks using multivariate time series usually adopt deep learning-based prediction models. However, most of the existing anomaly detection research only focuses on evaluating detection performance and rarely explains why data is marked as abnormal and which physical components have been attacked. Yet, in many scenarios, it is necessary to explain the decision-making process of detection. To address this concern, we propose an interpretable method for an anomaly detection model based on gradient optimization, which can perform batch interpretation of data without affecting model performance. Our method transforms the interpretation of anomalous features into solving an optimization problem in a normal “reference” state. In the selection of important features, we adopt the method of multiplying the absolute gradient by the input to measure the independent effects of different dimensions of data. At the same time, we use KSG mutual information estimation and multivariate cross-correlation to evaluate the relationship and mutual influence between different dimensional data within the same sliding window. By accumulating gradient changes, the interpreter can identify the attacked features. Comparative experiments were conducted on the SWAT and WADI datasets, demonstrating that our method can effectively identify the physical components that have experienced anomalies and their changing trends. Full article
(This article belongs to the Special Issue Novel Insights into Cryptography and Network Security)
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17 pages, 4019 KiB  
Article
Oil-Painting Style Classification Using ResNet with Conditional Information Bottleneck Regularization
by Yaling Dang, Fei Duan and Jia Chen
Entropy 2025, 27(7), 677; https://doi.org/10.3390/e27070677 - 25 Jun 2025
Viewed by 693
Abstract
Automatic classification of oil-painting styles holds significant promise for art history, digital archiving, and forensic investigation by offering objective, scalable analysis of visual artistic attributes. In this paper, we introduce a deep conditional information bottleneck (CIB) framework, built atop ResNet-50, for fine-grained style [...] Read more.
Automatic classification of oil-painting styles holds significant promise for art history, digital archiving, and forensic investigation by offering objective, scalable analysis of visual artistic attributes. In this paper, we introduce a deep conditional information bottleneck (CIB) framework, built atop ResNet-50, for fine-grained style classification of oil paintings. Unlike traditional information bottleneck (IB) approaches that minimize the mutual information I(X;Z) between input X and latent representation Z, our CIB minimizes the conditional mutual information I(X;ZY), where Y denotes the painting’s style label. We implement this conditional term using a matrix-based Rényi’s entropy estimator, thereby avoiding costly variational approximations and ensuring computational efficiency. We evaluate our method on two public benchmarks: the Pandora dataset (7740 images across 12 artistic movements) and the OilPainting dataset (19,787 images across 17 styles). Our method outperforms the prevalent ResNet with a relative performance gain of 13.1% on Pandora and 11.9% on OilPainting. Beyond quantitative gains, our approach yields more disentangled latent representations that cluster semantically similar styles, facilitating interpretability. Full article
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20 pages, 3934 KiB  
Article
Small Aperture Antenna Arrays for Direction of Arrival Estimation
by Krutant J. Mehta and Inder J. Gupta
Sensors 2025, 25(12), 3606; https://doi.org/10.3390/s25123606 - 8 Jun 2025
Viewed by 424
Abstract
In this paper, we establish criteria for the design of small aperture antenna arrays for Direction of Arrival (DOA) estimation. We define a small aperture antenna array as one consisting of a few elements with an average interelement spacing less than or equal [...] Read more.
In this paper, we establish criteria for the design of small aperture antenna arrays for Direction of Arrival (DOA) estimation. We define a small aperture antenna array as one consisting of a few elements with an average interelement spacing less than or equal to half a wavelength. We use the spatial covariance matrix of the antenna array to derive the design criterion. It is well known that the DOA estimation performance of an antenna array is strongly related to the amount of information in this matrix. Also, the Cramer-Rao Bound of the estimated DOA is closely related to this matrix. We establish and demonstrate that, for optimal DOA estimation performance, a small aperture antenna array should have non-uniformly spaced and dissimilar antenna elements. Since mutual coupling between antenna elements makes their in situ responses dissimilar, instead of mitigating mutual coupling, one should include mutual coupling in the DOA estimation process to enhance the DOA estimation performance of antenna arrays. Full article
(This article belongs to the Section Communications)
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15 pages, 12526 KiB  
Article
Research on Registration Methods for Coupled Errors in Maneuvering Platforms
by Qiang Li, Ruidong Liu, Yalei Liu and Zhenzhong Wei
Entropy 2025, 27(6), 607; https://doi.org/10.3390/e27060607 - 6 Jun 2025
Viewed by 332
Abstract
The performance limitations of single-sensor systems in target tracking have led to the widespread adoption of multi-sensor fusion, which improves accuracy through information complementarity and redundancy. However, on mobile platforms, dynamic changes in sensor attitude and position introduce coupled measurement and attitude errors, [...] Read more.
