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Keywords = direct digital synthesizer (DDS)

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18 pages, 2551 KiB  
Article
High-Precision Digital Clock Steering Method Based on Discrete Σ-Δ Modulation for GNSS
by Mingkai Liu, Zhijun Meng, Enqi Yan, Suyang Liu, Yinhong Lv, Xiye Guo and Jun Yang
Remote Sens. 2024, 16(15), 2794; https://doi.org/10.3390/rs16152794 - 30 Jul 2024
Viewed by 1248
Abstract
A high-precision time reference is fundamental to the positioning, navigation, and timing (PNT) of global navigation satellite systems (GNSS). The precision of clock steering determines the accuracy of practical applications that rely on the time–frequency reference. With the invention of direct digital synthesizer [...] Read more.
A high-precision time reference is fundamental to the positioning, navigation, and timing (PNT) of global navigation satellite systems (GNSS). The precision of clock steering determines the accuracy of practical applications that rely on the time–frequency reference. With the invention of direct digital synthesizer (DDS) technology, digital clock steering (DCS) has gradually become a mainstream technology. However, the key factor limiting DCS accuracy is the system quantization noise, which leads to a low frequency and phase adjustment accuracy. Here we propose a DCS method based on Σ-Δ modulation to address the issue of low resolution of DAC through shaping the quantization noise. A simulated GNSS time–frequency reference system experimental platform is constructed to validate the effectiveness of the proposed method. The experimental results demonstrate that this method achieves a phase adjustment accuracy of 0.48 ps and a frequency adjustment accuracy better than 0.48 pHz, which is two orders of magnitude higher than that of existing GNSS time–frequency reference systems. Thus, the proposed method offers a significant improvement in time–frequency reference systems, leading to better performance, reliability, and accuracy in a wide range of practical applications. Full article
(This article belongs to the Special Issue GNSS Positioning, Navigation, and TimingPresent and Beyond)
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23 pages, 24090 KiB  
Article
Research on Implementation of a PWM Generation Algorithm for Train Stationary Stopping Frequency
by Euntaek Han, Changsik Park, Ikjae Kim and Dongkyoo Shin
Electronics 2024, 13(4), 784; https://doi.org/10.3390/electronics13040784 - 16 Feb 2024
Viewed by 1688
Abstract
In industrial electronic equipment or communication equipment, a reference clock should be generated for stable operation of the equipment, which requires precise and stable reference frequency generation. As a method for generating this reference frequency, an analog method called PLL (phase locked-loop) has [...] Read more.
In industrial electronic equipment or communication equipment, a reference clock should be generated for stable operation of the equipment, which requires precise and stable reference frequency generation. As a method for generating this reference frequency, an analog method called PLL (phase locked-loop) has been devised and widely used. However, in order to make a more precise and stable reference frequency simple and economical, a DDS (direct digital synthesizer) has been developed. In this paper, we propose a stable and accurate method to generate a low frequency of the PWM method via pure logic circuit configuration without a microprocessor for digital reference frequency generation. Depending on the electronic communication equipment, the required reference frequency varies from a low frequency to a very high frequency. The reference frequency synthesis required in these frequency bands has been studied in various ways, but in industries such as railways, the low-frequency band based on the DDS method is used. In particular, it is very important to operate without a single operating error or failure in order to obtain information for stopping the train. Therefore, it is necessary to design a pure logic method that excludes a stored program type processor that minimizes the possibility of temporary interruption due to disturbance such as surge or high voltage. Therefore, through this study, the algorithm is implemented so that the duty ratio is output at 50:50, the circuit is configured so that two target frequencies are generated at the same time, and the performance is verified by generating the low-frequency band used for stopping the railway train. It was confirmed that the accuracy and stability were improved compared to the analog method used for stopping the railway train, and it was verified that the frequency resolution was superior to the similar results obtained in the digital frequency synthesis field so far. Full article
(This article belongs to the Section Circuit and Signal Processing)
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12 pages, 1455 KiB  
Article
Multipoint Lock-in Detection for Diamond Nitrogen-Vacancy Magnetometry Using DDS-Based Frequency-Shift Keying
by Qidi Hu, Luheng Cheng, Yushan Liu, Xinyi Zhu, Yu Tian and Nanyang Xu
Micromachines 2024, 15(1), 14; https://doi.org/10.3390/mi15010014 - 21 Dec 2023
Cited by 1 | Viewed by 2371
Abstract
In recent years, the nitrogen-vacancy (NV) center in diamonds has been demonstrated to be a high-performance multiphysics sensor, where a lock-in amplifier (LIA) is often adopted to monitor photoluminescence changes around the resonance. It is rather complex when multiple resonant points are utilized [...] Read more.
