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7 Results Found

  • Article
  • Open Access
13 Citations
6,732 Views
13 Pages

Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice

  • Manuel Garrosa,
  • Pilar Jiménez,
  • Jesús Tejero,
  • Patricia Cabrero,
  • Damián Cordoba-Diaz,
  • Emiliano J. Quinto,
  • Manuel J. Gayoso and
  • Tomás Girbés

2 February 2015

All parts of dwarf elder (Sambucus ebulus L.) studied so far contain a ribosome-inactivating protein with lectin activity (ribosome-inactivating lectin; RIL), known as ebulin. Green fruits contain ebulin f, the toxicity of which has been studied in...

  • Article
  • Open Access
3 Citations
2,834 Views
15 Pages

30 January 2021

Ebulin l is an A-B toxin, and despite the presence of a B chain, this toxin displays much less toxicity to cells than the potent A-B toxin ricin. Here, we studied the binding, mechanisms of endocytosis, and intracellular pathway followed by ebulin l...

  • Article
  • Open Access
10 Citations
5,366 Views
11 Pages

Unexpected Toxicity of Green Tea Polyphenols in Combination with the Sambucus RIL Ebulin

  • M. Ángeles Rojo,
  • Manuel Garrosa,
  • Pilar Jiménez,
  • Tomás Girbés,
  • Verónica Garcia-Recio,
  • Manuel Cordoba-Diaz and
  • Damián Cordoba-Diaz

22 August 2020

The safety of concentrated food complements intake is a major health concern. It has been well established that green tea polyphenols (GTPs) consumption promotes healthy effects. However, the ingestion of large amounts of GTPs is a matter of controve...

  • Review
  • Open Access
28 Citations
9,720 Views
11 Pages

Ebulin from Dwarf Elder (Sambucus ebulus L.): A Mini-Review

  • Pilar Jiménez,
  • Jesús Tejero,
  • Damián Cordoba-Diaz,
  • Emiliano J. Quinto,
  • Manuel Garrosa,
  • Manuel J. Gayoso and
  • Tomás Girbés

25 February 2015

Sambucus ebulus L. (dwarf elder) is a medicinal plant, the usefulness of which also as food is restricted due to its toxicity. In the last few years, both the chemistry and pharmacology of Sambucus ebulus L. have been investigated. Among the structur...

  • Article
  • Open Access
1,605 Views
17 Pages

Monitoring of Vitamin C Plasma Levels in a Reversible Model of Malabsorption Generated in Mice by Ebulin-f

  • Daniel Arranz-Paraiso,
  • M. Angeles Rojo,
  • Cristina Martin-Sabroso,
  • Manuel Cordoba-Diaz,
  • Tomás Girbés,
  • Manuel Garrosa and
  • Damian Cordoba-Diaz

30 June 2025

The development of reversible animal models for the study of intestinal pathologies is essential to reduce the number of animals used in research and to better understand disease mechanisms. In this study, we present a reversible model of intestinal...

  • Article
  • Open Access
17 Citations
7,654 Views
13 Pages

Isolation and Molecular Characterization of Two Lectins from Dwarf Elder (Sambucus ebulus L.) Blossoms Related to the Sam n1 Allergen

  • Pilar Jimenez,
  • Patricia Cabrero,
  • José E. Basterrechea,
  • Jesús Tejero,
  • Damian Cordoba-Diaz and
  • Tomas Girbes

14 October 2013

Sambucus species contain a number of lectins with and without antiribosomal activity. Here, we show that dwarf elder (Sambucus ebulus L.) blossoms express two D-galactose-binding lectins that were isolated and purified by affinity chromatography and...

  • Review
  • Open Access
33 Citations
11,557 Views
24 Pages

Elderberries: A Source of Ribosome-Inactivating Proteins with Lectin Activity

  • Jesús Tejero,
  • Pilar Jiménez,
  • Emiliano J. Quinto,
  • Damián Cordoba-Diaz,
  • Manuel Garrosa,
  • Manuel Cordoba-Diaz,
  • Manuel J. Gayoso and
  • Tomás Girbés

30 January 2015

Sambucus (Adoxaceae) species have been used for both food and medicine purposes. Among these, Sambucus nigra L. (black elder), Sambucus ebulus L. (dwarf elder), and Sambucus sieboldiana L. are the most relevant species studied. Their use has been som...