Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Search Results (338)

Search Parameters:
Keywords = burn infection

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
13 pages, 1189 KiB  
Article
The Role of Biodegradable Temporizing Matrix in Paediatric Reconstructive Surgery
by Aikaterini Bini, Michael Ndukwe, Christina Lipede, Ramesh Vidyadharan, Yvonne Wilson and Andrea Jester
J. Clin. Med. 2025, 14(15), 5427; https://doi.org/10.3390/jcm14155427 (registering DOI) - 1 Aug 2025
Viewed by 209
Abstract
Introduction: Biodegradable Temporizing Matrix (BTM) is a new synthetic dermal substitute suitable for wound closure and tissue regeneration. The data in paediatric population remain limited. The study purpose is to review the indications for BTM application in paediatric patients, evaluate the short-term and [...] Read more.
Introduction: Biodegradable Temporizing Matrix (BTM) is a new synthetic dermal substitute suitable for wound closure and tissue regeneration. The data in paediatric population remain limited. The study purpose is to review the indications for BTM application in paediatric patients, evaluate the short-term and long-term results, including complications and functional outcomes, as well as to share some unique observations regarding the use of BTM in paediatric population. Patients and Methods: Patients undergoing reconstructive surgery and BTM application during the last three years were included. Data collected included patient demographics, primary diagnosis, previous surgical management, post-operative complications and final outcomes. BTM was used in 32 patients. The indications varied including epidermolysis bullosa (n = 6), burns (n = 4), trauma (n = 7), infection (n = 4), ischemia or necrosis (n = 11). Results: The results were satisfying with acceptable aesthetic and functional outcomes. Complications included haematoma underneath the BTM leading to BTM removal and re-application (n = 1), BTM infection (n = 1) and split-thickness skin graft failure on top of BTM requiring re-grafting (n = 2). Conclusions: BTM can be a good alternative to large skin grafts, locoregional flaps or even free flaps. The big advantages over other dermal substitutes or skin grafts are that BTM is less prone to infection and offers excellent scarring by preserving the normal skin architecture. Specifically in children, BTM might not require grafting, resulting in spontaneous healing with good scarring. In critically ill patients, BTM reduces the operation time and there is no donor site morbidity. BTM should be considered in the reconstructive ladder when discussing defect coverage options in children and young people. Full article
(This article belongs to the Special Issue Trends in Plastic and Reconstructive Surgery)
Show Figures

Figure 1

7 pages, 1872 KiB  
Case Report
Tinea Incognito Caused by Microsporum spp. Mimicking Subacute Cutaneous Lupus Erythematosus—Case Report
by Marta Kasprowicz-Furmańczyk and Agnieszka Owczarczyk-Saczonek
J. Fungi 2025, 11(7), 530; https://doi.org/10.3390/jof11070530 - 17 Jul 2025
Viewed by 376
Abstract
Tinea incognito is an incorrectly diagnosed form of fungal infection due to a changed clinical picture as a result of systemic or topical corticosteroids or even local immunomodulators. This type of skin lesion is most often located on the trunk but can affect [...] Read more.
Tinea incognito is an incorrectly diagnosed form of fungal infection due to a changed clinical picture as a result of systemic or topical corticosteroids or even local immunomodulators. This type of skin lesion is most often located on the trunk but can affect any part of the body. We present a case report of 76-year-old woman with a history of systemic lupus erythematosus who was admitted to hospital because of extensive, painful, and burning erythematous and papular lesions in an annular pattern, covered with a thick, yellow crust, located on the scalp and neck. The skin lesions were accompanied by extensive hair loss. The patient had previously undergone intensified treatment of the underlying disease due to the exacerbation of skin lesions of a subacute cutaneous lupus erythematosus type. A suspicion of tinea incognito was raised, and direct mycological examination and culture confirmed the presence of dermatophytes (Microsporum spp.). Tinea incognito can be difficult to diagnose because the clinical picture is relatively nonspecific and can mimic other dermatoses, such as subacute lupus erythematosus. Therefore, in doubtful cases it is necessary to perform a direct test and culture for fungal infection, especially before initiating treatment with glucocorticosteroids and other immunosuppressive agents. Full article
(This article belongs to the Special Issue Advances in Human and Zoonotic Dermatophytoses)
Show Figures

