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  • Article
  • Open Access
1 Citations
2,248 Views
23 Pages

The Increase in the Peroxidase Activity of the Cytochrome C with Substitutions in the Universal Binding Site Is Associated with Changes in the Ability to Interact with External Ligands

  • Rita V. Chertkova,
  • Ilya P. Oleynikov,
  • Alexey A. Pakhomov,
  • Roman V. Sudakov,
  • Marina A. Semenova,
  • Alexander M. Arutyunyan,
  • Vasily V. Ptushenko,
  • Mikhail P. Kirpichnikov,
  • Dmitry A. Dolgikh and
  • Tatiana V. Vygodina

Cytochrome c (CytC), a one-electron carrier, transfers electrons from complex bc1 to cytochrome c oxidase (CcO) in the electron-transport chain. Electrostatic interaction with the partners, complex bc1 and CcO, is ensured by a lysine cluster near the...

  • Article
  • Open Access
7 Citations
3,320 Views
17 Pages

Enhancing Paraoxon Binding to Organophosphorus Hydrolase Active Site

  • Léa El Khoury,
  • David L. Mobley,
  • Dongmei Ye and
  • Susan B. Rempe

23 November 2021

Organophosphorus hydrolase (OPH) is a metalloenzyme that can hydrolyze organophosphorus agents resulting in products that are generally of reduced toxicity. The best OPH substrate found to date is diethyl p-nitrophenyl phosphate (paraoxon). Most stru...

  • Article
  • Open Access
12 Citations
3,404 Views
12 Pages

In drug design, the prediction of new active compounds from protein sequence data has only been attempted in a few studies thus far. This prediction task is principally challenging because global protein sequence similarity has strong evolutional and...

  • Article
  • Open Access
22 Citations
7,684 Views
15 Pages

The periplasmic oligopeptide binding protein A (OppA) represents a well-known example of water-mediated protein-ligand interactions. Here, we perform free-energy calculations for three different ligands binding to OppA, using a thermodynamic integrat...

  • Review
  • Open Access
47 Citations
10,436 Views
23 Pages

Insights on Cytochrome P450 Enzymes and Inhibitors Obtained Through QSAR Studies

  • Jayalakshmi Sridhar,
  • Jiawang Liu,
  • Maryam Foroozesh and
  • Cheryl L. Klein Stevens

3 August 2012

The cytochrome P450 (CYP) superfamily of heme enzymes play an important role in the metabolism of a large number of endogenous and exogenous compounds, including most of the drugs currently on the market. Inhibitors of CYP enzymes have important role...

  • Article
  • Open Access
4 Citations
2,522 Views
11 Pages

Introduction of a More Glutaredoxin-like Active Site to PDI Results in Competition between Protein Substrate and Glutathione Binding

  • Mirva J. Saaranen,
  • Heli I. Alanen,
  • Kirsi E. H. Salo,
  • Emmanuel Nji,
  • Pekka Kärkkäinen,
  • Constanze Schmotz and
  • Lloyd W. Ruddock

28 September 2022

Proteins in the thioredoxin superfamily share a similar fold, contain a -CXXC- active site, and catalyze oxidoreductase reactions by dithiol-disulfide exchange mechanisms. Protein disulfide isomerase (PDI) has two -CGHC- active sites. For in vitro st...

  • Article
  • Open Access
3 Citations
2,439 Views
18 Pages

Residual Helicity at the Active Site of the Histidine Phosphocarrier, HPr, Modulates Binding Affinity to Its Natural Partners

  • José L. Neira,
  • David Ortega-Alarcón,
  • Bruno Rizzuti,
  • Martina Palomino-Schätzlein,
  • Adrián Velázquez-Campoy and
  • Alberto Falcó

6 October 2021

The phosphoenolpyruvate-dependent phosphotransferase system (PTS) modulates the preferential use of sugars in bacteria. The first proteins in the cascade are common to all organisms (EI and HPr). The active site of HPr involves a histidine (His15) lo...

  • Article
  • Open Access
7 Citations
4,275 Views
16 Pages

The last step in the biosynthesis of flavin adenine dinucleotide (FAD) is considered a target for the design of antimicrobial drugs because it is carried out by two non-homologous proteins in eukaryotic and prokaryotic organisms. Monofunctional FMN:...

