Search Results (57)

Background and Objectives: Cyanoacrylate (CA) tissue adhesives have gained increasing attention as alternatives to sutures in oral surgery and periodontology. The objective of this scoping review is to assess their clinical applications and effectiveness in wound closure and postoperative management. Materials and Methods: The review was conducted following the JBI methodology and PRISMA-ScR guidelines. A comprehensive search was performed in PubMed, Scopus, and Web of Science to identify randomized controlled trials published between 2015 and 2025 evaluating the use of CAs in oral surgery and periodontal procedures. Results: A total of 19 studies were included. Cyanoacrylate adhesives demonstrated comparable or superior outcomes to other wound healing strategies in terms of operative time, postoperative pain reduction, and early wound healing. Their use was particularly beneficial in free gingival grafts and palatal donor site management. However, the findings across studies were not always consistent, and some trials did not report statistically significant differences. The use of long-chain CA formulations is associated with minimal toxicological risk, though these adhesives demonstrate intrinsic hemostatic and antimicrobial effects. Conclusions: Cyanoacrylate tissue adhesives represent a valid alternative to sutures in several dental surgical contexts, especially in procedures involving mucogingival grafts. Further high-quality clinical studies are needed to clarify their long-term outcomes and broaden their indications in dentistry. Full article

Cyanoacrylate-based adhesives have gained increasing attention in dentistry for their rapid polymerization, biocompatibility, and antimicrobial activity. This review analyzes the clinical use of cyanoacrylate adhesives—particularly the Glubran II formulation—in dental procedures, including wound closure, tissue management, and bleeding control. A comprehensive literature search was conducted across PubMed, Scopus, and Web of Science databases for studies published between 2000 and 2024, using specific inclusion criteria (clinical and in vitro studies focusing on dental applications of cyanoacrylates) and exclusion criteria (non-dental uses, insufficient data). The findings indicate that compared to traditional sutures, cyanoacrylates, especially n-butyl and octyl derivatives, significantly reduce operative time, postoperative pain, and infection rates. However, differences among formulations—such as degradation rate and cytotoxicity—require further exploration. Glubran II, in particular, shows promising results in hemostasis and wound stability. This review highlights the potential of cyanoacrylate adhesives as effective, minimally invasive alternatives in dental surgery and underlines the need for standardized protocols and long-term comparative studies. Full article

Ultrasonic tests are widely used, both in laboratory and industrial settings, to assess the quality of joints, mainly welded joints. Studies are being carried out on the possibility of ultrasonic evaluation of adhesive joints. This study was conducted using signal analysis in the time and frequency domains. The ultrasonic probes used in the tests were selected on the basis of the properties of the test elements. For example, when testing welded joints, ultrasonic probes with a water delay line bounded by a thin diaphragm were used. Since adhesives have different acoustic properties, it is necessary to evaluate the capabilities of different ultrasonic probes to test adhesive joints. Tests were conducted for two different adhesives (cyanoacrylate and structural) and eight ultrasonic probes with a frequency range of 1.660 to 13.70 MHz. In the literature, no studies have analyzed the use of ultrasonic probes at such different frequencies. Frequency has the greatest effect on the attenuation of ultrasonic waves and the ultrasonic wavelength, and it was noted that the adhesive could cause a 25 percent change in the maximum frequency of the ultrasonic pulse. It was also found that it is necessary to make reference samples before ultrasonic testing of adhesive joints, since specific frequencies can produce erroneous signals for the selected adhesives. Full article

The hydrolytic stability of thin poly(ethyl 2-cyanoacrylate), PECA, adhesive films on grit-blasted mild steel substrates was investigated using electrochemical impedance spectroscopy (EIS). Using this novel approach for such adhesive films, the effects of two additives, salicylic acid (SA) and phthalic anhydride (PA), were studied, specifically measuring their influence on polymer film/surface impedance and capacitance changes over a period of 14 days. Results indicate that SA decreased the polymer film hydrolytic stability rapidly, resulting in a substantial drop in impedance modulus from ~10 kΩcm² to ~10 Ωcm² at 100 Hz due to electrolyte ingress, whilst the PA-containing film modulus also diminished from ~4 MΩcm² to ~1 kΩcm² at 100 Hz. Furthermore, the capacitance values of the SA-containing films rose (up to ~100 µFcm⁻²), demonstrating the onset of a charge transfer (corrosion) process within the first 12 h exposure to a saline electrolyte. In contrast, the PA-containing film’s transition from a film-dominated capacitance (~0.01 µFcm⁻²) to a larger double-layer capacitance took (~1 µFcm⁻²) took several days and was accounted for by differences in the additive’s chemistry, demonstrating the ability of EIS to detect changes in both bulk film (e.g., moisture ingress and bond scission) and metal-film interfacial processes (e.g., onset of corrosion) in real time. Comparison was also made with a standard industry combined tensile test/hydrolytic accelerated ageing regime. Unlike, EIS this did not, however, give useful time-dependent information, although after 6 weeks a decrease in bond strength occurred in the order PA-containing film < PECA< SA-containing film in agreement with the EIS results, thus demonstrating the effectiveness of EIS for monitoring the degradation of such thin film adhesives. Full article

