Search Results (207)

A multidisciplinary study was conducted to reconstruct the paleoenvironmental evolution of Maladroxia Bay, one of the principal bays of the islet of Sant’Antioco in southwestern Sardinia, over the past eight millennia. As part of an archaeological landscape project, this study explores the paleogeography and environment of the bay from a diachronic perspective to gain insights into the Holocene relative sea level history, shoreline displacements, and the environmental conditions during different phases. This study is based on an analysis of four sediment cores in conjunction with a chronological model that is based on radiocarbon dates. Four relative sea level indicators were produced. These are the first such indicators from the early and middle Holocene for the island of Sant’Antioco. The results indicate that in the early Holocene, the area was a terrestrial, fluvial environment without marine influence. In the 6th millennium BCE, the rising sea level and marine transgression resulted in the formation of a shallow inner lagoon. It reached its maximum extent in the middle of the 5th millennium BCE. Afterwards, a gradual transition from lagoon to floodplain, and a seaward shift of the shoreline occurred. The lagoon potentially served as a valuable source of food and resources during the middle Holocene. During the Nuragic period (2nd to 1st millennium BCE), the Bay of Maladroxia was very similar to how it is today. Its location was ideal for use as an anchorage, due to the calm and sheltered conditions that prevailed. Full article

The southern Great Xing’an Range is located in the overlap zone of the Paleo-Asian Ocean metallogenic domain and the Circum-Pacific metallogenic domain. It hosts numerous Sn-polymetallic deposits, such as Weilasituo, Bianjiadayuan, Huanggang, and Dajing, and witnessed multiple episodes of magmatism during the Late Mesozoic. The study area is situated within the Huanggangliang-Ganzhuermiao metallogenic belt in the southern Great Xing’an Range. The region has witnessed extensive magmatism, with Mesozoic magmatic activities being particularly closely linked to regional mineralization. We present petrographic, zircon U-Pb chronological, lithogeochemical, and Lu-Hf isotopic analyses of the Yexilinhundi granites. The results indicate that the granite porphyry and granodiorite were emplaced during the Late Jurassic. Both rocks exhibit high SiO₂, K₂O + Na₂O, differentiation index (DI), and 10,000 Ga/Al ratios, coupled with low MgO contents. They show distinct fractionation between light and heavy rare earth elements (LREEs and HREEs), exhibit Eu anomalies, and have low whole-rock zircon saturation temperatures (T_zr), collectively demonstrating characteristics of highly fractionated I-type granites. The εHf(t) values of the granites range from 0.600 to 9.14, with young two-stage model ages (T_DM2 = 616.0~1158 Ma), indicating that the magmatic source originated from partial melting of Mesoproterozoic-Neoproterozoic juvenile crust. This study proposes that the granites formed in a post-collisional/post-orogenic extensional setting associated with the subduction of the Mongol-Okhotsk Ocean, providing a scientific basis for understanding the relationship between the formation of Sn-polymetallic deposits and granitic magmatic evolution in the study area. Full article

Chronic inflammatory response syndrome (CIRS) and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are debilitating multisystem illnesses that share overlapping symptoms and molecular patterns, including immune dysregulation, mitochondrial impairment, and vascular dysfunction. This review provides a chronological synthesis of biomarker development in CIRS, tracing its evolution from early functional tests such as visual contrast sensitivity (VCS) to advanced transcriptomic profiling. Drawing on peer-reviewed studies spanning two decades, we examine the layered integration of neuroendocrine, immunologic, metabolic, and genomic markers that collectively support a multisystem model of innate immune activation specific to environmentally acquired illness. Particular focus is given to the Gene Expression: Inflammation Explained (GENIE) platform’s use of transcriptomics to classify disease stages and distinguish CIRS from other fatiguing conditions. While ME/CFS research continues to explore overlapping pathophysiologic features, it has yet to establish a unified diagnostic model with validated biomarkers or exposure-linked mechanisms. As a result, many patients labeled with ME/CFS may, in fact, represent unrecognized CIRS cases. This review underscores the importance of structured biomarker timelines in improving differential diagnosis and guiding treatment in complex chronic illness and highlights the reproducibility of the CIRS framework in contrast to the diagnostic ambiguity surrounding ME/CFS. Full article