  • Article
  • Open Access
3 Citations
3,003 Views
12 Pages

1 October 2020

Glutathione transferases (GSTs) are enzymes that play a critical role in cellular detoxication by catalyzing the nucleophilic attack of glutathione on the electrophilic center of a number of xenobiotic compounds, including many therapeutic drugs. Mut...

  • Article
  • Open Access
5 Citations
2,384 Views
12 Pages

31 May 2023

The composition of amino acids forming the active site of a CYP enzyme is impactful in its substrate selectivity. For CYP2E1, the role of PHE residues in the formation of effective binding orientations for its aromatic substrates remains unclear. In...

  • Article
  • Open Access
4 Citations
3,380 Views
30 Pages

17 January 2023

Pathogenic changes in γ-secretase activity, along with its response to different drugs, can be affected by changes in the saturation of γ-secretase with its substrate. We analyze the saturation of γ-secretase with its substrate usin...

  • Article
  • Open Access
11 Citations
4,010 Views
10 Pages

Mutagenesis Studies and Structure-function Relationships for GalNAc/Gal-Specific Lectin from the Sea Mussel Crenomytilus grayanus

  • Svetlana N. Kovalchuk,
  • Nina S. Buinovskaya,
  • Galina N. Likhatskaya,
  • Valery A. Rasskazov,
  • Oksana M. Son,
  • Liudmila A. Tekutyeva and
  • Larissa A. Balabanova

27 November 2018

The GalNAc/Gal-specific lectin from the sea mussel Crenomytilus grayanus (CGL) with anticancer activity represents а novel lectin family with β-trefoil fold. Earlier, the crystal structures of CGL complexes with globotriose, galactose and galactosami...

  • Article
  • Open Access
2 Citations
2,483 Views
13 Pages

22 January 2025

Lysozyme plays a crucial role in the natural immune system, protecting against invading bacteria or viruses. The room-temperature (RT) structure of lysozymes is important for understanding accurate structural information compared to the crystal struc...

  • Article
  • Open Access
607 Views
18 Pages

17 October 2025

The antimalarial combination of sulfadoxine–pyrimethamine is used as a preventive treatment in pregnant women and children in Africa. Sulfadoxine inhibits the Plasmodium falciparum dihydropteroate synthase (PfDHPS), but resistance has emerged t...

  • Article
  • Open Access
8 Citations
3,445 Views
16 Pages

Knowledge of the cleavage specificity of ribonucleases is critical for their application in RNA modification mapping or RNA-protein binding studies. Here, we detail the cleavage specificity and efficiency of ribonuclease MC1 and cusativin using a cus...

  • Article
  • Open Access
6 Citations
2,914 Views
20 Pages

In Silico Design of New Dual Inhibitors of SARS-CoV-2 MPRO through Ligand- and Structure-Based Methods

  • Alessia Bono,
  • Antonino Lauria,
  • Gabriele La Monica,
  • Federica Alamia,
  • Francesco Mingoia and
  • Annamaria Martorana

The viral main protease is one of the most attractive targets among all key enzymes involved in the life cycle of SARS-CoV-2. Considering its mechanism of action, both the catalytic and dimerization regions could represent crucial sites for modulatin...

  • Article
  • Open Access
10 Citations
3,785 Views
14 Pages

Discovery of Novel Diarylamide N-Containing Heterocyclic Derivatives as New Tubulin Polymerization Inhibitors with Anti-Cancer Activity

  • Xu Liu,
  • Xiao-Jing Pang,
  • Yuan Liu,
  • Wen-Bo Liu,
  • Yin-Ru Li,
  • Guang-Xi Yu,
  • Yan-Bing Zhang,
  • Jian Song and
  • Sai-Yang Zhang

Tubulin has been regarded as an attractive and successful molecular target in cancer therapy and drug discovery. Vicinal diaryl is a simple scaffold found in many colchicine site tubulin inhibitors, which is also an important pharmacophoric point of...

  • Article
  • Open Access
6 Citations
3,157 Views
24 Pages

Novel Combretastatin A-4 Analogs—Design, Synthesis, and Antiproliferative and Anti-Tubulin Activity

  • Marta Jędrzejczyk,
  • Benedetta Morabito,
  • Barbara Żyżyńska-Granica,
  • Marta Struga,
  • Jan Janczak,
  • Maral Aminpour,
  • Jack A. Tuszynski and
  • Adam Huczyński

Combretastatins isolated from the Combretum caffrum tree belong to a group of closely related stilbenes. They are colchicine binding site inhibitors which disrupt the polymerization process of microtubules in tubulins, causing mitotic arrest. In vitr...