Figure 1

14 pages, 1574 KiB  
Article
Antimicrobial Efficacy of Impregnated Human Acellular Dermal Substitutes in Burn Wound Models
by Marianna Hajská, Elena Kurin, Silvia Bittner Fialová, Marian Vidiščák and Arpád Panyko
Antibiotics 2025, 14(7), 707; https://doi.org/10.3390/antibiotics14070707 - 14 Jul 2025
Viewed by 351
Abstract
Burn wound infections remain a major clinical challenge due to delayed healing, scarring, and the risk of sepsis, especially when complicated by multidrug-resistant (MDR) Gram-negative pathogens and biofilm formation. Acellular dermal matrices (ADMs) are widely used in reconstructive and burn surgery, yet they [...] Read more.
Burn wound infections remain a major clinical challenge due to delayed healing, scarring, and the risk of sepsis, especially when complicated by multidrug-resistant (MDR) Gram-negative pathogens and biofilm formation. Acellular dermal matrices (ADMs) are widely used in reconstructive and burn surgery, yet they lack intrinsic antimicrobial activity, necessitating their combination with topical agents. Background/Objectives: This study investigates the antimicrobial and cytocompatibility profiles of ADMs impregnated with various antimicrobial agents, using in vitro planktonic and biofilm burn wound models. While the incorporation of antimicrobials into scaffolds has been previously explored, this study is, to our knowledge, the first to directly compare seven clinically relevant antimicrobial agents after they were impregnated into an ADM in a standardized in vitro model. Methods: Seven topical antimicrobials were tested against MDR Pseudomonas aeruginosa and Acinetobacter baumannii from burn patients. Results: The ADM with 1% acetic acid (AA) showed superior antimicrobial activity, achieving > 7 log10 reductions in planktonic assays and complete inhibition of P. aeruginosa biofilms. In NIH 3T3 fibroblast cytotoxicity assays, the 1% AA ADM maintained cell viability at control levels, indicating excellent biocompatibility. Compared with agents such as Betadine®, Octenilin®, and colistin, which showed cytotoxicity, and Prontosan®, which showed low efficacy, 1% AA uniquely combined potent antibacterial effects with minimal toxicity. Conclusions: Among the seven antimicrobial agents impregnated into ADMs, 1% AA demonstrated a unique efficacy and safety profile, supporting its potential for clinical application in integrated wound dressings and implantable biomaterials for infection control in burn care. Full article
(This article belongs to the Special Issue Antimicrobial Resistance and Therapy in Intensive Care Unit)
Show Figures

Graphical abstract

21 pages, 13904 KiB  
Article
Cold Atmospheric Plasma Enhances TGF-β1, CTGF Protein Expression, and Healing in Full-Thickness Skin Burns: An Animal Study
by Sahar M. Gebril, Fakhr El din M. Lasheen, Mohamed Khalaf, Amr Abdelhamed, Manal I. Bahkali, Fayez El Hossary and Mahmoud Rezk Abdelwahed Hussein
Biomolecules 2025, 15(7), 924; https://doi.org/10.3390/biom15070924 - 24 Jun 2025
Viewed by 509
Abstract
Cold atmospheric plasma (CAP) interacts with tissues, leading to fast wound disinfection. Given the frequent global burden of burn injuries and the risks of infection associated with acute full-thickness burns (FTBs), this investigation examined CAP as a potential therapeutic method for wound healing [...] Read more.
Cold atmospheric plasma (CAP) interacts with tissues, leading to fast wound disinfection. Given the frequent global burden of burn injuries and the risks of infection associated with acute full-thickness burns (FTBs), this investigation examined CAP as a potential therapeutic method for wound healing due to its antimicrobial and pro-healing effects. Here, we examined the impacts of CAP on the healing of wounds resulting from acute FTSBs. We established an animal model that included four groups: (1) healthy control animals without burns, (2) untreated animals with acute FTSBs, (3) animals with acute FTSBs treated with CAP for 5 s per day for 21 days, and (4) animals with acute FTSBs treated with CAP for 10 s per day for 21 days. Wound healing was assessed using immunohistological methods. In animals with FTSBs, CAP therapy was accompanied by (i) accelerated wound closure, (ii) enhanced regeneration of the dermis and epidermis, and (iii) increased protein expression of transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF). These changes were more pronounced following CAP treatment for 10 s per day compared to CAP treatment for 5 s per day. Full article
(This article belongs to the Section Cellular Biochemistry)
Show Figures