Eutrophication has intensified in lacustrine systems across the American continent, which has been primarily driven by human activities such as intensive agriculture, wastewater discharge, and land-use change. This phenomenon adversely affects water quality, biodiversity, and ecosystem functioning. However, studies addressing the historical evolution of trophic states in lakes and reservoirs remain limited—particularly in tropical and subtropical regions. In this context, sedimentary records serve as invaluable archives for reconstructing the environmental history of water bodies. Paleolimnological approaches enable the development of robust chronologies to further analyze physical, geochemical, and biological proxies to infer long-term changes in primary productivity and trophic status. This review synthesizes the main methodologies used in paleolimnological research focused on trophic state reconstruction with particular attention to the utility of proxies such as fossil pigments, diatoms, chironomids, and elemental geochemistry. It further underscores the need to broaden spatial research coverage, fostering interdisciplinary integration and the use of emerging tools such as sedimentary DNA among others. High-resolution temporal records are critical for disentangling natural variability from anthropogenically induced changes, providing essential evidence to inform science-based lake management and restoration strategies under anthropogenic and climate pressures. Full article

The coexistence of three sub-ethnic architectural traditions, Cantonese, Hakka and Teochew, renders Guangdong Province a typical locality for cultural geographical study of Chinese building heritage. Focusing on timber structures as the key indicator of Chinese historical architecture, this paper conducts a typological–chronological study on Cantonese palatial-type (Diantang Shi) timber construction, a previously under-studied building type, aiming to establish for the first time its detailed evolutionary process. Through the interdisciplinary methodology of building archaeology, archaeological theory of material cultural evolution as well as archaeological methods of dating analysis are integrated, achieving more precision in architectural examination both geographically and historically. As a result, 20 cases are dated in the Ming and Qing dynasties with 12 structural elements rapidly evolving, substantiating periodization of Cantonese palatial-type timber construction into three evolutionary phases. Periodization further facilitates the identification of two dramatic structural variations in the second phase, revealing Hakka–Cantonese cultural transmission and political intervention as two different socio-cultural mechanisms underpinning architectural transformations. The typological–chronological study is thus transferred into socio-cultural discourse, presenting a new methodological paradigm for architectural heritage study to incorporate the diachronic scope into the static synchronic approach of cultural geographical scholarship. Full article

The possibility of collecting new archaeological elements useful in reconstructing the dynamics of population, production and commercial activities in the Bronze Age at the edge of the central-southern Venice Lagoon was provided between 2023 and 2024 thanks to an intervention of rescue archaeology planned during some water restoration works in the Giare–Mira area. Three small excavations revealed, approximately one meter below the current surface and covered by alluvial sediments, a rather complex palimpsest dated to the late Recent and the early Final Bronze Age. Three large circular pits containing exclusively purified grey/blue clay and very rare inclusions of vegetable fibres, and many large, fired clay vessels’ bases, walls and rims clustered in concentrated assemblages and random deposits point to potential on-site production. Two pyro-technological structures, one characterised by a sub-circular combustion chamber and a long inlet channel/praefurnium, and the second one with a sub-rectangular shape with arched niches along its southern side, complete the exceptional context here discovered. To analyse the relationship between the site and the natural sedimentary succession and to evaluate the possible extension of this site, three electrical resistivity tomography (ERT) and low-frequency electromagnetic (FDEM) measurements were collected. Several manual core drillings associated with remote sensing integrated the geophysical data in the analysis of the geomorphological evolution of this area, clearly related to different phases of fluvial activity, in a framework of continuous relative sea level rise. The typology and chronology of the archaeological structures and materials, currently undergoing further analyses, support the interpretation of the site as a late Recent/early Final Bronze Age productive site. Geophysical and geomorphological data provide information on the palaeoenvironmental setting, suggesting that the site was located on a fine-grained, stable alluvial plain at a distance of a few kilometres from the lagoon shore to the south-east and the course of the Brenta River to the north. The archaeological site was buried by fine-grained floodplain deposits attributed to the Brenta River. The good preservation of the archaeological structures buried by fluvial sediments suggests that the site was abandoned soon before sedimentation started. Full article

Optically stimulated luminescence (OSL) dating is an important method for determining the ages of late Quaternary sediments. However, partial bleaching of quartz in fluvial sediments remains a challenge, with debates on grain-size effects in different sedimentary environments. The aim of this paper is to explore the bleaching degree and its influencing factors of different grain-size quartz in fluvial sediments from the Yanchi section in the Daluze area, North China Plain. According to sedimentological methods and grain size analysis, lacustrine and fluvial layers were identified, and the ages of sediments were determined by OSL and ¹⁴C methods. The key findings are as follows: (1) Fine-grained quartz can be better bleached than coarse/medium-grained quartz for early–middle Holocene fluvial sediments. (2) The OSL method can yield reliable ages for early–middle Holocene fluvial sediments, while it overestimates these for late Holocene fluvial sediments. This probably results from variations in sediment sources and hydrodynamic conditions. (3) The dating results show that there are three fluvial activity periods in the Daluze area: 10.8~10.2 ka, 5.3~4.7 ka, and after 1 ka. This paper provides a reliable chronological framework for the evolution of regional sedimentary environments and offers references for luminescence dating of fluvial sediments in similar environments. Full article

