Search Results (91)

Background/Objectives: Lower extremity injuries represent a major health concern in elite snowsport disciplines, where high mechanical loads, complex movement patterns, and demanding environmental conditions substantially increase injury risk. Understanding injury incidence and burden in this population is essential for developing sport- and sex-specific prevention strategies. This retrospective study determined lower extremity injury incidence and burden among elite snowsport athletes. Methods: Ninety-nine Turkish National Snowsport Teams Training Camp athletes (34 females; 65 males) consented to a review of their medical records for injury incidence. Overall, sex- and sport-specific injury incidence (number/10,000 h) and burden (weeks missing/10,000 h) were calculated. Results: Overall, medial tibial stress syndrome (MTSS) was the highest burden (9.5 ± 38.7), and ankle sprain (1.7 ± 0.4) was the highest-incident injury. However, injury incidence and burden patterns differed by sex and sport. Notably, medial tibial stress syndrome (MTSS) showed comparable incidence in female and male athletes but resulted in a substantial injury burden in both sexes, reflecting prolonged time-loss from training and competition and indicating a meaningful negative impact on athletic performance. Specifically, the highest-burden injury for women was anterior cruciate ligament (ACL) rupture (16.2 ± 64.5), and for men the most common injury was MTSS (9.7 ± 40.7). For cross-country skiers, MTSS had the highest burden and incidence. For all other sports, and across sexes, ankle sprain was the highest incidence injury—women (1.3 ± 3.0), men (2.0 ± 4.5), biathletes (2.3 ± 5.7), Alpine skiers (2.8 ± 4.5), ski jumpers (1.6 ± 3.1), and snowboarders (3.2 ± 4.7)—plus the highest-burden injury for biathletes (6.9 ± 14.3) and ski jumpers (6.0 ± 14.0). The highest burden injury for Alpine skiers was ACL damage (34.3 ± 87.2), and for snowboarders it was knee collateral ligament injury (27.8 ± 78.6). Moreover, patellar tendinitis, hamstring strains, calf strains, Achilles ruptures, anterior tibial pain, meniscus tears, and hip injuries were frequently observed in injury patterns. Conclusions: Ankle sprains were the most frequent lower extremity injury in elite snowsport athletes, whereas medial tibial stress syndrome (MTSS) and anterior cruciate ligament (ACL) injuries accounted for the greatest injury burden. Injury incidence and burden differed by sex and snowsport discipline. Full article

Here we present a retrospective, integrative review of the approaches and discoveries of our “collaboratory”, a meta-laboratory comprising cross-disciplinary collaborations across laboratories at fourteen different universities and clinics in seven different countries with shared lead investigators. By tying together insights from four decades of research and discovery, applied across cell types, as well as different tissues, organ systems, and organisms, we have aimed to elucidate the interplay between organisms’ movement and the physiology of their tissues, organs, and organ systems’ resident cells. We highlight the potential of increasing imaging and computing power, as well as machine learning/artificial intelligence approaches, to delineate the Laws of Biology. Codifying these laws will provide a foundation for the future, to promote not only the discovery of underpinning mechanisms but also the sustainability of our natural resources, from our brains to our bones, which serve as veritable “hard drives”, physically rendering a lifetime of cellular experiences and millennia of evolution. Full article

The European agricultural sector has increasingly faced volatility in input and output prices, raising concerns about income stability and long-term performance. This study examines the relationship between agricultural price dynamics and sectoral performance across European countries from 2006 to 2024, with a particular focus on countries’ capacity to translate price movements into economic outcomes. Using Eurostat data, the analysis combines factor analysis to construct latent price and performance indicators, structural equation modeling to assess the structural association between price dynamics and real factor income and gross value added, and cluster analysis to identify cross-country heterogeneity. The results reveal a positive and statistically significant association between favorable price dynamics and agricultural performance at the aggregate level. Beyond this general relationship, the findings point to pronounced asymmetries across European agricultural systems. While some countries consistently convert favorable price dynamics into higher income and value creation, others remain structurally constrained and benefit less from similar market conditions. These differences give rise to identifiable groups of relative “winners” and “losers” within the EU agricultural market. The results indicate that price dynamics alone are insufficient to explain convergence in agricultural performance and that structural capacity plays a critical role in shaping outcomes. From a policy perspective, the study highlights the need for differentiated agricultural and regional policy approaches to strengthen resilience and reduce persistent structural disparities across European agriculture. Full article

This article presents a deterministic model describing the joint dynamics of canine and human rabies in a cross-border context. This model explicitly integrates dog mobility between two neighboring countries and allows us to assess the impact of these movements on disease persistence. We analyze the basic reproduction number ${\mathcal{R}}_0$, study the local and global stability of equilibrium points, identify the most influential parameters through sensitivity analysis, and perform numerical simulations to test the effectiveness of different vaccination and movement control strategies. Full article