  • Proceeding Paper
  • Open Access
1 Citations
2,203 Views
6 Pages

14 November 2020

HIV is one of the most deadly viruses known to humans and causes a disease, known as Acquired Immunodeficiency Syndrome (or, AIDS). There are only a handful of drugs which are totally effective against the virus. This is due to the enzyme reverse tra...

  • Article
  • Open Access
13 Citations
3,030 Views
18 Pages

Systematic Studies on Anti-Cancer Evaluation of Stilbene and Dibenzo[b,f]oxepine Derivatives

  • Filip Borys,
  • Piotr Tobiasz,
  • Marcin Poterała,
  • Hanna Fabczak,
  • Hanna Krawczyk and
  • Ewa Joachimiak

18 April 2023

Cancer is one of the most common causes of human death worldwide; thus, numerous therapies, including chemotherapy, have been and are being continuously developed. In cancer cells, an aberrant mitotic spindle—a microtubule-based structure neces...

  • Article
  • Open Access
14 Citations
5,461 Views
13 Pages

The DNA excision repair protein ERCC-1-DNA repair endonuclease XPF (ERCC1-XPF) is a heterodimeric endonuclease essential for the nucleotide excision repair (NER) DNA repair pathway. Although its activity is required to maintain genome integrity in he...

  • Article
  • Open Access
1 Citations
2,143 Views
18 Pages

Structural and Functional Insights into the Roles of Potential Metal-Binding Sites in Apostichopus japonicus Ferritin

  • Yan Wu,
  • Chunheng Huo,
  • Tinghong Ming,
  • Yan Liu,
  • Chang Su,
  • Xiaoting Qiu,
  • Chenyang Lu,
  • Jun Zhou,
  • Ye Li and
  • Xiurong Su
  • + 3 authors

8 December 2022

Ferritin is widely acknowledged as a conservative iron storage protein found in almost all living kingdoms. Apostichopus japonicus (Selenka) is among the oldest echinoderm fauna and has unique regenerative potential, but the catalytic mechanism of ir...

  • Review
  • Open Access
15 Citations
6,667 Views
25 Pages

Smart Designs of Mo Based Electrocatalysts for Hydrogen Evolution Reaction

  • Xingyuan Gao,
  • Huilin Deng,
  • Qiuping Dai,
  • Quanlong Zeng,
  • Shuxian Qiu and
  • Xihong Lu

21 December 2021

As a sustainable and clean energy source, hydrogen can be generated by electrolytic water splitting (i.e., a hydrogen evolution reaction, HER). Compared with conventional noble metal catalysts (e.g., Pt), Mo based materials have been deemed as a prom...

  • Article
  • Open Access
1 Citations
2,549 Views
17 Pages

19 February 2023

Dipeptidyl peptidase III (DPP III), a zinc exopeptidase, is involved in the final steps of intercellular protein degradation and has a marked affinity for opioid peptides such as enkephalins and endomorphins. Recently, we characterized a number of ne...

  • Article
  • Open Access
16 Citations
6,324 Views
53 Pages

Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4

  • Azizah M. Malebari,
  • Shu Wang,
  • Thomas F. Greene,
  • Niamh M. O’Boyle,
  • Darren Fayne,
  • Mohemmed Faraz Khan,
  • Seema M. Nathwani,
  • Brendan Twamley,
  • Thomas McCabe and
  • Mary J. Meegan
  • + 1 author

31 October 2021

Antimitotic drugs that target tubulin are among the most widely used chemotherapeutic agents; however, the development of multidrug resistance has limited their clinical activity. We report the synthesis and biological properties of a series of novel...

  • Feature Paper
  • Article
  • Open Access
12 Citations
3,910 Views
13 Pages

ACE Inhibitory Peptides from Bellamya bengalensis Protein Hydrolysates: In Vitro and In Silico Molecular Assessment

  • Tanmoy Kumar Dey,
  • Roshni Chatterjee,
  • Rahul Shubhra Mandal,
  • Anadi Roychoudhury,
  • Debjyoti Paul,
  • Souvik Roy,
  • Mirian Pateiro,
  • Arun K. Das,
  • Jose M. Lorenzo and
  • Pubali Dhar

29 July 2021

Bellamya bengalensis muscle meat is known for ethnopharmacological benefits. The present study focuses on the identification of ACE inhibitory peptides from the proteolytic digests of muscle protein of Bellamya bengalensis and its underlying mechanis...

