Search Results (1,726)

This study develops an end-to-end workflow, from laboratory measurements to Eulerian–Eulerian two-phase simulations with SedFoam, to investigate bed erosion in free-surface open-channel flow over a deformable granular bed. Experiments were conducted with a calibrated non-cohesive deposit of epoxy-coated spherical beads under steady, fully turbulent, subcritical conditions. Particle Image Velocimetry provided mean-flow and turbulence data, while a 3D camera workflow supplied bed-elevation fields and time-resolved maps of sediment rearrangement. These datasets were used to constrain a staged numerical strategy in which single-phase hydrodynamics were first reproduced and then extended to live-bed morphodynamics. Validation over a rigid bed showed that the 2006 k–$\omega$ closure, combined with a rough-wall treatment, reproduced the measured mean-velocity profiles and provided acceptable turbulent kinetic energy levels, yielding dynamically consistent near-bed shear conditions. In live-bed conditions, the simulations reproduced the streamwise organization of scour and deposition, predicted cumulative erosion rates of the correct order of magnitude, and captured bedform migration consistent with time-resolved bed reconstructions. The numerical results were compared with repeated experiments while accounting for run-to-run variability and the metrological limits of the 3D camera. This work proposes a transferable experimental–numerical methodology for assessing the predictive capability of live-bed morphodynamic simulations, in which hydraulic characterization, three-dimensional bed monitoring, erosion/deposition metrics, and repeated experiments are combined within a common comparison procedure. Full article

Stealthy sensor deception attacks in process industries are difficult to detect because they often exhibit weak anomalies, strong persistence, and can be obscured by normal process fluctuations. To address these challenges, this study proposes an attack-mechanism-informed Informer (AMI-Informer) detection framework that uses an Informer encoder as the detection backbone and incorporates an attack-mechanism-informed loss constructed from four mechanism-informed features into joint optimization with the data-driven loss. Experiments were conducted on the Tennessee Eastman Process benchmark, with reactor pressure under the min–max attack as the primary scenario, and were further extended to different attacked variables, surge attacks, and an additional Secure Water Treatment (SWaT) benchmark under the LIT101 min–max attack. In the XMEAS7 min–max attack scenario, AMI-Informer achieved an accuracy of 0.9782, a recall of 0.9627, and an F1-score of 0.9579, outperforming Informer, recurrent neural network (RNN), gated recurrent unit (GRU), and long short-term memory (LSTM); the standard Informer achieved a recall of 0.8702 and an F1-score of 0.9188. Across the five attacked-variable scenarios considered in this study, the average number of missed detections was reduced by 69.1% compared with Informer, and the framework also maintained higher recall and F1-score under surge attacks. On the SWaT benchmark, AMI-Informer achieved an F1-score of 0.8313, outperforming Informer, Anomaly Transformer, and cumulative sum (CUSUM). These results indicate that embedding attack evolution patterns into the loss function improves the detection of stealthy sensor deception attacks and enhances model stability in complex attack scenarios. Full article

Background/Objectives: Rare diseases have a substantial impact not only on affected individuals but also on their families, particularly parents who assume primary caregiving roles. Despite increasing attention to rare conditions, parents’ experiences remain fragmented across the literature. This integrative review aimed to synthesise existing evidence on the experiences and multidimensional impact of caring for a child with a rare disease on parents. Methods: An integrative review was conducted following Whittemore and Knafl’s methodology and reported according to PRISMA 2020 guidelines. A systematic search was performed across MEDLINE, CINAHL, PsycINFO, PsycARTICLES, and Scopus from 1 November 2025 to 31 January 2026. Twenty-two studies (qualitative, quantitative, mixed-methods, and reviews) were included. Data were analysed using thematic synthesis. Results: Three interrelated themes were identified: (1) the diagnostic journey, characterised by prolonged uncertainty, fragmented care, and the pivotal role of communication; (2) multidimensional caregiving burden, encompassing emotional, social, economic, and physical impacts, with notable gender differences; and (3) adaptive trajectories, involving dynamic coping processes, parental upskilling, and meaning-making. Across studies, caregiving burden emerged as a cumulative and system-influenced phenomenon, while adaptation was found to coexist with ongoing uncertainty rather than representing a linear resolution. Conclusions: Caring for a child with a rare disease profoundly affects parents across multiple domains. The findings highlight the need for integrated, family-centred care models, improved diagnostic communication, and sustained psychosocial support. Implications for nursing practice: Nurses play a key role in recognising caregiver burden, supporting adaptive processes, and promoting effective communication throughout the diagnostic and care trajectory. Full article