This paper investigates the determinants and transmission channels underlying the synchronization between financial and business cycles across European Union (EU) member states. For the empirical approach, we combine frequency-domain filtering techniques with spillover index analysis to track cross-country macro-financial interlinkages. We measure financial cycle correlations and spillovers in terms of common exposures to trade linkages, overlapping systemic risk episodes, and bilateral financial claims. An important finding is that financial and business cycles tend to move together, largely due to shared macro-financial conditions and systemic stress episodes. While the data reveal strong co-movement between these cycles, the analysis does not imply a specific direction of causality. In particular, it remains possible that shifts in financial conditions can amplify or even precede business-cycle fluctuations, as seen during major crises. The focus of this study is, therefore, on the interdependence and synchronization of these cycles rather than on causal sequencing. The analysis combines complementary filtering and variance-decomposition methods to quantify the interdependencies shaping EU financial stability, providing a basis for enhanced macroprudential policy coordination. The policy implications for macroprudential authorities entail taking into account cross-border effects and spillovers when implementing instruments for taming the financial cycle. Full article

This Perspective presents a framework for US hospitals treating foreign patients to reconceptualize international healthcare trade by leveraging all four modes of trade in health services under the General Agreement on Trade in Services (GATS), which include information exchange (Mode 1), patient travel/medical tourism (Mode 2), commercial presence (Mode 3), and temporary movement of healthcare personnel (Mode 4). This framework illustrates how hospitals could adopt multi-modal approaches and describes the strategic implications for hospitals and their international patient programs. Historically, US hospitals have focused primarily on international patient travel (Mode 2), but this narrow approach creates vulnerability to disruption. Mode 2 exports by US hospitals have not recovered to pre-pandemic levels, making expansion into other modes essential for maintaining competitive advantages while mitigating systemic risks. Diversification into other modes, such as digital health and telemedicine (Mode 1), co-branding and managing facilities (Mode 3) and visiting professorships (Mode 4) are single-mode approaches for diversification. Multi-country clinical trials are an example of cross-border trade that addresses all four modes of GATS. Overall, this perspective provides a new framework for US providers engaged in or considering entry into international markets that does not solely rely on Mode 2 medical tourism but instead adopts a multi-modal, cross-border health service paradigm. Full article

Background: It is important to investigate the combination of 24 h movement behaviors (24 h MB)—such as physical activity, screen time, and sleep—as children’s daily habitual behaviors significantly influence their health-related quality of life (HRQoL). However, such studies remain extremely limited in East Asia. This study aimed to examine whether adherence to the 24 h MB is associated with HRQoL among children from three East Asian countries. Methods: In this cross-sectional study, data were collected from primary school children aged 7–12 years in Japan (n = 786), China (n = 1246), and South Korea (n = 1011). HRQoL was assessed using the KIDSCREEN-27 questionnaire, while physical activity, screen time, and sleep duration were measured through a self-reported questionnaire survey. Results: Logistic regression analyses, adjusted for relevant covariates, confirmed significant associations with HRQoL subfactors including physical well-being, psychological well-being, social support, and peer relationships. Conclusions: Our findings highlight the critical relationship between adherence to 24 h MB and HRQoL in East Asian children, contributing valuable evidence to support integrated health promotion strategies in this region. Full article

Use of sedation for disbudding is common practice in a number European countries, with United Kingdom (UK) practices adopting its use. This study assessed the effects of disbudding with and without xylazine sedation on growth rates and calf health on a UK calf rearing unit. Data was collected from 485 dairy crossed with beef breed calves between April and August 2024 from a single calf rearing unit in England. Calves were purchased from multiple farms across the UK and arrived on site at approximately 21 days of age. Calves were disbudded—and, in the case of male calves, surgically castrated—at approximately three weeks after arrival on farm. Pens of calves were assigned to undergo disbudding with (SED, n = 238) or without (CTL = 234) xylazine sedation at a dose of 0.2 mg/kg administered intramuscularly. Calves from both groups were provided with local anaesthetic (procaine hydrochloride) as a cornual nerve block and a non-steroidal anti-inflammatory drug (meloxicam). While other studies have demonstrated some behavioural and physiological indicators of pain to be reduced with sedation, this study found that calves in the SED group had a reduced daily liveweight gain (DLWG) of 0.14 kg/day in the short term (mean 20 days) following disbudding (p < 0.001), but there was no difference in growth rates in the medium-term (mean 43 days) post-disbudding (p = 0.30). Some of this difference could be explained by the slightly higher DLWG pre-disbudding in the CTR group, and it is likely that the physiological impacts of sedation accounted for the rest of this difference. This initial reduction in DLWG following disbudding with sedation should be considered by vets, especially on farms where growth rates may already be compromised. In the sedated calves, 19.3% exhibited either some movement or entry into sternal recumbency. Specifically, a light plane of sedation with calves entering sternal recumbency was associated with a reduction in DLWG of 0.89 kg/day compared to 0.98 kg/day for those that remained in lateral recumbency throughout (p = 0.008). The light plane of sedation may have created additional calf stress, impacted feeding behaviours, and impinged welfare, with further work needed to establish the reasons for insufficient sedation. There was no difference in the number of post-disbudding treatment outcomes between calves disbudded with and without sedation (p = 0.97). Full article

