Search Results (1,677)

Background/Objectives: Early gut colonization by bifidobacteria, occurring more favorably in vaginally born infants than in those delivered via C-section, is crucial for maintaining overall health. The study investigated the health-promoting properties of Limosilactobacillus vaginalis BC17 both as viable cells and as postbiotics (i.e., cell-free supernatant and heat-killed cells), with the purpose of developing oral formulations to support intestinal health. Methods: The safety, effects on the adhesion of bifidobacteria and enteropathogens to intestinal cells, and anti-inflammatory properties of L. vaginalis BC17 viable cells and postbiotics were evaluated. Fast-disintegrating tablets were formulated by freeze-drying cell-free supernatant in combination with heat-killed or viable cells alongside maltodextrins. Results: The formulations were shown to be non-genotoxic and compatible with intestinal cell lines (Caco-2 and HT-29). BC17 viable cells survived in co-culture with intestinal cells up to 48 h and exhibited moderate adhesion to the cell lines. Notably, both BC17 viable cells and postbiotics enhanced the adhesion of beneficial bifidobacteria to Caco-2 cells by up to 250%, while reducing enteropathogens adhesion by 40–70%. Moreover, they exerted significant anti-inflammatory effects, reducing nitric oxide production in macrophages by 40–50% and protecting intestinal cells from SDS-induced damage. The formulations allowed administration of at least 10⁹ BC17 cells in infants and adults through easy and rapid dispersion in milk or water, or directly in the oral cavity without chewing, and preserved their functional properties for up to 3 months of storage. Conclusions: L. vaginalis BC17 viable cells and postbiotics, as well as fast-disintegrating tablets, showed promising functional and safety profiles. Although further in vivo validation is needed, this approach represents a compelling strategy for promoting gut health. Full article

This article analyzes the operating principle of the BMM sensor emitter in order to improve the accuracy of the wireless determination of the BMM sensor coordinates under a massif of destroyed rock in the context of the problem of determining the shift of rocks during gold ore mining. Using numerical simulations, FEM has been developed to develop digital models reflecting individual cases of the propagation of the magnetic field of the emitter located in various geological conditions and positions relative to the rock surface and the vertical axis. The accuracy of determining the coordinates of the radio beacon in the rock has been analyzed, and data on the deviation of the coordinates of the peaks of the magnetic field strength from the radio beacon axis have been obtained in cases of a heterogeneous composition of the rock massif, the influence of the deviation of the emitter axis angle from the vertical, the influence of the unevenness of the collapse relief, and the influence of the superposition of fields from different radiation sources. A study has been carried out to determine the direction of the radio beacon search based on the resulting vector of the emitter’s magnetic field strength. Full article

This study investigates the improvement effect and micro-mechanism of guar gum and palm fibers, two eco-friendly materials, on expansive soil. The study uses disintegration tests, unconfined compressive strength tests, triaxial compression tests, and SEM analysis to evaluate the enhancement of mechanical properties. The results show that the guar gum–palm fiber composite significantly improves the compressive and shear strength of expansive soil. The optimal ratio is 2% guar gum, 0.4% palm fiber, and 6 mm palm fiber length. Increasing fiber length initially boosts and then reduces unconfined compressive strength. Guar gum increases unconfined compressive strength by 187.18%, further improved by 20.9% with palm fibers. When fiber length is fixed, increasing palm fiber content increases and then stabilizes peak stress and shear strength (cohesion and internal friction angle), improving by 27.30%, 52.1%, and 12.4%, respectively, compared to soil improved with only guar gum. Micro-analysis reveals that guar gum enhances bonding between soil particles via a gel matrix, improving water stability and mechanical properties, while palm fibers reinforce the soil and inhibit crack propagation. The synergistic effect significantly enhances composite-improved soil performance, offering economic and environmental benefits, and provides insights for expansive soil engineering management. Full article

Oral delivery of hydrophobic compounds remains challenging due to their poor aqueous solubility and the potential toxicity associated with conventional surfactant-based emulsions. To address these issues, we present a surfactant-free encapsulation strategy using electrosprayed alginate hydrogel beads for the stable and controlled delivery of hydrophobic oils. Hydrophobic compounds were dispersed in high-viscosity alginate solutions without surfactants via ultrasonication, forming kinetically stable oil-in-water dispersions. These mixtures were electrosprayed into calcium chloride baths, yielding monodisperse hydrogel beads. Higher alginate concentrations improved droplet sphericity and suppressed phase separation by enhancing matrix viscosity. The resulting beads exhibited stimuli-responsive degradation and controlled release behavior in response to physiological ionic strength. Dense alginate networks delayed ion exchange and prolonged structural integrity, while elevated external ionic conditions triggered rapid disintegration and immediate payload release. This simple and scalable system offers a biocompatible platform for the oral delivery of lipophilic active compounds without the need for surfactants or complex fabrication steps. Full article