The performance limitations of single-sensor systems in target tracking have led to the widespread adoption of multi-sensor fusion, which improves accuracy through information complementarity and redundancy. However, on mobile platforms, dynamic changes in sensor attitude and position introduce coupled measurement and attitude errors, making accurate sensor registration particularly challenging. Most existing methods either treat these errors independently or rely on simplified assumptions, which limit their effectiveness in dynamic environments. To address this, we propose a novel joint error estimation and registration method based on a pseudo-Kalman filter (PKF). The PKF constructs pseudo-measurements by subtracting outputs from multiple sensors, projecting them into a bias space that is independent of the target’s state. A decoupling mechanism is introduced to distinguish between measurement and attitude error components, enabling accurate joint estimation in real time. In the shipborne environment, simulation experiments on pitch, yaw, and roll motions were conducted using two sensors. This method was compared with least squares (LS), maximum likelihood (ML), and the standard method based on PKF. The results show that the method based on PKF has a lower root mean square error (RMSE), a faster convergence speed, and better estimation accuracy and robustness. The proposed approach provides a practical and scalable solution for sensor registration in dynamic environments, particularly in maritime or aerial applications where coupled errors are prevalent. Full article
(This article belongs to the Section Information Theory, Probability and Statistics)
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15 pages, 1900 KiB  
Article
Research on Model Prediction of Remaining Service Life of Lithium-Ion Batteries Based on Chaotic Time Series
by Tongrui Zhang and Hao Sun
Electronics 2025, 14(11), 2280; https://doi.org/10.3390/electronics14112280 - 3 Jun 2025
Cited by 1 | Viewed by 394
Abstract
To address the conflicting demands of the energy crisis, environmental pollution, and economic growth, the electric vehicle (EV) industry has expanded rapidly, facilitating the widespread adoption of power batteries. This paper investigates the use of chaos theory and machine learning for predicting the [...] Read more.
To address the conflicting demands of the energy crisis, environmental pollution, and economic growth, the electric vehicle (EV) industry has expanded rapidly, facilitating the widespread adoption of power batteries. This paper investigates the use of chaos theory and machine learning for predicting the remaining useful life (RUL) of lithium-ion batteries. Firstly, the mutual information method determines the time delay of the monitoring sequence, while the improved false nearest neighbor method (Cao algorithm) establishes the embedding dimension, yielding the phase space reconstruction parameters. Secondly, the maximum Lyapunov exponent identifies the chaotic properties of the capacity decay time series, and a prediction dataset is constructed based on phase space reconstruction theory. Finally, leveraging the chaotic time-series features, a support vector machine (SVM) model is developed for lithium-ion battery RUL prediction. The algorithm is subsequently validated through simulation using the NASA battery dataset. The results demonstrate that the proposed method achieves high predictive accuracy and stability, providing reliable RUL estimates for the battery management system (BMS). Full article
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41 pages, 10161 KiB  
Article
Information-Theoretical Analysis of a Transformer-Based Generative AI Model
by Manas Deb and Tokunbo Ogunfunmi
Entropy 2025, 27(6), 589; https://doi.org/10.3390/e27060589 - 31 May 2025
Viewed by 929
Abstract
Large Language models have shown a remarkable ability to “converse” with humans in a natural language across myriad topics. Despite the proliferation of these models, a deep understanding of how they work under the hood remains elusive. The core of these Generative AI [...] Read more.