To sustain egg production and gut health in aging flocks, the poultry industry seeks alternative synbiotic feed supplements. This study aimed to optimize Pediococcus acidilactici V202-fermented rice bran (PFR) and evaluate its effects on nutrient digestibility and cecal microbial populations in aged laying hens. In experiment 1, solid-state fermentation conditions (substrate particle size, moisture, and temperature) were optimized for viable lactic acid bacteria (LAB) counts. In experiment 2, in vitro assays were used to assess cecal fermentation kinetics. Subsequently, an in vivo trial involving twenty 80-week-old Hy-Line Brown hens evaluated the impact of PFR supplementation on nutrient digestibility and microbial profiles compared to a control diet. For experiment 1, the optimized fermentation conditions consisted of 40-mesh rice bran, a 30:70 bran-to-water ratio, incubation at 39 °C for 12 h, and drying at 40 °C, which produced the highest viable LAB counts. For experiment 2, PFR enhanced in vitro cumulative cecal gas production. In vivo, compared to the control, PFR supplementation significantly increased the apparent digestibility of dry matter (82.69% vs. 77.03%; p = 0.014), crude protein (82.75% vs. 75.38%; p = 0.016), crude fiber (36.30% vs. 23.10%; p = 0.015), ether extract (86.70% vs. 82.91%; p = 0.016), and gross energy (78.31% vs. 74.99%; p = 0.026). Furthermore, PFR beneficially modulated cecal microbial populations, increasing LAB while reducing Salmonella spp. In conclusion, these findings suggest that optimized PFR could be a promising synbiotic supplement to improve digestive efficiency and support beneficial cecal microbial populations in aged laying hens. Full article

The soil of Siraitia grosvenorii (LHG) farmland often suffers from acidification, compaction, and declining organic matter content. As biochar helps improve soil quality and enhance soil carbon sequestration capacity, an increasing number of studies are utilizing biochar for soil quality improvement. To address the soil degradation problem in LHG farmland and achieve the goals of soil organic carbon (SOC) sequestration and nutrient increase, we conducted a 100-day indoor constant-temperature incubation experiment by adding different proportions of LHG vine biochar. We analyzed the changes in SOC mineralization, different carbon fractions, and soil nutrient content in LHG farmland. The main results showed that, compared with the control group, the cumulative mineralization (CumulMine) of SOC increased by 3% to 51%, and organic carbon content increased by 52.43% to 193.87%. As the LHG vine biochar application rate increased, the metabolic entropy (qCO₂) rose, whereas the microbial entropy (qMBC) showed an opposite trend. Similarly, compared with the control group, the addition of 1.0%, 2.0%, and 4.0% LC increased water-soluble organic carbon by 45.87 mg·kg⁻¹, 67.00 mg·kg⁻¹, and 81.73 mg·kg⁻¹, respectively, and soil nutrients also increased, but microbial biomass carbon (MBC) and readily oxidizable organic carbon (ROC) contents decreased. The main conclusions indicate that adding LHG vine biochar increases SOC content, which is associated with reduced microbial activity. Biochar-derived DOC may serve as a substrate for microbial respiration, thereby contributing to increased CO₂ release and accelerated nutrient release. The application of LHG vine biochar enhanced the carbon sequestration capacity of LHG farmland soil while improving soil nutrient content, with the 4% application rate treatment performing the best. Full article