Figure 1

13 pages, 226 KiB  
Article
Comparing Amniotic Membranes to Other Bioengineered Skin Substitutes in Wound Healing: A Propensity Score-Matched Analysis
by Micaela J. Tobin, Audrey K. Mustoe, Sasha Nickman, Tricia Mae Raquepo, Mohammed Yamin, Agustin N. Posso, Sarah J. Karinja, Bernard T. Lee and Ryan P. Cauley
J. Clin. Med. 2025, 14(12), 4272; https://doi.org/10.3390/jcm14124272 - 16 Jun 2025
Viewed by 420
Abstract
Background/Objectives: The amniotic membrane, which is widely available and inexpensive, has received recent attention for its potential applications in wound healing. This is the first study to use a large database to examine the efficacy of amniotic membrane grafting compared to other [...] Read more.
Background/Objectives: The amniotic membrane, which is widely available and inexpensive, has received recent attention for its potential applications in wound healing. This is the first study to use a large database to examine the efficacy of amniotic membrane grafting compared to other skin substitutes. Methods: The TriNetX electronic health database was queried in October 2024 for patients with burns or chronic skin ulcers. Patients were stratified by treatment with amniotic membrane grafts or another skin substitute. These patients were then 1:1 propensity score-matched based on age, demographics, and comorbidities. Group differences were assessed with risk ratios and p-values. Results: A total of 557 patients remained in each group after propensity score matching. Patients who were treated with amniotic membrane grafts had significantly decreased hypertrophic scarring (1.7% vs. 6.2%, p < 0.0001), local skin infections (17.4% vs. 29.9%, p < 0.0001), and acute postoperative pain (3.7% vs. 7.8%, p = 0.003). Additionally, subsequent split-thickness skin grafting was utilized significantly less after amniotic membrane grafts. When compared to skin substitutes for large wounds (>100 cm2), the advantages of amniotic membrane were even more pronounced. Conclusions: This multi-institutional study supports amniotic membranes as a viable alternative to conventional bioengineered skin substitutes. Further research should evaluate amniotic membranes in wound beds of different sizes to better characterize their use in preparation for or as an alternative to skin grafting itself. Full article
9 pages, 866 KiB  
Article
Anterolateral Thigh Flap for Acute/Primary Burn Reconstruction
by Eva Verdaguer, Antonio Bulla, Jordi Serracanta, Danilo Rivas and Juan P. Barret
Eur. Burn J. 2025, 6(2), 34; https://doi.org/10.3390/ebj6020034 - 10 Jun 2025
Viewed by 317
Abstract
Introduction: The indication for a free flap in acute burn reconstruction is very specific. It should avoid several complications that are more common in the burned patient population. We propose an anterolateral thigh (ALT) flap as a first option for primary burn reconstruction [...] Read more.
Introduction: The indication for a free flap in acute burn reconstruction is very specific. It should avoid several complications that are more common in the burned patient population. We propose an anterolateral thigh (ALT) flap as a first option for primary burn reconstruction in microvascular free flap reconstruction in burned patients. Patients and Methods: A retrospective review of all acutely burned patients treated with microvascular ALT free flap reconstruction between the years 2005 and 2022 in the Vall d’Hebron Barcelona Hospital Campus Burn Centre was conducted. Results: We performed 30 ALT flaps for primary burn reconstruction. The majority of patients were male (87.5%), with a mean age of 36.7 years, and 37% of patients were smokers. High-voltage electrical burns were the most common etiology. The mean time between burn injury and microsurgery was 22 days. The main recipient site was the lower limb. The flap survival rate was 96.6%. One patient required a meshed skin graft to cover a defect in the proximal third due to peripheral flap necrosis. One flap experienced mild congestion, which resolved spontaneously. Another flap had a local infection, which resolved with antibiotic therapy and surgical debridement. Conclusions: An ALT flap offers several advantages to a burned patient, provided that the surgical technique and postoperative management described in this study are followed. We propose it as the first option for primary burn reconstruction using free flaps in a burned patient. Full article
Show Figures