In recent years, the nitrogen-vacancy (NV) center in diamonds has been demonstrated to be a high-performance multiphysics sensor, where a lock-in amplifier (LIA) is often adopted to monitor photoluminescence changes around the resonance. It is rather complex when multiple resonant points are utilized to realize a vector or temperature-magnetic joint sensing. In this article, we present a novel scheme to realize multipoint lock-in detection with only a single-channel device. This method is based on a direct digital synthesizer (DDS) and frequency-shift keying (FSK) technique, which is capable of freely hopping frequencies with a maximum of 1.4 GHz bandwidth and encoding an unlimited number of resonant points during the sensing process. We demonstrate this method in experiments and show it would be generally useful in quantum multi-frequency excitation applications, especially in the portable and highly mobile cases. Full article
(This article belongs to the Special Issue Future Prospects of Quantum Chips and Their Applications)
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11 pages, 1756 KiB  
Article
R&D of an Innovative OFDM Communication Payload for Small-Size AUV
by Bin Li, Feng Tong, Xiujing Gao, Junhui Yao, Yuehai Zhou and Hongwu Huang
J. Mar. Sci. Eng. 2023, 11(5), 1029; https://doi.org/10.3390/jmse11051029 - 12 May 2023
Cited by 3 | Viewed by 1891
Abstract
With its superiorities of low cost, high flexibility and deployment convenience, small-size autonomous underwater vehicles (AUVs) have been extensively applied to perform a variety of undersea missions. While underwater acoustic (UWA) communication provides a practical way to establish a wireless link, it still [...] Read more.
With its superiorities of low cost, high flexibility and deployment convenience, small-size autonomous underwater vehicles (AUVs) have been extensively applied to perform a variety of undersea missions. While underwater acoustic (UWA) communication provides a practical way to establish a wireless link, it still poses a significant challenge due to the strict limitations of a small-size AUV platform in terms of load capacity, energy supply and cost. Orthogonal frequency division multiplexing (OFDM) has drawn extensive attention due to its high data rate capability and relative robustness to multipath, the performance of which is unfortunately sensitive to the widespread Doppler effect. While efficient Doppler compensation is significantly crucial for UWA OFDM mobile communication, most of the conventional approaches are conducted using software resampling, thus rendering a huge burden on memory and calculation capability as well as a considerable processing delay. In this paper, from the perspective of hardware completion an UWA OFDM communication payload based on STM32F407 processor is designed and implemented to facilitate agile Doppler compensation with low computational overhead. In particular, after estimating Doppler by calculating the time compression or extension of the preamble signal, Doppler compensation is performed by directly adjusting the direct digital frequency synthesizer (DDS)-driven sampling rate of the analog-to-digital converter (ADC). As the Doppler is compensated parallel to the ADC acquisition, processing delay and memory requirement can be avoided. Finally, hardware-in-loop (HIP) simulation is performed to demonstrate the effectiveness and superiority of the proposed system. The results show that the designed system has the potential to achieve an effective communication rate of 3.19 kbps with the admissible implementation overhead. Future work will entail the integration and performance evaluation of the proposed UWA OFDM communication payload on a practical small-size AUV platform. Full article
(This article belongs to the Special Issue Underwater Acoustic Communication and Network)
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16 pages, 8487 KiB  
Article
Measurement and Control System for Atomic Force Microscope Based on Quartz Tuning Fork Self-Induction Probe
by Yongzhen Luo, Xidong Ding, Tianci Chen, Tao Su and Dihu Chen
Micromachines 2023, 14(1), 227; https://doi.org/10.3390/mi14010227 - 15 Jan 2023
Cited by 1 | Viewed by 3500
Abstract
In this paper, we introduce a low-cost, expansible, and compatible measurement and control system for atomic force microscopes (AFM) based on a quartz tuning fork (QTF) self-sensing probe and frequency modulation, which is mainly composed of an embedded control system and a probe [...] Read more.
