Search Results (6,289)

We evaluated global radiotherapy practices in the management of early-stage (AJCC/UICC 8th edition stages I-II) glottic cancer (ESGC). A cross-sectional online survey was conducted in March 2025 across centers worldwide. Data was collected on clinical practices, including staging, CT simulation, target volumes delineation, organs-at-risk contouring, radiotherapy techniques, dose and fractionation schedules, treatment delivery techniques, and image guidance practices. A total of 181 responses were received, primarily from Asia (41.4%) and Europe (24.3%). Most respondents were from non-academic public centers (44.2%), with multidisciplinary team involvement reported by 84.5%. Head and neck CT scan was the most used staging modality (80.1%). Intensity-Modulated Radiation Therapy was the most common planning technique (82.9%). Hypofractionated radiotherapy schedules predominated for T1 (84%) and T2 (72.4%) disease. T1a was typically treated with whole-larynx target volume (72.4%). Use of ipsilateral involved vocal cord irradiation varied by geographical region (p = 0.015), being most common in North America (44.8%) and Europe (38.6%). Accelerated fractionation for T2 also differed significantly (p < 0.001), with the highest use reported in North America (41.4%). Daily Cone-Beam Computed Tomography was acquired by (58.2%). In total, 70% of respondents expressed interest in the results of a future phase III randomized trial comparing stereotactic body radiation therapy to conventional radiotherapy. Significant global variations in radiotherapy practices for ESGC were observed, likely reflecting disparities in access and differences in institutional protocols. The development and implementation of standardized, evidence-based global guidelines are essential to harmonize care, minimize toxicity, and improve outcomes for patients with ESGC. Full article

Body positivity and body neutrality are increasingly referred to as alternatives to the idealized body representations on social media. These images can play a powerful role in body image development during adolescence. However, insights into how adolescents give meaning to these concepts and perceive their potential effectiveness are still limited. This study aims to fill this gap by conducting focus groups among adolescents (N = 27; aged between 13 and 17 years old) on (1) their conceptualization and familiarity with body positivity and neutrality, and (2) perceived effectiveness of these movements for adolescents’ healthy body image development. Moreover, we analyzed potential sex differences. The results of a thematic analysis indicated that although body positivity and body neutrality were not well-known and were only occasionally observed, most participants believed they could help, especially girls, to feel better about their bodies. The adolescents, however, were also critical in the sense that the approaches cannot be applied too excessively and that more attention is needed for body positivity for men as well. Full article

In Latin America, the double burden of malnutrition is the region’s single most important public health concern for the incoming decade. Latin America’s burden of disease has distinct features in comparison to high-income countries: nearly 20 percent of NCDs are diagnosed in people under 60 years of age in Latin America, whereas only about 13 percent of people under 60 years of age in North America and Europe are diagnosed with these diseases. We aimed to better understand decision-making processes, preferences, and norms around food choices to provide input for future programming and policy suggestions at national and regional levels. We included key informant interviews and focus group discussions with parents and adolescents from urban and rural communities in three regions in Colombia and in Mexico. Results showed that food choices considered to be affordable, acceptable, accessible, and aspirational are driven by environmental and social factors that influence individual cognitive decisions. Across the study groups, cognitive biases influenced food decision-making in relation to eating out, natural, homemade, and “moderation”. At the sociological level, conversations, and social influences at home and in communities were strong indicators of dietary practices, health beliefs, and body size attitudes. Full article

Background/Objectives: Dieting is a widespread behavior that is associated with psychological distress, body dissatisfaction, and eating disorders. Recent research suggests that a body-positive attitude and mindful approach to eating may influence individuals’ experiences with dieting; however, their combined role has been insufficiently explored. Methods: A two-phase study was conducted among voluntary adults using online data collection. In Phase 1, a cross-sectional survey was completed by 180 participants (71.7% women), assessing dieting behavior, body appreciation, nutritional awareness, psychological distress, well-being, and eating disorders. Correlation analyses, group comparisons, and regression models were performed. In Phase 2, 90 participants entered the pilot and received a brief psychoeducational digital material promoting mindful eating and positive body image. The follow-up assessment was completed by 59, after one month of engagement. Results: Body appreciation and nutritional awareness were positively associated with mental well-being and inversely related to psychological distress (p < 0.001 for all) and to eating disorder screening scores (p < 0.001 and p = 0.046, respectively). More frequent dieting was associated with lower body appreciation (p < 0.001). According to the observed pattern of correlations, body appreciation may play a role in the relationship between dieting and psychological distress. In the intervention phase, greater engagement with the psychoeducational material was associated with higher reported levels of nutritional awareness (p = 0.003) and greater perceived body awareness (p = 0.026) at follow-up; however, due to the exploratory design, findings are preliminary. Conclusions: The results suggest that dieting, as a behavior, may be embedded in broader psychological processes that include body-related attitudes and nutritional awareness. Taking these factors into account may have potential implications for preventive measures aimed at promoting healthier dietary habits, a more positive relationship with one’s body, and mental well-being. Full article