This study examines the impact of personal remittances on housing prices in European Union (EU) countries, while also accounting for a broader set of macroeconomic, demographic, and structural variables. Using annual data for 27 EU countries from 2007 to 2022, we employ a comprehensive panel econometric approach, including cross-sectional dependence tests, second-generation unit root tests, pooled mean group–autoregressive distributed lag (PMG-ARDL) estimation, and panel causality tests, to capture both short- and long-term dynamics. Our findings confirm that remittances significantly and positively influence long-term housing price levels, underscoring their relevance as a demand-side driver. Other key variables such as net migration, GDP, travel credit to GDP, economic freedom, and real effective exchange rates also contribute to housing price movements, while supply-side indicators, including production in construction and building permits, exert moderating effects. Moreover, real interest rates are shown to have a significant long-term negative effect on property prices. The analysis reveals key causal links from remittances, FDI, and net migration to housing prices, highlighting their structural and predictive roles. Bidirectional causality between economic freedom, housing output, and prices indicates reinforcing feedback effects. These findings position remittances as both a development tool and a key indicator of real estate dynamics. The study highlights complex interactions between international financial flows, demographic pressures, and domestic economic conditions and the need for policymakers to consider remittances and migrant investments in real estate strategies. These findings offer important implications for policymakers seeking to balance housing affordability, investment, and economic resilience in the EU context and key insights into the complexity of economic factors and real estate prices. Importantly, the analysis identifies several causal relationships, notably from remittances, FDI, and net migration toward housing prices, underscoring their predictive and structural importance. Bidirectional causality between economic freedom and house prices, as well as between housing output and pricing, reflects feedback mechanisms that further reinforce market dynamics. These results position remittances not only as a developmental instrument but also as a key signal for real estate market performance in recipient economies. Full article

This study intends to provide insights and challenges for the shape of the B movement, an emerging paradigm that fosters cross-sectoral partnerships and encourages ethical business practices through so-called purpose-driven businesses. Focusing on Italy, the first European country to adopt this managerial model, the research investigates Italian Benefit Corporations, known as Società Benefit (SB), and their most appealing sustainability claims from a consumer perspective. The analysis intends to inform theory development by assuming the cultural and creative industry (CCI) as a field of interest, utilizing a within-subjects experimental design to analyze data from a diverse consumer sample across various contexts. The results indicate that messaging centered on economic sustainability emerged as the most effective in generating positive consumer responses, highlighting a prevailing inclination toward pragmatic factors such as affordability, economic accessibility, and tangible benefits rather than social issues. While sustainable behaviors are not yet widespread, latent ethical sensitivity for authentic, value-driven businesses suggests that economic and ethical dimensions can be strategically synthesized to enhance consumer engagement. This insight highlights the role of BCs in catalyzing a shift in consumption patterns within ethical-based and creative-driven sectors. Full article

Foot-and-mouth disease (FMD), bluetongue (BT), and Peste des Petits Ruminants (PPR) are major emerging and re-emerging viral infections affecting ruminants. These diseases can threaten livestock health, food security, and economic stability in low- and middle-income countries, including Algeria. However, their dynamics remain mostly unknown, limiting the implementation of effective preventive and control measures. We analyzed outbreak data reported by Algerian veterinary authorities and the WAHIS database from 2014 to 2022 for FMD; from 2006 to 2020 for BT; and from 2011 to 2022 for PPR to investigate their spatiotemporal patterns and environmental drivers. Over these periods, Algeria reported 1142 FMD outbreaks (10,409 cases; 0.16/1000 incidence), 167 BT outbreaks (602 cases; 0.018/1000), and 222 PPR outbreaks (3597 cases; 0.096/1000). Small ruminants were the most affected across all diseases, although cattle bore the highest burden of FMD. BT primarily impacted sheep, and PPR showed a higher incidence in goats. Disease peaks occurred in 2014 for FMD, 2008 for BT, and 2019 for PPR. Spatial analyses revealed distinct ecological hotspots: sub-humid and semi-arid zones for FMD and BT, and semi-arid/Saharan regions for PPR. These patterns may be influenced by species susceptibility, animal movement, trade, and climatic factors such as temperature and rainfall. The absence of consistent temporal trends and the persistence of outbreaks suggest multiple drivers, including insufficient vaccination coverage, under-reporting, viral evolution, and environmental persistence. Our findings underscore the importance of targeted species- and region-specific control strategies, including improved surveillance, cross-border coordination, and climate-informed risk mapping. Strengthening One Health frameworks will be essential to mitigate the re-emergence and spread of these diseases. Full article

