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3,726 Results Found

  • Article
  • Open Access
12 Citations
4,010 Views
12 Pages

In Vitro Toxicity Screening of Fifty Complex Mixtures in HepG2 Cells

  • Sunmi Kim,
  • Kyounghee Kang,
  • Haena Kim and
  • Myungwon Seo

2 February 2024

To develop the risk prediction technology for mixture toxicity, a reliable and extensive dataset of experimental results is required. However, most published literature only provides data on combinations containing two or three substances, resulting...

  • Article
  • Open Access
23 Citations
3,083 Views
22 Pages

29 July 2020

This study aims to study the freeze–thaw (F–T) resistance of asphalt mixture incorporating styrene–butadiene–styrene (SBS) polymer and basalt fiber by using the established complex master curves of the generalized Sigmoidal mo...

  • Feature Paper
  • Article
  • Open Access
11 Citations
3,585 Views
31 Pages

25 November 2021

For the first time, a universally applicable and methodical approach from characterization to a PAT concept for complex mixtures is conducted—exemplified on natural products extraction processes. Bearberry leaf (Arctostaphylos uva-ursi) extract...

  • Article
  • Open Access
14 Citations
4,671 Views
17 Pages

Comparative Study on Complex Modulus and Dynamic Modulus of High-Modulus Asphalt Mixture

  • Licheng Guo,
  • Qinsheng Xu,
  • Guodong Zeng,
  • Wenjuan Wu,
  • Min Zhou,
  • Xiangpeng Yan,
  • Xiaomeng Zhang and
  • Jincheng Wei

6 December 2021

In the French high-modulus asphalt mixture design system, the complex modulus of the mixture under the conditions of 15 °C and 10 Hz is taken as the design index. However, in China, the dynamic modulus under the conditions of 15 °C, 10 Hz, 20...

  • Concept Paper
  • Open Access
30 Citations
5,573 Views
14 Pages

Mixture Risk Assessment of Complex Real-Life Mixtures—The PANORAMIX Project

  • Beate I. Escher,
  • Marja Lamoree,
  • Jean-Philippe Antignac,
  • Martin Scholze,
  • Matthias Herzler,
  • Timo Hamers,
  • Tina Kold Jensen,
  • Marc Audebert,
  • Francois Busquet and
  • Anne Marie Vinggaard
  • + 15 authors

Humans are involuntarily exposed to hundreds of chemicals that either contaminate our environment and food or are added intentionally to our daily products. These complex mixtures of chemicals may pose a risk to human health. One of the goals of the...

  • Article
  • Open Access
44 Citations
5,470 Views
17 Pages

17 July 2020

Basalt fiber has been proved to be a good modified material for asphalt mixture. The performance of basalt fiber modified asphalt mixture has been widely investigated by extensive researches. However, most studies focused on ordinary static load test...

  • Article
  • Open Access
11 Citations
8,866 Views
13 Pages

13 December 2019

In the cosmetics industry, various natural complex mixtures such as botanical extracts and essential oils are used. In addition, finished consumer products may contain a number of constituents of natural origin but many products are derived from orga...

  • Article
  • Open Access
23 Citations
10,657 Views
11 Pages

Complex Mixture Analysis of Organic Compounds in Yogurt by NMR Spectroscopy

  • Yi Lu,
  • Fangyu Hu,
  • Takuya Miyakawa and
  • Masaru Tanokura

NMR measurements do not require separation and chemical modification of samples and therefore rapidly and directly provide non-targeted information on chemical components in complex mixtures. In this study, one-dimensional (1H, 13C, and 31P) and two-...

  • Review
  • Open Access
5 Citations
4,835 Views
22 Pages

Solvatochromism in Solvent Mixtures: A Practical Solution for a Complex Problem

  • Omar A. El Seoud,
  • Shirley Possidonio and
  • Naved I. Malek

3 January 2024

Many reactions are carried out in solvent mixtures, mainly because of practical reasons. For example, E2 eliminations are favored over SN2 substitutions in aqueous organic solvents because the bases are desolvated. This example raises the question: h...

  • Article
  • Open Access
3 Citations
3,237 Views
14 Pages

30 November 2021

Assessing complex environmental mixtures and their effects is challenging. In this study, we evaluate the utility of an avian in vitro screening approach to determine the effects of passive air sampler extracts collected from different global megacit...

  • Article
  • Open Access
2 Citations
2,856 Views
20 Pages

29 August 2020

This paper studies the safety control problem for rotating spacecraft proximity maneuver in presence of complex shaped obstacles. First, considering the attitude change of the target spacecraft, a dynamic model of close-range relative motion in a bod...