Background: Thalassemia is an inherited hemoglobin disorder and is among the most prevalent genetic diseases worldwide. In adolescents, the physical consequences of thalassemia extend beyond physiological impairment and affect daily functioning, education, and body image. Objective: This research aimed to promote resilience and quality of life among adolescents with thalassemia, with the goal of increasing mean resilience and quality-of-life scores before and after participation. Methods: This cluster quasi-experimental study employed a two-group pretest–posttest design with a sample of 58 adolescents aged 12–17 years diagnosed with thalassemia. Participants were allocated to the experimental (n = 29) and control (n = 29) groups using a cluster-based approach at the district level. The intervention lasted 8 weeks. The assessment tools included the Pediatric Quality of Life Inventory and the Resilience Scale. Data were analyzed using descriptive statistics, including frequency distributions, percentages, means, standard deviations, t-tests, chi-square tests, and Fisher’s exact tests. Results: Baseline comparisons indicated no statistically significant differences in personal characteristics between the two groups (p > 0.05). Before the intervention, the mean resilience scores in both groups were low. The mean quality-of-life scores for the experimental and control groups were moderate. After participating in the resilience enhancement program, the experimental group showed statistically significant increases in both resilience and quality-of-life scores relative to pre-intervention levels (p < 0.001). Additionally, these post-intervention scores were significantly higher than those of the control group (p < 0.001). Conclusions: These findings indicate that the resilience enhancement program effectively improved resilience and enhanced the quality of life among adolescents living with thalassemia. Full article

Judo, as a weight-category combat sport, exposes young athletes to body mass pressures that may foster abnormal eating behaviours. Building on a companion study that documented the prevalence and sex-specific characteristics of abnormal eating behaviours in this cohort, this secondary analysis aimed to identify training-related predictors of eating behaviours in young Polish judo athletes, examine body image satisfaction as a mediator, and assess whether patterns observed in elite adult athletes apply to younger populations. The participants were 150 athletes (70 girls, 80 boys) aged 12–17. Eating behaviours were assessed using the Three-Factor Eating Questionnaire (TFEQ-13) and the Test of Eating Situation Style (TSJ); training characteristics, pre-competition weight control, and appearance satisfaction were examined through hierarchical regression, mediation analysis, latent profile analysis, and two-way ANOVA. Training-related factors—including tenure, session frequency, competitive level, and pre-competition weight control—showed no significant associations with eating behaviours. However, in a subsample of N = 136 athletes, relative weight grouping predicted dietary restraint (p = 0.015, η²p = 0.066), with athletes in the heaviest tertile reporting higher restriction; lower appearance satisfaction was associated with greater restraint (p = 0.031, β = −0.192), independently of sport-mandated weight control; females demonstrated higher emotional eating across instruments (p < 0.001). These findings suggest that body image and weight classification may be more strongly associated with eating behaviours than training demands, highlighting the need for body image interventions and the monitoring of athletes near weight category boundaries. Full article

