Search Results (696)

Sepsis remains a leading global cause of mortality, with delayed recognition and empirical antibiotic overuse fueling poor outcomes and rising antimicrobial resistance. This systematic scoping review evaluates the current landscape of artificial intelligence (AI) and machine learning (ML) applications in sepsis care, focusing on early detection, personalized antibiotic management, and resistance forecasting. Literature from 2019 to 2025 was systematically reviewed following PRISMA-ScR guidelines. A total of 129 full-text articles were analyzed, with study quality assessed via the JBI and QUADAS-2 tools. AI-based models demonstrated robust predictive performance for early sepsis detection (AUROC 0.68–0.99), antibiotic stewardship, and resistance prediction. Notable tools, such as InSight and KI.SEP, leveraged multimodal clinical and biomarker data to provide actionable, real-time support and facilitate timely interventions. AI-driven platforms showed potential to reduce inappropriate antibiotic use and nephrotoxicity while optimizing outcomes. However, most models are limited by single-center data, variable interpretability, and insufficient real-world validation. Key challenges remain regarding data integration, algorithmic bias, and ethical implementation. Future research should prioritize multicenter validation, seamless integration with clinical workflows, and robust ethical frameworks to ensure safe, equitable, and effective adoption. AI and ML hold significant promise to transform sepsis management, but their clinical impact depends on transparent, validated, and user-centered deployment. Full article

Offsite construction (OSC) offers a promising alternative for accelerating refurbishment projects across Italy and Europe. However, its adoption remains limited due to technical, regulatory, and cultural barriers. This study, conducted as part of the OFFICIO project, maps the current European OSC landscape, with a focus on wood and light-steel technologies for sustainable building refurbishment. Combining a literature review, analysis of funded projects, and market data for 541 OSC products, the study develops tailored KPIs to assess these products’ technical maturity, prefabrication level, and environmental integration. The results reveal that wood-based OSC, although less widespread, is more mature and centered on the use of multi-layer panels, while steel-based systems, though more prevalent, remain largely tied to semi-offsite construction, indicating untapped development potential. Research efforts, especially concentrated in Mediterranean regions, focus on technological integration of renewable energy systems. A significant literature gap was identified in information concerning panel-to-wall connection, critical for renovation, limiting OSC’s adaptability to regeneration of existing buildings. The findings highlight the need for cross-sector collaboration, legislative clarity, and better alignment of public procurement standards with OSC characteristics. Addressing these issues is essential to bridge the gap between research prototypes and industrial adoption and accelerate the sustainable transformation of Europe’s construction sector to help meet climate neutrality targets. Full article

This comprehensive review maps the fast-evolving landscape in which artificial intelligence (AI) and deep-learning (DL) techniques converge with the Internet of Things (IoT) to manage energy, comfort, and sustainability across smart environments. A PRISMA-guided search of four databases retrieved 1358 records; after applying inclusion criteria, 143 peer-reviewed studies published between January 2019 and April 2025 were analyzed. This review shows that AI-driven controllers—especially deep-reinforcement-learning agents—deliver median energy savings of 18–35% for HVAC and other major loads, consistently outperforming rule-based and model-predictive baselines. The evidence further reveals a rapid diversification of methods: graph-neural-network models now capture spatial interdependencies in dense sensor grids, federated-learning pilots address data-privacy constraints, and early integrations of large language models hint at natural-language analytics and control interfaces for heterogeneous IoT devices. Yet large-scale deployment remains hindered by fragmented and proprietary datasets, unresolved privacy and cybersecurity risks associated with continuous IoT telemetry, the growing carbon and compute footprints of ever-larger models, and poor interoperability among legacy equipment and modern edge nodes. The authors of researches therefore converges on several priorities: open, high-fidelity benchmarks that marry multivariate IoT sensor data with standardized metadata and occupant feedback; energy-aware, edge-optimized architectures that lower latency and power draw; privacy-centric learning frameworks that satisfy tightening regulations; hybrid physics-informed and explainable models that shorten commissioning time; and digital-twin platforms enriched by language-model reasoning to translate raw telemetry into actionable insights for facility managers and end users. Addressing these gaps will be pivotal to transforming isolated pilots into ubiquitous, trustworthy, and human-centered IoT ecosystems capable of delivering measurable gains in efficiency, resilience, and occupant wellbeing at scale. Full article

