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19 pages, 2574 KiB  
Article
The Neuroregenerative Effects of IncobotulinumtoxinA (Inco/A) in a Nerve Lesion Model of the Rat
by Oscar Sánchez-Carranza, Wojciech Danysz, Klaus Fink, Maarten Ruitenberg, Andreas Gravius and Jens Nagel
Int. J. Mol. Sci. 2025, 26(15), 7482; https://doi.org/10.3390/ijms26157482 (registering DOI) - 2 Aug 2025
Viewed by 198
Abstract
The use of Botulinum Neurotoxin A (BoNT/A) to treat peripheral neuropathic pain from nerve injury has garnered interest for its long-lasting effects and safety. This study examined the effects of IncobotulinumtoxinA (Inco/A), a BoNT/A variant without accessory proteins, on nerve regeneration in rats [...] Read more.
The use of Botulinum Neurotoxin A (BoNT/A) to treat peripheral neuropathic pain from nerve injury has garnered interest for its long-lasting effects and safety. This study examined the effects of IncobotulinumtoxinA (Inco/A), a BoNT/A variant without accessory proteins, on nerve regeneration in rats using the chronic constriction injury (CCI) model. Inco/A was administered perineurally at two time points: on days 0 and 21 post CCI. Functional and histological assessments were conducted to evaluate the effect of Inco/A on nerve regeneration. Sciatic Functional Index (SFI) measurements and Compound Muscle Action Potential (CMAP) recordings were conducted at different time points following CCI. Inco/A-treated animals exhibited a 65% improved SFI and 22% reduction in CMAP onset latencies compared to the vehicle-treated group, suggesting accelerated functional nerve recovery. Tissue analysis revealed enhanced remyelination in Inco/A-treated animals and 60% reduction in CGRP and double S100β signal expression compared to controls. Strikingly, 30% reduced immune cell influx into the injury site was observed following Inco/A treatment, suggesting that its anti-inflammatory effect contributes to nerve regeneration. These findings show that two injections of Inco/A promote functional recovery by enhancing neuroregeneration and modulating inflammatory processes, supporting the hypothesis that Inco/A has a neuroprotective and restorative role in nerve injury conditions. Full article
(This article belongs to the Section Molecular Neurobiology)
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10 pages, 529 KiB  
Article
Comparative Outcomes in Metastatic Spinal Cord Compression and Femoral Metastatic Disease: Distinct Clinical Entities with Divergent Prognoses?
by Oded Hershkovich, Mojahed Sakhnini, Eyal Ramu, Boaz Liberman, Alon Friedlander and Raphael Lotan
Medicina 2025, 61(8), 1390; https://doi.org/10.3390/medicina61081390 - 31 Jul 2025
Viewed by 156
Abstract
Background and Objectives: Acute metastatic cord compression (AMSCC) and femoral impending/pathological fracture negatively impact a patient’s quality of life, morbidity and survival, and are considered significant life events. This study aims to compare AMSCC and FMD as distinct yet overlapping metastatic orthopedic [...] Read more.
Background and Objectives: Acute metastatic cord compression (AMSCC) and femoral impending/pathological fracture negatively impact a patient’s quality of life, morbidity and survival, and are considered significant life events. This study aims to compare AMSCC and FMD as distinct yet overlapping metastatic orthopedic emergencies, addressing whether they represent sequential disease stages or distinct patient subpopulations—an analysis critical for prognosis and treatment planning. Materials and Methods: Records of all patients who underwent surgery for a femoral metastatic disease (FMD) over a decade (2004–2015) and patients who were treated for acute metastatic spinal compression (AMSCC) (2007–2017) were retrieved. There were no patients lost to follow-up. Results: The treatment cohorts were similar in terms of age, gender, tumour origin, and the number of spinal metastases. Fifty-four patients were diagnosed with AMSCC. Following treatment, the Frankel muscle grading improved by 0.5 ± 0.8 grades. Two hundred and eighteen patients underwent surgical intervention for FMD. Seventy percent of femoral metastases were located in the femoral neck and trochanteric area. Impending fractures accounted for 52% of the cohort. The FMD cohort, including impending and pathological fractures, was similar to the AMSCC cohort in terms of age and the time interval between cancer diagnosis and surgery (56.7 ± 74.2 vs. 51.6 ± 69.6, respectively, p = 0.646). The Karnofsky functional score was higher for the FMD cohort (63.3 ± 16.2) than for the AMSCC cohort (48.5 ± 19.5; p < 0.001). The mean survival time for the FMD cohort was double that of the AMSCC, at 18.4 ± 23.5 months versus 9.1 ± 13.6 months, respectively (p = 0.006). Conclusions: In conclusion, this study is novel in proposing that FMD and AMSCC are distinct clinical entities, differing in their impact on patient function and, most importantly, on patient survival. Full article
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14 pages, 3376 KiB  
Case Report
Clinicopathologic Features, Surgical Treatment, and Pathological Characterization of Canine Dacryops with Different Localization
by Barbara Lamagna, Luigi Navas, Francesco Prisco, Dario Costanza, Valeria Russo, Francesco Lamagna, Cristina Di Palma, Valeria Uccello, Giuseppina Mennonna, Orlando Paciello, Flaviana La Peruta, Giovanni Flauto and Giovanni Della Valle
Vet. Sci. 2025, 12(8), 705; https://doi.org/10.3390/vetsci12080705 - 28 Jul 2025
Viewed by 183
Abstract
Lacrimal cysts (dacryops), which involve lacrimal tissue, are uncommon in dogs with an obscure/unclear pathogenesis. Compared to the current available literature, this report describes the clinicopathologic and immunohistochemical features of two cases of unusual dacryops in brachycephalic dogs. A three-year-old male Cane Corso [...] Read more.