Figure 1

13 pages, 517 KiB  
Review
Review of the 100 Most Cited Articles in Burns from 2014 to 2024: A Bibliometric Analysis
by Anna Jolly Neriamparambil, Richard Wong She, Paul Andrew Baker, Lindsay Damkat-Thomas and Joyce Antony
Eur. Burn J. 2025, 6(2), 33; https://doi.org/10.3390/ebj6020033 - 10 Jun 2025
Viewed by 377
Abstract
Substantial research interest has been shown over the past ten years in the management of burn injuries. This bibliometric analysis aims to identify and evaluate the most cited articles that have significantly advanced the field of burn injury management. The 100 most cited [...] Read more.
Substantial research interest has been shown over the past ten years in the management of burn injuries. This bibliometric analysis aims to identify and evaluate the most cited articles that have significantly advanced the field of burn injury management. The 100 most cited articles published from January 2014 to September 2024 were collated using the Web of Science database. The full text of each article was meticulously analyzed for descriptive parameters including subject matter, journal of publication, authorship, institutional affiliation, country of origin, and year of publication. The 100 most cited articles had an average of 203 citations, with the most cited article reaching 754 citations and the least cited article cited 105 times. The subjects ranged from enhancing wound care outcomes to metabolic support, fluid management, and infection prevention and management. These articles were distributed across 59 source journals, with 44% of articles having been published in just ten prominent journals. While bibliometric analyses do not accurately gauge scientific merit, this study illuminates the significant contributions to burn management over the past decade and provides valuable insights into research trends in the field. Full article
Show Figures

Figure 1

17 pages, 18881 KiB  
Article
Zinc Alginate Hydrogel-Coated Wound Dressings: Fabrication, Characterization, and Evaluation of Anti-Infective and In Vivo Performance
by Adelina-Gabriela Niculescu, Alexandra Cătălina Bîrcă, George Dan Mogoşanu, Marius Rădulescu, Alina Maria Holban, Daniela Manuc, Adina Alberts, Alexandru Mihai Grumezescu and Laurenţiu Mogoantă
Gels 2025, 11(6), 427; https://doi.org/10.3390/gels11060427 - 1 Jun 2025
Cited by 1 | Viewed by 1075
Abstract
The delayed healing and infection risks associated with chronic wounds and burns pose significant clinical challenges. Traditional dressings provide basic coverage but lack the bioactive properties needed for tissue regeneration and antimicrobial protection. In this study, we developed zinc alginate hydrogel-coated traditional wound [...] Read more.
The delayed healing and infection risks associated with chronic wounds and burns pose significant clinical challenges. Traditional dressings provide basic coverage but lack the bioactive properties needed for tissue regeneration and antimicrobial protection. In this study, we developed zinc alginate hydrogel-coated traditional wound dressings (WD@AlgZn) and evaluated their physicochemical properties, antimicrobial performance, and in vivo healing efficacy. Scanning electron microscopy (SEM) revealed a uniform coating of the zinc alginate network on dressing fibers, while Fourier-transform infrared spectroscopy (FT-IR) confirmed the successful incorporation of zinc ions. Antimicrobial assays further demonstrated that WD@AlgZn reduced bacterial loads (CFU/mL counts) by several orders of magnitude for both Staphylococcus aureus and Escherichia coli compared to uncoated controls. An in vivo rat burn wound model exhibited accelerated wound closure when using WD@AlgZn dressings compared to conventional wound care approaches, achieving a 90.75% healing rate by day 21, significantly outperforming the silver sulfadiazine (52.32%), uncoated-dressing (46.58%), and spontaneous-healing (37.25%) groups. Histological analysis confirmed enhanced re-epithelialization, neovascularization, and reduced inflammation in WD@AlgZn-treated tissues. The findings suggest that WD@AlgZn offers a promising alternative for advanced wound management, combining structural robustness with bioactive properties to support efficient wound healing and infection control. These results provide valuable insights into the potential clinical applications of metal-ion cross-linked biopolymeric hydrogel dressings for next-generation wound care strategies. Full article
(This article belongs to the Special Issue Recent Research on Alginate Hydrogels in Bioengineering Applications)
Show Figures