  • Article
  • Open Access
22 Citations
4,076 Views
20 Pages

Differential Microstrip Sensor for Complex Permittivity Characterization of Organic Fluid Mixtures

  • Amer Abbood al-Behadili,
  • Iulia Andreea Mocanu,
  • Teodor Mihai Petrescu and
  • Taha A. Elwi

26 November 2021

A microstrip highly sensitive differential sensor for complex permittivity characterization of urine samples was designed, fabricated and tested. The sensing area contains two pairs of open-stub resonators, and the working frequency of the unloaded s...

  • Communication
  • Open Access
7 Citations
3,565 Views
13 Pages

Identification of Specific Substances in the FAIMS Spectra of Complex Mixtures Using Deep Learning

  • Hua Li,
  • Jiakai Pan,
  • Hongda Zeng,
  • Zhencheng Chen,
  • Xiaoxia Du and
  • Wenxiang Xiao

14 September 2021

High-field asymmetric ion mobility spectrometry (FAIMS) spectra of single chemicals are easy to interpret but identifying specific chemicals within complex mixtures is difficult. This paper demonstrates that the FAIMS system can detect specific chemi...

  • Article
  • Open Access
6 Citations
3,854 Views
25 Pages

17 October 2020

This paper presents a new and novel hybrid modeling method for the segmentation of high dimensional time-series data using the mixture of the sparse principal components regression (MIX-SPCR) model with information complexity (ICOMP) criterion as the...

  • Article
  • Open Access
7 Citations
2,948 Views
15 Pages

Novel Design of Co-Poly(Hydrazide Imide) and Its Complex with Cu(I) for Membrane Separation of Methanol/Dimethyl Carbonate Mixture

  • Galina Polotskaya,
  • Nadezhda Tian,
  • Ilya Faykov,
  • Mikhail Goikhman,
  • Irina Podeshvo,
  • Nairi Loretsyan,
  • Iosif Gofman,
  • Konstantin Zolotovsky and
  • Alexandra Pulyalina

27 January 2023

Poly(2,2′-biquinoline-6,6′-dicarbohydrazide)-co-(bistrimelliteimide)methylene-bisanthranylide (PHI) and its metal–polymer complex PHI-Cu(I) containing several types of functional groups (hydrazide, carboxyl, amide, and imide fragmen...

  • Article
  • Open Access
14 Citations
3,454 Views
13 Pages

Identifying Major Drivers of Antioxidant Activities in Complex Polyphenol Mixtures from Grape Canes

  • Manon Ferrier,
  • Kévin Billet,
  • Samantha Drouet,
  • Duangjai Tungmunnithum,
  • Magdalena Anna Malinowska,
  • Cécile Marchal,
  • Sandrine Dedet,
  • Nathalie Giglioli-Guivarc’h,
  • Christophe Hano and
  • Arnaud Lanoue

23 June 2022

Grape canes represent a valuable source of numerous polyphenols with antioxidant properties, whose compositions vary depending on the genotype and environmental factors. Antioxidant activities of pure molecules are often reported without considering...

  • Protocol
  • Open Access
24 Citations
7,294 Views
14 Pages

11 February 2024

Secondary metabolites are essential components for the survival of plants. Secondary metabolites in complex mixtures from plants have been adopted and documented by different traditional medicinal systems worldwide for the treatment of various human...

  • Article
  • Open Access
3 Citations
2,592 Views
16 Pages

Straightforward Creation of Possibly Prebiotic Complex Mixtures of Thiol-Rich Peptides

  • Ibrahim Shalayel,
  • Naoual Leqraa,
  • Véronique Blandin and
  • Yannick Vallée

10 April 2023

At the origin of life, extremely diverse mixtures of oligomers and polymers could be obtained from relatively simple molecular bricks. Here, we present an example of the polymerization of two amidonitriles derived from cysteine, Cys-Ala-CN and Cys-Me...

  • Article
  • Open Access
15 Citations
6,396 Views
18 Pages

A novel approach to analysis of complex gaseous mixtures is presented. The approach is based on the utilization of a compact gas chromatograph in combination with an array of highly integrated and selective metal oxide (MOX) sensors. Thanks to the im...

  • Article
  • Open Access
2 Citations
3,043 Views
15 Pages

Evaluation of Alfalfa and Grass Species in Binary and Complex Mixtures on Performance under Soil Salinity Conditions

  • Enkhjargal Darambazar,
  • Kathy Larson,
  • Jeff Schoenau,
  • Gravel Wang,
  • Bill Biligetu,
  • Daalkhaijav Damiran and
  • Herbert A. Lardner

13 July 2022

The effect of synergies between saline-tolerant grass and legume species grown in saline soil, on yield, quality, composition, persistence, and weed suppression was studied in 2019–2021 in a moderately saline soil located in the dark brown soil...