Lacrimal cysts (dacryops), which involve lacrimal tissue, are uncommon in dogs with an obscure/unclear pathogenesis. Compared to the current available literature, this report describes the clinicopathologic and immunohistochemical features of two cases of unusual dacryops in brachycephalic dogs. A three-year-old male Cane Corso was referred with a 1-month history of swelling ventromedial to the left eye associated with blepharospasm and epiphora. Furthermore, a severe lower and upper eyelid entropion and a deep corneal ulcer were present. B-mode ultrasonography and a CT scan revealed a subcutaneous cyst, closely adherent to the maxillary bone. Surgical removal and the correction of entropion were performed. No recurrence and/or complication was detected by seven-year follow-up. Histopathology revealed a cystic structure with single- to double-cell-layered, nonciliated, cuboidal epithelia. Alcian blue stain revealed rare, disseminated goblet cells admixed with epithelial cells. The epithelium was strongly Cytokeratin-positive by immunohistochemistry and appeared lined by several layers of smooth muscle actin (SMA)-positive myoepithelial cells. A 1-year-old male French Bulldog with a 3-month lesion of the third eyelid of the right eye. The lesion (15 mm × 7 mm) beneath the conjunctiva appeared pale-pink, smooth, and multilobulated. Excision was performed by blunt dissection through the conjunctiva on the palpebral surface of the third eyelid. Recovery was uncomplicated, and no recurrence has been noted at three-year follow-up. Cytology of the cystic fluid and histopathology and immunohistochemistry of the cyst wall revealed findings for case 1. To further characterize the SMA-positive spindle cells located directly beneath the cyst-lining epithelium, double-color immunofluorescence for SMA and p63 (a myoepithelial cell marker) was performed on the sample from case 2. The analysis revealed that the SMA-positive cells lacked p63 expression, indicating a non-myoepithelial phenotype. The histological findings in our cases are consistent with previous reports of canine dacryops. The positivity of immunohistochemical staining for SMA in cells directly beneath the epithelium of dacryops in the cases here described in two brachycephalic dogs is consistent with previous reports in dogs and horses but in contrast with a retrospective study about a human dacryops. These results support the conclusion that the pathogenesis of dacryops in dogs should exclude failure of ductular “neuromuscular” contractility. Full article
(This article belongs to the Special Issue Spotlight on Ophthalmologic Pathology in Animals)
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17 pages, 2003 KiB  
Article
Effect of Caffeinated Chewing Gum on Maximal Strength, Muscular Power, and Muscle Recruitment During Bench Press and Back Squat Exercises
by Li Ding, Jue Liu, Yixuan Ma, Tze-Huan Lei, Mathew Barnes, Li Guo, Bin Chen, Yinhang Cao and Olivier Girard
Nutrients 2025, 17(15), 2455; https://doi.org/10.3390/nu17152455 - 28 Jul 2025
Viewed by 453
Abstract
Background/Objectives: This study aims to investigate the effects of caffeinated chewing gum on maximal strength, muscular power, and neural drive to the prime movers during bench press and back squat in resistance-trained men. Methods: Sixteen resistance-trained males participated in a double-blind, [...] Read more.