Figure 1

14 pages, 523 KiB  
Article
The Impact of Face and Neck Burns on Respiratory Complications and Mortality
by Rares-Adrian Giurgiu, Eliza-Maria Bordeanu-Diaconescu, Andreea Grosu-Bularda, Adrian Frunza, Sabina Grama, Raducu-Andrei Costache, Carina-Ioana Cristescu, Tiberiu-Paul Neagu, Ioan Lascar and Cristian-Sorin Hariga
Eur. Burn J. 2025, 6(2), 27; https://doi.org/10.3390/ebj6020027 - 22 May 2025
Viewed by 427
Abstract
Face and neck burns present significant clinical challenges due to their proximity to the airway, predisposing patients to inhalation injuries and subsequent respiratory complications. In our cohort of 206 patients, facial and neck burns were associated with a markedly higher incidence of inhalation [...] Read more.
Face and neck burns present significant clinical challenges due to their proximity to the airway, predisposing patients to inhalation injuries and subsequent respiratory complications. In our cohort of 206 patients, facial and neck burns were associated with a markedly higher incidence of inhalation injury (34.8% vs. 2.8%), necessitating more frequent endotracheal intubation (51.9% vs. 14.1%). Furthermore, respiratory infections were significantly more common in patients with facial and neck burns (26.7% vs. 7%, p < 0.001), with respiratory secretion cultures revealing a predominance of Pseudomonas aeruginosa (39.58%), Acinetobacter baumanii (18.75%), and Klebsiella pneumoniae (6.25%). In contrast, patients without facial and neck burns primarily exhibited Pseudomonas aeruginosa (50%) in their cultures. These complications translated into a significantly increased mortality rate in patients with facial and neck burns (31.1% vs. 12.7%), with a reduced mean survival period (66.7 days vs. 84.3 days) and a 2.8-fold increase in the hazard of mortality. Additionally, older age emerged as a significant determinant for the development of respiratory infections. Multivariable model regression analysis revealed that only TBSA remained a consistent and independent predictor for adverse respiratory outcomes and increased mortality, while face and neck burns are more causally associated with TBSA. Full article
Show Figures