In this paper, we introduce a low-cost, expansible, and compatible measurement and control system for atomic force microscopes (AFM) based on a quartz tuning fork (QTF) self-sensing probe and frequency modulation, which is mainly composed of an embedded control system and a probe system. The embedded control system is based on a dual-core OMAPL138 microprocessor (DSP + ARM) equipped with 16 channels of a 16-bit high-precision general analog-to-digital converter (ADC) and a 16-bit high-precision general digital-to-analog converter (DAC), six channels of an analog-to-digital converter with a second-order anti-aliasing filter, four channels of a direct digital frequency synthesizer (DDS), a digital input and output (DIO) interface, and other peripherals. The uniqueness of the system hardware lies in the design of a high-precision and low-noise digital—analog hybrid lock-in amplifier (LIA), which is used to detect and track the frequency and phase of the QTF probe response signal. In terms of the system software, a software difference frequency detection method based on a digital signal processor (DSP) is implemented to detect the frequency change caused by the force gradient between the tip and the sample, and the relative error of frequency measurement is less than 3%. For the probe system, a self-sensing probe controller, including an automatic gain control (AGC) self-excitation circuit, is designed for a homemade balanced QTF self-sensing probe with a high quality factor (Q value) in an atmospheric environment. We measured the quality factor (Q value) of the balanced QTF self-sensing probes with different lengths of tungsten tips and successfully realized AFM topography imaging with a tungsten-tip QTF probe 3 mm in length. The results show that the QTF-based self-sensing probe and the developed AFM measurement and control system can obtain high quality surface topography scanning images in an atmospheric environment. Full article
(This article belongs to the Special Issue Nanoscale Materials and Measurements)
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17 pages, 2718 KiB  
Article
Frequency-Modulated Signal Measurement Using Closed-Loop Methodology
by Xinglin Sun, Haojie Wu, Xinyue Tan, Wenrui Wang, Lingyun Ye and Kaichen Song
Sensors 2022, 22(20), 7822; https://doi.org/10.3390/s22207822 - 14 Oct 2022
Cited by 8 | Viewed by 2271
Abstract
Frequency-modulated (FM) signals are widely used in sensing, measurement, and signal detection due to their strong anti-interference and easy transmission characteristics. Although the high-precision measurement methods for static signals are quite complete, the high-precision measurement methods for dynamic FM signals still need to [...] Read more.
Frequency-modulated (FM) signals are widely used in sensing, measurement, and signal detection due to their strong anti-interference and easy transmission characteristics. Although the high-precision measurement methods for static signals are quite complete, the high-precision measurement methods for dynamic FM signals still need to be studied, and the measurement accuracy in the high-sampling system still has room for improvement. Traditionally, the equal-precision measurement method is widely applied in most scenarios. However, its accuracy is limited by the quantization error of ±1 word and the sampling gate time, making it difficult to improve the frequency measurement accuracy while ensuring a high sampling rate at the same time. In this paper, a high-precision feedback frequency measurement system with the capability to eliminate the quantization error of ±1 word is proposed. The proposed system consists of two stages, the rough measurement stage based on the equal-precision measurement method and the precise measurement stage based on the negative feedback tracking architecture using the phase–frequency detector (PFD) and direct digital synthesizer (DDS). The effectiveness and feasibility of the system are verified by both simulation and experiment. At the sampling rate of 2 kHz, the frequency measurement accuracy is improved by more than 30 dB. Full article
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13 pages, 4725 KiB  
Article
An Automatic Clock-Induced-Spurs Detector Based on Energy Detection for Direct Digital Frequency Synthesizer
by Xin Lei, Junan Zhang, Jun Deng, Peng Yin, Zhou Shu and Fang Tang
Sensors 2022, 22(9), 3396; https://doi.org/10.3390/s22093396 - 28 Apr 2022
Cited by 2 | Viewed by 2142
Abstract
A clock-induced-spurs detector, composed of a programmable low-pass filter (LPF), energy detector and spur detection algorithm, is presented and applied to a four-channel 1 gigabit-samples-per-second (GSPS) direct digital frequency synthesizer (DDS). The proposed detector realizes the detection of spurs based on energy-detection, and [...] Read more.