Background/Objectives: This study aims to investigate the effects of caffeinated chewing gum on maximal strength, muscular power, and neural drive to the prime movers during bench press and back squat in resistance-trained men. Methods: Sixteen resistance-trained males participated in a double-blind, randomized trial, chewing either caffeinated gum (4 mg/kg) or placebo gum on two separate occasions, seven days apart. After chewing for 5 min, participants performed a maximal strength test followed by muscular power assessments at 25%, 50%, 75%, and 90% of their one-repetition maximum (1RM), completing with 3, 2, 1, and 1 repetition (s), respectively, for bench press and back squat. Surface electromyography data were recorded for each repetition. Results: Caffeinated gum did not significantly improve one-repetition maximum (1RM) for bench press (p > 0.05), but increased mean frequency (MF) and median frequency (MDF) in anterior deltoid, pectoralis major, and biceps brachii (all p < 0.05) compared to placebo. For back squat, 1RM increased with caffeinated gum, along with higher MF and MDF in vastus medialis (all p < 0.05). Caffeinated gum also improved mean and peak velocities, and mean and peak power outputs at 25–75% 1RM during the bench press (all p < 0.05), along with elevated MDF in pectoralis major and biceps brachii (all p < 0.05). Similar improvements were seen in mean and peak velocities during the back squat at 25–90% 1RM (all p < 0.05), along with higher MF and MDF in vastus medialis and increased normalized root mean square activity in gluteus maximus (all p < 0.05). Conclusions: Caffeinated chewing gum (4 mg/kg) enhanced muscular power (25–75% 1RM) in the bench press and improved maximal strength and muscular power (25–90% 1RM) in the back squat by increasing muscle recruitment in resistance-trained men. Full article
(This article belongs to the Special Issue Energy Drink Effectiveness on Human Health and Exercise Performance)
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16 pages, 1503 KiB  
Study Protocol
Effect of a Peripheral Neuromodulation Protocol Combined with the Application of Therapeutic Exercise in Patients Diagnosed with Urinary Incontinence—A Study Protocol for a Randomized Controlled Trial
by Jesica Leal-García, Paula Blanco-Giménez, Eloy Jaenada-Carrillero, Marta Martínez-Soler, Borja Huertas-Ramírez, Alex Mahiques-Sanchis and Juan Vicente-Mampel
Healthcare 2025, 13(14), 1759; https://doi.org/10.3390/healthcare13141759 - 21 Jul 2025
Viewed by 275
Abstract
Introduction: Overactive bladder (OAB) and urinary incontinence (UI) are prevalent, particularly in older adults, and affect quality of life. OAB involves urgency, frequency, nocturia, and urgency incontinence, often linked to involuntary detrusor contractions. Treatment guidelines recommend a stepwise approach, starting with pelvic floor [...] Read more.
Introduction: Overactive bladder (OAB) and urinary incontinence (UI) are prevalent, particularly in older adults, and affect quality of life. OAB involves urgency, frequency, nocturia, and urgency incontinence, often linked to involuntary detrusor contractions. Treatment guidelines recommend a stepwise approach, starting with pelvic floor muscle training (PFMT), followed by pharmacological or minimally invasive therapies, such as neuromodulation. However, the combined effects of PFMT and neuromodulation have not been well established. This study aimed to evaluate the impact of combining pelvic floor exercises with neuromodulation versus PFMT with sham neuromodulation or standard physiotherapy after a 12-week intervention in individuals with OAB and UI. Methods/Materials: A double-blind, randomized controlled trial was designed with three groups: PFMT + neuromodulation, PFMT + sham, and conventional physiotherapy (control) in a 1:1:1 ratio. This study followed the CONSORT guidelines and was registered at ClinicalTrials.gov (NCT06783374). The sample size was calculated using GPower® software, assuming a Cohen’s effect size of 1.04, a power of 0.80, an alpha of 0.05, and a 15% dropout rate, totaling 63 participants (21 per group). Participants attended 24 sessions over 12 weeks (2 sessions per week). The interventions were based on previously validated protocols. Outcomes: The primary outcomes included health-related quality of life, pelvic floor muscle function, pain, adherence, and general health. The secondary outcomes included Incontinence Quality of Life questionnaire, 3-day bladder diary, International Consultation on Incontinence Questionnaire–Urinary Incontinence Short Form, kinesiophobia, and electromyographic data. Full article
(This article belongs to the Special Issue Pelvic Floor Health and Care)
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17 pages, 1774 KiB  
Article
A Randomized Double-Blind Trial of the Effect of Liupao Tea on Metabolic Parameters, Body Composition, and Gut Microbiota in Adults with Metabolic Syndrome
by Yuyang Wang, Qiang Hu, Qiliu Jiang, Jiamin Jiang, Biandi Li and Defu Ma
Nutrients 2025, 17(14), 2371; https://doi.org/10.3390/nu17142371 - 19 Jul 2025
Viewed by 612
Abstract
Background: Metabolic syndrome (MetS) represents a significant global health challenge. Liupao tea (LPT), a post-fermented dark tea, has shown potential metabolic benefits, but clinical evidence remains limited. Objectives: This study aimed to investigate the effects of LPT with varying aging durations [...] Read more.