Japan’s 8.5 million vacant homes (Akiyas) represent a paradox of scarcity amid surplus: while rural depopulation leaves properties abandoned, housing shortages and bureaucratic inefficiencies hinder their reuse. This study proposes AKI2ALL, an AI-blockchain framework designed to automate the circular repurposing of Akiyas into ten high-value community assets—guesthouses, co-working spaces, pop-up retail and logistics hubs, urban farming hubs, disaster relief housing, parking lots, elderly daycare centers, exhibition spaces, places for food and beverages, and company offices—through smart contracts and data-driven workflows. By integrating circular economy principles with decentralized technology, AKI2ALL streamlines property transitions, tax validation, and administrative processes, reducing operational costs while preserving embodied carbon in existing structures. Municipalities list properties, owners select uses, and AI optimizes assignments based on real-time demand. This work bridges gaps in digital construction governance, proving that automating trust and accountability can transform systemic inefficiencies into opportunities for community-led, low-carbon regeneration, highlighting its potential as a scalable model for global vacant property reuse. Full article

This strategic document outlines Bulgaria’s roadmap for modernizing its cartographic sector from 2025 to 2035, addressing the outdated geospatial infrastructure, lack of standardized digital practices, lack of coordinated digital infrastructure, outdated standards, and fragmented data management systems. The strategy was developed in accordance with the national methodology for strategic planning and through preliminary consultations with key stakeholders, including research institutions, business organizations, and public institutions. It aims to build a human-centered, data-driven geospatial framework aligned with global standards such as ISO 19100 and the EU INSPIRE Directive. Core components include: (1) modernization of the national geodetic system, (2) adoption of remote sensing and AI technologies, (3) development of interactive, web-based geospatial platforms, and (4) implementation of quality assurance and certification standards. A SWOT analysis highlights key strengths—such as existing institutional expertise—and critical challenges, including outdated legislation and insufficient coordination. The strategy emphasizes the need for innovation, regulatory reform, inter-institutional collaboration, and sustained investment. It ultimately positions Bulgarian cartography as a strategic contributor to national sustainable development and digital transformation. Full article

With the continuous expansion of data center scales worldwide, the problem of energy consumption has become increasingly prominent. To address the multi-parameter control challenge in environmental temperature regulation for large data center computer rooms, achieve precise control of hot-aisle temperatures in data centers, and reduce energy waste, this paper designs a multi-parameter model-free adaptive control (MMFAC) algorithm suitable for computer room environmental temperatures. The algorithm integrates the model-free adaptive control (MFAC) algorithm with a weight matrix to perform scaling transformations. Considering the large parameter space of the MFAC controller and the dynamic complexity of data center temperature control systems, compact-form dynamic linearization (CFDL) technology and optimization mathematical methods are used to simplify the parameter identification of the pseudo-Jacobian matrices and the calculation of control quantities for the regulation devices. Simulation experiments based on measured data from a data center show that the proposed algorithm can calculate control quantities for equipment such as air conditioners according to real-time environmental parameter measurements and drive each device based on these control quantities. Meanwhile, the algorithm can reduce errors in key parameters by adjusting the weight matrix. Comparative tests with other control algorithms show that the algorithm has faster response in temperature control and smaller control errors, verifying the effectiveness and application prospects of the algorithm in data center temperature control. Full article