This article discusses the digital activism model for advocacy of press freedom in Indonesia. This study examined the model and characteristics of digital activism and inhibiting factors in advocacy of press freedom, carried out by civil society organizations, social activists, and media professionals. Using qualitative methods, this paper provides answers to the question of how is the digital activism model aimed at countering threats to press freedom in a post-authoritarian country with a case study of Indonesia? How does digital activism emerge and form cross-sector collaboration? Given the broad scope of digital activism in Indonesia, the researchers chose two cities that represent the national and regional/provincial spectrum, namely Jakarta as the nation’s capital and Yogyakarta as a prominent student city in the country. The current study found a unique digital activism model in Indonesia that is a spectator collaboration: participants and initiators of activism are involved together in clicktivism, metavoicing, and assertion. Social activists and independent media activists develop systematic collective actions in the digital realm, such as online petitions and press releases, republication, and fundraising for the sustainability of the activism itself. This paper also found a gladiatorial model: media managers as victims and activists merged with more organized social movements, signaling that press freedom has become a collective agenda of pro-democracy advocates in Indonesia. Full article

This paper examines the extent of stock-returns’ co-movements among firms in different countries and explores how various measures of closeness affect those co-movements by estimating a spatial autoregressive (SAR) convex combination model that merges four weight matrices—geographical distance, bilateral trade, sector similarity, and company size—into one global matrix. Our results reveal strong spatial stock-market dependence, show that spatial proximity is better captured by financial-distance measures than by pure geographical distance, and indicate that the weight matrix based on sector similarities outperforms the other linkages in explaining firms’ co-movements. Extending the traditional SAR model, the study simultaneously evaluated cross-country and within-country dependencies, providing insights valuable to investors building optimal portfolios and to policymakers monitoring contagion and systemic risk. Full article

The Women, Life, Freedom (WLF) movement in Iran represents an existentialist and humanist liberation struggle against the country’s oppressive clerical regime. Grounded in existentialist philosophy, particularly Simone de Beauvoir’s concepts of autonomy, self-realization, and the pursuit of freedom, WLF extends beyond political reform to advocate for both personal and national liberation. The movement emphasizes self-determination, bodily autonomy, and agency, rejecting imposed identities and societal constraints. With over 120 years of Iranian women’s struggles as its foundation, WLF builds on past movements, such as the One Million Signatures Campaign, which raised awareness of legal discrimination and violence against women. The movement has also been shaped by globalization and “glocal” processes, fostering cross-cultural feminist solidarity among Iranian women both inside and outside the country. These transnational feminist networks connect local, national, and global movements, strengthening advocacy efforts. A defining feature of WLF is the role of male allies. Some men, particularly as partners in solidarity, actively challenge patriarchal norms and advocate for gender equality. Their participation reflects a shared commitment to human rights, national dignity, and freedom while acknowledging the importance of gender in shaping lived experiences and struggles. Ultimately, WLF is not just a gendered struggle but a unifying force that redefines Iranian identity. By intertwining personal and societal liberation within a global framework, the movement advances a transformative vision, one that challenges oppression, reclaims agency, and aspires for a just and equitable society. Full article

Background: The demand for children’s palliative care is increasingly urgent, with over 21 million children worldwide needing access, yet only 5–10% currently receiving it. Mapping the development of children’s palliative care is important in tracking progress and focusing priorities for future work. Methods: In 2023, a cross-sectional survey was conducted to assess the status of children’s palliative care globally, focusing on eight key indicators. Children’s palliative care experts and stakeholders were asked to evaluate the perceived levels of development in their countries across five defined levels, ranging from no known provision to broad integration into health care services. Efforts were made to engage non-responding countries. Regional palliative care associations were consulted to validate the results. Results: The survey was distributed to experts in 167/197 countries (85%), achieving data collection for 131 countries (78% of surveys sent). A total of 42% of countries (83) were at the lowest level of development (Level 1), while only 6% (11) of countries reached the highest level (Level 5), showing significant regional variation. An overall increase in children’s palliative care globally was seen, including significant movement between levels. Variations were seen between regions and across country income categories, providing insight to inform ongoing efforts in service development, advocacy, education, research and access to essential medicines. Conclusions: There has been global progress in children’s palliative care, although substantial gaps remain in access, particularly between high-income countries and low- and middle-income countries (LMICs). The study highlights the importance of a comprehensive approach to children’s palliative care, with advocacy and education and training programmes being crucial for sustainable development. Full article