Search Results (2,309)

Background/Objectives: Collaboration in mental health care is essential for implementing a model oriented towards the psychosocial rehabilitation of people based on multifaceted interventions involving different actors and sectors of society to respond to demands. Despite the benefits presented by the scientific evidence, there are still many barriers to collaborative care, and professionals continue to struggle in reorienting their conduct. The current situation demands organization and the framing of well-founded action plans to overcome challenges, which in turn requires a detailed understanding of collaborative practices in mental health care and their conceptual boundaries. A concept analysis was undertaken to propose a working definition of collaborative practices in mental health care (CPMHC). Methods: This paper used the Walker and Avant concept analysis method. This includes identifying the defining concept attributes, antecedents, consequences, and empirical referents. A literature search was carried out from November 2024 to February 2025 in three databases (Medline, CINAHL, and LILACS), considering studies published between 2010 and 2024. Results: The final sample of literature investigated consisted of 30 studies. The key attributes were effective communication, building bonds, co-responsibility for care, hierarchical flexibility, articulation between services, providers and community, monitoring and evaluating of care processes, and attention to the plurality of sociocultural contexts. Conclusions: This comprehensive analysis contributes to guiding future research and policy development of collaborative practices in mental health, considering the individual, relational, institutional, and social levels. Further research is possible to deepen the understanding of the production of collaborative practices in mental health in the face of the complexity of social relations and structural inequities. Full article

Osteoarthritis (OA) remains a major contributor to pain and disability; however, the current management is largely reactive, focusing on symptoms rather than preventing irreversible cartilage loss. This review first examines the mechanistic foundations for pharmacological chondroprotection—illustrating how conventional agents, such as glucosamine sulfate and chondroitin sulfate, can potentially restore extracellular matrix (ECM) components, may attenuate catabolic enzyme activity, and might enhance joint lubrication—and explores the delivery challenges posed by avascular cartilage and synovial diffusion barriers. Subsequently, a practical “What–How–When” framework is introduced to guide community pharmacists in risk screening, DMOAD selection, chronotherapeutic dosing, safety monitoring, and lifestyle integration, as exemplified by the CHONDROMOVING infographic brochure designed for diverse health literacy levels. Building on these strategies, the P4–4P Chondroprotection Framework is proposed, integrating predictive risk profiling (physicians), preventive pharmacokinetic and chronotherapy optimization (pharmacists), personalized biomechanical interventions (physiotherapists), and participatory self-management (patients) into a unified, feedback-driven OA care model. To translate this framework into routine practice, I recommend the development of DMOAD-specific clinical guidelines, incorporation of chondroprotective chronotherapy and interprofessional collaboration into health-professional curricula, and establishment of multidisciplinary OA management pathways—supported by appropriate reimbursement structures, to support preventive, team-based management, and prioritization of large-scale randomized trials and real-world evidence studies to validate the long-term structural, functional, and quality of life benefits of synchronized DMOAD and exercise-timed interventions. This comprehensive, precision-driven paradigm aims to shift OA care from reactive palliation to true disease modification, preserving cartilage integrity and improving the quality of life for millions worldwide. Full article

Effective building operation requires a careful balance between energy conservation and indoor environmental comfort. Although numerous methods have been developed to reduce energy consumption during the operational phase, their objectives and applications vary widely. However, the complexity of building energy management makes it challenging to identify the most suitable methods that simultaneously achieve both comfort and efficiency goals. Existing studies often lack a systematic framework that supports integrated decision-making under comfort constraints. This research aims to address this gap by proposing a decision-making tree for selecting energy conservation methods during building operation with an explicit consideration of indoor environmental comfort. A comprehensive literature review is conducted to identify four main energy-consuming components during building operation: the building envelope, HVAC systems, lighting systems, and plug loads and appliances. Three key comfort indicators—thermal comfort, lighting comfort, and air quality comfort—are defined, and energy conservation methods are categorized into three strategic groups: passive strategies, control optimization strategies, and behavioural intervention strategies. Each method is assessed using a defined set of evaluation criteria. Subsequently, a questionnaire survey is administered for the calibration of the decision tree, incorporating stakeholder preferences and expert judgement. The findings contribute to the advancement of understanding regarding the co-optimization of energy conservation and occupant comfort in building operations. Full article

Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, with hypercholesterolemia identified as a major, but modifiable risk factor. This review serves as the second part of a comprehensive analysis of dyslipidemia management. The first installment laid the groundwork by detailing the key pathophysiological mechanisms of lipid metabolism, the development of atherosclerosis, major complications of hyperlipidemia, and the importance of cardiovascular risk assessment in therapeutic decision-making. It also examined non-pharmacological interventions and conventional therapies, with a detailed focus on statins and ezetimibe. Building upon that foundation, the present article focuses exclusively on emerging pharmacological therapies designed to overcome limitations of standard treatment. It explores the mechanisms, clinical applications, safety profiles, and pharmacogenetic aspects of novel agents such as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors (alirocumab, evolocumab), small interfering RNA (siRNA) therapy (inclisiran), adenosine triphosphate–citrate lyase (ACL) inhibitor (bempedoic acid), microsomal triglyceride transfer protein (MTP) inhibitor (lomitapide), and angiopoietin-like protein 3 (ANGPTL3) inhibitor (evinacumab). These agents offer targeted strategies for patients with high residual cardiovascular risk, familial hypercholesterolemia (FH), or statin intolerance. By integrating the latest advances in precision medicine, this review underscores the expanding therapeutic landscape in dyslipidemia management and the evolving potential for individualized care. Full article

This paper presents an ethnographically informed analysis of research in Cairo and Sharm El-Sheikh (Egypt) surrounding the 2022 United Nations Framework Convention on Climate Change (UNFCCC) Conference of Parties (COP27) summit. I discuss the geopolitics and geopolitical disruptions of researching activism and activist lives in politically sensitive environments. As shown here, developing new methodological interventions plays a crucial role in understanding contextual methodological limitations, dealing with logistical challenges, and building authentic relationships with research participants. Here, I introduce counter-interviews as a methodological strategy to build trust and invest in researcher–participant relationships. This article draws on participant observation, conversations with environmental and climate activists and non-activists in Cairo prior to and after COP27 and in Sharm El-Sheikh during the second week of the summit, reflective field notes, and 20 semi-structured interviews conducted online between February and August 2023. Here, I use the term “environmental non-activism” to draw attention to the sensitivity, complexity, and fragility of political or apolitical environmental and climate action in an authoritarian context where any form of collective action is highly monitored, regulated, and sometimes criminalized by the state. The main argument of this paper is that examining interlocking power dynamics that shape and reshape the activist space in relation to the state is a requirement for understanding and researching the complexities and specificities of climate activism and non-activism in authoritarian contexts. Along with this argument, this paper invites climate education researchers to reevaluate what non-movements and non-activists in the Global South offer to their analyses of possible alternatives, socio-political change, and politics of hope (and to the broader field of activism in educational research, where commitment to disruption, refusal, and subversion play a key role. Full article

Educational buildings, including schools, nurseries and universities, face stricter regulation and design control on indoor air quality (IAQ) and thermal conditions than other built environments, as these may affect children’s health and wellbeing. In this scoping review, wide-ranging health, performance, and absenteeism consequences of poor—and benefits of good—IAQ and thermal conditions are evaluated, focusing on source control, ventilation and air purification interventions. Economic impacts of interventions in educational buildings have been evaluated to enable the assessment of tangible building-related costs and savings, alongside less easily quantifiable improvements in educational attainment and reduced healthcare. Key recommendations are provided to assist decision makers in pathways to provide clean air, at an optimal temperature for students’ learning and health outcomes. Although the role of educational buildings can be challenging to isolate from other socio-economic confounders, secondary short- and long-term impacts on attainment and absenteeism have been demonstrated from the health effects associated with various pollutants. Sometimes overlooked, source control and repairing existing damage can be important cost-effective methods in minimising generation and preventing ingress of pollutants. Existing ventilation standards are often not met, even when mechanical and hybrid ventilation systems are already in place, but can often be achieved with a fraction of a typical school budget through operational and maintenance improvements, and small-scale air-cleaning and ventilation technologies, where necessary. Full article