Parkinson’s disease (PD) is a progressive neurological disorder with motor and non-motor symptoms that are inadequately addressed by current pharmacological and surgical therapies. Brain–computer interfaces (BCIs), particularly those based on electroencephalography (eBCIs), provide a promising, non-invasive approach to personalized neurorehabilitation. This narrative review explores the clinical potential of BCIs in PD, discussing signal acquisition, processing, and control paradigms. eBCIs are well-suited for PD due to their portability, safety, and real-time feedback capabilities. Emerging neurophysiological biomarkers—such as beta-band synchrony, phase–amplitude coupling, and altered alpha-band activity—may support adaptive therapies, including adaptive deep brain stimulation (aDBS), as well as motor and cognitive interventions. BCIs may also aid in diagnosis and personalized treatment by detecting these cortical and subcortical patterns associated with motor and cognitive dysfunction in PD. A structured search identified 11 studies involving 64 patients with PD who used BCIs for aDBS, neurofeedback, and cognitive rehabilitation, showing improvements in motor function, cognition, and engagement. Clinical translation requires attention to electrode design and user-centered interfaces. Ethical issues, including data privacy and equitable access, remain critical challenges. As wearable technologies and artificial intelligence evolve, BCIs could shift PD care from intermittent interventions to continuous, brain-responsive therapy, potentially improving patients’ quality of life and autonomy. This review highlights BCIs as a transformative tool in PD management, although more robust clinical evidence is needed. Full article

The integration of Lesson Study (LS) and Didactic Suitability Criteria (DSC) presents an innovative framework for enhancing mathematics teacher training in higher education. This study examines how LS-DSC fosters instructional refinement, professional growth, and pedagogical transformation among in-service teachers. Using a quasi-experimental mixed-methods approach, the study analyzed data from 520 mathematics educators participating in a six-month training program incorporating collaborative lesson planning, structured pedagogical assessment, and reflective teaching practices. Findings indicate significant improvements in instructional design, mathematical discourse facilitation, and adaptive teaching strategies, with post-training evaluations demonstrating a strong positive correlation (r = 0.78) between initial competency levels and learning gains. Participants reported increased confidence in implementing student-centered methodologies and sustained engagement in peer collaboration beyond the training period. The results align with prior research emphasizing the effectiveness of lesson study models and structured evaluation frameworks in teacher professionalization. This study contributes to higher education policy and practice by advocating for the institutional adoption of LS-DSC methodologies to promote evidence-based professional development. Future research should explore the long-term scalability of LS-DSC in diverse educational contexts and its impact on student learning outcomes. Full article

Henri Lefebvre’s “right to the city” has rarely been examined through an intersectional feminist lens, leaving unnoticed the uneven burdens that urban design and policy place on women. This article bridges that gap by combining constitutional analysis, survey data (n = 736), in-depth interviews, and participatory observation to assess how Quito’s public spaces affect women’s safety and mobility. Quantitative results show that 81% of respondents endured sexual or offensive remarks, 69.8% endured obscene gestures, and 38% endured severe harassment in the month before the survey; 43% of these incidents occurred only days or weeks beforehand, underscoring their routine nature. Qualitative narratives reveal behavioral adaptations—altered routes, self-policing dress codes, and distrust of authorities—and identify poorly lit corridors and weak institutional presence as spatial amplifiers of violence. Analysis of Quito’s “Safe City” program exposes a gulf between its ambitious rhetoric and its narrow, transport-centered implementation. We conclude that constitutional guarantees of participation, appropriation, and urban life will remain aspirational until urban planning mainstreams gender-sensitive design, secures intersectoral resources, and embeds women’s substantive participation throughout policy cycles. A feminist reimagining of Quito’s public realm is therefore indispensable to transform the right to the city from legal principle into lived reality. Full article

