Search Results (599)

Understanding the effects of light on the body at different times of the 24 h solar day is a topic of increasing interest. In this paper, we use a mathematical model from the literature to simulate what would be expected of the human circadian clock on different light schedules. We first reproduce an influential experiment which found eBooks, when compared to a paper book, delayed sleep by roughly 10 min and melatonin onset by 1.5 h. The model is able to match the delay in sleep onset but struggles to reproduce the melatonin phase delay. However, certain initial conditions and parameters are capable of phase shifts consistent with the original study’s magnitude, suggesting that the original study’s finding may have been influenced by the pre-study entrainment or variability among the participants. We next simulate the same protocol under higher daytime light levels (increasing baseline illumination from 90 to 500 lux) and find that brighter daytime exposure reduces both sleep onset latency and the variability in phase delay attributable to evening eBook light. Finally, we explore how the timing of a bright light pulse during the day changes outcomes, such as sleep onset and circadian amplitude, and how these effects interact with light during the other hours of the 24 h day. Together, these modeling results suggest robust daytime light exposure confers resilience against the circadian-disruptive effects of evening light, generating testable predictions regarding the timing and intensity of beneficial light interventions for maintaining circadian alignment. Full article

This study investigates the hydrodynamic characteristics of single-layer heave plates with varying salient edges and triple-layer configurations with size mismatches under forced oscillation, utilizing 3D overset mesh numerical simulations. For single-layer plates, the 0° edge configuration maintains high hydrodynamic coefficients across all conditions, whereas the 135° edge peaks under specific parameters. Introducing horizontal gaps consistently degrades performance. For triple-layer plates, increasing the spacing ratio mitigates spatial flow interference, significantly enhancing hydrodynamic coefficients. Furthermore, introducing size differences creates a stepped mismatched configuration that effectively mitigates wake shielding and enhances fluid entrainment. Consequently, the coefficients increase steadily with the absolute size difference, reaching optimal heave suppression in the triple-layer arrangement with a large spacing and a ±20 m size mismatch. Finally, a highly accurate empirical formula (R² > 0.92) is proposed to predict the damping (C_d) and added mass (C_a) coefficients, effectively capturing the nonlinear coupling effects of spacing ratio and size difference. These findings provide practical theoretical guidance for optimizing vibration reduction systems in offshore platforms. Full article

While check dams are crucial for debris flow mitigation, they face increasing failure risks under extreme weather and seismic activities. Their collapse can severely amplify debris flow magnitude, yet quantitative understanding of this amplification mechanism remains limited. Based on field investigations in southern Gansu, China, and a total of 12 flume experiments (comprising 11 distinct scenarios and 1 representative repeatability test), this study quantitatively assesses the amplification effect of dam breaches under varying channel slopes, check dam types, and bed conditions. Results indicate that dam-breach debris flow evolution comprises three stages: material initiation and deposition, breaching and material release, and recession. Crucially, dam breaching shifts the initiation mode from progressive retrogressive erosion to a near-instantaneous release of mass and potential energy. Compared to no-dam scenarios, breaches amplified peak discharge, erosion rate, and downstream inundated area by factors of 1.65–3.04, 1.44–1.55, and 2.14–2.77, respectively. This amplification is driven by the rapid initial release of material and energy, compounded by erosional entrainment during the transport phase. Furthermore, check dam type and channel slope act as key controlling factors. By revealing how check dams transition from protective structures to hazard sources, this study provides quantitative experimental evidence for optimizing dam design and advancing resilient disaster risk reduction strategies in mountainous regions. Full article