Background: Acute myeloid leukemia (AML) is a common and aggressive adults hematological malignancies. This study explored megakaryocyte–erythroid progenitors (MEPs) signature genes and constructed a prognostic model. Methods: Uniform manifold approximation and projection (UMAP) identified distinct cell types, with differential analysis between AML-MEP and normal MEP groups. Univariate and the least absolute shrinkage and selection operator (LASSO) Cox regression selected biomarkers to build a risk model and nomogram for 1-, 3-, and 5-year survival prediction. Results: Ten differentially expressed genes (DEGs) related to overall survival (OS), six (AHSP, MYB, VCL, PIM1, CDK6, as well as SNHG3) were retained post-LASSO. The model exhibited excellent efficiency (the area under the curve values: 0.788, 0.77, and 0.847). Pseudotime analysis of UMAP-defined subpopulations revealed that MYB and CDK6 exert stage-specific regulatory effects during MEP differentiation, with MYB involved in early commitment and CDK6 in terminal maturation. Finally, although VCL, PIM1, CDK6, and SNHG3 showed significant associations with AML survival and prognosis, they failed to exhibit pathological differential expression in quantitative real-time polymerase chain reaction (qRT-PCR) experimental validations. In contrast, the downregulation of AHSP and upregulation of MYB in AML samples were consistently validated by both qRT-PCR and Western blotting, showing the consistency between the transcriptional level changes and protein expression of these two genes (p < 0.05). Conclusions: In summary, the integration of single-cell/transcriptome analysis with targeted expression validation using clinical samples reveals that the combined AHSP-MYB signature effectively identifies high-risk MEP-AML patients, who may benefit from early intensive therapy or targeted interventions. Full article

As autonomous driving technologies advance, the need for human-in-the-loop systems becomes increasingly critical to ensure safety, adaptability, and public confidence. This paper presents the design and evaluation of a context-aware immersive teleoperation interface that integrates real-time simulation, virtual reality, and multimodal feedback to support remote interventions in emergency scenarios. Built on a modular ROS2 architecture, the system allows seamless transition between simulated and physical platforms, enabling safe and reproducible testing. The experimental results show a high task success rate and user satisfaction, highlighting the importance of intuitive controls, gesture recognition accuracy, and low-latency feedback. Our findings contribute to the understanding of human-robot interaction (HRI) in immersive teleoperation contexts and provide insights into the role of multisensory feedback and control modalities in building trust and situational awareness for remote operators. Ultimately, this approach is intended to support the broader acceptability of autonomous driving technologies by enhancing human supervision, control, and confidence. Full article

Indoor soundscape is a relatively new and developing field compared to urban soundscape in practice. To address this gap, this study aims to identify the key influencing factors as a first step of the indoor soundscape intervention approach. The study employed a two-phase methodology. Phase one involved a Systematic Review (SR) of the literature, conducted through the PRISMA 2020 guidelines, to collate data on the influencing factors and intervention criteria of the indoor soundscape approach. Searching was conducted using two databases, Web of Science and Scopus. As a result of the search, a total of 29 studies were included in the review. The review included studies addressing the soundscape influencing factors and theoretical frameworks. Studies that did not address these criteria were excluded. Phase two comprised the application of the Grounded Theory (GT) coding process to organize, categorize, and merge the data collected in phase one. As a result of the coding process, three levels of categories were achieved; L1: key concept, L2: overarching category, L3: core category. Four core categories were identified as ‘Sound’, ‘People’, ‘Building’, and ‘Environment’ by proposing the Indoor Soundscape Intervention (ISI) criteria. The repeatable and updatable nature of the proposed method allows it to be adapted to further studies and different contexts/cases. Full article