Background: Human immunodeficiency virus (HIV) remains a global health challenge despite significant advancements in antiretroviral therapy and prevention strategies. Developing a safe and effective vaccine that protects people worldwide has been a major goal, yet the genetic variability and rapid mutation rate of the virus continue to pose substantial challenges. Methods: In this review paper, we aim to provide a comprehensive review of previous vaccine candidates and the progress made in HIV vaccine clinical trials, spanning from the late 1990s to 2025. PubMed and ClinicalTrials.gov were searched for English-language Phase 1–3 HIV vaccine trials published from 1990 to March 2025. After de-duplication, titles/abstracts and then full texts were screened; trial phase, regimen, immunogenicity, efficacy, and correlates were extracted into a structured spreadsheet. Owing to platform heterogeneity, findings were synthesized narratively and arranged chronologically to trace the evolution of vaccine strategies. Results: Early vaccine trials demonstrated that a protein subunit vaccine failed to protect against infection, revealing the complexity of HIV evasion strategies and shifting the focus to a comprehensive immune response, including both antibody and T-cell responses. Trials evaluating the role of viral vectors in generating cell-mediated immunity were also insufficient, and suggested that targeting T cell response alone was not enough. In 2009, the RV144 trial made a breakthrough by showing partial protection against HIV infection and providing the first indication of efficacy. This partial success influenced subsequent trials, prompting researchers to further explore the complex immune response required for protection and consider combinations of vaccine technologies to achieve robust, long-lasting immunity. Conclusion: Despite setbacks, decades of rigorous efforts have provided significant contributions to HIV vaccine discovery and development, offering hope for preventing and protecting against HIV infection. The field remains active by continuing to advance our understanding of the virus, refining vaccine strategies, and employing novel technologies. Full article

Credit relations in Muslim societies have attracted significant scholarly attention across disciplines due to the prohibition of interest. In the Ottoman Empire, renowned for its vast resources, the presence of sophisticated credit mechanisms alongside its strong Muslim identity has often been perceived as paradoxical. While this apparent contradiction has been extensively studied, the perception and legitimacy of these credit mechanisms within Islamic law, particularly in English-language scholarship, remains underexamined. This study addresses this gap by analyzing bayʿ al-wafāʾ, a significant financing mechanism in which asset ownership is temporarily transferred to a lender in exchange for a loan, with the understanding that the asset will be returned upon full repayment. This transaction, employed for centuries across diverse regions as an interest-avoiding solution, has been extensively debated within Hanafi jurisprudence. This research chronologically examines bayʿ al-wafāʾ’s integration into Hanafi legal thought from its emergence through the 18th-century Ottoman Empire, drawing on primary sources across various genres of Hanafi legal literature. The findings reveal that bayʿ al-wafāʾ could not be categorized within existing Islamic contract frameworks. Instead, it is recognized as a contract with unique provisions deriving legitimacy from custom and necessity. This study illuminates both how this transaction achieved legal and legitimate status within Hanafi jurisprudence and, more broadly, demonstrates the dynamic evolution of Islamic law within the Hanafi school from the 10th to 18th centuries. Through this analysis, this study demonstrates how the paradoxical challenge of providing interest-free financing was resolved within the framework of Islamic legal principles. Full article