  • Article
  • Open Access
2 Citations
2,835 Views
20 Pages

Complex Mixtures: Array PBPK Modeling of Jet Fuel Components

  • Teresa R. Sterner,
  • Tammie R. Covington and
  • David R. Mattie

17 February 2023

An array physiologically-based pharmacokinetic (PBPK) model represents a streamlined method to simultaneously quantify dosimetry of multiple compounds. To predict internal dosimetry of jet fuel components simultaneously, an array PBPK model was coded...

  • Article
  • Open Access
347 Views
15 Pages

6 December 2025

The selective identification of CH4 in alkane gas mixtures remains challenging due to overlapping infrared absorption spectra among alkane species. This study introduces a novel algorithmic filter paradigm that fundamentally shifts from hardware-base...

  • Article
  • Open Access
14 Citations
5,133 Views
19 Pages

Full-Length Multi-Barcoding: DNA Barcoding from Single Ingredient to Complex Mixtures

  • Peng Zhang,
  • Chunsheng Liu,
  • Xiasheng Zheng,
  • Lan Wu,
  • Zhixiang Liu,
  • Baosheng Liao,
  • Yuhua Shi,
  • Xiwen Li,
  • Jiang Xu and
  • Shilin Chen

7 May 2019

DNA barcoding has been used for decades, although it has mostly been applied to some single-species. Traditional Chinese medicine (TCM), which is mainly used in the form of combination-one type of the multi-species, identification is crucial for clin...

  • Article
  • Open Access
2 Citations
1,263 Views
20 Pages

20 December 2024

High-Performance Thin Layer Chromatography (HPTLC) is widely utilized in natural products research due to its simplicity, low cost, and short total analysis time, including data treatment. While bioautography can be used for rapid detection of bioact...

  • Review
  • Open Access
3 Citations
2,592 Views
34 Pages

20 August 2025

Skin sensitization is a complex biological process induced by a wide range of chemicals, from single molecules to complex mixtures and finished products. While single chemical entities were used to design and validate sophisticated safety assessment...

  • Article
  • Open Access
15 Citations
5,983 Views
16 Pages

Evaluating Complex Mixtures in the Zebrafish Embryo by Reconstituting Field Water Samples: A Metal Pollution Case Study

  • Ellen D. G. Michiels,
  • Lucia Vergauwen,
  • An Hagenaars,
  • Erik Fransen,
  • Stefan Van Dongen,
  • Steven J. Van Cruchten,
  • Lieven Bervoets and
  • Dries Knapen

Accurately assessing the toxicity of complex, environmentally relevant mixtures remains an important challenge in ecotoxicology. The goal was to identify biological effects after exposure to environmental water samples and to determine whether the ob...

  • Article
  • Open Access
13 Citations
10,944 Views
24 Pages

PCR-DGGE Analysis: Unravelling Complex Mixtures of Badnavirus Sequences Present in Yam Germplasm

  • Aliyu A. Turaki,
  • Moritz Bömer,
  • Gonçalo Silva,
  • P. Lava Kumar and
  • Susan E. Seal

11 July 2017

Badnaviruses (family Caulimoviridae, genus Badnavirus) have emerged as serious pathogens especially affecting the cultivation of tropical crops. Badnavirus sequences can be integrated in host genomes, complicating the detection of episomal infections...

  • Article
  • Open Access
33 Citations
11,987 Views
16 Pages

Antioxidant Capacity of Pure Compounds and Complex Mixtures Evaluated by the ORAC-Pyrogallol Red Assay in the Presence of Triton X-100 Micelles

  • Max Romero,
  • Benjamin Rojano,
  • Jaime Mella-Raipán,
  • Carlos David Pessoa-Mahana,
  • Eduardo Lissi and
  • Camilo López-Alarcón

1 September 2010

The protective effect of different antioxidants and complex mixtures on the consumption of pyrogallol red (PGR) induced by peroxyl radicals was studied in the absence and presence of Triton X-100 micelles. The presence of micelles decreased significa...

  • Article
  • Open Access
14 Citations
3,973 Views
17 Pages

Novel Polyester Amide Membranes Containing Biquinoline Units and Complex with Cu(I): Synthesis, Characterization, and Approbation for n-Heptane Isolation from Organic Mixtures

  • Alexandra Pulyalina,
  • Ilya Faykov,
  • Vera Nesterova,
  • Mikhail Goikhman,
  • Irina Podeshvo,
  • Nairi Loretsyan,
  • Alexander Novikov,
  • Iosif Gofman,
  • Alexander Toikka and
  • Galina Polotskaya

12 March 2020

The wide possibilities of designing a chemical structure and creating complexes with transition metals make polymers of heteroaromatic structure interesting objects, from both scientific and practical aspects. In this work, modern biquinoline-contain...