Figure 1

15 pages, 1185 KiB  
Article
LC-MS/MS Determination of Quorum Sensing Molecules in Plasma from Burn Patients with Septic Shock Sustained by Acinetobacter Baumannii
by Nicolò Carpenito, Marta Leporati, Alberto Sciarrillo, Anna Pensa, Roberto Gambino, Giovanni Musso, Alberto Mella, Luigi Biancone, Daniela Risso, Filippo Mariano and Domenico Cosseddu
Antibiotics 2025, 14(5), 517; https://doi.org/10.3390/antibiotics14050517 - 16 May 2025
Viewed by 726
Abstract
Background/Objectives: Quorum Sensing (QS) refers to the communication mechanism in bacterial cells, which occurs through the production and detection of small signaling molecules to coordinate activities and monitor population size. In Gram-negative bacteria, QS is typically mediated by N-acyl-homoserine lactones (HSLs) and [...] Read more.
Background/Objectives: Quorum Sensing (QS) refers to the communication mechanism in bacterial cells, which occurs through the production and detection of small signaling molecules to coordinate activities and monitor population size. In Gram-negative bacteria, QS is typically mediated by N-acyl-homoserine lactones (HSLs) and 2-alkyl-4(1H)-quinolone metabolites (AQ). The present study aims to develop and validate an LC-MS/MS method for detecting QS molecules and apply it to the analysis of plasma samples from burn patients with septic shock caused by Acinetobacter baumannii. Methods: The LC-MS/MS method was developed and fully validated for the quantitative, simultaneous determination of five HSLs and four AQ molecules, ultimately derived from the plasma of three patients with septic shock, with samples collected over three consecutive days. Results: The developed method proved to be both specific and selective, demonstrating a good fit and linearity over the entire range of interest. Trueness and accuracy were satisfactory. The method showed excellent intra-assay precision (CV% was lower than 15%) and limits of quantification (LOQ) ranging from 0.02 to 0.79 ng/mL. In the patients’ samples, the concentration of 3-OH-C12-HSL peaked at 1.5 ng/mL on the first day, and C7-PQS, C9-PQS, HHQ, and HQNO ranged from 0.5 to 1.5 ng/mL, peaking at 5 ng/mL in one patient on the third day. Conclusions: A method for the simultaneous determination of nine QS molecules by LC-MS/MS was developed and validated. When applied, it showed good performance for the analysis of plasma samples and could be a useful tool for an improvement in the diagnosis, prognosis, or treatment monitoring of infections in burn patients caused by Acinetobacter baumannii. Full article
Show Figures

Figure 1

18 pages, 3636 KiB  
Article
The Reconstruction of Various Complex Full-Thickness Skin Defects with a Biodegradable Temporising Matrix: A Case Series
by Julie van Durme, Thibaut Dhont, Ignace De Decker, Michiel Van Waeyenberghe, Kimberly De Mey, Henk Hoeksema, Jozef Verbelen, Petra De Coninck, Nathalie A. Roche, Phillip Blondeel, Stan Monstrey and Karel E. Y. Claes
Eur. Burn J. 2025, 6(2), 24; https://doi.org/10.3390/ebj6020024 - 14 May 2025
Viewed by 1013
Abstract
Background and Objectives: Traditionally, full-thickness skin defects (FTSDs) are covered with split-thickness skin grafts (STSGs). This usually provides an epidermal coverage but entails a high risk of hypertrophic scarring mainly due to the absence of the dermal layer. The Novosorb® Biodegradable Temporising [...] Read more.
Background and Objectives: Traditionally, full-thickness skin defects (FTSDs) are covered with split-thickness skin grafts (STSGs). This usually provides an epidermal coverage but entails a high risk of hypertrophic scarring mainly due to the absence of the dermal layer. The Novosorb® Biodegradable Temporising Matrix (BTM) is a novel synthetic dermal substitute that has been used for the reconstruction of various complex and/or large defects in our center. The aim of this article is to evaluate the clinical performance of the BTM as a synthetic dermal substitute for complex FTSD reconstruction in a European context. Materials and methods: This case series focused on the treatment of complex FTSDs with the BTM. After wound debridement, the BTM was applied according to a defined protocol. Once adequate vascularization was observed, the sealing membrane was removed and the neo-dermis was covered with STSGs. Patient demographics, comorbidities, wound defect localization and etiology, wound bed preparations, time of BTM application and removal, time to complete wound healing after STSG, complications, and HTS formation were recorded. Results: The BTM was used to treat FTSDs in six patients with complex wounds from degloving (3), burns (1), ulcerations (1), and necrotizing fasciitis (1). Successful integration occurred in five cases (83%), with one partial integration. The BTM remained in situ for an average of 20.7 days before delamination and STSG coverage. No major complications occurred, though one case had hypergranulation with secondary STSG infection. Two patients were lost to follow-up, while the remaining four had excellent aesthetic and functional outcomes with good-quality scars. Conclusions: Within the limits of this small and heterogeneous case series, the BTM appears to be a promising option for the reconstruction of complex FTSDs of varying etiologies. Its successful integration in most cases and limited complication rate support its clinical potential. However, given this study’s retrospective design and limited sample size, further prospective studies are required to validate these findings and assess long-term outcomes. Full article
Show Figures