The growing volume of construction and demolition waste has made discarded concrete a major source of urban solid waste, placing increasing pressure on land resources and the environment. Recycling waste concrete into recycled aggregate concrete (RAC) offers an effective solution for resource conservation and carbon reduction, aligning with the goals of sustainable development. However, due to the residual mortar, high porosity, and microcracks of recycled aggregates, RAC generally exhibits lower compactness, strength, and durability than conventional concrete, particularly under freeze–thaw conditions where degradation accelerates and service life decreases. To address these challenges, this study investigates the optimization of RAC mix design and its frost resistance performance for pavement base applications. An orthogonal experimental design was employed, with the water-to-binder ratio, recycled aggregate replacement ratio, and air-entraining agent dosage as key variables, while 7-day compressive strength, permeability coefficient, and rebound modulus served as evaluation indices. The influence and interaction of these factors were analyzed to determine an optimal mix meeting both mechanical and durability requirements. Rapid freeze–thaw cycling tests were then conducted to examine the variations in mass loss, relative dynamic modulus, and compressive strength retention, followed by exponential and damage variable modeling to characterize the degradation process. Results show that the water-to-binder ratio primarily governs strength, the replacement ratio affects stiffness and permeability, and the air-entraining agent significantly enhances frost resistance by improving pore structure. The optimized mix retained over 70% of its relative dynamic modulus after 300 freeze–thaw cycles, exhibiting superior durability. This work establishes a systematic framework for multi-factor optimization and durability evaluation of RAC, providing theoretical and practical guidance for its application in cold-region pavement bases. Full article

The hydrojet-shield machine, a rapidly advancing shield machine type, uses slurry for excavation and muck removal via a pipeline system. The pipeline includes a flushed feeding system that injects slurry into areas at risk of obstruction. This study provides a computational fluid dynamics (CFD) analysis of the flow characteristics of a large hydraulic shield machine, proposing the Particle Lifting Coefficient (L) and Regional Improvement Ratio (I) as innovative criteria to evaluate the effects of flow rate distribution and cutting wheel rotational velocity. By adjusting the proportion of scouring flow in the lower part of the chambers to 30%, 50%, and 100%, three flow distribution strategies, labeled as FC1, FC2, and FC3, were obtained to suit normal slurry transport conditions, address cutterhead mud accumulation, and deal with the deposition of rock and soil particles at the bottom of the chamber, respectively. The FC3 strategy amplifies the flow of symmetric jets in the lower scouring region, strengthening the upward flow that entrains surrounding fluid, thereby significantly increasing the L and I values in the targeted area and showing great potential for inhibiting the settlement and deposition of rock and soil debris. This study also emphasizes the need to integrate slurry jet distribution strategies with real-time monitoring of cutterhead mud accumulation and chamber deposition, while adjusting cutterhead rotation speed based on geological conditions. Full article

Background: Circadian disruption exacerbates type 2 diabetes mellitus (T2DM). Time-restricted feeding (TRF) and exercise (EX) improve metabolic health, but their combinatory effect remains unclear. This study investigated whether combined TRF and EX additively ameliorates metabolism via circadian reprogramming in db/db mice. Methods: Eight-week-old male db/db mice were assigned to control (Con), diabetic model (DM), TRF (8 h feeding window), EX (treadmill, 60 min/day, 5 days/week), or combined TRF + EX groups for 8 weeks (n = 8/group). Body weight, glucose/insulin tolerance, and 24 h energy metabolism (CLAMS) were assessed. Mitochondrial function, oxidative stress, inflammation, and expression of mitophagy (Pink1, Park2, Bnip3, Fundc1) and thermogenic (Ucp1, Pgc1a, Prdm16, Cidea) genes were measured. Results: Compared with the con group, DM mice showed obesity, hyperglycemia and blunted circadian metabolic rhythm. The TRF and EX groups improved these defects. Specifically, combined TRF + EX reduced fasting blood glucose from 25.3 ± 3.1 mmol/L (DM) to 13.2 ± 1.8 mmol/L (p < 0.05), body weight from 49.8 ± 2.5 g to 39.5 ± 1.7 g (p < 0.05), and body fat percentage from 45.6 ± 3.2% to 32.1 ± 2.2% (p < 0.05). GTT area under the curve (AUC) decreased from 3711.0 ± 186.5 (DM) to 2118.0 ± 112.4 (p < 0.05), and ITT AUC decreased from 2617.5 ± 135.8 to 1260.0 ± 68.9 (p < 0.05). Notably, the combination of TRF + EX produced greater effects than either intervention alone: body weight, fasting blood glucose, and glucose/insulin tolerance were greatly improved (p < 0.05). In addition, compared with the DM group, the diurnal metabolic amplitude and phase were improved in the TRF or EX group; the combination group showed further improvements in these parameters. Furthermore, TRF and EX each resulted in significantly higher expression of key thermogenic genes (Ucp1, Pgc1a, Prdm16, Cidea) in white adipose tissue (WAT) and brown adipose tissue (BAT) (p < 0.05), and the TRF + EX group showed the highest expression levels. Combined intervention also restored skeletal muscle SOD activity (31.2 ± 2.9 U/mg prot vs. DM 20.1 ± 2.5 U/mg prot, p < 0.05) and reduced serum TNF-α (28.5 ± 4.5 pg/mL vs. DM 65.8 ± 8.5 pg/mL, p < 0.05) and IL-6 (21.6 ± 3.8 pg/mL vs. DM 50.3 ± 7.1 pg/mL, p < 0.05). Conclusions: TRF + EX additively restores metabolic homeostasis in diabetes by re-entraining circadian energy rhythms, improving mitochondrial quality, and activating adipose thermogenesis, supporting further investigation of integrated lifestyle timing as a potential therapeutic strategy. Full article