  • Article
  • Open Access
12 Citations
4,580 Views
11 Pages

Enhancing the Drag Reduction Phenomenon within a Rotating Disk Apparatus Using Polymer-Surfactant Additives

  • Musaab K. Rashed,
  • Mohamad Amran Mohd Salleh,
  • Hayder A. Abdulbari and
  • Mohd Halim Shah Ismail

6 December 2016

Pipelines and tubes play important roles in transporting economic liquids, such as water, petroleum derivatives, and crude oil. However, turbulence reduces the initial flow rate at which liquids are pumped, thereby making liquid transportation throug...

  • Article
  • Open Access
12 Citations
4,328 Views
14 Pages

20 February 2022

Quality identification of multi-component mixtures is essential for production process control. Artificial sensory evaluation is a conventional quality evaluation method of multi-component mixture, which is easily affected by human subjective factors...

  • Article
  • Open Access
4 Citations
9,207 Views
15 Pages

25 April 2007

In this analysis, based on the bubble point method, a physical model wasestablished clarifying the interactions (mass and heat) between the species present in thestreams in circulation in the column. In order to identify the externally controlled ope...

  • Article
  • Open Access
7 Citations
9,980 Views
15 Pages

25 September 2007

To analyze the performance of the separation process, we have introduced thethermodynamic concept of exergy through the exergetic efficiency of the column. Thesimulation results show that the exergetic output is relatively low and that the producedir...

  • Feature Paper
  • Review
  • Open Access
4 Citations
8,809 Views
38 Pages

State-of-the-art purification of biomolecules, as well as separation of complex omic mixtures, is crucial for modern biomedical research. Mass spectroscopy (MS) represents a technique that both requires very clean biomedical samples and can substanti...

  • Article
  • Open Access
12 Citations
5,519 Views
18 Pages

30 August 2018

Covalent modification of functionally important cell proteins by lipid oxidation products (LOPs) is a known mechanism initiating pathological consequences of oxidative stress. Identification of new proteins covalently modified by electrophilic lipids...

  • Article
  • Open Access
3 Citations
1,380 Views
18 Pages

19 April 2024

Microwave heating is an emerging alternative pretreatment method for road maintenance in cold seasons. The thermal behavior of asphalt pavement under microwave heating is mainly determined by the complex permittivity of the asphalt mixture. In this s...

  • Article
  • Open Access
7 Citations
3,065 Views
15 Pages

Chemical Element Mixtures and Kidney Function in Mining and Non-Mining Settings in Northern Colombia

  • Laura A. Rodriguez-Villamizar,
  • Olga M. Medina,
  • Oscar Flórez-Vargas,
  • Eugenio Vilanova,
  • Alvaro J. Idrovo,
  • Santiago A. Araque-Rodriguez,
  • José A. Henao and
  • Luz H. Sánchez-Rodríguez

The exposure to chemical mixtures is a problem of concern in developing countries and it is well known that the kidney is the major target organ for toxic elements. This cross-sectional study aimed to estimate the individual and composite mixture eff...

  • Article
  • Open Access
28 Citations
4,358 Views
16 Pages

Self-Consistent Mean Field Calculations of Polyelectrolyte-Surfactant Mixtures in Solution and upon Adsorption onto Negatively Charged Surfaces

  • Eduardo Guzmán,
  • Laura Fernández-Peña,
  • Gustavo S. Luengo,
  • Ana María Rubio,
  • Antonio Rey and
  • Fabien Léonforte

9 March 2020

Self-Consistent Mean-Field Calculations (SCF) have provided a semi-quantitative description of the physico-chemical behavior of six different polyelectrolyte-surfactant mixtures. The SCF calculations performed showed that both the formation of polyme...

  • Article
  • Open Access
10 Citations
2,678 Views
16 Pages

In this work we apply dry glass reference perturbation theory (DGRPT) within the context of fully mutualized diffusion theory to predict the temperature and pressure dependent separations of complex liquid mixtures using SBAD-1 glassy polymer membran...

  • Article
  • Open Access
12 Citations
3,728 Views
18 Pages

Characterizing the Complex Modulus of Asphalt Concrete Using a Scanning Laser Doppler Vibrometer

  • Navid Hasheminejad,
  • Cedric Vuye,
  • Alexandros Margaritis,
  • Wim Van den bergh,
  • Joris Dirckx and
  • Steve Vanlanduit

29 October 2019

Asphalt mixtures are the most common types of pavement material used in the world. Characterizing the mechanical behavior of these complex materials is essential in durable, cost-effective, and sustainable pavement design. One of the important proper...

