Search Results (707)

With the continuous growth of data-intensive applications and artificial intelligence workloads, traditional dynamic random access memory (DRAM) is increasingly struggling to meet demands in terms of capacity scale, energy consumption constraints, and data retention after power failure. Consequently, non-volatile memory (NVM) has emerged as a crucial technology for bridging the gap between the memory and storage layers. However, due to inherent differences in write life, read–write performance variations, and consistency guarantee after failure, the systematic application of NVM still faces a series of challenges. Addressing these issues, this paper takes as its starting point the adaptation of medium characteristics and system design, and summarizes the research progress in aspects such as write optimization, consistency and security coordination mechanisms, data structure modification under hybrid memory architecture, and cross-layer resource collaboration. It also conducts an in-depth analysis of representative solutions and evaluation methods. The review results show that current research has shifted from improving a single performance bottleneck to multi-mechanism collaborative optimization. Various technical approaches have proven complementary in alleviating write amplification, enhancing persistence efficiency, and optimizing access patterns. This paper demonstrates that achieving stable and scalable application of NVM requires establishing a more systematic collaborative design concept between durability, security, and performance. As AI training workloads and big data analytics place increasing demands on memory bandwidth and persistence, the techniques surveyed here provide a foundational basis for next-generation memory-centric computing infrastructures. Full article

With the development of geological data analysis and big data technology, intelligent mineral prospectivity mapping (MPM) has become a key direction in the integration of geoscience and artificial intelligence, showing promising applications in the identification and evaluation of strategic mineral resources such as gold. To address the limitations of conventional methods—including insufficient training samples, complex model structures, and weak capability in recognizing anomalous zones—this study proposes an improved convolutional neural network (CNN) approach for mineral prediction. A lightweight, modular CNN structure with repeatable stacking is designed to reduce computational cost while enhancing model robustness and generalization. In addition, a dynamic learning rate scheduling strategy is adopted to optimize the training process, significantly improving convergence speed and training stability. Furthermore, high-probability prediction samples and low-probability background samples are combined to form a new training dataset for regional prospectivity evaluation, yielding a high area under the curve (AUC) score. The method is applied and validated in the Xiong’ershan region, and the predicted high-potential zones account for 30% of the study area and contain 81.4% of the known gold deposits. These results demonstrate the method’s effectiveness in mineral information extraction and blind-area targeting, offering a new approach for mineral prospectivity mapping. Full article

Blue space, as an important natural and social composite feature system in cities, not only provides supporting, regulating, and provisioning services, but also plays a key role in human well-being, recreational experience, and urban sustainable development. The blue space cultural ecosystem service (CES) has gradually attracted the attention of academia in recent years, but there is a lack of systematic integration research in related fields. Therefore, it is necessary to conduct a comprehensive analysis of current studies to clarify how, and to what extent, blue spaces influence CESs. This study adopts a PRISMA-based systematic search combined with qualitative synthesis, aiming to review the research status of CES and its developmental trajectory within blue space studies, and to identify future research trends and critical gaps. A total of 52 studies meeting the inclusion criteria were finally selected through database screening. The research innovatively divides the evolution of blue space CES into three stages (2012–2017/2018–2022/2023–2025), revealing a shift in research focus from single value identification to complex policy support. Secondly, through the mapping of six typical blue space types (such as rivers and wetlands) and 10 CES indicators, combined with a Pearson correlation heatmap, it provides quantitative insights into the coupling mechanisms between indicators, such as the significant synergy between spiritual and educational values. Methodologically, it systematically discriminates between the application boundaries of monetary valuation based on the contingent valuation method and non-monetary valuation represented by social media big data and PPGIS, pointing out that technological progress is driving the evaluation toward high dynamics and refinement. Finally, the study points out current bottlenecks such as uneven geographical distribution and insufficient planning transformation, emphasizing that future research should use artificial intelligence to improve data processing accuracy and transform blue space CESs from “invisible welfare” into “explicit policy assets” to guide sustainable urban renewal and healthy space design. Full article