Entrained gas in hydraulic oil undermines system stability. A rapid engineering method for predicting the separation efficiency of gas–liquid cyclone separators is still lacking. This study proposes an engineering-oriented predictive framework by combining the split ratio, the characteristic scale of the locus of zero vertical velocity envelope, and the axial residence time. A relative migration index, derived from maximum tangential velocity and axial residence time, is coupled with a relative overflow-pipe insertion indicator to characterize the interaction between swirl intensity and effective separation space. The separation-capability transition is described using a coupled logistic mapping. Model coefficients are identified via Eulerian–Eulerian simulations on a calibration set. The model was evaluated on isolated simulation validation sets with varying geometries and inlet gas volume fractions, yielding an R² of 0.762 and a root mean square error (RMSE) of 0.07. Particle Image Velocimetry validation tests on one representative prototype geometry gave RMSE values of 0.061 for simulation versus test and 0.108 for prediction versus test. The framework captures the macroscopic trend of separation efficiency within the investigated range, with the caveat that part of the model coefficients and intermediate inputs remain conditioned by simulation-derived quantities. Full article

Hydrocyclones are widely applied devices in mineral processing due to their simple design, high capacity and low operational costs. Some of the main applications are classification in closed grinding circuits and desliming, as well as dewatering. However, hydrocyclones have an inherent inefficiency known as the fine particles bypass to the underflow stream, often associated with entrainment by water flow. Several approaches have been proposed to mitigate fine particle bypass, such as optimizing hydrocyclone design, adjusting apex and vortex finder diameters, water injection systems and improved inlet design. The objective of the present work was to assess hydrocyclone performance on different apex and vortex diameter combinations, seeking the reduction in fine particles bypass to underflow on the Paragominas bauxite processing industrial desliming circuit. Two different bauxite samples were used in a hydrocyclone classification test work, carried out on a specially built pilot plant. Six different combinations of apex and vortex were evaluated in a 254 mm diameter hydrocyclone, covering a range of apex-to-vortex diameters from 0.38 to 0.57. The results indicate operating conditions that significantly reduce fine particles bypass to underflow, increasing classification efficiency with minor effects in overflow selected size distribution parameter—d₉₅. Accordingly, smaller apex-to-vortex ratios result in overall better performances, reducing fine particles bypass to underflow from 33% to 7%, as well as reducing the partition curve slope from 0.52 to 0.21 for one of the tested samples. Significant benefits are also obtained in terms of reducing the contents of reactive silica in the underflow of the optimized desliming hydrocyclone. Full article