Currently, exploring digital immersive experiences is a new trend in the innovation and development of cultural tourism. This study addresses the growing demand for digital immersion in cultural tourism by examining the integration of spatial narrative and digitally gamified architectural scenarios. This study synthesizes an optimized framework for narrative design in digitally gamified architectural scenarios, integrating spatial narrative theory and feedback-informed design. The proposed model comprises four key components: (1) developing spatial narrative design methods for such scenarios; (2) constructing a spatial language system for spatial narratives using linguistic principles to organize narrative expression; (3) building a preliminary digitally gamified scenario based on the “Wuhu Jiaoji Temple Renovation Project” after architectural and environmental enhancements; and (4) optimization through thermal feedback experiments—collecting visitor trajectory heatmaps, eye-tracking heatmaps, and oculometric data. The results show that the optimized design, validated in the original game Dreams of Jiaoji, effectively enhanced spatial narrative execution by refining both on-site and in-game architectural scenarios. Post-optimization visitor feedback confirmed the validity of the proposed optimization strategies and principles, providing theoretical and practical references for innovative digital cultural tourism models and architectural design advancements. In the context of site-specific architectural conservation, this approach achieves two key objectives: the generalized interpretation of architectural cultural resources and their visual representation through gamified interactions. This paradigm not only enhances public engagement through enabling a multidimensional understanding of historical building cultures but also accelerates the protective reuse of heritage sites, allowing heritage value to be maximized through contemporary reinterpretation. The interdisciplinary methodology promotes sustainable development in the digital transformation of cultural tourism, fostering user-centered experiences and contributing to rural revitalization. Ultimately, this study highlights the potential use of digitally gamified architectural scenarios as transformative tools for heritage preservation, cultural dissemination, and rural community revitalization. Full article

Accurate forecasting of electricity production is crucial for the stability of the entire energy sector. However, predicting future renewable energy production and its value is difficult due to the complex processes that affect production using renewable energy sources. In this article, we examine the performance of basic deep learning models for electricity forecasting. We designed deep learning models, including recursive neural networks (RNNs), which are mainly based on long short-term memory (LSTM) networks; gated recurrent units (GRUs), convolutional neural networks (CNNs), temporal fusion transforms (TFTs), and combined architectures. In order to achieve this goal, we have created our benchmarks and used tools that automatically select network architectures and parameters. Data were obtained as part of the NCBR grant (the National Center for Research and Development, Poland). These data contain daily records of all the recorded parameters from individual solar and wind farms over the past three years. The experimental results indicate that the LSTM models significantly outperformed the other models in terms of forecasting. In this paper, multilayer deep neural network (DNN) architectures are described, and the results are provided for all the methods. This publication is based on the results obtained within the framework of the research and development project “POIR.01.01.01-00-0506/21”, realized in the years 2022–2023. The project was co-financed by the European Union under the Smart Growth Operational Programme 2014–2020. Full article

Digital transformation is reshaping the healthcare field by streamlining diagnostic workflows and improving disease management. Within this transformation, Digital Twins (DTs), which are virtual representations of physical systems continuously updated by real-world data, stand out for their ability to capture the complexity of human physiology and behavior. When coupled with Artificial Intelligence (AI), DTs enable data-driven experimentation, precise diagnostic support, and predictive modeling without posing direct risks to patients. However, their integration into healthcare requires careful consideration of ethical, regulatory, and safety constraints in light of the sensitivity and nonlinear nature of human data. In this review, we examine recent progress in DTs over the past seven years and explore broader trends in AI-augmented DTs, focusing particularly on movement rehabilitation. Our goal is to provide a comprehensive understanding of how DTs bolstered by AI can transform healthcare delivery, medical research, and personalized care. We discuss implementation challenges such as data privacy, clinical validation, and scalability along with opportunities for more efficient, safe, and patient-centered healthcare systems. By addressing these issues, this review highlights key insights and directions for future research to guide the proactive and ethical adoption of DTs in healthcare. Full article