Background/Objectives: Arterial hypertension might lead to serious organ damage and complications like hypertensive retinopathy. The retina is the only place in the human body where microscopic blood vessels can be directly investigated. This enables early diagnosis of arterial hypertension-mediated organ damage. Untreated hypertensive retinopathy leads to vision loss in its advanced stages. There are many methods of assessing changes in the arterioles; however, the most accurate is adaptive optics (RTX1™ device with AODetectArtery software, ver. 3.0., Imagine Eyes, Orsay, France). It provides a resolution of 1.6 μm, which is superior to conventional imaging techniques. Optical coherence tomography angiography can serve as an early, minimally invasive marker of microvascular damage. Across the studies analyzed, the WLR (Wall-to-Lumen Ratio) exhibited significantly higher values when comparing individuals with hypertensive retinopathy to normotensives (0.31 vs. 0.26). The main aim of this review is to present the application of adaptive optics in the early diagnosis of hypertensive retinopathy. Methods: The search strategy included 267 original studies, among which 12 were selected to be described and analyzed in this review based on criteria including original research and studies performed on humans with hypertensive retinopathy. Results: RTX1™ enables the assessment of arterial parameters such as the Wall Thickness (WT), Lumen Diameter (LD), Outer Diameter (OD), Wall-to-Lumen Ratio (WLR) and Wall Cross Sectional Area (WCSA). These parameters differ depending on the arterial hypertension. The WLR was identified to be the parameter that differs in the vast majority of analyzed studies when comparing hypertensive patients to normotensive patients. Vascular parameters were also found to change depending on different organisms’ states, treatment applications and etiological causes of disease. Furthermore, changes in retinal arterial parameters were associated with increased cardiovascular risk in observational studies. RTX1™ was also identified to provide very good intra- and interobserver variability. Conclusions: RTX1™ is a valuable tool in the examination of arterial vessels and in establishing associations between retinal vascular parameters and a patient’s clinical state. Full article

Mindfulness and body image anxiety are psychological factors associated with disordered eating and may contribute to orthorexia nervosa, yet their combined effects remain underexplored. In this cross-sectional online survey, 382 adults in Greece completed the Mindful Attention Awareness Scale (MAAS-15), the Orthorexia scale (ORTO-6), the Social Physique Anxiety Scale (SPAS-12), and measures of body mass index (BMI) and physical activity (PAVS). Descriptive statistics, correlations, regression analyses, and mediation analysis were conducted to examine the associations among mindfulness, body image anxiety, and orthorexia. Mindfulness correlated negatively with orthorexia and body image anxiety, whereas body image anxiety correlated positively with orthorexia. In multinomial logistic regression, higher body image anxiety increased the odds of low (OR = 1.194, 95% CI 1.114–1.280) and moderate mindfulness (OR = 1.125, 95% CI 1.068–1.185); orthorexia also increased the odds of low (OR = 1.146, 95% CI 1.040–1.264) and moderate mindfulness (OR = 1.099, 95% CI 1.026–1.176). Overall, psychological factors (mindfulness, body image anxiety) appeared more influential than anthropometric or lifestyle factors (BMI, physical activity) in relation to orthorexia. These findings indicate that mindfulness was inversely associated with orthorexia tendencies, while body image anxiety was positively associated with orthorexia and was statistically linked to this association in the mediation analysis. Full article

Objective: To examine the associations of metabolic health and obesity phenotypes with liver fat accumulation and hepatic steatosis in adults. Methods: We analyzed 676 non-Hispanic white adults (18–95 years; 55.8% female) from the Fels Longitudinal Study using a cross-sectional design. Participants were classified into metabolically healthy normal weight (MHNW), metabolically healthy obesity (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy obesity (MUO) phenotypes. Metabolically unhealthy status was defined as the presence of ≥1 metabolic dysfunction, consistent with prior epidemiological definitions; secondary analyses using ≥2 were also performed. Obesity was defined using DXA-derived body fat percentage. Liver fat (%) was quantified using magnetic resonance imaging, and hepatic steatosis was defined as liver fat > 5.56%. Multivariable linear and probit regression models were used to evaluate associations, adjusting for demographic and lifestyle covariates; secondary models additionally examined dietary intake. Results: Mean liver fat was 5.95% (SE = 0.23), and steatosis was present in 29.8% of participants. Compared to MHNW individuals, liver fat was significantly higher in MHO (mean 3.77% vs. 2.67%), MUNW (4.63%), and MUO (8.47%) phenotypes. After covariate adjustment, liver fat was 33.8% (95% CI: 13.7–57.5%) higher in MHO, 28.1% (10.1–49.0%) higher in MUNW, and 113.0% (85.3–144.7%) higher in MUO relative to MHNW. Corresponding increases in steatosis probabilities were observed across phenotypes. No individual dietary component or dietary pattern was significantly associated with liver fat after adjustment. Conclusions: Metabolically healthy obesity was associated with higher liver fat and steatosis probability compared with metabolically healthy normal weight, with levels comparable to metabolically unhealthy normal weight individuals. These findings suggest that the absence of overt metabolic abnormalities does not necessarily indicate a metabolically benign state with respect to liver fat accumulation. Given the cross-sectional design, these results should be interpreted as associations rather than causal relationships. Full article