Large Language models have shown a remarkable ability to “converse” with humans in a natural language across myriad topics. Despite the proliferation of these models, a deep understanding of how they work under the hood remains elusive. The core of these Generative AI models is composed of layers of neural networks that employ the Transformer architecture. This architecture learns from large amounts of training data and creates new content in response to user input. In this study, we analyze the internals of the Transformer using Information Theory. To quantify the amount of information passing through a layer, we view it as an information transmission channel and compute the capacity of the channel. The highlight of our study is that, using Information-Theoretical tools, we develop techniques to visualize on an Information plane how the Transformer encodes the relationship between words in sentences while these words are projected into a high-dimensional vector space. We use Information Geometry to analyze the high-dimensional vectors in the Transformer layer and infer relationships between words based on the length of the geodesic connecting these vector distributions on a Riemannian manifold. Our tools reveal more information about these relationships than attention scores. In this study, we also show how Information-Theoretic analysis can help in troubleshooting learning problems in the Transformer layers. Full article
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26 pages, 1272 KiB  
Article
Distributed Relative Pose Estimation for Multi-UAV Systems Based on Inertial Navigation and Data Link Fusion
by Kun Li, Shuhui Bu, Jiapeng Li, Zhenyv Xia, Jvboxi Wang and Xiaohan Li
Drones 2025, 9(6), 405; https://doi.org/10.3390/drones9060405 - 30 May 2025
Viewed by 645
Abstract
Accurate self-localization and mutual state estimation are essential for autonomous aerial swarm operations in cooperative exploration, target tracking, and search-and-rescue missions. However, achieving reliable formation positioning in GNSS-denied environments remains a significant challenge. This paper proposes a UAV formation positioning system that integrates [...] Read more.
Accurate self-localization and mutual state estimation are essential for autonomous aerial swarm operations in cooperative exploration, target tracking, and search-and-rescue missions. However, achieving reliable formation positioning in GNSS-denied environments remains a significant challenge. This paper proposes a UAV formation positioning system that integrates inertial navigation with data link-based relative measurements to improve positioning accuracy. Each UAV independently estimates its flight state in real time using onboard IMU data through an inertial navigation fusion method. The estimated states are then transmitted to other UAVs in the formation via a data link, which also provides relative position measurements. Upon receiving data link information, each UAV filters erroneous measurements, time aligns them with its state estimates, and constructs a relative pose optimization factor graph for real-time state estimation. Furthermore, a data selection strategy and a sliding window algorithm are implemented to control data accumulation and mitigate inertial navigation drift. The proposed method is validated through both simulations and real-world two-UAV formation flight experiments. The experimental results demonstrate that the system achieves a 76% reduction in positioning error compared to using data link measurements alone. This approach provides a robust and reliable solution for maintaining precise relative positioning in formation flight without reliance on GNSS. Full article
(This article belongs to the Special Issue Advances in Guidance, Navigation, and Control)
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22 pages, 1502 KiB  
Article
PCMINN: A GPU-Accelerated Conditional Mutual Information-Based Feature Selection Method
by Nikolaos Papaioannou, Georgios Myllis, Alkiviadis Tsimpiris, Stamatis Aggelopoulos and Vasiliki Vrana
Information 2025, 16(6), 445; https://doi.org/10.3390/info16060445 - 27 May 2025
Cited by 1 | Viewed by 622
Abstract
In feature selection, it is crucial to identify features that are not only relevant to the target variable but also non-redundant. Conditional Mutual Information Nearest-Neighbor (CMINN) is an algorithm developed to address this challenge by using Conditional Mutual Information (CMI) to assess the [...] Read more.
In feature selection, it is crucial to identify features that are not only relevant to the target variable but also non-redundant. Conditional Mutual Information Nearest-Neighbor (CMINN) is an algorithm developed to address this challenge by using Conditional Mutual Information (CMI) to assess the relevance of individual features to the target variable, while identifying redundancy among similar features. Although effective, the original CMINN algorithm can be computationally intensive, particularly with large and high-dimensional datasets. In this study, we extend the CMINN algorithm by parallelizing it for execution on Graphics Processing Units (GPUs), significantly enhancing its efficiency and scalability for high-dimensional datasets. The parallelized CMINN (PCMINN) leverages the massive parallelism of modern GPUs to handle the computational complexity inherent in sequential feature selection, particularly when dealing with large-scale data. To evaluate the performance of PCMINN across various scenarios, we conduct both an extensive simulation study using datasets with combined feature effects and a case study using financial data. Our results show that PCMINN not only maintains the effectiveness of the original CMINN in selecting the optimal feature subset, but also achieves faster execution times. The parallelized approach allows for the efficient processing of large datasets, making PCMINN a valuable tool for high-dimensional feature selection tasks. We also provide a package that includes two Python implementations to support integration into future research workflows: a sequential version of CMINN and a parallel GPU-based version of PCMINN. Full article
(This article belongs to the Special Issue Feature Papers in Information in 2024–2025)
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20 pages, 2430 KiB  
Article
A Bayesian Network Approach to Predicting Severity Status in Nuclear Reactor Accidents with Resilience to Missing Data
by Kaiyu Li, Ling Chen, Xinxin Cai, Cai Xu, Yuncheng Lu, Shengfeng Luo, Wenlin Wang, Lizhi Jiang and Guohua Wu
Energies 2025, 18(11), 2684; https://doi.org/10.3390/en18112684 - 22 May 2025
Viewed by 510
Abstract
Nuclear energy is a cornerstone of the global energy mix, delivering reliable, low-carbon power essential for sustainable energy systems. However, the safety of nuclear reactors is critical to maintaining operational reliability and public trust, particularly during accidents like a Loss of Coolant Accident [...] Read more.