Natural products (NPs) have historically provided the foundational scaffolds for drug development, yet traditional bioprospecting faces critical limitations: high rediscovery rates, laborious isolation workflows, and substantial attrition during clinical translation. The emergence of big data technologies is fundamentally transforming this landscape, enabling a shift from serendipity-based discovery toward systematic, data-driven approaches. This review examines how the integration of artificial intelligence (AI), machine learning (ML), and multi-omics datasets is accelerating natural product research across three key domains: (1) genome mining for biosynthetic gene cluster identification using platforms such as antiSMASH, (2) cheminformatics-driven prediction of structure–activity relationships and ADMET properties, and (3) metabolomics-guided dereplication to prioritize novel bioactive scaffolds. We evaluate the convergence of genomics, metabolomics, and computational chemistry in enabling in silico lead optimization and the discovery of cryptic metabolites from previously inaccessible microbial taxa. While challenges in data standardization and scalability persist, the synergy between big data and NP research is accelerating clinical translation. Despite persistent challenges in data standardization, scalability, and equitable benefit-sharing, the convergence of big data and NP research is poised to redefine drug development. These advances position computational NP research as a cornerstone of next-generation drug development. Full article

This study investigates the evolving relationship between supply chain integration (SCI) and firm performance through a comprehensive bibliometric analysis of 148 publications retrieved from the Scopus database. Using VOSviewer 1.6.20 software, the research maps the intellectual structure of the field, highlighting influential authors, journals, and thematic developments. Findings reveal that SCI conceptualized across internal, supplier, and customer integration has consistently been linked to improved operational efficiency, responsiveness, and competitive advantage. However, empirical evidence also indicates mixed outcomes, particularly under conditions of environmental uncertainty and excessive dependence on partners. Recent scholarship demonstrates a notable shift toward sustainability-oriented integration and the adoption of digital technologies such as blockchain, big data analytics, and artificial intelligence, which collectively enhance resilience and adaptability. The analysis underscores gaps in research across developing economies and service industries, suggesting opportunities for future inquiry. Overall, the study deepens understanding of SCI’s role in shaping resilient, sustainable, and technologically enabled supply chains. Full article

This study examines the role of artificial intelligence (AI) technologies in identifying and sustaining leadership talent within the educational sector in Oman, addressing the increasing demand for evidence-based and innovative approaches to leadership development. A qualitative phenomenological research design was employed to explore how AI experts and educational leaders perceive, evaluate, and conceptualize AI-driven tools for leadership talent identification and sustainability. In-depth semi-structured interviews were conducted with 25 participants from three major Omani educational institutions. Data were analyzed using thematic analysis, allowing systematic identification of recurring patterns, conceptual relationships, and shared professional insights. The findings indicate that AI applications—including big data analytics, behavioral assessment tools, competency identification platforms, and predictive analytics—provide effective mechanisms for early detection and assessment of leadership potential. Furthermore, integrating AI into personalized professional development programs and continuous performance evaluation contributes to the long-term sustainability and strategic utilization of leadership talent. This study underscores the potential of AI to enhance strategic leadership planning within educational institutions. The results expand our empirical understanding of AI-driven leadership development and offer practical insights for implementing AI-informed strategies in Oman and the broader Gulf region. Full article