The COVID-19 pandemic’s rapid shift to working from home has fundamentally challenged residential acoustic design, which traditionally prioritises rest and relaxation rather than sustained concentration. However, a clear gap exists in understanding how acoustic needs and the subjective evaluation of soundscape appropriateness (SA) differ between these conflicting activities within the same domestic space. Addressing this gap, this study reveals critical differences in how people experience and evaluate home soundscapes during work versus relaxation activities in the same residential spaces. Through an online survey of 247 Chinese participants during lockdown, we assessed soundscape perception attributes, the perceived saliencies of various sound types, and soundscape appropriateness (SA) ratings while working and relaxing at home. Our findings demonstrate that working at home creates a more demanding acoustic context: participants perceived indoor soundscapes as significantly less comfortable and less full of content when working compared to relaxing (p < 0.001), with natural sounds becoming less noticeable (−13.3%) and distracting household sounds more prominent (+7.5%). Structural equation modelling revealed distinct influence mechanisms: while comfort significantly mediates SA enhancement in both activities, the effect is stronger during relaxation (R² = 0.18). Critically, outdoor man-made noise, building-service noise, and neighbour sounds all negatively impact SA during work, with neighbour sounds showing the largest detrimental effect (total effect size = −0.17), whereas only neighbour sounds and outdoor man-made noise significantly disrupt relaxation activities. Additionally, natural sounds act as a positive factor during relaxation. These results expose a fundamental mismatch: existing residential acoustic environments, designed primarily for rest, fail to support the cognitive demands of work activities. This study provides evidence-based insights for acoustic design interventions, emphasising the need for activity-specific soundscape considerations in residential spaces. As hybrid work arrangements become the norm post-pandemic, our findings highlight the urgency of reimagining residential acoustic design to accommodate both focused work and restorative relaxation within the same home. Full article

The modern Chinese architectural heritage combines sturdy Western materials with delicate Chinese styling, mainly adopting brick-timber structural systems that are highly vulnerable to fire damage. The study assesses the fire spread characteristics of the First Faculty House, a 20th-century architectural heritage located at a university in China. The assessment is carried out by analyzing building materials, structural configuration, and fire load. By using FDS (Fire Dynamics Simulator (PyroSim version 2022)) and SketchUp software (version 2023) for architectural reconstruction and fire spread simulation, explores preventive measures to reduce fire risks. The result show that the total fire load of the building amounts to 1,976,246 MJ. After ignition, flashover occurs at 700 s, accompanied by a sharp increase in the heat release rate (HRR). The peak ceiling temperature reaches 750 °C. The roof trusses have critical structural weaknesses when approaching flashover conditions, indicating a high potential for collapse. Three targeted fire protection strategies are proposed in line with the heritage conservation principle of minimal visual and functional intervention: fire sprinkler systems, fire retardant coating, and fire barrier. Simulations of different strategies demonstrate their effectiveness in mitigating fire spread in elongated architectural heritages with enclosed ceiling-level ignition points. The efficacy hierarchy follows: fire sprinkler system > fire retardant coating > fire barrier. Additionally, because of chimney effect, for fire sources located above the ceiling and other hidden locations need to be warned in a timely manner to prevent the thermal plume from invading other sides of the ceiling through the access hole. This research can serve as a reference framework for other Modern Chinese Architectural Heritage to develop appropriate fire mitigation strategies and to provide a methodology for sustainable development of the Chinese architectural heritage. Full article

Effective water governance is essential for sustainable development amidst water scarcity challenges in semi-arid regions like Esmeraldas Province, which has substantial agrotourism potential. Yet, fragmented governance and chronic water shortages threaten its viability. Using a mixed-method approach, this study analyzed how sustainable water governance can support agrotourism development in Esmeraldas Province, Ecuador. This study combined policy gaps analysis, stakeholder surveys (policymakers, farmers, community leaders, and tourism operators), and water availability using the Standardized Precipitation Evapotranspiration Index (SPEI) from 1980 to 2022. The results revealed a lack of policy regulation and water infrastructure as the major governance gaps that need more intervention. The survey respondents indicated that water is mainly used for domestic and economic activities and the conservation of natural ecosystems. The SPEI revealed a significant drought trend falling below −3, with severe drought years coinciding with many crop losses and a fall in tourism. This study highlights the interconnection between water governance and agrotourism in Esmeraldas, Ecuador, proposing a strategic framework that incorporates adaptive governance principles and inclusive participation mechanisms, emphasizing targeted capacity building to strengthen water management practices and enhance the Sustainable Development Goals for agrotourism resilience. Full article