Background: Metabolic syndrome (MetS) represents a significant global health challenge. Liupao tea (LPT), a post-fermented dark tea, has shown potential metabolic benefits, but clinical evidence remains limited. Objectives: This study aimed to investigate the effects of LPT with varying aging durations on clinical parameters, body composition and gut microbiota in individuals with MetS. Methods: In a randomized, double-blind trial, patients with MetS were randomly assigned to intervention groups, receiving 6 g/day of LPT aged for 1, 4, 7, or 10 years, respectively, over a 90-day intervention period. Blood pressure, lipid and glucose levels, body weight, body composition, and gut microbiota were assessed at baseline and post-intervention. Results: A total of 71 participants, with a mean age of 53.5 years, were included. At the final assessment, significant reductions in both systolic and diastolic blood pressure were observed in the 10-year-aged groups (p < 0.05). In terms of lipid profiles, the 1-year-aged group showed a significant decrease in total cholesterol (TC), while low-density lipoprotein cholesterol (LDL-C) levels significantly decreased in the 1-, 4-, 7-, and 10-year-aged groups (p < 0.05). All intervention groups showed significant reductions in body weight, body fat mass (BFM), along with an increase in muscle mass (MM) (p < 0.05). A decrease in the Firmicutes/Bacteroides (F/B) ratio was observed in the 10-year-aged group. No significant differences in clinical parameters or body composition regulation were observed between groups with varying aging durations (p > 0.05). Conclusions: LPT intervention effectively improves metabolic health and modulates gut microbiota in MetS patients, irrespective of aging duration. These findings support LPT as a functional beverage for the management of MetS. Full article
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15 pages, 1206 KiB  
Article
Expanding the Therapeutic Profile of Topical Cannabidiol in Temporomandibular Disorders: Effects on Sleep Quality and Migraine Disability in Patients with Bruxism-Associated Muscle Pain
by Karolina Walczyńska-Dragon, Jakub Fiegler-Rudol, Stefan Baron and Aleksandra Nitecka-Buchta
Pharmaceuticals 2025, 18(7), 1064; https://doi.org/10.3390/ph18071064 - 19 Jul 2025
Viewed by 454
Abstract
Background: Cannabidiol (CBD) has demonstrated potential as a therapeutic agent for muscle tension, pain, and sleep bruxism, yet its broader impact on comorbid conditions such as sleep disturbance and migraine disability remains underexplored. This study aimed to assess the effects of topical [...] Read more.
Background: Cannabidiol (CBD) has demonstrated potential as a therapeutic agent for muscle tension, pain, and sleep bruxism, yet its broader impact on comorbid conditions such as sleep disturbance and migraine disability remains underexplored. This study aimed to assess the effects of topical CBD on sleep quality and migraine-related disability in patients with bruxism-associated muscular pain. Methods: In a randomized, double-blind clinical trial, 60 participants with bruxism were allocated equally into three groups: control (placebo gel), 5% CBD gel, and 10% CBD gel. Participants applied the gel intraorally to the masseter muscles nightly for 30 days. Sleep quality and migraine-related disability were assessed using the Pittsburgh Sleep Quality Index (PSQI) and the Migraine Disability Assessment Scale (MIDAS), respectively. Surface electromyography (sEMG) and the Bruxoff® device were used for objective evaluation of muscle tension and bruxism intensity. Results: Both CBD treatment groups demonstrated statistically significant improvements in PSQI and MIDAS scores compared to the control group (p < 0.001). No significant differences were observed between the 5% and 10% CBD groups, suggesting comparable efficacy. The sEMG findings corroborated a reduction in muscle tension. Improvements in sleep and migraine outcomes were positively correlated with reductions in muscle activity and pain. Conclusions: Topical CBD gel significantly improved sleep quality and reduced migraine-related disability in patients with bruxism-associated muscular pain, supporting its role as a multifaceted therapeutic option in the management of TMD and related comorbidities. Further research is needed to confirm long-term benefits and determine optimal dosing strategies. Full article
(This article belongs to the Special Issue The Therapeutic Potential of Cannabidiol)
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17 pages, 534 KiB  
Systematic Review
The Impact of Electromyostimulation on Strength, Recovery, and Performance in Soccer Athletes: A Systematic Review
by Meng-Yuan Shu, Hyoung Suk Oh, Young-Jin Jo, Seon-Ho Eom, Jian Liang, Sang Mok Jung, Ki-Wan Kim, Joo-Ha Jung, Chae Woo Ma and Chul-Hyun Kim
Appl. Sci. 2025, 15(14), 7950; https://doi.org/10.3390/app15147950 - 17 Jul 2025
Viewed by 522
Abstract
Soccer, as a high-intensity sport, places significant physical demands on athletes and is associated with a high risk of injury. Electrical muscle stimulation (EMS), a training and rehabilitation technology, has gained attention for its potential benefits in sports settings. This systematic review, conducted [...] Read more.