A clock-induced-spurs detector, composed of a programmable low-pass filter (LPF), energy detector and spur detection algorithm, is presented and applied to a four-channel 1 gigabit-samples-per-second (GSPS) direct digital frequency synthesizer (DDS). The proposed detector realizes the detection of spurs based on energy-detection, and the spur detection algorithm is adopted to automatically extract the amplitude and phase of clock-induced spurs, generated by the intermodulation of harmonic spurs and multiple clocks. Finally, the extracted features are sent to auxiliary DDS to decrease the target spur, following which the detector can be turned off to save power. Additionally, the detected characteristics under different output conditions can be read out through the interface for rapid frequency switching. The proposed detector integrated into a DDS is fabricated with a 65 nm complementary metal oxide semiconductor (CMOS) process and has an area of 190 μm × 320 μm. The measured power consumption is roughly 38 mW, consuming 6% that of a single-channel DDS. The test results show that the spurious-free dynamic range (SFDR) of this DDS can be successfully enhanced from −43.1 dBc to roughly −59.9 dBc without any off-chip instruments. This effectively proves that the detection accuracy of this detector can reach around −81 dBm. Full article
(This article belongs to the Section Physical Sensors)
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16 pages, 3693 KiB  
Article
Implementation of the Configuration Structure of an Integrated Computational Core of a Pulsed NQR Sensor Based on FPGA
by Andriy Samila, Oleksandra Hotra and Jacek Majewski
Sensors 2021, 21(18), 6029; https://doi.org/10.3390/s21186029 - 9 Sep 2021
Cited by 5 | Viewed by 2224
Abstract
This paper presents a method for implementing the configuration structure of an integrated computational core of a pulsed nuclear quadrupole resonance (NQR) sensor based on a field-programmable gate array (FPGA), which comprises the following modules: a three-channel direct digital synthesizer (DDS), a pulse [...] Read more.
This paper presents a method for implementing the configuration structure of an integrated computational core of a pulsed nuclear quadrupole resonance (NQR) sensor based on a field-programmable gate array (FPGA), which comprises the following modules: a three-channel direct digital synthesizer (DDS), a pulse sequence shaper and a software-defined radio. Experimental studies carried out using the in-circuit analyzer SignalTap Logic Analyzer have confirmed the reliability of the correct and stable operation of the functional modules of the configuration structure at all stages of signal transformations, starting from the formation of the envelope of the excitation pulses and ending with the obtainment of low-frequency quadrature signals at the outlet of the compensating filters. The time and frequency dependences of the amplitude of the output signals generated using the DDS based on a 48 bit phase accumulator are investigated. This development can be used when creating pulsed coherent NQR sensors in the frequency range of 1 MHz–50 MHz. Full article
(This article belongs to the Section Physical Sensors)
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48 pages, 3859 KiB  
Article
Accurate Power-Efficient Format-Scalable Multi-Parallel Optical Digital-to-Analogue Conversion
by Moshe Nazarathy and Ioannis Tomkos
Photonics 2021, 8(2), 38; https://doi.org/10.3390/photonics8020038 - 4 Feb 2021
Cited by 19 | Viewed by 4804
Abstract
In optical transmitters generating multi-level constellations, optical modulators are preceded by Electronic Digital-to-Analog-Converters (eDAC). It is advantageous to use eDAC-free Optical Analog to Digital Converters (oDAC) to directly convert digital bitstreams into multilevel PAM/QAM optical signals. State-of-the-art oDACs are based on Segmented Mach-Zehnder-Modulators [...] Read more.