Many granitic enclaves are developed in the volcanic channel of the Xiangshan volcanic basin. To explore their genesis, this study examined the petrography, geochemistry, LA-ICP-MS zircon U–Pb chronology, and zircon Hf isotopes of the granitic enclaves and compared them with the porphyroclastic lavas. In general, the granitic enclaves and porphyroclastic lavas have similar structures, and the rock-forming minerals and accessory minerals have relatively close compositions. In terms of rock geochemical characteristics, the granitic enclaves are richer in silicon and alkalis but have lower abundances of aluminum, magnesium, iron, and calcium than the porphyroclastic lavas. Rb, Th, K, Sm, and other elements are more enriched, whereas Ba, Ti, Nb, P, and other elements are more depleted. The granitic enclaves have lower rare earth contents (195.53 × 10⁻⁶–271.06 × 10⁻⁶) than the porphyroclastic lavas (246.67 × 10⁻⁶–314.27 × 10⁻⁶). The rare earth element distribution curves of the two are generally consistent, both right-leaning, and enriched with light rare earth patterns. The weighted average zircon U–Pb ages of two granitic enclave samples were 135.45 ± 0.54 Ma (MSWD = 0.62, n = 17) and 135.81 ± 0.60 Ma (MSWD = 0.40, n = 20), respectively, which are consistent with the weighted average age of a single porphyroclastic lava sample of 134.01 ± 0.53 Ma (MSWD = 2.0, n = 20). The zircons of the two kinds of rocks crystallize at almost the same temperature. The consistent trend of the rare earth element distribution curve of zircons in the granitic enclaves and the porphyroclastic lava samples indicates that the zircons of the two samples were formed in the same stage. The formation process of granitic enclaves may be that the lower crustal melt is induced to rise, and the crystallization differentiation occurs in the magma reservoir and is stored in the form of crystal mush, forming a shallow crystal mush reservoir. The crystal mush reservoir is composed of a large number of rock-forming minerals such as quartz, feldspar, and biotite, as well as accessory mineral crystals such as zircon and flowable intergranular melt. In the later stage of magma high evolution, a small and short-time magmatic activity caused a large amount of crystalline granitic crystal mush to pour into the volcanic pipeline. In the closed system of volcanic pipeline, the pressure and temperature decreased rapidly, and the supercooling degree increased, and the immiscibility finally formed pale granitic enclaves. Full article

Magnetic zeolite nanocomposites (NCs) have emerged as a promising class of hybrid materials that combine the high surface area, porosity, and ion exchange capacity of zeolites with the magnetic properties of nanoparticles (NPs), particularly iron oxide-based nanomaterials. This review provides a comprehensive overview of the synthesis, characterization, and diverse applications of magnetic zeolite NCs. We begin by introducing the fundamental properties of zeolites and magnetic nanoparticles (MNPs), highlighting their synergistic integration into multifunctional composites. The structural features of various zeolite frameworks and their influence on composite performance are discussed, along with different interaction modes between MNPs and zeolite matrices. The evolution of research on magnetic zeolite NCs is traced chronologically from its early stages in the 1990s to current advancements. Synthesis methods such as co-precipitation, sol–gel, hydrothermal, microwave-assisted, and sonochemical approaches are systematically compared, emphasizing their advantages and limitations. Key characterization techniques—including X-Ray Powder Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning and Transmission Electron Microscopy (SEM, TEM), Thermogravimetric Analysis (TGA), Nitrogen Adsorption/Desorption (BET analysis), Vibrating Sample Magnetometry (VSM), Zeta potential analysis, Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES), and X-Ray Photoelectron Spectroscopy (XPS)—are described, with attention to the specific insights they provide into the physicochemical, magnetic, and structural properties of the NCs. Finally, the review explores current and potential applications of these materials in environmental and biomedical fields, focusing on adsorption, catalysis, magnetic resonance imaging (MRI), drug delivery, ion exchange, and polymer modification. This article aims to provide a foundation for future research directions and inspire innovative applications of magnetic zeolite NCs. Full article

The Southern Beishan Orogenic Belt (SBOB), an integral part of the Southern Central Asian Orogenic Belt (CAOB), is characterized by extensive Late Paleozoic magmatism. These igneous rocks are the key to studying the tectonic evolution process and the ocean–continent tectonic transformation in the southern margin of the CAOB and Paleo-Asian Ocean. We present zircon U-Pb chronology, in situ Lu-Hf isotopes, and whole-rock geochemistry data for Early–Middle Devonian volcanic rocks in the Sangejing Formation and granites from the Shuangyingshan-Huaniushan (SH) unit in the SBOB. The Wudaomingshiu volcanic rocks (Ca. 411.5 Ma) are calc-alkaline basalt-basaltic andesites with low SiO₂ (47.35~55.59 wt.%) and high TiO₂ (1.46~4.16 wt.%) contents, and are enriched in LREEs and LILEs (e.g., Rb, Ba, and Th), depleted in HREEs and HFSEs (Nb, Ta, and Ti), and weakly enriched in Zr-Hf. These mafic rocks are derived from the partial melting of the depleted lithosphere metasomatized by subduction fluid and contaminated by the lower crust. Wudaomingshui’s high-K calc-alkaline I-type granite has a crystallization age of 383.6 ± 2.2 Ma (MSWD = 0.11, n = 13), high Na₂O (3.46~3.96 wt.%) and MgO (1.25~1.68 wt.%) contents, and a high DI differentiation index (70.69~80.45); it is enriched in LREEs and LILEs (e.g., Rb, Ba, and Th) and depleted in HREEs and HFSEs (e.g., Nb, Ta, and Ti). Granites have variable zircon ε_Hf(t) values (−2.5~3.3) with Mesoproterozoic T_DM2 ages (1310~1013 Ma) and originated from lower crustal melting with mantle inputs and minor upper crustal assimilation. An integrated analysis of magmatic suites in the SBOB, including rock assemblages, geochemical signatures, and zircon ε_Hf(t) values (−2.5 to +3.3), revealed a tectonic transition from advancing to retreating subduction during the Early–Middle Devonian. Full article