Background and Objectives: To report the outcomes of cyanoacrylate tissue adhesive (CTA) in patients with corneal perforations and thinning. Materials and Methods: A retrospective interventional study of 83 eyes treated with CTA for corneal thinning or perforation at a single institution between 2010 and 2020. Primary endpoints leading to CTA failure, visual acuity, and surgical outcomes were evaluated. Results: At presentation, 55 (66%) had frank perforations and 28 (34%) had thinning or desmetocele. Univariate analysis showed that only multiple CTA applications were associated with CTA failure (p = 0.047). Multivariate analysis did not show any statistically significant variables associated with CTA failure. No variables were associated with the need for future surgery at 30 days or any further point. Older patients (p = 0.005), use of topical steroids before gluing (p = 0.03), corneal thinning (vs. perforation) (p = 0.02), location of pathology (p = 0.048), and multiple CTA applications (p = 0.046) were associated with worse visual outcomes in univariate analysis. Multivariate logistic regression analysis showed that older age (OR 1.05) and use of topical steroids before gluing (OR 3.84) showed higher odds, and systemic immunosuppression (OR 0.08) and single (versus multiple) CTA application (OR 0.11) showed lower odds of worse visual acuity (BCVA ≥ 20/200). The presence of an anterior chamber prior to gluing was associated with spontaneous dislocation of CTA (p = 0.015). Spontaneous dislocation versus manual removal of glue was not associated with final visual acuity (p = 0.7), nor was duration of glue on the cornea (p = 0.2). Conclusions: CTA remains a mainstay of management in patients with corneal thinning or perforation. Only multiple CTA applications were associated with CTA failure, and duration of glue on the cornea was not associated with final visual acuity. Full article

This paper focuses on the evaluation of the surface pretreatment of glass specimens and its effect on the strength of bonded joints. The experimental portion of this study includes the testing of three types of surface treatments (degreasing, blasting and etching) and the use of three types of adhesives (two-component epoxy, instant cyanoacrylate and two-component acrylate). Surface roughness measurements and bond strength testing using the pull-off test and shear tests were performed on the samples. The results showed that surface etching in conjunction with the Auratech AR 708 acrylic adhesive provided the highest bond strength. These findings contribute to the development of more reliable and stronger bonded joints for industrial applications. Scientific knowledge lies in determining the effect of appropriate glass surface treatment on adhesive adhesion under load with respect to joint aging due to environmental effects (UV, temperature, humidity) for transparent adhesives. This study provides an assessment of the effect of surface cleanliness on adhesion to glass. Full article

Superhydrophobic surfaces, known for their exceptional water-repellent properties with contact angles exceeding 150°, are highly regarded for their effectiveness in applications including self-cleaning, antifouling, and ice prevention. However, the structural fragility and weak durability of conventional coating limit their long-term use. In this research, a new approach is proposed for the fabrication of long-lasting superhydrophobic surfaces using ethyl cyanoacrylate (ECA) and a primer. The application of the primer creates a curing rate disparity between the surface and bulk of the ECA layer, resulting in the formation of wrinkled microstructures essential for achieving superhydrophobicity. The fabricated surfaces were further functionalized through plasma treatment and hydrophobic silane (OTS) coating, enhancing their water-repellent properties. This straightforward and scalable method produced surfaces with excellent superhydrophobicity and robust adhesion to substrates. Durability tests, including roller abrasion and microscratch evaluations, indicated that the wrinkled structure and strong substrate adhesion contributed to sustained performance even under mechanical stress. Additionally, mechanical properties were assessed through nanoindentation, demonstrating enhanced resistance to physical damage compared to conventional superhydrophobic coatings. This study highlights the potential of ECA-based superhydrophobic surfaces for applications requiring durability and mechanical stability, such as architectural coatings, automotive exteriors, and medical devices. The approach offers a promising solution to the limitations of existing superhydrophobic technologies and opens new avenues for further research into wear-resistant and environmentally resilient coatings. Full article