This study used fresh (young) and old (mature) ginger tissues as model systems to investigate how plant maturity modulates the response to pulsed electric field (PEF), a non-thermal processing technology. Specifically, the influence of tissue maturity on dielectric behavior and its downstream effect on juice yield and bioactive compound extraction was systematically evaluated. At 2.5 kV/cm, old ginger exhibited a pronounced dielectric breakdown effect due to enhanced electrolyte content and cell wall lignification, resulting in a higher degree of cell disintegration (0.65) compared with fresh ginger (0.44). This translated into a significantly improved juice yield of 90.85% for old ginger, surpassing the 84.16% limit observed in fresh ginger. HPLC analysis revealed that the extraction efficiency of 6-gingerol and 6-shogaol increased from 1739.16 to 2233.60 µg/g and 310.31 to 339.63 µg/g, respectively, in old ginger after PEF treatment, while fresh ginger showed increases from 1257.88 to 1824.05 µg/g and 166.43 to 213.52 µg/g, respectively. Total phenolic content (TPC) and total flavonoid content (TFC) also increased in both tissues, with OG-2.5 reaching 789.57 µg GAE/mL and 336.49 µg RE/mL, compared with 738.19 µg GAE/mL and 329.62 µg RE/mL in FG-2.5. Antioxidant capacity, as measured by ABTS^•+ and DPPH^• inhibition, improved more markedly in OG-2.5 (37.8% and 18.7%, respectively) than in FG-2.5. Moreover, volatile compound concentrations increased by 177.9% in OG-2.5 and 137.0% in FG-2.5 compared with their respective controls, indicating differential aroma intensification and compound transformation. Structural characterization by SEM and FT-IR further corroborated enhanced cellular disruption and biochemical release in mature tissue. Collectively, these results reveal a maturity-dependent mechanism of electro-permeabilization in plant tissues, offering new insights into optimizing non-thermal processing for functional food production. Full article

Slender masonry structures, in the absence of disintegration phenomena, can be idealized as rigid bodies subjected to seismic excitation. In this study, a closed-form expression for the behavior factor (q-factor) associated with overturning collapse under out-of-plane seismic loading is derived. The analysis considers five-step pulse seismic inputs. In the proposed approach, valid for slender masonry structures, sliding failure is neglected, and collapse is assumed to occur when, at the end of the seismic excitation, the rotation of the structure reaches a value equal to its slenderness. Based on this criterion, it is possible to derive a formulation for the q-factor as a function of a dimensionless parameter that combines the geometric characteristics of the slender structure and the period of the applied accelerogram. To validate the proposed formulation, a comparative analysis is conducted against the results obtained from a numerical integration of the motion equation using a set of 20 natural accelerograms recorded in Italy. The characteristic period of each accelerogram is evaluated through different methodologies, with the aim of identifying the most suitable approach for application in simplified seismic assessment procedures. Full article

Background/Objectives: Hot-melt extrusion (HME) has gained prominence for the manufacture of sustained-release oral dosage forms, yet the application of wax-based matrices and their resilience to alcohol-induced dose dumping (AIDD) remains underexplored. This study aimed to develop and characterise wax-based sustained-release felodipine formulations, with a particular focus on excipient functionality and robustness against AIDD. Methods: Felodipine sustained-release formulations were prepared via HME using Syncrowax HGLC as a thermally processable wax matrix. Microcrystalline cellulose (MCC) and lactose monohydrate were incorporated as functional fillers and processing aids. The influence of wax content and filler type on mechanical properties, wettability, and drug release behaviour was systematically evaluated. Ethanol susceptibility testing was conducted under simulated co-ingestion conditions (4%, 20%, and 40% v/v ethanol) to assess AIDD risk. Results: MCC-containing tablets demonstrated superior sustained-release characteristics over 24 h, showing better wettability and disintegration. In contrast, tablets formulated with lactose monohydrate remained structurally intact during dissolution, overly restricting drug release. This limitation was effectively addressed through granulation, where reduced particle size significantly improved surface accessibility, with 0.5–1 mm granules achieving a satisfactory release profile. Ethanol susceptibility testing revealed divergent behaviours between the two filler systems. Unexpectedly, MCC-containing tablets showed suppressed drug release in ethanolic media, likely resulting from inhibitory effect of ethanol on filler swelling and disintegration. Conversely, formulations containing lactose monohydrate retained their release performance in up to 20% v/v ethanol, with only high concentrations (40% v/v) compromising matrix drug-retaining functionality and leading to remarkably increased drug release. Conclusions: This study highlights the pivotal role of excipient type and constitutional ratios in engineering wax-based sustained-release formulations. It further contributes to the understanding of AIDD risk through in vitro assessment and offers a rational design strategy for robust, alcohol-resistant oral delivery systems for felodipine. Full article

