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Point of Care Sensing Devices: Better Care for Everyone
Open AccessArticle

Design of a Portable Orthogonal Surface Acoustic Wave Sensor System for Simultaneous Sensing and Removal of Nonspecifically Bound Proteins

Department of Chemical & Biomedical Engineering, University of South Florida, Tampa, FL 33620, USA
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Author to whom correspondence should be addressed.
Sensors 2019, 19(18), 3876; https://doi.org/10.3390/s19183876
Received: 30 July 2019 / Revised: 1 September 2019 / Accepted: 5 September 2019 / Published: 8 September 2019
(This article belongs to the Special Issue Point-of-Care Sensing Devices)
One challenge for current surface acoustic wave (SAW) biosensors is reducing nonspecific adsorption. A device propagating Rayleigh and shear horizontal surface acoustic waves in orthogonal directions fabricated in ST quartz has the capability of achieving simultaneous detection and nonspecific binding (NSB) protein removal. Current measurement methods for a SAW sensor system based on this device require large-size and expensive equipment such as a vector network analyzer (VNA), signal generator, and frequency counter, which are not suitable for portable, especially point-of-care, applications. In this work, a portable platform based on a direct digital synthesizer (DDS) is investigated for the orthogonal SAW sensor, integrating signal synthesis, gain control, phase/amplitude measurement, and data processing in a small, portable electronic system. This prototype was verified for both stability and repeatability, and the results matched very well with VNA measurements. Finally, system performance in real-time sensing and NSB removal was evaluated. View Full-Text
Keywords: surface acoustic wave; portable sensor; quartz; non-specific binding; protein fouling; biosensing; direct digital synthesis surface acoustic wave; portable sensor; quartz; non-specific binding; protein fouling; biosensing; direct digital synthesis
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Li, S.; Bhethanabotla, V.R. Design of a Portable Orthogonal Surface Acoustic Wave Sensor System for Simultaneous Sensing and Removal of Nonspecifically Bound Proteins. Sensors 2019, 19, 3876.

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