Background: Breast cancer (BC) survivors frequently experience depression, which is associated with poorer quality of life (QoL), increased healthcare utilization, and worse prognosis. Although traditional Chinese medicine (TCM) is commonly used as an adjunctive therapy among Chinese populations for cancer-related symptom relief and supportive care, population-based evidence remains limited regarding whether integrated Chinese and Western medicine (ICWM) confers measurable benefits over Western medicine (WM) alone in terms of healthcare utilization and survival. Taiwan’s National Health Insurance (NHI) system offers a unique nationwide setting to address this gap because it reimburses patients for both WM and TCM services and captures care from a large number of TCM clinics across Taiwan, allowing evaluation of adjunctive TCM use in routine clinical practice at a scale rarely possible in prior studies. We used emergency department visits, hospitalization, and length of stay as pragmatic proxy indicators of patients’ daily functioning and disease burden. Leveraging a 10-year enrollment window (2004–2013) and up to 17 years of follow-up, we hypothesized that ICWM would be associated with a reduced risk of acute care events and lower healthcare expenditures compared with WM alone. This hypothesis was examined in a large cohort of breast cancer patients treated across nearly 4000 medical facilities nationwide, encompassing the entire Taiwanese population. Methods: A retrospective cohort study was performed to analyze Taiwan’s National Health Insurance Research Database and Cancer Registry. Women newly diagnosed with breast cancer between 2004 and 2013 who subsequently developed depression (≥3 outpatient diagnoses or 1 hospitalization) were followed until death or 31 December 2021. Patients receiving ≥30 cumulative days of TCM after diagnosis were classified as the ICWM group, whereas those receiving <30 days were classified as the WM group. Multivariable Cox proportional hazards models were used to estimate adjusted hazard ratios (aHRs) for all-cause mortality. Healthcare utilization, including emergency department visits, hospitalization, and medical expenditures, was analyzed on a per-person-year basis. Results: A total of 1193 patients were included, with 488 in the WM group and 705 in the ICWM group. Compared with WM users, ICWM users were younger, had lower body mass index, and were more likely to have stage 0–II disease. ICWM was associated with lower total, inpatient, and emergency healthcare expenditures per person-year, as well as fewer emergency visits per person-year, although outpatient and overall visits were higher. In stage-stratified multivariable analyses, ICWM was associated with lower all-cause mortality in both stage 0–II disease (aHR = 0.61, 95% CI: 0.39–0.94) and stage III–IV disease (aHR = 0.38, 95% CI: 0.21–0.67). Kaplan–Meier analyses likewise showed significantly better overall survival in the ICWM group in both early-stage and advanced-stage disease. Conclusions: In this nationwide retrospective cohort of breast cancer patients with depression, adjunctive ICWM was associated with better survival, lower acute care utilization, and lower healthcare expenditures compared with WM alone. However, because quality of life was not directly measured and the study was based on observational data, QoL-related interpretations should be made cautiously, with healthcare utilization outcomes viewed as indirect proxy indicators rather than direct evidence of improved daily QoL. Full article

Chronic obstructive pulmonary disease (COPD), which includes chronic bronchitis and emphysema, is highly prevalent worldwide and is the third leading cause of death. While some aspects of the disease were known since the Enlightenment, Laennec’s work in the 19th century began the process of our current understanding of this disease. In this narrative review, 13 clinicians and scientists with over three centuries of cumulative experience treating and studying COPD give their perspectives on the science underpinning our modern concept of this disease and its management. These include (1) the challenges of coming up with a name for what is a complex syndrome; (2) the evolution of our thinking on the natural history of the disease; (3) the importance of particulate matter inhalation in its pathogenesis; (4) the often-overlooked but important—and often treatable—systemic effects of the disease that contribute to its morbidity and mortality; (5) the changes in our perspective of not just addressing pathologic or physiologic abnormalities but also measuring outcomes, such as breathlessness or health-related quality of life, that are of considerable importance to the patient; (6) the role of pharmacologic therapy in not only providing symptomatic relief by increasing airway caliber but also in disease modification, especially by reducing exacerbation frequency; (7) lung hyperinflation as an essential feature of COPD pathophysiology, driving symptom burden, exercise limitation, and mortality risk; (8) long-term oxygen therapy, despite being demonstrated to prolong survival in a defined set of hypoxemic patients with COPD, still having unanswered questions regarding its application and delivery; and (9) pulmonary rehabilitation, a major component of the non-pharmacologic treatment of COPD patients and prominently situated in clinical guidelines for this disease. While this, by necessity, must be a brief review of a very complex disease, the perspectives of these esteemed clinicians and scientists should be of use to other clinicians in understanding and managing this disease. Full article

