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4 Results Found

  • Review
  • Open Access
5 Citations
11,537 Views
13 Pages

17 March 2022

Deep penetrating nevus (DPN) is an uncommon acquired melanocytic lesion with a distinct histopathological appearance that typically behaves in an indolent manner. The lesion is characterized by a symmetrical proliferation of epithelioid to spindled m...

  • Article
  • Open Access
1 Citations
2,976 Views
18 Pages

Genetic and Methylation Analysis of CTNNB1 in Benign and Malignant Melanocytic Lesions

  • Anne Zaremba,
  • Philipp Jansen,
  • Rajmohan Murali,
  • Anand Mayakonda,
  • Anna Riedel,
  • Dieter Krahl,
  • Hans Burkhardt,
  • Stefan John,
  • Cyrill Géraud and
  • Klaus Griewank
  • + 14 authors

23 August 2022

Melanocytic neoplasms have been genetically characterized in detail during the last decade. Recurrent CTNNB1 exon 3 mutations have been recognized in the distinct group of melanocytic tumors showing deep penetrating nevus-like morphology. In addition...

  • Article
  • Open Access
3 Citations
1,740 Views
12 Pages

Pediatric Atypical Melanocytic Proliferations: Single-Site Retrospective Cohort Assessment of Treatment and Long-Term Follow-Up

  • Emily Hatheway Marshall,
  • Gabriella Alvarez,
  • Bangchen Wang,
  • Jennifer Crimmins,
  • Michelle M. Schneider,
  • M. Angelica Selim and
  • Rami N. Al-Rohil

12 December 2023

Atypical and malignant cutaneous tumors are understudied in the pediatric population, with limited data on long-term follow-up. This study examines pediatric (0–18 years) atypical melanocytic proliferations over a twenty-year period (January 20...

  • Article
  • Open Access
12 Citations
3,526 Views
13 Pages

NGS-Based Analysis of Atypical Deep Penetrating Nevi

  • Antonella Manca,
  • Maria Cristina Sini,
  • Anna Maria Cesinaro,
  • Francesca Portelli,
  • Carmelo Urso,
  • Maria Lentini,
  • Roberta Cardia,
  • Llucia Alos,
  • Martin Cook and
  • Daniela Massi
  • + 5 authors

19 June 2021

Deep penetrating nevi (DPNs) are rare melanocytic neoplasms consisting of pigmented spindled or epithelioid melanocytes with a distinctive wedge-shaped configuration showing activation of the WNT pathway, with unusual cyto-architectural features. It...