In optical transmitters generating multi-level constellations, optical modulators are preceded by Electronic Digital-to-Analog-Converters (eDAC). It is advantageous to use eDAC-free Optical Analog to Digital Converters (oDAC) to directly convert digital bitstreams into multilevel PAM/QAM optical signals. State-of-the-art oDACs are based on Segmented Mach-Zehnder-Modulators (SEMZM) using multiple modulation segments strung along the MZM waveguides to serially accumulate binary-modulated optical phases. Here we aim to assess performance limits of the Serial oDACs (SEMZM) and introduce an alternative improved Multi-Parallel oDAC (MPoDAC) architecture, in particular based on arraying multiple binary-driven MZMs in parallel: Multi-parallel MZM (MPMZM) oDAC. We develop generic methodologies of oDAC specification and optimization encompassing both SEMZM and MPMZM options in Direct-Detection (DD) and Coherent-Detection (COH) implementations. We quantify and compare intrinsic performance limits of the various serial/parallel DD/COH subclasses for general constellation orders, comparing with the scant prior-work on the multi-parallel option. A key finding: COH-MPMZM is the only class synthesizing ‘perfect’ (equi-spaced max-full-scale) constellations while maximizing energy-efficiency-SEMZM/MPMZM for DD are less accurate when maximal energy-efficiency is required. In particular, we introduce multiple variants of PAM4|8 DD and QAM16|64 COH MPMZMs, working out their accuracy vs. energy-efficiency-and-complexity tradeoffs, establishing their format-reconfigurability (format-flexible switching of constellation order and/or DD/COH). Full article
(This article belongs to the Special Issue Reconfigurable Photonic Interconnects)
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14 pages, 2879 KiB  
Article
Reduction of Spurious Signal Upconversion in Frequency Multipliers
by Zenon Szczepaniak and Tomasz Rogala
Electronics 2020, 9(7), 1126; https://doi.org/10.3390/electronics9071126 - 10 Jul 2020
Cited by 1 | Viewed by 3130
Abstract
Usually many applications of radar transceivers and heterodyne frequency synthesizers assume a spurious signal power level below −60 dBc. In the case of modern synthesizers using direct digital synthesis (DDS) systems, the number of emerging spurious signal frequencies is very large, and spectral [...] Read more.
Usually many applications of radar transceivers and heterodyne frequency synthesizers assume a spurious signal power level below −60 dBc. In the case of modern synthesizers using direct digital synthesis (DDS) systems, the number of emerging spurious signal frequencies is very large, and spectral purity within −60 dBc can only be obtained in the relatively narrow tuning band of the DDS unit. For the purposes of widening this useful frequency range, the frequency multiplying operation is applied commonly. Then, during the process of frequency multiplication of the baseband signal containing inband spurious signals, the effect of the upconversion of spurious signals occurs. The paper contains an analysis of the undesirable effects of the conversion of spurious signal frequencies accompanying the process of frequency multiplication. A method of reducing the level of upconverted spurious signals is proposed. The numerical calculations and measurement results are provided. For the case of a frequency multiplier with a multiplying factor equal to N, the power ratio between the desired output signal and upconverted spurious signal drops by an additional 1/N2. It has been found that the application of the presented method during the design process of the frequency multiplier allows this ratio to be improved by 6 dB. Full article
(This article belongs to the Special Issue RF/Mm-Wave Circuits Design and Applications)
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13 pages, 4457 KiB  
Article
Design of a Portable Orthogonal Surface Acoustic Wave Sensor System for Simultaneous Sensing and Removal of Nonspecifically Bound Proteins
by Shuangming Li and Venkat R. Bhethanabotla
Sensors 2019, 19(18), 3876; https://doi.org/10.3390/s19183876 - 8 Sep 2019
Cited by 12 | Viewed by 4986
Abstract
One challenge for current surface acoustic wave (SAW) biosensors is reducing nonspecific adsorption. A device propagating Rayleigh and shear horizontal surface acoustic waves in orthogonal directions fabricated in ST quartz has the capability of achieving simultaneous detection and nonspecific binding (NSB) protein removal. [...] Read more.