Administrative fragmentation, whereby political boundaries are used as analytical extents, can disrupt ecological flows and weaken ecological network planning by creating a mismatch between governance units and ecological processes. However, the pathways through which such fragmentation alters network structure and function remain insufficiently quantified. This study quantifies these effects and identifies the landscape conditions that shape the effectiveness of cross-boundary integration. Using a multi-scale buffer experiment (1–32 km) across 30 representative counties in China, we constructed ecological networks based on Morphological Spatial Pattern Analysis and on the minimum cumulative resistance model. Results show that relaxing administrative boundaries reduced structural distortions and lowered total ecological flow cost, indicating that fragmentation increases connectivity costs. Mechanistically, reducing redundant internal links and forced detours improved network efficiency mainly by shortening corridors and lowering flow costs, whereas mean corridor resistance changed little. This suggests that functional degradation is driven primarily by topological disruption rather than by declines in corridor quality. The benefits of cross-boundary integration were greater in counties with regular shapes, high grassland cover, humid climates, and rugged terrain, but weaker under strong human pressure and warmer temperatures. Improvements leveled off beyond 32 km, suggesting a 32 km buffer (study-specific) for integration and supporting context-specific strategies for ecological network planning. Full article

The Colonel Blotto game is a classical model of competitive resource allocation, but equilibrium computation becomes difficult in heterogeneous and asymmetric instances. In this research, we study a finite-horizon dynamic reformulation in which players allocate resources sequentially over publicly observed stages, while the payoff depends only on terminal cumulative allocations. The purpose of the reformulation is not to change the primitive objective, but to represent the same terminal-payoff problem as a zero-sum Markov game. We first show that the dynamic formulation admits a pathwise payoff-equivalent Markov representation through telescoping rewards. Under a known finite horizon, costless carryover, and terminal-only payoff evaluation, the dynamic game and the corresponding static Blotto game have the same minimax value at every reachable continuation state. This is a value-equivalence result; it does not imply a one-to-one correspondence between static and dynamic equilibrium strategy sets. The proof is based on terminal-deferral upper and lower bounds for the two players. We also study action-independent geometric termination, for which the discounted telescoping return coincides exactly with the expected stopped terminal payoff, and we provide a probability-controlled mismatch bound for truncated stopping rules. Numerical finite-grid experiments illustrate the value identity and report residual diagnostics. The results clarify when sequential Markov representations preserve the original Blotto objective and when additional primitives, such as carryover depreciation or primitive flow payoffs, require separate analysis. Full article

Programs aimed at reducing the CO₂e footprint associated with the residential building stock should be informed by several key elements, including the expected evolution of the occupied housing stock, projected population dynamics driven by socio-economic and cultural factors, available implementation budgets, and the specific costs of intervention measures. However, in regions characterized by high seismic hazard, the occurrence of a major earthquake may substantially alter the projected outcomes of emission-reduction programs, as seismically vulnerable buildings may experience severe structural damage. This paper presents the results obtained by applying an integrated methodology for assessing the CO₂e footprint associated with residential buildings. The methodology accounts for emissions related to building operation (space heating), energy-renovation interventions, and seismic retrofitting works. While the proposed approach is applicable to other seismically exposed regions, the results presented herein refer specifically to the residential building stock in Romania and its local seismic conditions. The methodology integrates information on the existing building stock, the projected evolution of population and the built environment, energy consumption associated with building operation, changes in the energy fuel mix, construction practices across different historical periods with respect to energy efficiency and seismic protection, and the CO₂e footprint associated with energy renovation and seismic retrofitting. In addition, the analysis explicitly considers the potentially negative effects of a major earthquake, particularly the disruption of greenhouse-gas emission-reduction programs. The assessment is conducted at the building stock level and is based on combining building stock evolution with average, representative CO₂e intensity values for heating, energy renovation, and seismic retrofitting. The results demonstrate that when the sole objective is to reduce the CO₂e footprint associated with space heating, renovation of the energy fuel mix represents the most effective measure. At the same time, the analysis shows that the CO₂e footprint generated by construction works for energy renovation and/or seismic retrofitting represents only a small fraction of the emissions associated with building operation. The occurrence of a major earthquake is likely to jeopardize overall environmental objectives by increasing emissions related to building operation, energy renovation, reactive seismic retrofitting, and replacement of severely damaged buildings. Conversely, systematic preventive seismic retrofitting of the building stock does not lead to an increase in cumulative CO₂e emissions over the program implementation period. Full article