  • Communication
  • Open Access
3 Citations
7,153 Views
11 Pages

The Role of Active Site Residues in ATP Binding and Catalysis in the Methanosarcina thermophila Acetate Kinase

  • Cheryl Ingram-Smith,
  • Jeffrey Wharton,
  • Christian Reinholz,
  • Tara Doucet,
  • Rachel Hesler and
  • Kerry Smith

12 March 2015

Acetate kinase (ACK), which catalyzes the reversible phosphorylation of acetate by ATP, is a member of the acetate and sugar kinase/heat shock cognate/actin (ASKHA) superfamily. ASKHA family members share a common core fold that includes an ATPase do...

  • Article
  • Open Access
2 Citations
1,869 Views
14 Pages

5 September 2025

Ivermectin (IVM), a broad-spectrum anthelmintic agent, has anti-inflammatory properties, and affects cellular and humoral immune responses. We recently showed that multiple pro-inflammatory cytokines (e.g., FGF2, CCL5, CD40L) bind to the allosteric s...

  • Article
  • Open Access
18 Citations
5,406 Views
16 Pages

Competitive Binding of Magnesium to Calcium Binding Sites Reciprocally Regulates Transamidase and GTP Hydrolysis Activity of Transglutaminase 2

  • Eui Man Jeong,
  • Ki Baek Lee,
  • Gi Eob Kim,
  • Chang Min Kim,
  • Jin-Haeng Lee,
  • Hyo-Jun Kim,
  • Ji-Woong Shin,
  • Mee-ae Kwon,
  • Hyun Ho Park and
  • In-Gyu Kim

Transglutaminase 2 (TG2) is a Ca2+-dependent enzyme, which regulates various cellular processes by catalyzing protein crosslinking or polyamination. Intracellular TG2 is activated and inhibited by Ca2+ and GTP binding, respectively. Although aberrant...

  • Article
  • Open Access
6 Citations
2,009 Views
14 Pages

31 July 2023

CD40L is expressed in activated T cells, and it plays a major role in immune response and is a major therapeutic target for inflammation. High IgM syndrome type 1 (HIGM1) is a congenital functional defect in CD40L/CD40 signaling due to defective CD40...

  • Article
  • Open Access
2 Citations
1,367 Views
16 Pages

21 April 2025

We showed that multiple inflammatory cytokines (e.g., CCL5, CXCL12, CX3CL1, CD40L, and FGF2) bind to the allosteric site (site 2) of integrins, distinct from the classical RGD-binding site (site 1), and allosterically activate integrins. A major infl...

  • Article
  • Open Access
2 Citations
3,196 Views
20 Pages

22 January 2024

Na+,K+-ATPase actively extrudes three cytoplasmic Na+ ions in exchange for two extracellular K+ ions for each ATP hydrolyzed. The atomic structure with bound Na+ identifies three Na+ sites, named I, II, and III. It has been proposed that site III is...

  • Article
  • Open Access
1 Citations
2,172 Views
13 Pages

25 September 2024

MicroRNAs (miRNA) exert regulatory actions via base pairing with their binding sites on target mRNAs. Cooperative binding, i.e., synergism, among binding sites on an mRNA is biochemically well characterized. We studied whether this synergism is refle...

  • Article
  • Open Access
2 Citations
3,491 Views
12 Pages

The Role of Active-Site Residues Phe98, His239, and Arg243 in DNA Binding and in the Catalysis of Human Uracil–DNA Glycosylase SMUG1

  • Danila A. Iakovlev,
  • Irina V. Alekseeva,
  • Yury N. Vorobjev,
  • Nikita A. Kuznetsov and
  • Olga S. Fedorova

28 August 2019

Human SMUG1 (hSMUG1) hydrolyzes the N-glycosidic bond of uracil and some uracil lesions formed in the course of epigenetic regulation. Despite the functional importance of hSMUG1 in the DNA repair pathway, the damage recognition mechanism has been el...