There are many advantages of the smelting of vanadium–titanium magnetite pellets by hydrogen-based shaft furnace pre-reduction and electric arc furnace process, including high reduction efficiency, low carbon dioxide emission and high recovery of titanium and so on. However, vanadium–titanium magnetite pellets are highly susceptible to severe reduction disintegration when reduced in the gas-based shaft furnaces. H₂ and CO are the primary reducing gas components in the gas-based shaft furnace process, which significantly influences the reduction behavior of vanadium–titanium magnetite pellets. In this study, the reduction disintegration behavior and reduction kinetics of vanadium–titanium magnetite under mixed H₂–CO atmospheres at low temperatures (450–600 °C) were investigated. The differences in the reduction capacities and rates of H₂ and CO on iron oxides and titanium–iron oxides were revealed, along with their impact on the reduction disintegration behavior of the pellets at low temperatures. At lower temperatures, CO exhibited a greater reducing capability for vanadium–titanium magnetite. As the reduction temperature increased, the reduction capacities of both H₂ and CO improved; however, the reduction capacity of H₂ was more significantly influenced by the temperature. The disparity in the reduction capacities of H₂ and CO for vanadium–titanium magnetite pellets caused an inconsistent expansion rate in different regions of the pellet, increasing internal stress, contributing to a more severe reduction disintegration of vanadium–titanium magnetite pellets in the mixed H₂–CO atmospheres. Full article

Three-dimensional (3D) computational fluid dynamic (CFD) simulations have been performed to investigate the complex flow features and stripping of fluid materials from a cylindrical water drop at the late-stage in a Shock Liquid Drop Interaction (SLDI) process when the drop’s downstream end experiences compression after it is impacted by a supersonic shock wave ($Ma$ = 1.47). The drop trajectory/breakup has been simulated using a Lagrangian model and the unsteady Reynolds-averaged Navier–Stokes (URANS) approach has been employed for simulating the ambient airflow. The Kelvin–Helmholtz Rayleigh–Taylor (KHRT) breakup model has been used to capture the liquid drop fragmentation process and a coupled level-set volume of fluid (CLSVOF) method has been applied to investigate the topological transformations at the air/water interface. The predicted changes of the drop length/width/area with time have been compared against experimental measurements, and a very good agreement has been obtained. The complex flow features and the qualitative characteristics of the material stripping process in the compression phase, as well as disintegration and flattening of the drop are analyzed via comprehensive flow visualization. Characteristics of the drop distortion and fragmentation in the stripping breakup mode, and the development of turbulence at the later stage of the shock drop interaction process are also examined. Finally, this study investigated the effect of increasing $Ma$ on the breakup of a water drop by shear stripping. The results show that the shed fluid materials and micro-drops are spread over a narrower distribution as $Ma$ increases. It illustrates that the flattened area bounded by the downstream separation points experienced less compression, and the liquid sheet suffered a slower growth. Full article

Barro Alto processes nickel laterite ore using rotary kilns and six-in-line rectangular electric arc furnaces. This study evaluated the briquetting of ferronickel ore to reduce kiln fines, improve furnace charge permeability, and enhance process safety. Binderless briquettes were produced from screened ore at two size fractions (−6.3 mm and −12.5 mm), with moisture contents of 16% and 24%, cured under closed and open conditions. The physical and metallurgical properties of the briquettes were assessed using ISO standard tests. The results confirmed successful agglomeration of the ore into binderless briquettes. Screening the run-of-mine (ROM) ore improved the feed quality, increasing the NiO grade from 2.0% to 2.2% in the −6.3 mm fraction. The briquettes from the −6.3 mm ore at 16% moisture exhibited the highest green strength (559 N). Higher moisture content reduced the briquette strength and increased both the reduction disintegration and decrepitation indices. The decrepitation index increased from 0.33% to 0.61% for the −6.3 mm briquettes when the moisture increased from 16% to 24%. The reduction levels were 33.4% and 39.2% for −6.3 mm and −12.5 mm briquettes with 16% moisture, respectively. This study concludes that optimal performance was achieved using −6.3 mm ore, 16% moisture, and open curing, thereby balancing reduction efficiency and mechanical stability. Full article