Short-rotation sugar beet (Beta vulgaris L.) cultivation in the Western Forest-Steppe of Ukraine is often accompanied by increased phytopathogenic pressure and impaired rhizosphere functioning, creating a need for biological tools to stabilize the plant–soil system. This study evaluated the effects of arbuscular mycorrhiza and an antagonistic microbial consortium on pathogen pressure, rhizosphere activity, yield, and technological quality of sugar beet under different crop rotations. Field experiments were conducted in 2023–2025 using a three-factor design that included rotation, mycorrhizal inoculation, and microbial inoculation. The highest phytopathogenic pressure was recorded in the maize–soybean–sugar beet rotation, where the cumulative frequency of dominant pathogens reached 94.0% and the root rot severity index in the control was 28.6%. Arbuscular mycorrhiza reduced disease development by 14.6–16.4%, whereas the antagonistic consortium reduced it by 25.6–27.9% relative to the control. Their combined application was most effective, decreasing root rot severity to 9.6–17.1% and increasing root colonization, available phosphorus, and dehydrogenase activity in the rhizosphere. The highest yield (80.5 t/ha) and sugar content (18.5%) were obtained in the soybean–winter wheat–sugar beet rotation under combined inoculation. AMF can improve phosphorus acquisition and mycorrhiza-induced tolerance, whereas antagonistic fungi can directly suppress soil-borne pathogens through competition, antibiosis, and mycoparasitism, their combined use may provide complementary protection in disease-conducive rotations. Overall, integrating arbuscular mycorrhiza with antagonistic microorganisms is a promising approach for reducing pathogen pressure and improving sugar beet performance in short-rotation systems. Full article

Severe foaming and a significant decrease in desulfurization performance were noted in a novel UDS solvent applied in a natural gas field in western Sichuan, China. The effects of hydrocarbon and ionic impurities on foaming behavior and the purification performance of candidate adsorbents were investigated. An extraction-gas chromatography method was established and validated for determining total hydrocarbons in amine solutions, enabling quantitative evaluation of hydrocarbon contamination. Controlled contamination experiments revealed that hydrocarbons had the strongest effect on foaming, while sulfate and chloride strongly promoted foam formation; organic acid anions showed only minor effects. Fixed-bed screening identified A-98FM anion-exchange resin as the most effective for anionic impurity removal and AC-02 activated carbon as the best candidate for hydrocarbon purification, with a cumulative adsorption capacity q_0–12 of 14.86 mg/g over 12 h. Pore-structure and thermal-release analyses suggested that conventional pore descriptors alone could not fully explain the dynamic purification performance, while hydrocarbon-related loadings in spent AC-02 occupied accessible pore space and contributed to performance decay. Treatment of a field-aged UDS lean solvent further showed that reductions in target impurities were accompanied by lower foam height and shorter defoaming time. This work provides experimental support for impurity monitoring, foaming-risk identification, and adsorptive purification of UDS desulfurization solvent under flowback-contamination conditions. Full article

In close-range monocular visual measurement and cooperative target pose estimation, conventional planar targets are constrained by viewpoint changes and are prone to perspective distortion. Although spherical targets provide omnidirectional observability, their PnP-based pose estimation may still suffer from large errors under limited fields of view and sparse feature observations. To address this issue, this paper proposes an integrated visual measurement framework covering both high-precision spherical target construction and robust pose estimation. First, a composite marker layout based on adaptively scaled latitude–longitude topology is designed. To suppress cumulative distortion caused by long-sequence multi-view rigid registration, a center-to-pole point-cloud stitching strategy is developed, and multiple observations are fused using geometric-consistency weighting to accurately reconstruct the feature-point coordinate system of the target. Second, a joint optimization method is proposed by combining feature-point reprojection error with a contour center consistency constraint. Specifically, the theoretical contour center is predicted from the analytical projection model of the sphere and constrained to agree with the observed contour center fitted from the image. In addition, an SQPnP-based sequential reinitialization mechanism is introduced to improve robustness under sparse-point observations. Simulation results demonstrate that the proposed method achieves higher accuracy and robustness under continuous pose changes, sparse feature points, and different noise levels, compared with EPnP, EPnP+LM, LM, and SQPnP, while real-image experiments further demonstrate its practical feasibility. Full article