Traditional playground settings are often less effective in fostering STEAM (Science, Technology, Engineering, Arts, and Mathematics)-related activities, as fixed play structures tend to restrict the diversity of play behaviors and inhibit children’s ability to engage in self-directed, imaginative exploration. Using a research-through-design methodology, this study investigated how playground design (temporary landscape interventions) influences children’s engagement in informal STEAM learning activities and enhances the STEAM learning affordances of the playground. Conducted at an early learning center in Lubbock, Texas, the research involved GIS-based Environment–Behavior Mapping (E-B Mapping) and video analysis of 21 preschool-age children to compare pre- and post-intervention STEAM learning behaviors. The intervention incorporated fourteen nature-based landscape elements—such as sand and water play areas, sensory gardens, loose parts, art areas, etc.—to enhance affordances for informal STEAM activities. The results showed a marked decrease in passive behaviors and a notable rise in constructive play; collaborative interactions; and STEAM-related activities such as building, hypothesizing, observing, and experimenting. Engagement shifted away from fixed play structures to more diverse and naturalized play settings. The findings underscore the critical role of integrating diverse landscape settings and elements into playgrounds in enriching STEAM learning experiences for young children. Full article

The impacts of renovation actions on pre- and post-retrofitting building performances are complex to analyse, particularly small and potentially self-actuated actions, such as adding insulation layers to a cold roof slab or changing doors. These interventions are widespread in small residential houses and cases where the owners are the residents. However, a large research gap currently remains regarding the impact of sustainable solutions on building performance. This study aims to address this issue by proposing a methodology based on commercial cloud monitoring solutions and middleware development that analyses and reports on the impact of such solutions to end users, allowing for an analysis of real variations in air temperature levels. The methodology is applied to two single/double-family residential houses, acting as demo cases for verification, across a multi-year time horizon. In both cases, measurements were conducted before and after typical limited renovation actions. Alongside the proposed methodology, descriptions of the smart solutions’ requirements are provided. The results mainly focus on temperature variations. Finally, the impact of the solutions on energy consumption was analysed for one of the buildings, and feedback was briefly provided by the users. Full article

In order to fulfil SDG 13—taking urgent action to combat climate change and its impact—SDG 2—ending hunger and poverty—and the African Union CAADP Strategy and Action Plan: 2026–2035, which’s goal is ending hunger and intensifying sustainable food production, agro-industrialisation, and trade, the resilience of commercial livestock farmers to agricultural droughts needs to be enhanced. Agricultural drought has affected the economies of many sub-Saharan African countries, including South Africa, and still poses a challenge to commercial livestock farming. This study identifies and determines the factors affecting commercial livestock farmers’ level of resilience to agricultural drought. Primary data from 123 commercial livestock farmers was used in a principal component analysis to estimate the agricultural drought resilience index as an outcome variable, and the probit model was used to determine the factors influencing the resilience of commercial livestock farmers in the Northern Cape Province of South Africa. This study provides a valuable contribution towards resilience-building strategies that are critical for sustaining commercial livestock farming in arid regions by developing a formula for calculating the Agricultural Drought Resilience Index for commercial livestock farmers, significantly contributing to the pool of knowledge. The results showed that 67% of commercial livestock farming households were not resilient to agricultural drought, while 33% were resilient. Reliance on sustainable natural water resources, participation in social networks, education, relative support, increasing livestock numbers, and income stability influence the resilience of commercial livestock farmers. It underscores the importance of multidimensional policy interventions to enhance farmer drought resilience through education and livelihood diversification. Full article