Pig weighing is an essential procedure for monitoring growth and animal health; however, conventional methods are often labor-intensive, costly, and potentially stressful. In this context, this study proposes a non-invasive approach for estimating the body weight of pigs during the growing stage based on computer vision and the YOLOv11 algorithm, enabling automatic segmentation and individual identification in multi-animal environments. The study used RGB images of 10 group-housed pigs captured throughout the growing phase, in which automatic dorsal segmentation was combined with individual identification through numerical markings. From the generated binary masks, the segmented dorsal area was extracted and used as a predictor variable in Linear Regression and a Multilayer Perceptron (MLP) Artificial Neural Network. The YOLOv11 model showed consistent performance in the segmentation task, achieving test-set metrics of Precision = 0.849, Recall = 0.886, mAP@0.50 = 0.936, and mAP@0.50–0.95 = 0.819, demonstrating good generalization capability in scenarios with intense animal interaction. In the weight prediction stage, Linear Regression and the MLP achieved high coefficients of determination (R² = 0.96 and 0.95, respectively) with low errors (RMSE = 1.52 kg and 1.63 kg; MAE = 1.20 kg and 1.25 kg), indicating a strong correlation between segmented dorsal area and actual body weight. Class-wise analysis revealed superior performance for classes 7 and 9, with R² values up to 0.98 and RMSE below 1.1 kg, whereas class 8 showed greater error dispersion, associated with higher morphological variability and a smaller number of available samples. These results demonstrate that the direct use of morphometric information extracted from segmented masks in 2D images constitutes a robust, accurate, and low-cost approach for automatic pig body-weight estimation. Moreover, this study is among the few addressing this task specifically during the growing stage, highlighting its potential for future deployment in embedded systems and intelligent monitoring platforms for precision pig farming, although further evaluation of computational efficiency and real-time performance is still required. Full article

Background: Pubic symphysis plating is a common method for stabilizing traumatic pubic symphysis disruptions, yet reported rates of implant failure vary widely in the literature. This variability may reflect inconsistent definitions and failure to distinguish clinically significant early construct failure from later asymptomatic postoperative radiographic changes. Methods: We performed a retrospective observational study of 30 patients with traumatic pubic symphysis disruption without associated fractures of the pubic body or pubic rami treated with open reduction and plate fixation. Pubic symphysis distance (PSD) was measured on admission CT, immediate postoperative anteroposterior pelvic radiographs, and follow-up CT scans obtained at 3, 6, and ≥12 months. Early mechanical failure, qualitative radiographic signs of implant loosening, and radiographic loss of reduction were predefined. Non-parametric tests were used to compare patients with and without early mechanical failure and to evaluate longitudinal PSD changes; analyses of potential associated factors were exploratory. Results: Early mechanical failure occurred in 4 patients (13.3%) within 30 days and presented as an acute symptomatic event with imaging-confirmed construct compromise requiring revision. In exploratory univariable analysis, early failure was more frequent in female patients and in those with obesity or osteoporosis, although these findings should be interpreted cautiously given the very small number of events. PSD changed significantly over time (p < 0.001), with minimal increase during the first 3 months, greater widening between 3 and 6 months, and little additional change thereafter. Qualitative radiographic signs of implant loosening and widening were observed in 8 patients (26.7%) during follow-up without clinically documented pain, instability, or need for revision. No clear association was demonstrated between PSD widening and final functional outcome measured by the Majeed score, although these analyses were limited by sample size and wide confidence intervals. Conclusions: In this retrospective cohort, postoperative radiographic widening and qualitative signs of implant loosening were not by themselves associated with clinically evident failure requiring revision during the available follow-up. Early failure was identified by acute clinical symptoms with imaging-confirmed construct compromise, whereas delayed widening was often observed without clinically documented pain, instability, or reoperation. These findings suggest that postoperative imaging should be interpreted together with symptoms and overall pelvic stability, while recognizing the methodological limitations of the study. Full article