This paper investigates the combustion dynamics of interacting lazy multi-component gas plumes (i.e., buoyancy-dominated gas releases with a low initial momentum flux), a configuration relevant to coal mining waste emissions. By coupling a three-dimensional large eddy simulation (mesh size of 10⁻² m; paralleling with 2048 processors) with detailed chemical kinetics (GRI-Mech 3.0), we analyzed the sensitivity of the flow structure and plume stabilization to the vent spacing of twin hydrogen-rich multi-component gas plumes (H₂-CO-CH₄-air). The results identified a distinct topological transition. While gas plumes from vents spaced at $\delta /D=5$ ($\delta$ and D are the spacing and width of gas vents, respectively) evolve independently, those at closely spaced sources ($\delta /D=5/4$) exhibit rapid coalescence driven by hydrodynamic shielding. This hydrodynamic merging results in a unified column with an effective hydraulic diameter of $D_{eff}\approx \sqrt{2}D$. This leads to a significant reduction in the surface-to-volume ratio available for ambient air entrainment, maintaining a coherent combustible-rich core to higher altitudes than isolated-source correlations would predict. However, despite this mass retention, the rapid vertical acceleration of buoyancy-dominated flows induces high strain rates, significantly disrupting the reaction zone structure. These findings establish that, for clustered emission sources, the dispersion hazard is governed by a coupling between hydrodynamic coalescence, which maintains reactant concentration, and finite-rate chemistry, restricting oxidation efficiency. This paper provides critical insights for designing gas capture infrastructure and assessing flammability limits in multi-vent systems. Full article

Flotation circuits typically incorporate grinding stages, yet mathematical models for these processes often operate on different principles, leading to misalignment in circuit design. Building on a previously established grinding model for flotation performance, this research introduces significant advances to develop a more comprehensive and industrially relevant framework. The primary innovation is the integration of mechanical entrainment and gangue recovery into the kinetic model, distinguishing between species captured by true flotation and those carried to the surface despite being non-hydrophobic. We developed a robust set of grinding-mill equations based on first-order kinetics to describe the mass-fraction transformation of both true-flotation and entrainment species. To ensure practical applicability, a systematic experimental and modeling methodology for parameter adjustment is introduced, providing a clear sequence for identifying breakage rate constants and flotation kinetic parameters. The proposed strategy was validated using two distinct case studies: an expanded analysis of a copper sulfide ore (ore A) and a new case involving significant gangue entrainment (ore B). The results demonstrate that the model accurately predicts species kinetics, providing a high-fidelity, cost-effective tool to optimize mineral recovery and prevent economic losses from overgrinding in industrial processing plants. Full article

In recent years, frequent blockage of water intake structures at nuclear power plants (NPPs) by marine organisms has increased the risk of cooling source loss for the plants. Optimizing the layout of water intake structure to actively avoid or divert blockages near the intake entrance is one of the effective measures for cooling source risk prevention and control, and relevant research remains scarce at present. Taking a certain NPP as the research object, this paper simulates the flow field and particle transport in the sea area around the water intake based on a hydrodynamic-particle coupling model. A method for determining the maximum water source range and critical tidal conditions under risk source uncertainty is proposed. The flow pattern and entrainment risks of different open channel inlet types are compared. The results show that when the water intake open channel is arranged perpendicular to the ambient flow, a large recirculation zone exists at the intake entrance. Simply increasing the width at the intake entrance by expanding the local opening has an insignificant effect on reducing the water intake velocity and entrainment risk, while adopting additional side opening intake plays a certain role in dispersing the water intake entrainment intensity. The research results provide a basis for the optimal design and operation of water intake at NPPs. Full article