Background: Mitral regurgitation due to Barlow’s disease remains surgically demanding. Despite widespread experience, consensus is lacking on whether the Alfieri repair can serve as a deliberate and durable rather than a rescue strategy in this complex pathology. Methods: We retrospectively analyzed patients undergoing mitral valve repair due to severe mitral regurgitation resulting from Barlow’s disease using either the Alfieri or Neochordae repair techniques. Patients received a uniform semi–rigid annuloplasty ring, while leaflet resection and concomitant coronary or aortic procedures were excluded. Results: Baseline demographics and echocardiography were broadly comparable. Perioperative mortality was 0% in both cohorts, with similarly low rates of major complications. Aortic cross–clamp time was significantly shorter with Alfieri repair (p < 0.001). No relevant postoperative transmitral gradient or systolic anterior motion occurred. At a mean follow–up of 4.2 years, more–than–moderate MR was observed in one patient per group (Alfieri 2.4% vs. Neochordae 1.2%). At 10 years, the cumulative incidence of more–than–moderate mitral regurgitation and redo mitral surgery was similarly low between techniques (p = 0.810 and p = 0.460). Most patients were NYHA class I–II at last follow–up, demonstrating improved functional status. Echocardiography showed left ventricular reverse remodeling without intergroup differences. Conclusions: These data indicate that the Alfieri approach provides durable competence and hemodynamic safety comparable to the Neochordae technique while reducing cross–clamp time, supporting its use as a deliberate strategy rather than a bailout in anatomically suitable valves. Full article

Soil salinization is one of the most severe forms of land degradation in arid and semi-arid regions, posing substantial threats to agroecosystem stability and food security. In this study, saline–alkali soil collected from the Wuding River Basin in Yulin, Shaanxi Province was used to construct a three-factor amendment system comprising superabsorbent polymers (SAP), biochar, and humic acid. A systematic assessment was conducted to elucidate their combined effects on soil water–salt transport and crop growth. Results from one-dimensional constant-head infiltration experiments using indoor soil columns demonstrated that the application of amendments significantly increased cumulative infiltration and improved the uniformity of wetting-front advancement. Specifically, the treatments regulated the redistribution of salts within the soil profile; while surface salinity reduction varied, the leaching efficiency was significantly enhanced in the A2B2C2 treatment. Soil bulk density (BD) showed dynamic fluctuations during the growth cycle, peaking at 1.628 cm⁻³ during the branching stage, while high-rate biochar (A3) reduced BD by up to 13.64% compared to the control by the initial flowering stage. Fitting results based on the Philip and Kostiakov models further indicated that the combined amendment strategy—particularly the A2B2C2 treatment (30 kg/ha SAP, 15,000 kg/ha biochar, and 600 kg/ha humic acid)—markedly enhanced both the initial infiltration rate and the steady infiltration capacity. Field experiments corroborated the indoor findings: plant height and dry biomass of Melilotus officinalis (L.)Lam. were significantly higher under amendment treatments than in the control, driven by improved water availability, mitigated salt stress, and enhanced soil structure. Single-factor and multi-factor interaction analyses revealed that SAP exerted pronounced effects during early growth stages, whereas biochar and humic acid contributed more substantially during the middle to late stages through sustained regulatory functions. Collectively, the results demonstrate that the combined application of SAP, biochar, and humic acid improves the water–salt regime of saline–alkali soils through a coupled “water–salt–structure–plant” mechanism, ultimately enhancing crop productivity. This study provides both theoretical insights and practical guidance for the amelioration of saline–alkali soils. Full article