Background/Objectives: The Individualized Neuromuscular Quality-of-Life Questionnaire (INQoL) is a widely used measure of quality of life in patients with various neuromuscular diseases. This study aimed to adapt and test the validity and reliability of this measure in Hungarian patients with neuromuscular disease. Methods: According to the widely accepted method of validation, we first translated the original INQoL version into Hungarian, and then a native English speaker translated it back into English to test its validity. Following a pretest procedure, the INQoL was administered to 80 patients with various muscular diseases and 30 age-matched controls. The internal consistency and test–retest reliability were assessed. Concurrent validity was measured using the 36-item Short Form Survey (SF-36) questionnaire. Results: For all INQoL subscales, Cronbach’s alpha was above 0.7, demonstrating the reliability of the subscales. The highest Cronbach alpha value was for the Weakness subscale (0.983) and the lowest for the Treatment subscale (0.794). The intraclass correlation coefficient test values ranged from 0.810 (Treatment) to 0.988 (Pain), indicating excellent test–retest reliability. There was a strong correlation between the SF-36 Physical Function and multiple INQoL subscales, including Weakness (r = 0.754, p < 0.001), Fatigue (r = 0.704, p < 0.001), Activities (r = 0.744) p < 0.001, Independence (r = 0.791 p < 0.001), Body Image (r = 0.714 p < 0.001), and overall Quality of Life (r = 0.742 p < 0.001). Conclusions: Our findings indicate that the Hungarian-language adaptation of the questionnaire possesses adequate reliability and construct validity for assessing the quality of life in patients with muscular disorders. Full article

The interpretation of geophysical multi-attribute surveys is often subjective and complicated by large datasets, prompting the need for automated fusion methods that preserve structures and enhance anomalies. This study introduces an image fusion approach that combines the non-subsampled contourlet transform (NSCT) with the New Metric Parameter (NMP) rule to integrate multi-source polarizability and resistivity data for copper–nickel exploration. Using NSCT, source images are decomposed into multi-scale, multi-directional low- and high-frequency sub-bands. Low-frequency components are fused through dynamic weighting, while high-frequency components are merged using the NMP rule. The sensitivity to key parameters—such as low-frequency weight, grid size, and grid angle—was assessed using field data. Results indicate that NSCT + NMP fusion enhances spatial resolution and boundary definition of anomalies, effectively merging low resistivity with high polarizability signals. Quantitative field validation shows that 82.43% of the gabbroic mineralization zone has a judging coefficient below 0.45, confirming the fusion accuracy. Optimal parameter choices include dynamically adjusted low-frequency weights, a grid size that balances detail and noise suppression, and a 45° square grid for directional neutrality. This method offers a practical strategy for joint multi-physical data analysis and improved spatial recognition of mineralized bodies in exploration. Full article

Background/Objectives: Patients with cystic fibrosis (CF) have been reported to have eating disorders. This can contribute to poor weight gain, which can result in increased morbidity and mortality. The aim of this review is to understand the prevalence and impact of eating disorders (ED) and body image disturbance in the CF population. Methods: A review of the current literature on eating disorders in CF. Results: Disordered eating behaviors appear common in CF. However, it is unclear if the prevalence is greater or similar to that of the general population. Conclusions: Routine screening for eating disorders is important in the care of CF patients to help prolong survival and quality of life in this patient population. Full article

Background and objectives: Intolerance of uncertainty (IU) is a well-established transdiagnostic process in anxiety (ANX) and major depressive disorder (MDD), and has been increasingly implicated in anorexia nervosa (AN). However, most previous research including patients with AN has relied on total or subscale scores from eating disorder measures, which obscures how specific eating attitudes and body dissatisfaction symptoms relate to distinct facets of IU. The primary objective of the present study was to characterize item-level networks linking eating attitudes, body dissatisfaction, and IU in a pooled clinical mental health sample, alongside a control group (CG). Methods: Data were drawn from a sample including individuals with symptoms related to AN (N = 105), MDD (N = 97), and ANX (N = 240), a comorbid group (N = 84) with symptoms of two or more of these conditions, and a CG (N = 842). Separate item-level networks were estimated for clinical and control groups, and network structure and centrality indices were compared. Results: Network analyses revealed distinct organizational patterns between the clinical and control subsamples. Although both networks showed identical diameters, the clinical network exhibited a shorter average path length and higher clustering, indicating stronger local connectivity, whereas the control network showed higher modularity. In the clinical subsample, nodes related to binge eating, post-eating guilt, and IU emerged as the most central and acted as key connectors between clusters. In contrast, the control network displayed a more distributed centrality pattern, suggesting a more integrated and homogeneous network organization. Conclusions: This study provides new evidence to refine our understanding of how IU relates to eating attitudes and body dissatisfaction across diagnostic mental health boundaries. Identifying highly influential psychopathological symptoms across eating, mood, and anxiety disorders, as well as bridge nodes linking these mental health domains, is important for understanding transdiagnostic symptom dynamics. These insights may inform the development of more sensitive screening and diagnostic tools, as well as targeted intervention points to support more personalized and mechanism-focused treatments. Full article