Determining the optimal harvest time is among the most critical economic decisions for peanut (Arachis hypogaea L.) growers, directly influencing yield, quality, and market value. Unlike many other crops, peanuts are indeterminate, continuing to flower and produce pods throughout their life cycle. As a result, pod development and maturation are asynchronous, making harvest timing particularly challenging. Conventional maturity estimation techniques, including the hull scrape method, pod blasting, and visual maturity profiling, are invasive, labor-intensive, time-consuming, and spatially limited. Moreover, differences in cultivar maturity rates and agroclimatic conditions exacerbate inconsistencies in maturity prediction. These challenges highlight the urgent need for scalable, objective, and data-driven methods to support growers in achieving optimal harvest outcomes. This review synthesizes the current understanding of peanut pod maturity and evaluates existing traditional and non-invasive approaches for maturity estimation. It aims to identify the limitations of conventional techniques and explore the integration of advanced sensing technologies, artificial intelligence (AI), and geospatial analytics to enhance precision and scalability in peanut maturity assessment and harvest decision-making. This review examines traditional destructive techniques such as the hull scrape method and pod blasting, followed by emerging non-invasive methods employing proximal and remote sensing platforms. Applications of vegetation indices, multispectral and hyperspectral imaging, and AI-based data analytics are discussed in the context of maturity prediction. Additionally, the potential of multimodal remote sensing data fusion and digital frameworks integrating spatial big data analytics, centralized data management, and cloud-based graphical interfaces is explored as a pathway toward end-to-end decision-support systems. Recent advances in non-invasive sensing and AI-assisted modeling have demonstrated significant improvements in scalability, precision, and automation compared with traditional manual approaches. However, their effectiveness remains constrained by the limited inclusion of agroclimatic, phenological, and cultivar-specific variables. Furthermore, the translation of model outputs into actionable, field-level harvest decisions is still underdeveloped, underscoring the need for integrated, user-centric digital infrastructure. Achieving a robust and transferable digital peanut maturity estimation system will require comprehensive ground-truth data across cultivars, regions, and growing seasons. Multidisciplinary collaborations among agronomists, data scientists, growers, and technology providers will be essential for developing practical, field-ready solutions. Integrating AI, multimodal sensing, and geospatial analytics holds immense potential to transform peanut maturity estimation. Such innovations promise to enhance harvest precision, economic returns, and sustainability while reducing manual effort and uncertainty, ultimately improving the efficiency and quality of life for peanut producers worldwide. Full article

Hydropower remains one of the primary sources of power generation. It can be operated as either a base-load or peak-load plant due to its rapid, easy start-up and stop-down capability. However, power plants, old or new, need to be operated and maintained optimally to meet energy demand and maximise economic returns. While the older plants without digital controls such as the Supervisory Control and Data Acquisition (SCADA) system are unable to leverage the evolving technology including big data and Artificial Intelligence (AI), the newer plants or plants that already have some form of data acquisition system have the advantage of leveraging the newer platforms for efficient operation, monitoring and fault diagnosis. Thus, an Artificial Neural Network (ANN), a machine learning (ML) algorithm, was chosen for this case study to predict the generator’s operational stator temperature by selecting six parameters that could potentially affect it. Real data from the 336 MW Chhukha Hydropower Plant (CHP) in Bhutan were used to train the ANN. The prediction of temperature using an ANN in MATLAB^® yielded an R² (correlation coefficient) of 96.8%, which is impressive but can be further improved through various optimisation and tuning methods with increased data volume and complexity. The performance of ANN prediction was validated against other regression models, and the ANN was found to outperform them. This demonstrated its capability to predict and detect generator temperature faults before failures, thereby enhancing hydropower operation and maintenance (O&M) efficiency. The model’s interpretation was also done through Shapley Additive ExPlanations (SHAP). Full article

All forms of neural communications, from cognition to emotion, are regulated by neurotransmitters, which are otherwise the chemical language of the brain. Precise detection of these neurotransmitters is essential for the perception of neurophysiology and diagnosis of neurodegenerative diseases as well. Among the existing techniques for the detection of these molecules, fluorescence sensing is evolving as a powerful approach in terms of high sensitivity, rapid response, and real-time visualization of the chemical events occurring in the neural system. In recent years, nanomaterials have transformed this field by integrating tunable optical properties, excellent photostability, and modifiable surface chemistry into biocompatible nanostructures. We summarize the recent advances of these architectures to show how the material type and dimensionality, as well as the surface functionality, play roles in sensing through the mechanisms of Förster resonance energy transfer (FRET), photoinduced electron transfer (PET), inner filter effect (IFE), and aggregation-induced emission (AIE). The discussion has also been extended to the correlation of fluorescence modulation with the selectivity and sensitivity in the mechanism-to-function relationship. The potential utility of such innovative technologies, including artificial intelligence, spectral deconvolution analysis via big data algorithms, and chip-integrated sensing, was explored as a means to enable real-time neurochemical detection. This converging area of nanotechnology and neuroscience leaves a mark not just in analytical accuracy, but also parallels human brain rhythms. Full article