One challenge for current surface acoustic wave (SAW) biosensors is reducing nonspecific adsorption. A device propagating Rayleigh and shear horizontal surface acoustic waves in orthogonal directions fabricated in ST quartz has the capability of achieving simultaneous detection and nonspecific binding (NSB) protein removal. Current measurement methods for a SAW sensor system based on this device require large-size and expensive equipment such as a vector network analyzer (VNA), signal generator, and frequency counter, which are not suitable for portable, especially point-of-care, applications. In this work, a portable platform based on a direct digital synthesizer (DDS) is investigated for the orthogonal SAW sensor, integrating signal synthesis, gain control, phase/amplitude measurement, and data processing in a small, portable electronic system. This prototype was verified for both stability and repeatability, and the results matched very well with VNA measurements. Finally, system performance in real-time sensing and NSB removal was evaluated. Full article
(This article belongs to the Special Issue Point-of-Care Sensing Devices)
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11 pages, 757 KiB  
Article
Comparative Study of DDS with Different Types of Phase Accumulators
by Oleksiy Polikarovskykh, Lesia Karpova, Ihor Hula and Vasyl Melnychuk
Inventions 2019, 4(3), 35; https://doi.org/10.3390/inventions4030035 - 17 Jul 2019
Viewed by 5793
Abstract
The paper deals with the problems of delayed transfer signals in the direct digital synthesizer (DDS) phase accumulator adders. Transfer delay is one of the factors that affect the maximum output frequency of the DDS synthesizer. The main types of adders used in [...] Read more.
The paper deals with the problems of delayed transfer signals in the direct digital synthesizer (DDS) phase accumulator adders. Transfer delay is one of the factors that affect the maximum output frequency of the DDS synthesizer. The main types of adders used in DDS synthesizers are described. Separately, attention was paid to the adder with a consistent transfer of the transfer signal, adders with a transmission carry signal with a fixed block length, adders with a signal transmission delay with a variable block length, and a mathematical analysis of the origin and duration of the delay of the transfer signal in them. It was found that the use of a transfer adder with a variable length of a block in the core of a direct digital synthesizer would increase the maximum output frequency by 2.4 times compared to the adder with a parallel transfer, and by 1.43 times as compared with the adder with a fixed length the block. Full article
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14 pages, 10042 KiB  
Article
An Accurate DDS Method Using Compound Frequency Tuning Word and Its FPGA Implementation
by Yuqing Hou, Changlong Li and Sheng Tang
Electronics 2018, 7(11), 330; https://doi.org/10.3390/electronics7110330 - 16 Nov 2018
Cited by 7 | Viewed by 6519
Abstract
Because of its high resolution, low cost, small volume, low power dissipation and less conversion time consumption, the direct digital synthesizer (DDS) method has been applied more and more in the fields of frequency synthesis and signal generation. However, only a limited number [...] Read more.