Figure 1

20 pages, 3047 KiB  
Review
Comprehensive Management of Severe Burn Injuries: A Multidisciplinary Approach from Resuscitation to Rehabilitation
by Maryum Merchant, Scott B. Hu, Chris Miller, Tamana Ahmadi, Edwin Garcia and Malcolm I. Smith
Emerg. Care Med. 2025, 2(2), 26; https://doi.org/10.3390/ecm2020026 - 14 May 2025
Viewed by 2802
Abstract
Severe burns are among the most traumatic injuries, characterized by tissue damage, systemic inflammation, significant fluid shifts, and a high risk of complications such as infections, organ failure, anemia, malnutrition, and psychological trauma. This article reviews recent literature from the PubMed and Google [...] Read more.
Severe burns are among the most traumatic injuries, characterized by tissue damage, systemic inflammation, significant fluid shifts, and a high risk of complications such as infections, organ failure, anemia, malnutrition, and psychological trauma. This article reviews recent literature from the PubMed and Google Scholar databases to outline critical components of burn care, from initial resuscitation and stabilization through rehabilitation. Key topics include early airway management to prevent respiratory compromise, meticulous fluid resuscitation to maintain tissue perfusion while avoiding complications like fluid overload, and optimal pain management. It also discusses nutritional support tailored to the burn patient’s hypermetabolic state and surgical techniques like early debridement and skin grafting. Beyond physical recovery, the review emphasizes the importance of addressing the psychological impact of burn injuries, including depression, anxiety, and post-traumatic stress, which can significantly affect long-term outcomes. By integrating the expertise of a multidisciplinary team with a personalized approach and practical recommendations, this review aims to provide clinicians with a comprehensive framework for managing severe burns, from the initial emergency response to the challenges of inpatient care and, finally, rehabilitation. Full article
Show Figures

Figure 1

34 pages, 7587 KiB  
Review
Multifunctional Carbon-Based Nanocomposite Hydrogels for Wound Healing and Health Management
by Tianyi Lu, Yaqian Chen, Meng Sun, Yuxian Chen, Weilong Tu, Yuxuan Zhou, Xiao Li and Tao Hu
Gels 2025, 11(5), 345; https://doi.org/10.3390/gels11050345 - 6 May 2025
Viewed by 1469
Abstract
Compared with acute wounds, typical chronic wounds (infection, burn, and diabetic wounds) are susceptible to bacterial infection and hard to heal. As for the complexity of chronic wounds, biocompatible hydrogel dressings can be employed to regulate the microenvironment and accelerate wound healing with [...] Read more.
Compared with acute wounds, typical chronic wounds (infection, burn, and diabetic wounds) are susceptible to bacterial infection and hard to heal. As for the complexity of chronic wounds, biocompatible hydrogel dressings can be employed to regulate the microenvironment and accelerate wound healing with their controllable physical and chemical properties. Recently, various nanomaterials have been introduced into hydrogel networks to prepare functional nanocomposite hydrogels. Among them, carbon-based nanomaterials (CBNs) have attracted wide attention in the biomedical field due to their outstanding physicochemical properties. However, comprehensive reviews on the use of CBNs for multifunctional hydrogel wound dressings in the past 10 years are very scarce. This review focuses on the research progress on hydrogel dressings made with typical CBNs. Specifically, a series of CBNs (carbon dots, graphene quantum dots, fullerenes, nanodiamonds, carbon nanotubes, graphene, graphene oxide and reduced graphene oxide) employed in the preparation of hydrogels are described as well as carbon-based nanocomposite hydrogels (CBNHs) with versatility (conductivity, antibacterial, injectable and self-healing, anti-inflammatory and antioxidant properties, substance delivery, stimulus response and real-time monitoring). Moreover, applications of CBNHs in treating different chronic wounds are concretely discussed. This review may provide some new inspirations for the future development of CBNHs in wound care and tissue engineering. Full article
(This article belongs to the Special Issue Gel-Based Materials for Sensing and Monitoring)
Show Figures