Soccer, as a high-intensity sport, places significant physical demands on athletes and is associated with a high risk of injury. Electrical muscle stimulation (EMS), a training and rehabilitation technology, has gained attention for its potential benefits in sports settings. This systematic review, conducted under the PRISMA guidelines, rigorously assessed the effectiveness of EMS in improving muscle strength, promoting post-exercise recovery, and facilitating injury rehabilitation among soccer players. A comprehensive search of the PubMed, Scopus, and Web of Science databases identified 10 studies meeting the inclusion criteria. Among these, six studies demonstrated a significant improvement in athletic performance following local or whole-body EMS application. Four studies provided evidence supporting EMS’s efficacy in enhancing post-exercise recovery and reducing recovery time after injuries, with observed reductions in recovery time. However, the majority of the included studies were not double-blind, which limits the strength of the evidence. None of the included studies reported EMS-related adverse effects. Overall, the current results suggest that EMS may be a useful adjunct to improve athletic performance and facilitate recovery in soccer players. This review offers actionable insights for coaches and athletes regarding the safe and effective application of EMS in soccer training and rehabilitation programs. Full article
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15 pages, 1454 KiB  
Article
A Thermal Imaging Camera as a Diagnostic Tool to Study the Effects of Occlusal Splints on the Elimination of Masticatory Muscle Tension
by Danuta Lietz-Kijak, Adam Andrzej Garstka, Lidia Szczucka, Roman Ardan, Monika Brzózka-Garstka, Piotr Skomro and Camillo D’Arcangelo
Dent. J. 2025, 13(7), 313; https://doi.org/10.3390/dj13070313 - 11 Jul 2025
Viewed by 397
Abstract
Medical Infrared Thermography (MIT) is a safe, non-invasive technique for assessing temperature changes on the skin’s surface that may reflect pathological processes in the underlying tissues. In temporomandibular joint disorders (TMDs), which are often associated with reduced mobility and muscle overactivity, tissue metabolism [...] Read more.
Medical Infrared Thermography (MIT) is a safe, non-invasive technique for assessing temperature changes on the skin’s surface that may reflect pathological processes in the underlying tissues. In temporomandibular joint disorders (TMDs), which are often associated with reduced mobility and muscle overactivity, tissue metabolism and blood flow may be diminished, resulting in localized hypothermia. Aim: The purpose of this study was to evaluate muscle tone in the masseter, suprahyoid, and sternocleidomastoid muscles following the application of two types of occlusal splints, a Michigan splint and a double repositioning splint, based on temperature changes recorded using a Fluke Ti401 PRO thermal imaging camera. Materials and Methods: Sixty dental students diagnosed with TMDs were enrolled in this study. After applying the inclusion and exclusion criteria, participants were randomly assigned to one of two groups. Group M received a Michigan splint, while group D was treated with a double repositioning splint. Results: The type of occlusal splint influenced both temperature distribution and muscle tone. In the double repositioning splint group, temperature decreased by approximately 0.8 °C between T1 and T3, whereas in the Michigan splint group, temperature increased by approximately 0.7 °C over the same period. Conclusions: Occlusal splint design has a measurable impact on temperature distribution and muscle activity. The double repositioning splint appears to be more effective in promoting short-term muscle relaxation and may provide relief for patients experiencing muscular or myofascial TMD symptoms. Full article
(This article belongs to the Special Issue Management of Temporomandibular Disorders)
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13 pages, 5075 KiB  
Article
The FT3/FT4 Ratio as a Metabolic Marker of Frailty and Prognosis in Older Adults with Heart Failure
by Chukwuma Okoye, Tessa Mazzarone, Filippo Niccolai, Alberto Finazzi, Emma Esposito, Giuseppe Bellelli and Agostino Virdis
J. Clin. Med. 2025, 14(14), 4840; https://doi.org/10.3390/jcm14144840 - 8 Jul 2025
Viewed by 356
Abstract
Background/Objectives: Frailty is a key determinant of outcomes in older adults with heart failure (HF). The free triiodothyronine/free thyroxine (FT3/FT4) ratio has emerged as a promising frailty biomarker that reflects metabolic and systemic resilience. This study investigates its association [...] Read more.