Purpose: This study systematically reviews research on six emerging technologies in external auditing, Big Data, Blockchain, Machine Learning, Deep Learning, Artificial Intelligence (AI), and Robotic Process Automation (RPA), to clarify what is currently known and to identify where the main gaps remain. Rather than treating each technology in isolation, this study brings them together under a single integrative review to provide a consolidated reference point for scholars assessing their impact on external audit practices. Design/Methodology/Approach: Following a structured systematic review protocol, searches were conducted in Scopus, ScienceDirect and SpringerLink (2000–2024) using technology-related keywords combined with “audit”, “auditor” and “auditing”. After applying explicit inclusion and exclusion criteria, 471 records were reduced to 32 ABS-listed journal articles, which were analysed thematically. Findings: The review shows that research on emerging technologies in external auditing is still fragmented, with substantial variation in the depth and maturity of evidence across the six technologies. The strongest empirical base is concentrated in Big Data analytics and ML-based predictive models (including more advanced Deep Learning variants), whereas Blockchain and RPA work remains predominantly conceptual or confined to small-scale design-science implementations. Across technologies, most studies are single-country and either rely on auditors’ self-reported perceptions of adoption and impact or evaluate model performance without tracing effects on audit strategies and engagement outcomes, which limits external validity and construct measurement. Very few articles explicitly integrate the Audit Risk Model or other formal theories, and almost no work examines multi-technology “audit stacks” or generative AI, leaving substantial gaps in understanding how these tools jointly reshape inherent, control and detection risk across the audit cycle. Originality/Value: By integrating six technologies within a single external audit framework, the review offers a technology-specific evidence map and a targeted future research agenda that can guide scholars, audit firms and regulators in designing studies and policies aligned with actual gaps in the current literature. Full article

Background: Cardiothoracic surgery is among the most technologically advanced and resource-intensive medical specialties, placing it at the intersection of rapid digital innovation and growing demands for environmental sustainability. Addressing these parallel pressures requires integrated strategies that reconcile clinical excellence with ecological responsibility. Methods: This narrative review synthesizes PubMed-indexed literature published over the past two decades, supplemented by relevant policy documents and guidelines. The review examines digital transformation and sustainability initiatives in cardiothoracic surgery through the lens of the twin transformation framework, which conceptualizes digitalization and sustainability as interdependent and mutually reinforcing processes. Results: Key domains of digital transformation include artificial intelligence and big data-driven decision-making, robotic and minimally invasive surgical techniques, digital twins and simulation-based training, telemedicine and remote monitoring, and interoperable electronic health records. Sustainability-related themes encompass the substantial environmental burden of operating rooms, green surgical practices, sustainable procurement, and hospital-level decarbonization strategies. Emerging evidence suggests that aligning digital technologies with sustainability objectives can improve clinical outcomes, enhance operational efficiency, and reduce environmental impact. However, current evidence is largely derived from pilot studies and single-center experiences. Conclusions: Twin transformation offers a coherent and forward-looking framework for the future evolution of cardiothoracic surgery, demonstrating that digital innovation and sustainability can be synergistic rather than competing goals. While significant challenges remain—including high implementation costs, limited long-term data, and fragmented regulatory frameworks—integrating digital health technologies with sustainable practices represents a promising pathway toward high-quality, efficient, and environmentally responsible cardiothoracic care. Full article