  • Article
  • Open Access
476 Views
21 Pages

8 January 2026

This study investigates the oxidative steam reforming (OSR) of simulated bio-oil aqueous fractions using Co/CeO2-SBA-15 catalysts. Five representative compounds—methanol, acetic acid, hydroxyacetone, phenol, and furfural—were evaluated to...

  • Communication
  • Open Access
6 Citations
6,753 Views
9 Pages

Validation of a Cell Proliferation Assay to Assess the Potency of a Dialyzable Leukocyte Extract Intended for Batch Release

  • Gregorio Carballo-Uicab,
  • José E. Linares-Trejo,
  • Gabriela Mellado-Sánchez,
  • Carlos A. López-Morales,
  • Marco Velasco-Velázquez,
  • Lenin Pavón,
  • Sergio Estrada-Parra,
  • Sonia Mayra Pérez-Tapia and
  • Emilio Medina-Rivero

20 September 2019

Transferon® is a blood product with immunomodulatory properties constituted by a complex mixture of peptides obtained from a human dialyzable leukocyte extract (DLE). Due to its complex nature, it is necessary to demonstrate batch consistency in...

  • Communication
  • Open Access
5 Citations
3,358 Views
8 Pages

24 January 2020

The analysis of chaotic time series is usually a challenging task due to its complexity. In this communication, a method of complex network construction is proposed for univariate chaotic time series, which provides a novel way to analyze time series...

  • Article
  • Open Access
29 Citations
5,120 Views
15 Pages

Cytotoxic and Genotoxic Effects of Cyanobacterial and Algal Extracts—Microcystin and Retinoic Acid Content

  • Michal Bittner,
  • Alja Štern,
  • Marie Smutná,
  • Klára Hilscherová and
  • Bojana Žegura

2 February 2021

In the last decade, it has become evident that complex mixtures of cyanobacterial bioactive substances, simultaneously present in blooms, often exert adverse effects that are different from those of pure cyanotoxins, and awareness has been raised on...

  • Article
  • Open Access
24 Citations
3,442 Views
16 Pages

2 September 2020

In this paper, a permeable steel-slag–bitumen mixture (PSSBM) was first prepared according to the designed mixture ratio. Then, the interaction characteristics between steel slag and bitumen were studied. The chemical interaction between bitume...

  • Feature Paper
  • Article
  • Open Access
23 Citations
7,764 Views
20 Pages

19 May 2019

As of today, industrial process development for liquid-liquid extraction and scale-up of extraction columns is based on an experimental procedure that requires tests in pilot-scale. This methodology consumes large amounts of material and time and the...

  • Article
  • Open Access
8 Citations
2,830 Views
14 Pages

7 April 2023

The study presented in this paper investigates the application of asphalt bitumen modification using a fast-reacting SBS polymer at a low modifier percentage. The hypothesis is that a fast-reacting styrene–butadiene–styrene (SBS) polymer...

  • Review
  • Open Access
34 Citations
8,360 Views
39 Pages

8 March 2022

Moisture content is a critical variable for the harvesting, processing, storing and marketing of cereal grains, oilseeds and legumes. Efficient and accurate determination of grain moisture content even with advanced nondestructive techniques, remains...

  • Feature Paper
  • Article
  • Open Access
31 Citations
6,813 Views
15 Pages

Trichoderma: Evaluation of Its Degrading Abilities for the Bioremediation of Hydrocarbon Complex Mixtures

  • Chiara Daccò,
  • Lidia Nicola,
  • Marta Elisabetta Eleonora Temporiti,
  • Barbara Mannucci,
  • Federica Corana,
  • Giovanna Carpani and
  • Solveig Tosi

30 April 2020

Hydrocarbons can have very harmful effects on organisms and the environment, and conventional techniques for their removal are expensive and require the use of chemicals and long-term actions. Trichoderma is an ascomycete genus known to be active on...

  • Article
  • Open Access
16 Citations
8,374 Views
20 Pages

Classification of the Biogenicity of Complex Organic Mixtures for the Detection of Extraterrestrial Life

  • Nicholas Guttenberg,
  • Huan Chen,
  • Tomohiro Mochizuki and
  • H. James Cleaves

12 March 2021

Searching for life in the Universe depends on unambiguously distinguishing biological features from background signals, which could take the form of chemical, morphological, or spectral signatures. The discovery and direct measurement of organic comp...

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