Background/Objectives: Frailty is a key determinant of outcomes in older adults with heart failure (HF). The free triiodothyronine/free thyroxine (FT3/FT4) ratio has emerged as a promising frailty biomarker that reflects metabolic and systemic resilience. This study investigates its association with frailty, nutrition, muscle strength, inflammation, and one-year mortality in very old patients with HF. Methods: In this longitudinal, single-center study, we enrolled 193 older outpatients (mean age, 86.5 ± 6.1 years; 56% women) recently discharged after acute HF. All patients underwent physical examination, blood testing, and comprehensive geriatric assessment, including handgrip strength (HGS). Participants were stratified by FT3/FT4 ratio (<1.7 vs. ≥1.7). Associations with the Clinical Frailty Scale (CFS) were examined using multivariable linear regression. Spearman’s correlations assessed relationships with inflammatory and nutritional biomarkers. Cox regression evaluated the association with all-cause mortality. Results: Patients with a low FT3/FT4 ratio (31.1%) exhibited greater frailty (CFS: median [IQR], 6 [2] vs. 4 [3]; p = 0.020), poorer nutritional status (Mini Nutritional Assessment: 10 [4] vs. 12 [3]; p = 0.008), and lower HGS (mean ± SD, 16.8 ± 3.7 kg vs. 20.3 ± 4.8 kg; p = 0.002). An inverse association was identified between the FT3/FT4 ratio and frailty (adjusted β = −0.09; p = 0.019). Individuals with low FT3/FT4 also showed elevated inflammatory markers and had more than double the one-year mortality rate compared to those with higher ratios [HR 2.32 (95% CI, 1.24–4.34; p = 0.007)]. Conclusions: In very old adults recently hospitalized for HF, a lower FT3/FT4 ratio was associated with frailty, malnutrition, inflammation, and increased mortality, supporting its potential role as a marker of biological vulnerability. Full article
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20 pages, 1189 KiB  
Article
Five-Day Supplementation with an Isotonic Beetroot Juice Drink Improves Sprint Interval Exercise and Muscle Oxygenation in Physically Active Individuals: A Randomized Crossover Trial
by Tak Hiong Wong, Delicia Shu Qin Ooi and Stephen F. Burns
Beverages 2025, 11(4), 97; https://doi.org/10.3390/beverages11040097 - 1 Jul 2025
Viewed by 774
Abstract
This study investigated whether the addition of nitrate (from beetroot) to an isotonic drink provided over 5 days would affect sprint interval exercise (SIE) performance and muscle oxygenation. Twenty (seven female) physically active participants (mean ± SD; age 28 ± 6 years, BMI [...] Read more.
This study investigated whether the addition of nitrate (from beetroot) to an isotonic drink provided over 5 days would affect sprint interval exercise (SIE) performance and muscle oxygenation. Twenty (seven female) physically active participants (mean ± SD; age 28 ± 6 years, BMI 22.6 ± 2.0 kg/m2) completed a double-blind, randomized, crossover study where they consumed 570 mL of either isotonic drink (ISO-C) or isotonic beetroot juice drink (ISO-BR) for 5 days before performing SIE (six 10 s maximal effort, interspersed with 50 s active recovery) on a cycle ergometer. Both drinks contained equal osmolality (290 mOsm/kg) but differed in the nutrients from beetroot extract, particularly the nitrate content (ISO-C: 0 mmol, ISO-BR: 12.9 mmol). ISO-BR significantly reduced the average time to peak power (ISO-C: 2.0 ± 0.18 s vs. ISO-BR: 1.6 ± 0.37 s; main effect of drink, p = 0.003, partial η2 = 0.04) and increased muscle deoxygenation (ΔHHb) (main effect of drink, p = 0.002, partial η2 = 0.021) compared to ISO-C. Five-day supplementation with ISO-BR improved the time to peak power but not the peak or mean power output for SIE compared with ISO-C. Full article
(This article belongs to the Section Quality, Nutrition, and Chemistry of Beverages)
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13 pages, 958 KiB  
Article
Efficient Manufacturing of Steerable Eversion Robots with Integrated Pneumatic Artificial Muscles
by Thomas Mack, Cem Suulker, Abu Bakar Dawood and Kaspar Althoefer
J. Manuf. Mater. Process. 2025, 9(7), 223; https://doi.org/10.3390/jmmp9070223 - 1 Jul 2025
Viewed by 458
Abstract
Soft-growing robots based on the eversion principle are renowned for their ability to rapidly extend along their longitudinal axis, allowing them to access remote, confined, or otherwise inaccessible spaces. Their inherently compliant structure enables safe interaction with delicate environments, while their simple actuation [...] Read more.