Because of its high resolution, low cost, small volume, low power dissipation and less conversion time consumption, the direct digital synthesizer (DDS) method has been applied more and more in the fields of frequency synthesis and signal generation. However, only a limited number of precise frequency signals can be synthesized by the traditional DDS, for the reason that its accumulator modulus is fixed, and its frequency tuning word must be integer. In this paper, a precise DDS method using compound frequency tuning word is proposed, which improves the accuracy of synthesized signals at any frequency points on the premise of guaranteeing the stability of synthesized signals. In order to verify the effectiveness of the new method, a DDS frequency synthesizer based on FPGA is designed and implemented. Taking the rubidium atomic clock PRS10 as standard frequency source, the experiments shows that the frequency stability of the synthesized signal is better than 8.0 × 10−12/s, the relative frequency error is less than 4.8 × 10−12, and that the frequency accuracy is improved by three orders of magnitude compared with the traditional DDS method. Full article
(This article belongs to the Special Issue Signal Processing and Analysis of Electrical Circuit)
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25 pages, 2875 KiB  
Article
Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages
by David Alejandro Bejarano, Maria C. Puertas, Kathleen Börner, Javier Martinez-Picado, Barbara Müller and Hans-Georg Kräusslich
Viruses 2018, 10(11), 620; https://doi.org/10.3390/v10110620 - 10 Nov 2018
Cited by 28 | Viewed by 5943
Abstract
Macrophages are natural target cells of human immunodeficiency virus type 1 (HIV-1). Viral replication appears to be delayed in these cells compared to lymphocytes; however, little is known about the kinetics of early post-entry events. Time-of-addition experiments using several HIV-1 inhibitors and the [...] Read more.
Macrophages are natural target cells of human immunodeficiency virus type 1 (HIV-1). Viral replication appears to be delayed in these cells compared to lymphocytes; however, little is known about the kinetics of early post-entry events. Time-of-addition experiments using several HIV-1 inhibitors and the detection of reverse transcriptase (RT) products with droplet digital PCR (ddPCR) revealed that early replication was delayed in primary human monocyte-derived macrophages of several donors and peaked late after infection. Direct imaging of reverse-transcription and pre-integration complexes (RTC/PIC) by click-labeling of newly synthesized DNA further confirmed our findings and showed a concomitant shift to the nuclear stage over time. Altering the entry pathway enhanced infectivity but did not affect kinetics of viral replication. The addition of viral protein X (Vpx) enhanced productive infection and accelerated completion of reverse transcription and nuclear entry. We propose that sterile alpha motif (SAM) and histidine/aspartate (HD) domain-containing protein 1 (SAMHD1) activity lowering deoxyribonucleotide triphosphate (dNTP) pools is the principal factor delaying early HIV-1 replication in macrophages. Full article
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9 pages, 2346 KiB  
Article
Creation of Optimal Frequency for Electrostatic Force Microscopy Using Direct Digital Synthesizer
by Seunghyun Moon, Mingyu Kang, Jung-Hwan Kim, Kyeo-Reh Park and ChaeHo Shin
Appl. Sci. 2017, 7(7), 704; https://doi.org/10.3390/app7070704 - 8 Jul 2017
Cited by 6 | Viewed by 5366
Abstract
Electrostatic force microscopy (EFM) is a useful technique when measuring the surface electric potential of a substrate regardless of its topography. Here, we have developed a frequency detection method for alternating current (AC) bias in EFM. Instead of an internal lock-in amplifier (LIA) [...] Read more.
Electrostatic force microscopy (EFM) is a useful technique when measuring the surface electric potential of a substrate regardless of its topography. Here, we have developed a frequency detection method for alternating current (AC) bias in EFM. Instead of an internal lock-in amplifier (LIA) for EFM that only detects ωe and e, we have used other LIAs that can amplify the amplitude of specific frequency by direct digital synthesizer (DDS), that finds the optimal frequency of surface charge images. In order to confirm the performance of the proposed methods, the electrical properties of lead zirconate titanate (PZT) and triglycine sulfate (TGS) samples were measured. In addition, we compared the performances of the frequency-detection method and the conventional EFM method. Ultimately, enhanced images could be achieved using the frequency-detection method. The optimal modulated frequency-shift for force–gradient measurements was found to be 2 kHz. Additionally, we have shown that it is possible to use a hard cantilever (K = 42 N/m, 330 kHz). Therefore, we expect that this technique can be applied to measure the electrical properties of bio-molecular films. Full article
(This article belongs to the Section Materials Science and Engineering)
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