This study investigates the feasibility of producing low-carbon FeCr via metallothermic smelting of Cr concentrate and chromite spinel powder using a complex FeAlSiCa alloy as the reductant in an induction furnace. The proposed approach offers an alternative to conventional carbothermic and oxygen-blown technologies, reducing both the carbon footprint and airborne emissions. Three charge compositions were tested with varying FeAlSiCa additions (12, 14, and 16 kg per 100 kg of Cr source) and partial replacement of Cr concentrate with up to 20% CSP. Thermodynamic and microstructural analyses were conducted, and the effects of the slag basicity, temperature profiles, and holding time were assessed. In optimal conditions, Cr recovery reached up to 80% with minimal Cr₂O₃ losses in slag, and the resulting alloys met ISO 5448-81 requirements for nitrogen-containing low-carbon FeCr. Microstructural examination revealed the formation of Fe-Cr solid solutions and CrN phases, with V incorporation from the FeAlSiCa alloy. The process proved stable and energy-efficient, producing compact, non-disintegrating slag. This study highlights the potential of induction furnace smelting and chromite spinel powder valorization as a sustainable path for FeCr production. Full article

Background/Objective: Oral lichen planus (OLP) is a chronic inflammatory disorder of the oral mucosa with unclear etiology. Increasing evidence implicates oral microbial dysbiosis in its pathogenesis, but little is known about supragingival plaque communities in relation to clinical subtypes. This cross-sectional case–control study aimed to characterize the supragingival plaque microbiota and microbial interaction networks in erosive OLP (E-OLP), non-erosive OLP (NE-OLP), and healthy controls (HCs), to elucidate microbial patterns associated with disease severity. Methods: Supragingival plaque samples were collected from 90 participants (30 per group) and analyzed using 16S rRNA gene sequencing. Alpha and beta diversity metrics, differential abundance, and co-occurrence network analyses were performed. Results: E-OLP exhibited pronounced dysbiosis, including the enrichment of pro-inflammatory taxa (e.g., Prevotella, Parvimonas) and depletion of health-associated commensals (e.g., Rothia, Capnocytophaga). Network analysis revealed the stepwise disintegration of microbial community structure from HC to NE-OLP to E-OLP, with reduced connectivity and increased dominance of pathogenic clusters in E-OLP. These microbial alterations aligned with clinical findings, as E-OLP patients showed significantly higher Reticulation/keratosis, Erythema, and Ulceration (REU) scores for erythema and ulceration compared to NE-OLP. Conclusions: Supragingival plaque dysbiosis and ecological disruption are strongly associated with OLP severity and subtype. This study highlights the utility of plaque-based microbial profiling in capturing lesion-proximal dysbiotic signals, which may complement mucosal and salivary analyses in future diagnostic frameworks. Multi-omics approaches incorporating fungal, viral, and metabolic profiling are warranted to fully elucidate host–microbe interactions in OLP. Full article

Loess Plateau is the region with the most concentrated loess distribution and the deepest loess soil layer in the world, and it is facing serious problems of soil erosion and ecological degradation. The nano carbon modification of soil surface properties is a novel strategy for soil improvement and enhancing the soil’s capacity to sequester carbon, which has been extensively researched. However, the mechanisms underlying the influence of carbon surface structure on the efficacy of loess soil remediation remain unclear. Herein, graphene oxide (GO) with a unique two-dimensional structure and adjustable surface properties was optimized as a model carbon filler to investigate the modification effect on loess. As a result, the addition amount of 0.03% GO significantly reduced the disintegration amount of loess, but, if inhibited for a long time, the disintegration effect would weaken. The highly reduced GO can delay the loess disintegration rate due to its enhanced hydrophobicity, but the inhibitory effect fails over a long period of time. After adjusting the reduce degree with a 50% SA (sodium ascorbate), the water-holding capacity of the modified soil in the high suction range is enhanced. This study reveals the synergistic mechanism of the sheet structure and surface properties of GO on the water stability of loess, providing a reference for the prevention and control of soil erosion and ecological restoration in the Loess Plateau. Full article