Nuclear energy is a cornerstone of the global energy mix, delivering reliable, low-carbon power essential for sustainable energy systems. However, the safety of nuclear reactors is critical to maintaining operational reliability and public trust, particularly during accidents like a Loss of Coolant Accident (LOCA) or a Steam Line Break Inside Containment (SLBIC). This study introduces a Bayesian Network (BN) framework used to enhance nuclear energy safety by predicting accident severity and identifying key factors that ensure energy production stability. With the integration of simulation data and physical knowledge, the BN enables dynamic inference and remains robust under missing-data conditions—common in real-time energy monitoring. Its hierarchical structure organizes variables across layers, capturing initial conditions, intermediate dynamics, and system responses vital to energy safety management. Conditional Probability Tables (CPTs), trained via Maximum Likelihood Estimation, ensure accurate modeling of relationships. The model’s resilience to missing data, achieved through marginalization, sustains predictive reliability when critical energy system variables are unavailable. Achieving R2 values of 0.98 and 0.96 for the LOCA and SLBIC, respectively, the BN demonstrates high accuracy, directly supporting safer nuclear energy production. Sensitivity analysis using mutual information pinpointed critical variables—such as high-pressure injection flow (WHPI) and pressurizer level (LVPZ)—that influence accident outcomes and energy system resilience. These findings offer actionable insights for the optimization of monitoring and intervention in nuclear power plants. This study positions Bayesian Networks as a robust tool for real-time energy safety assessment, advancing the reliability and sustainability of nuclear energy production. Full article
(This article belongs to the Special Issue Operation Safety and Simulation of Nuclear Energy Power Plant)
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19 pages, 3010 KiB  
Article
Multi-Source Causal Invariance for Cuffless Blood Pressure Estimation Based on Photoplethysmography Signal Features
by Yiliu Xu, Zhaoming He and Hao Wang
Sensors 2025, 25(11), 3254; https://doi.org/10.3390/s25113254 - 22 May 2025
Viewed by 533
Abstract
Cuffless continuous blood pressure (BP) monitoring is essential for personal health management. However, its accuracy is challenged by the diversity and heterogeneity of physiological data sources. We propose a multi-source feature selection framework based on Markov blanket theory and the concept of causal [...] Read more.
Cuffless continuous blood pressure (BP) monitoring is essential for personal health management. However, its accuracy is challenged by the diversity and heterogeneity of physiological data sources. We propose a multi-source feature selection framework based on Markov blanket theory and the concept of causal invariance. We extracted 218 BP-related photoplethysmography (PPG) features from three heterogeneous datasets (differing in subject population, acquisition devices, and methods) and constructed a causal feature set using the Multi-Dataset Stable Feature Selection via Ensemble Markov Blanket (MDSFS-EMB) algorithm. BP estimation was then performed using four machine learning models. The MDSFS-EMB algorithm integrated PPFS and HITON-MB, enabling adaptability to different data scales and distribution scenarios. It employed Gaussian Copula Mutual Information, which was robust to outliers and capable of modeling nonlinear relationships. To validate the effectiveness of the selected feature set, we conducted experiments using an independent external validation dataset and explored the impact of data segmentation strategies on model prediction outcomes. The results demonstrated that the MDSFS-EMB algorithm has advantages in feature selection efficiency, prediction accuracy, and generalization capability. This study innovatively explores the causal relationships between PPG features and BP across multiple data sources, providing a clinically applicable approach for cuffless BP estimation. Full article
(This article belongs to the Section Wearables)
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33 pages, 6442 KiB  
Article
Genomic-Thermodynamic Phase Synchronization: Maxwell’s Demon-like Regulation of Cell Fate Transition
by Masa Tsuchiya, Kenichi Yoshikawa and Alessandro Giuliani
Int. J. Mol. Sci. 2025, 26(10), 4911; https://doi.org/10.3390/ijms26104911 - 20 May 2025
Viewed by 1081
Abstract
Dynamic criticality—the balance between order and chaos—is fundamental to genome regulation and cellular transitions. In this study, we investigate the distinct behaviors of gene expression dynamics in MCF-7 breast cancer cells under two stimuli: heregulin (HRG), which promotes cell fate transitions, and epidermal [...] Read more.