Figure 1

14 pages, 1212 KiB  
Systematic Review
Enhancing Burn Recovery: A Systematic Review on the Benefits of Electrical Stimulation in Accelerating Healing
by Dale O. Edwick, Kerry L. Burns, Lara N. Buonvecchi, Xiaolu Wang, Audrey M. Lim and Dale W. Edgar
Eur. Burn J. 2025, 6(2), 21; https://doi.org/10.3390/ebj6020021 - 5 May 2025
Viewed by 748
Abstract
Prolonged healing time of acute burn wounds is associated with increased pain, infection, risk of scarring, poorer mobility and higher financial and emotional burden. Electrical stimulation (ES) reduces healing time in chronic wounds; however, its reported use on acute burn wounds is limited. [...] Read more.
Prolonged healing time of acute burn wounds is associated with increased pain, infection, risk of scarring, poorer mobility and higher financial and emotional burden. Electrical stimulation (ES) reduces healing time in chronic wounds; however, its reported use on acute burn wounds is limited. This systematic review (SR) aimed to evaluate the relative benefit of ES compared to routine wound care on the healing time of acute burn wounds in adults. The online databases queried included Cochrane Database of SR’s, MEDLINE, EMBASE, PUBMED and CINAHL. The search criteria included RCTs involving the application of ES of varying voltage, duration and modality in acute burn patients aged ≥18 years. The primary outcome investigated was days to burn wound closure, while the secondary outcomes included edema and infection. Four RCTs were discovered, involving a total of 143 participants with a mean age 35.5 years. Two RCTs demonstrated (a) 36% (2.6 days) reduction in time to wound closure with ES (p < 0.001); and (b) significant reduction in wound area with ES (11.2 ± 3.2 cm2, p < 0.001) compared to controls at 21 days. Two RCTs found ES promoted better wound-healing environments, reducing edema, bacterial infection, and biofilm. This review highlighted low-risk wound-healing benefits with ES as a feasible adjunct to routine burn care. Full article
Show Figures

Figure 1

25 pages, 1597 KiB  
Review
Current State and Advances in Antimicrobial Strategies for Burn Wound Dressings: From Metal-Based Antimicrobials and Natural Bioactive Agents to Future Perspectives
by Andrea Osmokrovic, Jasmina Stojkovska, Tanja Krunic, Predrag Petrovic, Vesna Lazic and Jovana Zvicer
Int. J. Mol. Sci. 2025, 26(9), 4381; https://doi.org/10.3390/ijms26094381 - 5 May 2025
Cited by 1 | Viewed by 1752
Abstract
Burn wounds represent a complex clinical challenge, primarily due to their high susceptibility to infections and the frequent formation of the biofilm, which significantly hinder the healing process. Therefore, effective infection prevention and management are critical components of burn wound care. This review [...] Read more.
Burn wounds represent a complex clinical challenge, primarily due to their high susceptibility to infections and the frequent formation of the biofilm, which significantly hinder the healing process. Therefore, effective infection prevention and management are critical components of burn wound care. This review provides a comprehensive overview of the current and emerging antimicrobial strategies in burn management, with a particular focus on alternative approaches to conventional antiseptics and antibiotics. This manuscript highlights the role of metals and metal-based agents, including silver, zinc oxide, and copper compounds, alongside plant-derived bioactive substances such as aloe vera, marigold, and turmeric. Additionally, the potential of antimicrobial peptides and probiotics as innovative therapeutic options is explored, emphasizing their antimicrobial, anti-inflammatory, and pro-healing properties. Finally, this review presents an analysis of recent patents in the field of burn wound care, offering insights into current trends and future directions in the development of advanced wound dressings. By addressing both established and novel strategies, this review aims to provide a valuable resource for clinicians, researchers, and innovators seeking to improve outcomes in burn wound management. Full article
Show Figures

Figure 1

Back to TopTop