Soft-growing robots based on the eversion principle are renowned for their ability to rapidly extend along their longitudinal axis, allowing them to access remote, confined, or otherwise inaccessible spaces. Their inherently compliant structure enables safe interaction with delicate environments, while their simple actuation mechanisms support lightweight and low-cost designs. Despite these benefits, implementing effective navigation mechanisms remains a significant challenge. Previous research has explored the use of pneumatic artificial muscles mounted externally on the robot’s body, which, when contracting, induce directional bending. However, this method only offers limited bending performance. To enhance maneuverability, pneumatic artificial muscles embedded in between the walls of double-walled eversion robots have also been considered and shown to offer superior bending performance and force output as compared to externally attached muscle. However, their adoption has been hindered by the complexity of the current manufacturing techniques, which require individually sealing the artificial muscles. To overcome this multi-stage fabrication approach in which muscles are embedded one by one, we propose a novel single-step method. The key to our approach is the use of non-heat-sealable inserts to form air channels during the sealing process. This significantly simplifies the process, reducing production time and effort and improving scalability for manufacturing, potentially enabling mass production. We evaluate the fabrication speed and bending performance of robots produced in this manner and benchmark them against those described in the literature. The results demonstrate that our technique offers high bending performance and significantly improves the manufacturing efficiency. Full article
(This article belongs to the Special Issue Advances in Robotic-Assisted Manufacturing Systems)
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14 pages, 684 KiB  
Article
Correlation Between Core Stability and Plantar Pressure Distribution During Double-Leg Stance, Single-Leg Stance, and Squat Positions in Healthy Male Athletes
by Reem Abdullah Babkair, Shibili Nuhmani, Turki Abualait and Qassim Muaidi
Medicina 2025, 61(7), 1188; https://doi.org/10.3390/medicina61071188 - 30 Jun 2025
Viewed by 341
Abstract
Background: Core stability is a cornerstone of optimum athletic performance, and its reduction is a risk factor for athletic injuries. Evidence has shown that core impairments can alter lower-limb mechanics through the kinetic chains. Additionally, plantar pressure can be influenced by proximal [...] Read more.
Background: Core stability is a cornerstone of optimum athletic performance, and its reduction is a risk factor for athletic injuries. Evidence has shown that core impairments can alter lower-limb mechanics through the kinetic chains. Additionally, plantar pressure can be influenced by proximal conditions, such as core muscle fatigue. Therefore, this study aimed to investigate the correlation between core endurance and plantar pressure distribution (PPD) during double-leg stance, single-leg stance, and single-leg squat positions in healthy male athletes. Methods: A total of 21 healthy male recreational athletes between 19 and 26 years of age volunteered to participate in this correlational study. The McGill core endurance test was used to measure the endurance of their core flexors, extensors, and lateral flexors. The participants’ PPD was evaluated using the Tekscan Mobile Mat pressure measurement system in three positions (double-leg stance, single-leg stance, and single-leg squat) for both the dominant and non-dominant feet. Results: There was a poor and insignificant correlation (p > 0.05) between the core flexors’, extensors’, and side flexors’ endurance and the peak and total PPD in all the tested positions for both the dominant and non-dominant feet. Conclusions: Core muscle endurance is neither a component that affects nor is affected by the PPD in this study population. Thus, the endurance of core flexors, extensors, and side flexors may not be considered in screening, examination, or intervention for the total and peak pressure during double-leg stance, single-leg stance, and single-leg squat positions for both the dominant and non-dominant feet in the study population. Further similar studies are warranted in various sports and during dynamic tasks to better understand the different dimensions of the studied relationship in athletes. Full article
(This article belongs to the Special Issue Clinical Recent Research in Rehabilitation and Preventive Medicine)
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16 pages, 908 KiB  
Article
Melatonin Supplementation Enhances Next-Day High-Intensity Exercise Performance and Recovery in Trained Males: A Placebo-Controlled Crossover Study
by Nourhène Mahdi, Slaheddine Delleli, Arwa Jebabli, Khouloud Ben Maaoui, Juan Del Coso, Hamdi Chtourou, Luca Paolo Ardigò and Ibrahim Ouergui
Sports 2025, 13(6), 190; https://doi.org/10.3390/sports13060190 - 19 Jun 2025
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Abstract
Background/Objectives: Sleep and recovery are critical for optimising exercise performance. However, the efficacy of melatonin supplementation in improving sleep quality and next-day physical performance remains unclear. This study examined the effects of melatonin ingestion on sleep and performance-related outcomes the following day in [...] Read more.