Effective rehabilitation tools are essential for improving language outcomes in chronic aphasia. Speech entrainment is a behavioral treatment that has shown promise in enhancing speech output in nonfluent aphasia, potentially by acting as an external mechanism to synchronize anterior and posterior language regions in the left hemisphere. Transcranial alternating current stimulation has been hypothesized to enhance functional connectivity between brain regions by amplifying endogenous oscillations. This proof-of-concept study explored whether high-definition tACS (HD-tACS) could improve speech fluency in nonfluent aphasia when paired with speech entrainment. In a double-blind, pseudorandomized study, 1 mA of HD-tACS at 7 Hz was applied to anterior and posterior left-hemisphere regions of individuals with nonfluent aphasia (N = 13). Stimulation was applied under three conditions: in-phase, anti-phase, and sham, and paired speech entrainment. Three outcome measures were examined: (1) number of words produced; (2) number of errors, and (3) ‘entrainment’ to the speech entrainment model. Group-level analyses for two of the three outcome measures reveal statistically significant differences between the experimental conditions. In-phase alternating current stimulation yielded more words and better entrainment to the audiovisual model than the sham condition. This study provides promising evidence that HD-tACS could improve speech production in individuals with nonfluent aphasia. These results contribute to growing evidence supporting the therapeutic potential of non-invasive brain stimulation approaches as an adjuvant to traditional behavioral speech-language therapy in stroke survivors. Full article

This narrative review synthesizes research demonstrating the multi-domain import of nasal breathing across developmental, physiological, immunological, and neuropsychological domains, with the aim of communicating its potential clinical relevance and motivating future empirical investigation. We broadly address developmental and evolutionary foundations and the pathways through which nasal breathing influences health, functioning, and subjective experience. Across these areas, evidence implicates nasal breathing in immune defense, autonomic and emotion regulation, limbic entrainment, and aspects of consciousness. Notably, many contemplative traditions—including yogic pranayama, Sufi, and Buddhist practices—have long emphasized nasal breathing for its physical and spiritual benefits, and contemporary evidence increasingly buttresses components of these traditional beliefs, with growing convergence between contemporary scientific findings and longstanding traditional observation. More broadly, the epistemic basis of the evidence supporting nasal breathing’s effects reviewed here ranges considerably, from well-controlled experimental and mechanistic work to preliminary and small-sample studies whose clinical translation remains tenuous, and specific therapeutic inferences should be made cautiously. Nonetheless, nasal breathing represents an underappreciated, low-cost, and accessible adjunctive approach with genuine clinical potential. Realizing that potential will require controlled trials attending to parameter specificity—e.g., respiratory phase, laterality, and rate—and designs that isolate nasal breathing from other aspects of contemplative practices across well-defined populations and outcomes. Full article

Carryover slag (COS) entrained from the basic oxygen furnace (BOF) during tapping is highly oxidizing and affects secondary steelmaking by increasing deoxidizer consumption, refractory wear, P reversion, and decreasing steel cleanliness. A kinetic COS amount estimation model was developed by using the effective equilibrium reaction zone (EERZ) method. The amount of COS was determined by iteratively adjusting the carryover slag coefficient (CSC) until predicted steel and slag compositions approached industrial measurements. Validation with four industrial heats confirmed that the model effectively predicts COS under both complete and incomplete deoxidation conditions. Further simulation results show that increasing the CSC from 2 to 4 kg per tonne of steel leads to 9.3 ppm P reversion. The calculations also confirmed that larger COS amounts accelerate refractory wear due to the higher input of readily reducible components, particularly FeO and MnO. Full article

Liquid entrainment presents a significant challenge in wet flue gas desulfurization systems, leading to downstream corrosion and secondary pollution. This study systematically investigates the characteristics of liquid entrainment and pressure drop in a gas cyclone–liquid jet absorption separator (GLAS) through both experimental and simulation methods. The effects of inlet gas flow rate (Q_G), absorbent flow rate (Q_L), overflow pipe insertion depth, and the presence of a liquid-guiding cover (LGC) were evaluated. The results revealed that liquid entrainment initially increased and then decreased with rising Q_G, Q_L, and insertion depth of overflow pipe, given the competing effects of turbulent jet breakup and centrifugal separation. To mitigate liquid entrainment, a novel LGC was introduced at the overflow pipe outlet. This intervention resulted in a reduction in liquid entrainment by up to 23.9%, achieved through physical interception and inertial impaction, while maintaining the difference value of pressure drop of less than 302 Pa. The numerical simulations further analyzed the gas–liquid two-phase distributions in GLAS under various operating conditions, with results that align well with experimental observations. These findings offer valuable insights for mitigating liquid entrainment in GLAS and optimizing its industrial applications. Full article