  • Review
  • Open Access
284 Citations
20,621 Views
25 Pages

Plant Nucleotide Binding Site–Leucine-Rich Repeat (NBS-LRR) Genes: Active Guardians in Host Defense Responses

  • Daniela Marone,
  • Maria A. Russo,
  • Giovanni Laidò,
  • Anna M. De Leonardis and
  • Anna M. Mastrangelo

2 April 2013

The most represented group of resistance genes are those of the nucleotide binding site–leucine-rich repeat (NBS-LRR) class. These genes are very numerous in the plant genome, and they often occur in clusters at specific loci following gene duplicatio...

  • Article
  • Open Access
3 Citations
2,405 Views
12 Pages

Enhancement of Inhibitory Activity by Combining Allosteric Inhibitors Putatively Binding to Different Allosteric Sites on Cathepsin K

  • Shun Sato,
  • Kana Yamamoto,
  • Moeno Ito,
  • Katsutoshi Nishino,
  • Takanao Otsuka,
  • Kazuhiro Irie and
  • Masaya Nagao

Background: Cathepsin K, which is involved in bone resorption, is a good target for treating osteoporosis, but no clinically approved medicine has been developed. Recently, allosteric inhibitors with high specificity and few side effects have been at...

  • Article
  • Open Access
2 Citations
1,785 Views
15 Pages

10 November 2023

Mammalian fertilization is a species-selective event that involves a series of interactions between sperm proteins and the oocyte’s zona pellucida (ZP) glycoproteins. Bovine ZP consists of three glycoproteins: bZP2, bZP3, and bZP4. In our previ...

  • Feature Paper
  • Communication
  • Open Access
2 Citations
5,218 Views
9 Pages

30 November 2017

Site I inactivation of calmodulin (CaM) was used to examine the importance of aspartic acid 22 at position 3 in CaM calcium binding, protein folding, and activation of the Bordetella pertussis adenylate cyclase toxin domain (CyaA-ACD). NMR calcium ti...

  • Article
  • Open Access
12 Citations
9,748 Views
12 Pages

Glycine-Binding Site Stimulants of NMDA Receptors Alleviate Extrapyramidal Motor Disorders by Activating the Nigrostriatal Dopaminergic Pathway

  • Saki Shimizu,
  • Shunsaku Sogabe,
  • Ryoto Yanagisako,
  • Akiyoshi Inada,
  • Megumi Yamanaka,
  • Higor A. Iha and
  • Yukihiro Ohno

Dysfunction of the N-methyl-d-aspartate (NMDA) receptor has been implicated in the pathogenesis of schizophrenia. Although agonists for the glycine-binding sites of NMDA receptors have potential as new medication for schizophrenia, their modulation o...

  • Article
  • Open Access
12 Citations
4,054 Views
19 Pages

Computational-Based Discovery of the Anti-Cancer Activities of Pyrrole-Based Compounds Targeting the Colchicine-Binding Site of Tubulin

  • Sergei Boichuk,
  • Kirill Syuzov,
  • Firuza Bikinieva,
  • Aigul Galembikova,
  • Svetlana Zykova,
  • Ksenia Gankova,
  • Sergei Igidov and
  • Nazim Igidov

30 April 2022

Despite the tubulin-binding agents (TBAs) that are widely used in the clinic for cancer therapy, tumor resistance to TBAs (both inherited and acquired) significantly impairs their effectiveness, thereby decreasing overall survival (OS) and progressio...

  • Article
  • Open Access
33 Citations
5,432 Views
27 Pages

The Design, Synthesis, and Biological Activities of Pyrrole-Based Carboxamides: The Novel Tubulin Inhibitors Targeting the Colchicine-Binding Site

  • Sergei Boichuk,
  • Aigul Galembikova,
  • Kirill Syuzov,
  • Pavel Dunaev,
  • Firuza Bikinieva,
  • Aida Aukhadieva,
  • Svetlana Zykova,
  • Nazim Igidov,
  • Ksenia Gankova and
  • Pavel Kopnin
  • + 1 author

24 September 2021

Microtubule targeting agents (MTAs) that interfere with the dynamic state of the mitotic spindle are well-known and effective chemotherapeutic agents. These agents interrupt the microtubule network via polymerization or depolymerization, halting the...

  • Article
  • Open Access
10 Citations
3,751 Views
14 Pages

26 January 2022

αS1-Casein (encoded by the CSN1S1 gene) is associated with food allergy more than other milk protein components. Milk allergy caused by αS1-casein is derived from cow milk, goat milk and other ruminant milk. However, little is known about...