Cyanoacrylates, known for their rapid polymerization and strong bonding capabilities, are widely used in industrial and medical applications. This study investigates the impacts of different process atmospheres with varying water and oxygen contents—air, argon, and argon/silane—on the curing and adhesion mechanisms of cyanoacrylate adhesives on oxidized copper substrates. Raman spectroscopy indicated that the curing process in argon and argon/silane atmospheres was slower compared to ambient air, likely due to the reduced moisture content of the atmosphere. However, the degree of curing and the inter- and intramolecular interactions within the adhesive volume showed no significant differences across atmospheres. X-ray photoelectron spectroscopy (XPS) and infrared reflection absorption spectroscopy (IRRAS) revealed that strong ionic interactions between cyanoacrylate and the copper surface oxide were absent in the low-moisture argon atmosphere. The introduction of silane resulted in the formation of silicon oxides and other silane-derived compounds, which probably contributed to the formation of these ionic interactions, similar to those observed in air. This study highlights the critical influence of the surrounding atmosphere on the adhesive properties of cyanoacrylates, with implications for optimizing bonding processes in various environments. Full article

Background: This study aims to investigate the degree of penetration, permanence of occlusion, and vascular changes induced by a newly modified mixture of n-butyl cyanoacrylate (Glubran 2^®), ethanol, and Lipidol^® (GEL) in the endovascular treatment of experimental aneurysms induced in swine. Methods: Bilateral pouch aneurysms were created in the wall of the internal carotid artery in eighteen pigs. The sixteen aneurysms were treated with a new mixture of GEL with different component proportions. Angiograms were obtained at the time of treatment and at 1, 4, and 16 weeks after treatment. According to the scheduled experimental design, subjects were sacrificed at the time of treatment and 7, 30, and 90 days after the embolization of experimentally induced aneurysms. The internal carotid artery and aneurysms were removed en bloc and sampled for histopathologic study. Results: The mixture induced complete and stable occlusion without recanalization in all experimentally induced aneurysms throughout the study period. Histopathological studies showed focal angionecrosis and acute inflammatory reactions from 7 dpi, followed by chronic inflammation and vessel wall thickening. Conclusions: The GEL mixture may be useful in future clinical applications for the embolization of arteriovenous malformations, the control of acute bleeding, and the isolation of aneurysms due to its very short polymerization time and minimal adhesion to the microcatheter. Full article

Objectives: There are no studies related to the use of PRF associated with cyanoacrylates in fresh post-extraction sockets. Thus, the aim of this study was to assess the effect of ethyl-cyanoacrylate combined with PRF in fresh sockets of rabbits subjected to anticoagulant therapy. Methods: Twelve adults rabbits were selected and premedicated with heparin 1 week before surgery to induce and simulate anticoagulant therapy. Upper and lower first premolars on the right side were extracted and then were divided into four groups of three animals each, with the groups distributed according to the type of intervention in the sockets (n = 6): (1) clot and suture (control); (2) PRF and suture; (3) clot and ethyl-cyanoacrylate; (4) PRF and ethyl-cyanoacrylate. At 12 weeks, the animals were sacrificed and the sockets were analyzed histologically and quantitatively. Total bone area, inflammation infiltrate, and adhesive remnants were assessed. Results: No remnants of adhesive were found in the samples. Groups 1 and 2 showed the highest bone area (G1 = 37.87% ± 17.86; G2 = 30.31 ± 9.36) with significant differences to those treated with ethyl-cyanoacrylate adhesive (G3 = 26.6% ± 11.82; G4 = 24.29% ± 6.25). Conclusions: The groups that used ethyl-cyanoacrylate as a closure method in sockets exhibited less bone area than the groups that used sutures. Both groups that used PRF as therapy did not show a significant improvement in bone healing at 12 weeks compared with the clot groups. Full article

In recent times, the value of data has grown. This tendency is also observeable in the construction industry, where research and digitalisation are increasingly oriented towards the collection, processing and analysis of different types of data. In addition to planning data, measurement data is a main focus. fibre optic measurements offer a highly precise and comprehensive approach to data collection. It is, however, important to note that this technology is still in research regarding concrete structures. This paper presents two methods of integrating filigree sensors into concrete structures. The first approach entails wrapping a fibre around a tendon duct and analysing the installation and associated measurements. The second method involves bonding polyimide and acrylate-coated fibres with 2K epoxy and cyanoacrylate in the grooves of rebars, exposing them to chemical environments. The resulting measurement data is evaluated qualitatively and quantitatively to ascertain its resilience to environmental factors. These developed criteria are consolidated in a decision matrix. Fibre-adhesive combinations necessitate protection from chemical and mechanical influences. The limitations of the solutions are pointed out, and alternative options are proposed. Full article

