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Review

17 Citations

3,589 Views

11 Pages

From Melanocytes to Melanoma Cells: Characterization of the Malignant Transformation by Four Distinctly Different Melanin Fluorescence Spectra (Review)

Dieter Leupold,
Lutz Pfeifer,
Maja Hofmann,
Andrea Forschner,
Gerd Wessler and
Holger Haenssle

Int. J. Mol. Sci.2021, 22(10), 5265;https://doi.org/10.3390/ijms22105265

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17 May 2021

The melanin fluorescence emitted by pigment cells of the human skin has been a central research topic for decades, because melanin, on the one hand, protects against (solar) radiation in the near-UV range, whereas on the other hand, melanocytes are t...

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Article

19 Citations

7,186 Views

11 Pages

Diagnostic Performance of a Support Vector Machine for Dermatofluoroscopic Melanoma Recognition: The Results of the Retrospective Clinical Study on 214 Pigmented Skin Lesions

Łukasz Szyc,
Uwe Hillen,
Constantin Scharlach,
Friederike Kauer and
Claus Garbe

Diagnostics2019, 9(3), 103;https://doi.org/10.3390/diagnostics9030103

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25 August 2019

The need for diagnosing malignant melanoma in its earliest stages results in an increasing number of unnecessary excisions. Objective criteria beyond the visual inspection are needed to distinguish between benign and malignant melanocytic tumors in v...

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Article

10 Citations

5,785 Views

13 Pages

Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma

Dieter Leupold,
Lukasz Szyc,
Goran Stankovic,
Sabrina Strobel,
Hans-Ullrich Völker,
Ulrike Fleck,
Thomas Müller,
Matthias Scholz,
Peter Riederer and
Camelia-Maria Monoranu

Cells2019, 8(6), 592;https://doi.org/10.3390/cells8060592

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15 June 2019

Parkinson’s disease is associated with an increased risk of melanoma (and vice versa). Several hypotheses underline this link, such as pathways affecting both melanin and neuromelanin. For the first time, the fluorescence of melanin and neurome...

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