  • Article
  • Open Access
4 Citations
2,898 Views
9 Pages

In this work we examined the properties of thrombin-binding aptamer (TBA) modified by the introduction of inversion of polarity sites (IPS) in order to assess the effect of modification on the activation of TBA to serve as DNAzyme with peroxidase-lik...

  • Article
  • Open Access
7 Citations
3,902 Views
21 Pages

The D1 dopamine receptor (D1R) is a G protein-coupled receptor that signals through activating adenylyl cyclase and raising intracellular cAMP levels. When activated, the D1R also recruits the scaffolding protein β-arrestin, which promotes recep...

  • Article
  • Open Access
19 Citations
3,983 Views
18 Pages

Engineering the Catalytic Properties of Two-Domain Laccase from Streptomyces griseoflavus Ac-993

  • Ilya Kolyadenko,
  • Anastasia Scherbakova,
  • Kirill Kovalev,
  • Azat Gabdulkhakov and
  • Svetlana Tishchenko

Laccases catalyze the oxidation of substrates with the concomitant reduction of oxygen to water. Recently, we found that polar residues located in tunnels leading to Cu2 and Cu3 ions control oxygen entrance (His 165) and proton transport (Arg 240) of...

  • Communication
  • Open Access
3 Citations
2,510 Views
10 Pages

Trans-Activator Binding Site Context in RCNMV Modulates Subgenomic mRNA Transcription

  • Jennifer S. H. Im,
  • Laura R. Newburn,
  • Gregory Kent and
  • K. Andrew White

10 November 2021

Many positive-sense RNA viruses transcribe subgenomic (sg) mRNAs during infections that template the translation of a subset of viral proteins. Red clover necrotic mosaic virus (RCNMV) expresses its capsid protein through the transcription of a sg mR...

  • Article
  • Open Access
1 Citations
4,331 Views
19 Pages

In Silico Activity Prediction and Docking Studies of the Binding Mechanisms of Levofloxacin Structure Derivatives to Active Receptor Sites of Bacterial Type IIA Topoisomerases

  • Elena V. Uspenskaya,
  • Vasilisa A. Sukhanova,
  • Ekaterina S. Kuzmina,
  • Tatyana V. Pleteneva,
  • Olga V. Levitskaya,
  • Timur M. Garaev and
  • Anton V. Syroeshkin

20 December 2023

The need for new antimicrobial agents (AntAg) is driven by the persistent antibiotic resistance in microorganisms, as well as the increasing frequency of pandemics. Due to the deficiency of AntAg, research aimed at developing speedy approaches to fin...

  • Article
  • Open Access
4 Citations
2,879 Views
16 Pages

The Mucus Binding Factor Is Not Necessary for Lacticaseibacillus rhamnosus CRL1505 to Exert Its Immunomodulatory Activities in Local and Distal Mucosal Sites

  • Kae Tomotsune,
  • Fernanda Raya Tonetti,
  • Hiroya Mizuno,
  • Mariano Elean,
  • Kohtaro Fukuyama,
  • Binghui Zhou,
  • Wakako Ikeda-Ohtsubo,
  • Keita Nishiyama,
  • Akihiro Yamamura and
  • Julio Villena
  • + 5 authors

18 November 2022

Both viable and non-viable orally administered Lacticaseibacillus rhamnosus CRL1505 modulate immunity in local (intestine) and distal (respiratory) mucosal sites. So, intestinal adhesion and colonization are not necessary for this probiotic strain to...

  • Correction
  • Open Access
930 Views
3 Pages

28 June 2024

The changes below represent the corrections the authors wish to make to the original paper [...]

  • Article
  • Open Access
13 Citations
5,717 Views
27 Pages

Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities

  • Romeo Romagnoli,
  • Paola Oliva,
  • Filippo Prencipe,
  • Stefano Manfredini,
  • Federica Budassi,
  • Andrea Brancale,
  • Salvatore Ferla,
  • Ernest Hamel,
  • Diana Corallo and
  • Giampietro Viola
  • + 4 authors

21 August 2022

A further investigation aiming to generate new potential antitumor agents led us to synthesize a new series of twenty-two compounds characterized by the presence of the 7-(3′,4′,5′-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine...

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