Dynamic criticality—the balance between order and chaos—is fundamental to genome regulation and cellular transitions. In this study, we investigate the distinct behaviors of gene expression dynamics in MCF-7 breast cancer cells under two stimuli: heregulin (HRG), which promotes cell fate transitions, and epidermal growth factor (EGF), which binds to the same receptor but fails to induce cell-fate changes. We model the system as an open, nonequilibrium thermodynamic system and introduce a convergence-based approach for the robust estimation of information-thermodynamic metrics. Our analysis reveals that the Shannon entropy of the critical point (CP) dynamically synchronizes with the entropy of the rest of the whole expression system (WES), reflecting coordinated transitions between ordered and disordered phases. This phase synchronization is driven by net mutual information scaling with CP entropy dynamics, demonstrating how the CP governs genome-wide coherence. Furthermore, higher-order mutual information emerges as a defining feature of the nonlinear gene expression network, capturing collective effects beyond simple pairwise interactions. By achieving thermodynamic phase synchronization, the CP orchestrates the entire expression system. Under HRG stimulation, the CP becomes active, functioning as a Maxwell’s demon with dynamic, rewritable chromatin memory to guide a critical transition in cell fate. In contrast, under EGF stimulation, the CP remains inactive in this strategic role, passively facilitating a non-critical transition. These findings establish a biophysical framework for cell fate determination, paving the way for innovative approaches in cancer research and stem cell therapy. Full article
(This article belongs to the Special Issue Molecular Advances and Insights in Cancer Genomics)
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14 pages, 2755 KiB  
Article
Objective Detection of Auditory Steady-State Responses (ASSRs) Based on Mutual Information: Receiver Operating Characteristics and Performance Across Modulation Rates and Levels
by Gavin M. Bidelman and Claire McElwain Horn
Audiol. Res. 2025, 15(3), 60; https://doi.org/10.3390/audiolres15030060 - 15 May 2025
Viewed by 941
Abstract
Background: Auditory steady-state responses (ASSRs) are sustained potentials used to assess the physiological integrity of the auditory pathway and objectively estimate hearing thresholds. ASSRs are typically analyzed using statistical procedures to remove the subjective bias of human operators. Knowing when to terminate [...] Read more.
Background: Auditory steady-state responses (ASSRs) are sustained potentials used to assess the physiological integrity of the auditory pathway and objectively estimate hearing thresholds. ASSRs are typically analyzed using statistical procedures to remove the subjective bias of human operators. Knowing when to terminate signal averaging in ASSR testing is critical for making efficient clinical decisions and obtaining high-quality data in empirical research. Here, we report on stimulus-specific (frequency, level) properties and operating ranges of a novel ASSR detection metric based on mutual information (MI). Methods: ASSRs were measured in n = 10 normal-hearing listeners exposed to various stimuli varying in modulation rate (40, 80 Hz) and level (80–20 dB SPL). Results: MI-based classifiers applied to ASSR recordings showed that the accuracy of ASSR detection ranged from ~75 to 99% and was better for 40 compared to 80 Hz responses and for higher compared to lower stimulus levels. Receiver operating characteristics (ROCs) were used to establish normative ranges for MI for reliable ASSR detection across levels and rates (MI = 0.9–1.6). Relative to current statistics for ASSR identification (F-test), MI was a more efficient metric for determining the stopping criterion for signal averaging. Conclusions: Our results confirm that MI can be applied across a broad range of ASSR stimuli and might offer improvements to conventional objective techniques for ASSR detection. Full article
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