Background/Objectives: Sleep and recovery are critical for optimising exercise performance. However, the efficacy of melatonin supplementation in improving sleep quality and next-day physical performance remains unclear. This study examined the effects of melatonin ingestion on sleep and performance-related outcomes the following day in trained males. Methods: In a randomised, double-blind, placebo-controlled crossover study, 12 trained males (age: 21.92 ± 2.84 years) ingested 6 mg of melatonin (MEL) or a placebo (PLA) the night before performing the 5 m shuttle test (5mSRT). Before and after the 5mSRT, blood samples were collected. Peak heart rate (HRpeak) and rating of perceived exertion (RPE) were recorded throughout the test. Perceived recovery status (PRS) and delayed onset muscle soreness (DOMS) were measured before, 5 min, 24 h, 48 h, and 72 h after the test. The sleep/wake cycle was monitored during the night after ingestion. Results: Data were analysed using paired t-tests, Wilcoxon tests, and two-way ANOVAs, with significance set at p < 0.05. Compared to PLA, MEL did not modify any sleep parameters or blood markers (all p > 0.05). However, MEL improved total distance, fatigue index, the percentage decrement between sprints, and HRpeak (all p < 0.05) in the 5mSRT compared to PLA. MEL also enhanced PRS values up to 72 h post-exercise and reduced DOMS (all p < 0.05). Conclusion: In summary, 6 mg of melatonin taken at night enhanced next-day high-intensity exercise performance and improved perceived recovery up to 72 h post-exercise. Full article
(This article belongs to the Special Issue Current Research in Applied Sports Nutrition)
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Article
The Effects of Abdominal Draw-In Maneuvers Combined with Blood Flow Restriction on the Transverse Abdominis in University Students with Sedentary Lifestyles
by Yueh-Ling Hsieh, Tzu-Yu Weng, Nian-Pu Yang, Yu-Liang Lai and Andy Chien
Life 2025, 15(6), 965; https://doi.org/10.3390/life15060965 - 17 Jun 2025
Viewed by 892
Abstract
The abdominal drawing-in maneuver (ADIM) is one of the most valuable exercises for explicitly targeting and strengthening the transversus abdominis (TrA), a key muscle in the deep core. However, using the ADIM for the selective training of the transverse abdominis can be challenging [...] Read more.
The abdominal drawing-in maneuver (ADIM) is one of the most valuable exercises for explicitly targeting and strengthening the transversus abdominis (TrA), a key muscle in the deep core. However, using the ADIM for the selective training of the transverse abdominis can be challenging for certain individuals. This study investigated the effects of combining ADIM with blood flow restriction (BFR) training on TrA strengthening in sedentary university students. Forty university students with sedentary lifestyles (mean age: 23.28 ± 2.468 years; range 20–25 years) were randomly assigned to an ADIM+BFR group and a control group (ADIM only). Both groups underwent 25 min ADIM training sessions twice weekly for four weeks. Ultrasound measurements assessed TrA thickness, contraction ratio, and preferential activation. Core stability, strength, and endurance were evaluated using the double leg lowering, abdominal strength, and abdominal static endurance tests. The ADIM+BFR group showed significant improvements in TrA thickness, contraction ratio, and preferential activation compared to the control group following the four-week training intervention (p < 0.05). The ADIM+BFR group demonstrated improved core stability and enhanced abdominal strength and endurance compared to the control group (p < 0.05). The results support the effectiveness of ADIM+BFR training in enhancing TrA contraction and activation in sedentary university students. This approach also improves core stability, strength, and endurance. BFR provides a novel and readily applicable method for promoting TrA activation during ADIM training. Full article
(This article belongs to the Special Issue Innovative Perspectives in Physical Therapy and Health)
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