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Article

Unexpected Toxicity of Green Tea Polyphenols in Combination with the Sambucus RIL Ebulin

1
Area of Experimental Sciences, Miguel de Cervantes European University, 47012 Valladolid, Spain
2
Area of Histology, Faculty of Medicine and INCYL, University of Valladolid, 47005 Valladolid, Spain
3
Area of Nutrition and Food Sciences, Faculty of Medicine, University of Valladolid, 47005 Valladolid, Spain
4
Area of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain
5
University Institute of Industrial Pharmacy (IUFI), Complutense University of Madrid, 28040 Madrid, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Toxins 2020, 12(9), 542; https://doi.org/10.3390/toxins12090542
Received: 17 June 2020 / Revised: 12 August 2020 / Accepted: 20 August 2020 / Published: 22 August 2020
(This article belongs to the Special Issue Plant Toxins and Related Proteins: Pharmacology and Toxicology)
The safety of concentrated food complements intake is a major health concern. It has been well established that green tea polyphenols (GTPs) consumption promotes healthy effects. However, the ingestion of large amounts of GTPs is a matter of controversy due to reported adverse effects. We underwent a preliminary exploration of the effects of the oral administration of a standardized concentrated GTPs preparation on mice which suffered from reversible intestinal derangement promoted by sublethal amounts of the antiribosomal lectin ebulin f from dwarf elder (Sambucus ebulus L.). Neither independent oral administration of 30 mg/kg body weight Polyphenon 60 nor intraperitoneal administration of 2.5 mg/kg body weight ebulin f triggered lethal toxicity. In contrast, the simultaneous administration of these same doses of both Polyphenon 60 and ebulin f triggered an important and unexpected synergistic toxic action featured by the biphasic reduction of weight, which continued after eight days, reaching a reduction of 40%. Lethality appeared 2 days after the onset of the combined treatment and reached more than 50% after 10 days. View Full-Text
Keywords: green tea polyphenols; Sambucus ebulus; ebulin f; RIP; lectin; ribosome-inactivating protein; ricin green tea polyphenols; Sambucus ebulus; ebulin f; RIP; lectin; ribosome-inactivating protein; ricin
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MDPI and ACS Style

Rojo, M.Á.; Garrosa, M.; Jiménez, P.; Girbés, T.; Garcia-Recio, V.; Cordoba-Diaz, M.; Cordoba-Diaz, D. Unexpected Toxicity of Green Tea Polyphenols in Combination with the Sambucus RIL Ebulin. Toxins 2020, 12, 542. https://doi.org/10.3390/toxins12090542

AMA Style

Rojo MÁ, Garrosa M, Jiménez P, Girbés T, Garcia-Recio V, Cordoba-Diaz M, Cordoba-Diaz D. Unexpected Toxicity of Green Tea Polyphenols in Combination with the Sambucus RIL Ebulin. Toxins. 2020; 12(9):542. https://doi.org/10.3390/toxins12090542

Chicago/Turabian Style

Rojo, M. Á., Manuel Garrosa, Pilar Jiménez, Tomás Girbés, Verónica Garcia-Recio, Manuel Cordoba-Diaz, and Damián Cordoba-Diaz. 2020. "Unexpected Toxicity of Green Tea Polyphenols in Combination with the Sambucus RIL Ebulin" Toxins 12, no. 9: 542. https://doi.org/10.3390/toxins12090542

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