The growing importance of customer experience management (CEM) in the tourism sector has led to a proliferation of research interests in satisfaction enhancement, loyalty, and value co-creation. This study proposes a systematic and exhaustive thematic and bibliometric analysis of 3874 articles on CEM in the tourism industry published in the Scopus database between 1979 and 2024. Following the guidelines of the PRISMA protocol, the study uses Bibliometrix (version 4.4.1) in R and VOSviewer (version 1.6.20) to map publication trends, author networks, thematic and chronological evolution, and influential contributions. A qualitative content analysis of the most cited works, guided by grounded theory, revealed the main antecedents, consequences, mediators, and moderators of customer experience management. This analysis is embodied in the proposal of a conceptual model that illustrates the dynamic relationship between these elements and provides the basis for future research for theoretical enrichment and empirical validation. The results offer actionable insights for academics and industry practitioners alike, with the aim of promoting authentic and memorable tourism experiences. Full article

The Heilongjiang Complex provides a crucial geological record of the evolutionary history of the Mudanjiang Ocean, making it significant for understanding the accretion process between the Jiamusi Block and the Songliao Block. In this study, we analyzed samples from the Heilongjiang Complex in the Huanan region using zircon U-Pb and ⁴⁰Ar/³⁹Ar isotopic dating. The LA-ICP-MS U-Pb dating results show that the deposition time of the mica quartz schist is Late Triassic (237–207 Ma), while the protolith age of the amphibolite is Middle Triassic (245.5 ± 1.2 Ma). Detrital zircon ages from the mica quartz schist reveal four groups: 155–229 Ma, 237–296 Ma, 485–556 Ma, and 585–2238 Ma. The provenances are related to the magmatic and metamorphic activities at the junction of the Jiamusi Block and Songliao Block. ⁴⁰Ar/³⁹Ar isotopic dating yielded a plateau age of 183.40 ± 1.83 Ma for phengite in the mica quartz schist, with the metamorphic ages obtained from zircon U-Pb dating. We identify three major metamorphic events in the Heilongjiang Complex: (1) ~229 Ma, marking the earliest tectonic thermal disturbance in the complex; (2) 207–202 Ma, corresponding to the metamorphic event related to the collision between the Jiamusi Block and Songliao Block; and (3) ~183 Ma, indicating the closure of the Mudanjiang Ocean. Integrating these new findings with the results of previous research on magmatism and metamorphism, we reconstruct the tectonic evolution of the Mudanjiang Ocean from the Late Paleozoic to the Mesozoic. During the Early Permian, the Mudanjiang Ocean had already opened. Between the Middle Permian and Middle Triassic, bidirectional subduction occurred. In the Late Triassic, the Mudanjiang Ocean entered a subduction dormancy period. By the Early to Middle Jurassic, the Mudanjiang Ocean closed due to continental collision, leading to the final positioning of the Heilongjiang Complex. Full article

Tuberculosis (TB) remains a major cause of global mortality and is a significant public health challenge, including in specific Portuguese regions. Key aspects in understanding TB’s historical dynamics and impacts on past and present populations are to consider cultural changes and the implementation of public health policies through time. Therefore, this survey aims to provide a more accurate history of TB in Portugal, based on the analysis of sanitary measures through time, illustrating the role of TB in the evolution of public health in Portugal. For this, bibliographic research was conducted across various academic databases and major Portuguese libraries, statistical archives, and public health repositories. Therefore, a detailed chronology, along with some new statistical data, is presented and correlated with sanitary and public health measures, illustrating the role of TB in the evolution of the public health system in Portugal. This research enhances our understanding of the past and sheds light on ongoing TB challenges. Full article