Small and medium-sized enterprises (SMEs) in the manufacturing sector often struggle to make effective use of production data due to fragmented systems and limited digital infrastructure. This paper presents a case study of implementing an AI-enhanced digital twin in a custom sportswear manufacturing SME developed under the AI and Robotics Estonia (AIRE) initiative. The solution integrates real-time production data collection using the Digital Manufacturing Support Application (DIMUSA); data processing and control; clustering-based data analysis; and virtual simulation for evaluating improvement scenarios. The framework was applied in a live production environment to analyze workstation-level performance, identify recurring bottlenecks, and provide interpretable visual insights for decision-makers. K-means clustering and DBSCAN were used to group operational states and detect process anomalies, while simulation was employed to model production flow and assess potential interventions. The results demonstrate how even a lightweight AI-driven system can support human-centered decision-making, improve process transparency, and serve as a scalable foundation for Industry 5.0-aligned digital transformation in SMEs. Full article

Background/Objectives: The combination of venetoclax (VEN) and hypomethylating agents (HMA), such as azacitidine (AZA) or decitabine (DEC), has transformed the treatment landscape for acute myeloid leukemia (AML) in patients unfit for intensive chemotherapy. However, optimal management of neutropenia and the impact of post-remission treatment interruptions (washouts) remain unclear. This study aimed to evaluate the safety and efficacy of post-remission washouts and their effect on clinical outcomes. Methods: We conducted a retrospective single-center study of 44 AML patients treated with HMA/VEN between 2020 and 2021. Clinical, molecular, and treatment-related data were collected, including treatment duration, post-remission washout duration, response rates, disease-free survival (DFS), and overall survival (OS). Statistical analyses included Fisher’s exact test and univariate and multivariate Cox models. Results: Overall, 61% of patients responded to therapy, with significantly higher response rates among those potentially eligible for the VIALE-A trial (86% vs. 39%, p = 0.002). Neither treatment duration nor post-remission washout length was associated with DFS or OS. DFS was significantly longer in patients treated with AZA compared to DEC (p = 0.006). Median OS was 7.7 months, with longer OS observed in patients who did not meet VIALE-A trial eligibility criteria (p = 0.021). Achieving complete remission (CR) was associated with improved OS (14.5 months). Conclusions: Post-remission treatment interruptions (washouts) did not negatively impact DFS or OS, suggesting they may be a safe strategy to support hematologic recovery. However, the choice of HMA appears to influence response duration, with AZA outperforming DEC in maintaining disease control. Full article

The global trend toward Industry 4.0 has intensified the demand for intelligent, adaptive, and energy-efficient manufacturing systems. Machine learning (ML) has emerged as a crucial enabler of this transformation, particularly in high-mix, high-precision environments. This review examines the integration of machine learning techniques, such as convolutional neural networks (CNNs), reinforcement learning (RL), and federated learning (FL), within Taiwan’s advanced manufacturing sectors, including semiconductor fabrication, smart assembly, and industrial energy optimization. The present study draws on patent data and industrial case studies from leading firms, such as TSMC, Foxconn, and Delta Electronics, to trace the evolution from classical optimization to hybrid, data-driven frameworks. A critical analysis of key challenges is provided, including data heterogeneity, limited model interpretability, and integration with legacy systems. A comprehensive framework is proposed to address these issues, incorporating data-centric learning, explainable artificial intelligence (XAI), and cyber–physical architectures. These components align with industrial standards, including the Reference Architecture Model Industrie 4.0 (RAMI 4.0) and the Industrial Internet Reference Architecture (IIRA). The paper concludes by outlining prospective research directions, with a focus on cross-factory learning, causal inference, and scalable industrial AI deployment. This work provides an in-depth examination of the potential of machine learning to transform manufacturing into a more transparent, resilient, and responsive ecosystem. Additionally, this review highlights Taiwan’s distinctive position in the global high-tech manufacturing landscape and provides an in-depth analysis of patent trends from 2015 to 2025. Notably, this study adopts a patent-centered perspective to capture practical innovation trends and technological maturity specific to Taiwan’s globally competitive high-tech sector. Full article