The Permian–Triassic magmatic record in the eastern Central Asian Orogenic Belt (CAOB) provides critical insights into the terminal stages of the Paleo-Asian Ocean (PAO) evolution, including collisional and post-collisional processes following its Late Permian closure. The northeastern China region, tectonically situated within the eastern segment of the CAOB, is traditionally known as the Xingmeng Orogenic Belt (XOR). This study integrates zircon U-Pb geochronology, whole-rock geochemistry, and zircon Hf isotopic analyses of intermediate-acid volcanic rocks and intrusive rocks from the former “Tongjiatun Formation” in the Faku area of northern Liaoning. The main objective is to explore the petrogenesis of these igneous rocks and their implications for the regional tectonic setting. Zircon U-Pb ages of these rocks range from 260.5 to 230.1 Ma, indicating Permian–Triassic magmatism. Specifically, the Gongzhuling rhyolite (260.5 ± 2.2 Ma) and Gongzhuling dacite (260.3 ± 2.4 Ma) formed during the Middle-Late Permian (270–256 Ma); the Wangjiadian dacite (243 ± 3.0 Ma) and Wafangxi rhyolite (243.9 ± 3.0 Ma) were formed in the late Permian-early Middle Triassic (256–242 Ma); the Haoguantun rhyolite (240.9 ± 2.2 Ma) and Sheshangou pluton (230.1 ± 1.7 Ma) were formed during the Late Middle-Late Triassic (241–215 Ma). Geochemical studies, integrated with the geochronological results, reveal distinct tectonic settings during successive stages: (1) Middle-Late Permian (270–256 Ma): Magmatism included peraluminous A-type rhyolite with in calc-alkaline series (e.g., Gongzhuling) formed in an extensional environment linked to a mantle plume, alongside metaluminous, calc-alkaline I-type dacite (e.g., Gongzhuling) associated with the subduction of the PAO plate. (2) Late Permian-Early Middle Triassic (256–242 Ma): Calc-alkaline I-type magmatism dominated, represented by dacite (e.g., Wangjiadian) and rhyolite (e.g., Wafangxi), indicative of a collisional uplift environment. (3) Late Middle-Late Triassic (241–215 Ma): Magmatism transitioned to high-K calc-alkaline with A-type rocks affinities, including rhyolite (e.g., Haoguantun) and plutons (e.g., Sheshangou), formed in a post-collisional extensional environment. This study suggests that the closure of the PAO along the northern margin of the North China Craton (NCC) occurred before the Late Triassic. Late Triassic magmatic rocks in this region record a post-orogenic extensional setting, reflecting tectonic processes following NCC-XOR collision rather than PAO subduction. Combined with previously reported age data, the tectonic evolution of the eastern segment of the CAOB during the Permian-Triassic can be divided into four stages: active continental margin (293–274 Ma), plate disintegration (270–256 Ma), final collision and closure (256–241 Ma), and post-orogenic extension (241–215 Ma). Full article

During the construction of subgrade, the remolding water content w of lime–sand-stabilized clay usually varies in a wide range, leading to inconsistent effectiveness in strength enhancement. Until now, this aspect has not been investigated. In this study, an unconfined compression test and microscopic observation were carried out on clay and stabilized clay (adding 4% lime by mass and 50% sand by volume). The results show the following: (1) remolding water content w had a strong effect on the soil fabrics of pure clay and lime-stabilized clay. An increase in the w from the dry to wet side of optimum reduced matric suction, which diminished the aggregation effect among fine-grained particles in both clay and lime-stabilized clay. Correspondingly, fine-grained aggregate progressively disintegrated, and dispersed fine-grained particles increased. As a result, the w increment at w ≤ w_cha made the dispersed fine-grained particles successively fill the large pores between aggregates, densifying the soil fabric. In contrast, at w > w_cha, the ongoing disintegration of aggregate resulted in progressive structural weakening. Herein, w_cha was defined as the characteristic water content at which the soil fabric transitioned from structural densification to weakening. (2) The UCS of both pure clay and lime–sand-stabilized clay followed a bell-shaped pattern as the w increased, with w_cha acting as the turning point. For pure clay soils, the UCS increased with increasing w up to w_cha because of structural densification, but decreased beyond w_cha due to structural weakening. In lime–sand-stabilized clay, where a sand grain skeleton developed, the compression of lime-stabilized clay induced by the movement of sand grains during shearing activated its contribution to the overall strength. The compressive capacity of the lime-stabilized clay varied in a bell-shaped manner with w, and this trend was mirrored in the UCS of lime–sand-stabilized clay. (3) At a low w, the fact that the clay aggregate exhibited sand-like mechanical behavior reduced the effectiveness of incorporating sand and lime for enhancing the UCS. As the w increased at w ≤ w_cha, the breakdown of aggregates enlarged the distinction between pure clay and sand, resulting in a more pronounced improvement in the UCS with the addition of sand and lime. At w > w_cha, the lubrication effect occurring at the contact between sand grains diminished the interlocking between the sand grains. Consequently, the effectiveness of the UCS enhancement decreased. Full article