Cyanoacrylate-based adhesives are widely used in wound closure, providing good cosmetic results and little discomfort. However, reports in the literature are found about negative effects that include the release of cytotoxic chemicals during biodegradation. In this study, we sought to evaluate and compare the effectiveness of four cyanoacrylate-based adhesives on the closure of skin incisions in Rattus norvegicus. The animals (n = 140) were divided into five groups of 28 animals each according to the wound closure technique: G1 and G2 (n-2-ethyl-cyanoacrylate); G3 (n-2-butyl-cyanoacrylate); G4 (n-2-octyl-cyanoacrylate); and G5 (5 nylon stitches). Midline incisions measuring 5.0 cm in length were created and closed using the different materials evaluated, and on D3, D7, D14, and D21, tensiometric and histopathological analyses were performed. Shorter wound closure and adhesion times were observed in G4 animals. At D3 and D7, G5 presented greater tensiometric resistance in the animals of G5, with a decrease in D14 and D21 compared to the other groups. On the other hand, the wounds of G3 and G4 were more resistant in D14 and D21, reaching maximum resistance values. Polymorphonuclear and mononuclear cells are more prevalent and more granulation tissue was observed in G5. The deposition of type III collagen was more evident in G5, whilst there was no difference in the amount of type I collagen in any of the groups treated with cyanoacrylate adhesives. Larger areas stained positive for VEGF-α in G2 and smaller areas in G4, with peaks at D7 and D14. In general, cyanoacrylate adhesives cause less intense inflammatory reactions, resulting in shorter healing times when compared to nylon sutures. Full article

Silica nanoparticles are innovative solutions of surgical glue that can readily adhere to various tissue-like substrates without the need for time-consuming chemical reactions or ultraviolet irradiation. Herein, 10 nm-sized silica nanoparticle (SiNP₁₀) treatment exhibited maximum adhesion strength in the porcine heart tissue model, which was approximately 7.15 times higher than that of the control group of non-treatment. We assessed the effects of silica nanoparticle treatment on in vivo skin wounds by scoring tissue adhesion and inflammation using histological images. Compared to the commercial cyanoacrylate skin adhesive (Dermabond), suppression of inflammatory cytokine levels in the incision wound skin was observed. We further quantified the expression of angiogenic growth factors and connective tissue formation-related proteins. On day 5 after wound closing treatment, the expression levels of PDGF-BB growth factor were significantly higher in SiNP₁₀ treatment (0.64 ± 0.03) compared to Dermabond (0.07 ± 0.05). This stimulated angiogenesis and connective tissue formation in the skin of the incision wound may be associated with the promoting effects of SiNP₁₀ treatment on wound closure and tissue adhesion. Full article

Natural-based and synthetic tissue adhesives have attracted extensive attention in the last two decades for their ability to stabilize uncontrolled bleeding instances. However; these materials present several drawbacks during use that scientists have tried to minimize in order to optimize their usage. This study comprises the development of a novel wound dressing, combining the excellent properties of polylactic acid (PLA) non-woven textile, as substrate, obtained through electrospinning, and a cyanoacrylate-based (CA) tissue adhesive, for rapid hemostatic action. Thus, the fabrication of electrospun PLA membranes at three different PLA concentrations, the design and manufacturing of the support system and the production of surgical patches were carried out. SEM and FT-IR methods were employed for analyzing the morphology as well as the indicative markers for the shelf life evolution of the obtained patches. PLA fibers with well-defined structures and a mean diameter varying between 4.6 and 7.24 μm were obtained with the increase of the concentration of the PLA solutions. In vivo tests on a rat model as well as peeling tests for good patch adhesion on liver fragments harvested from the test animals, with a limit for the strength of the liver tissue of 1.5 N, were carried out. The devices exhibited excellent adhesion to the parenchymal tissue and a long enough shelf life to be used with success in surgical procedures, also facilitating prompt hemostatic action. Full article

This research investigates the generation and evaluation of various geometric surface textures on PLA components produced via fused filament fabrication (FFF). Textures, including grooves, pyramids, and cylinders, were created at different depth levels on the PLA surfaces. The surface quality of these textures was assessed using a 3D optical system, focusing on area parameters such as Sa and Sz. The wettability of each texture was evaluated through contact angle and sliding angle tests, revealing the ability to modulate contact angles and achieve either hydrophobic or hydrophilic surfaces depending on the texture type. Subsequently, pairs of textured PLA pieces were bonded using a cyanoacrylate adhesive following standardised protocols, and shear tests were conducted to determine the maximum shear stress at bond (τ_max) of each texture. Notably, textured surfaces generally exhibited hydrophobic properties that reduce the adhesion between the adhesive and the piece, leading to reduced maximum shear stress at bond values compared to non-textured surfaces. However, groove textures notably increased τ_max values. The results were analysed to establish correlations between surface quality, wettability, and shear strength. This comprehensive evaluation aims to elucidate the influence of surface texture on the mechanical performance and adhesive properties of FFF-manufactured PLA components. Full article