Background. NOTCH receptors play a pivotal role in carcinogenesis. Upon ligand binding, a cascade of proteolytic cleavages mediated by ADAM proteases and the γ-secretase complex activates the receptor, ultimately releasing the NOTCH intracellular domain (NICD). NICD translocates to the nucleus, where it regulates gene expression. This review mainly aims to evaluate γ-secretase inhibitors (GSIs) as anticancer agents in preclinical and clinical settings, with a focus on their ability to block tumor progression, target cancer stem cells, and overcome resistance to standard therapies. Methods. A systematic search was conducted in the ISI Web of Science, PubMed, and Scopus databases, following PRISMA guidelines. The review included preclinical in vitro and in vivo studies, as well as clinical trials, investigating GSIs, either as monotherapy or in combination with other treatments, in TNBC, metastatic melanoma, PDAC, gastric cancer, and NSCLC. Exclusion criteria included duplicates, non-English articles, studies published before 2010, studies on non-cancer conditions, research unrelated to NOTCH signaling, and studies outside the selected cancer types. Overall, 69 articles were included and categorized into the five types of cancer analyzed (20 on NSCLC, 22 on TNBC, 11 on metastatic melanoma, 7 on GC, and 9 on PDAC). Of these, 60 studies corresponded to preclinical research in the types of cancer, and 9 studies corresponded to clinical trials in the types of cancer except for GC. Two independent authors screened and extracted relevant data, with disagreements resolved by the corresponding author. Findings were synthesized qualitatively across cancer types under study. Results. This review summarizes therapeutic advances involving GSIs in cancers driven by oncogenic NOTCH signaling, based on the 69 articles included. Preclinical studies show that GSIs synergize with chemotherapy and radiotherapy, particularly in NSCLC, melanoma, and TNBC, and block EMT, overcome therapeutic resistance, and improve prognosis. Commonly used GSIs include DAPT and RO4929097, which enhance the efficacy of agents, such as gemcitabine (PDAC), paclitaxel, osimertinib, erlotinib, and crizotinib (NSCLC), and 5-FU (gastric cancer, TNBC). Promising strategies include combining GSIs with SAHA, ATRA, CB-103, and other NOTCH signaling targeting molecules, either alone or with chemo- and radiotherapy. Clinical trials with GSIs, however, remain limited. RO4929097 is the most extensively tested GSI in clinical settings. PDAC trials combining GSIs with gemcitabine showed no benefit; melanoma trials yielded modest outcomes; and TNBC trials demonstrated partial responses to GSIs but overall low efficacy and significant adverse events. Discussion and Conclusions. Despite encouraging preclinical evidence, clinical trials with GSIs have underperformed, largely due to tumor heterogeneity, dosing limitations, and the non-selective nature of γ-secretase inhibition. Other NOTCH inhibitors, such as DLL4 antibodies, also resulted in partial responses and secondary effects. Future strategies should prioritize receptor-specific NOTCH inhibitors, patient stratification based on NOTCH pathway activation, and optimized combination regimens. Emerging approaches include integrating immunotherapy with advanced technologies such as CRISPR, CAR-T cells, and bispecific antibodies, as well as targeted delivery systems to enhance efficacy and reduce toxicity. Additional research directions include addressing the tumor microenvironment and EMT-driven resistance, elucidating the mechanisms of immune evasion, and inhibiting tumor angiogenesis. Finally, leveraging artificial intelligence and big-data-driven personalized medicine, including sex-specific considerations, will be essential for improving patient outcomes. Full article

The transition to electric mobility requires the coordinated evolution of vehicles, charging infrastructure, power systems, and intelligent digital platforms. This study examines the role of Industry 4.0 technologies in enabling large-scale electric vehicle (EV) adoption and effective EV grid integration and synthesizes the existing evidence into a coherent analytical framework to support planning and policy decision-making. A systematic review of 27 peer-reviewed studies published between 2018 and 2025 was conducted in accordance with PRISMA 2020 guidelines, capturing the acceleration of electromobility following the consolidation of Industry 4.0 technologies and the emergence of large-scale policy commitments worldwide. The analysis covers six technology families, including the Internet of Things, big data and analytics, artificial intelligence and machine learning, blockchain, digital twins, and extended reality, and examines their applications in smart charging, grid vehicle coordination, fleet optimization, and vehicle-to-grid services. The findings show that analytics and artificial intelligence consistently enhance operational reliability and efficiency, while digital twins are increasingly applied to infrastructure siting, grid impact assessment, and scenario analysis. Building on these results, the study proposes a three-layer analytical framework composed of physical, digital, and decision layers, together with a functional EV grid generation integration model that links technology readiness to system-level deployment. In addition, a transition timeline for the 2025–2040 period and a concise set of key performance indicators are introduced to support evaluation and comparison. Policy implications for Ecuador and Latin America emphasize interoperability, data governance, realistic cost assessment, and a phased approach to vehicle-to-grid deployment. Full article

The brain is a complex structural network. The employment of fluorescent labeling techniques in conjunction with advanced imaging methodologies facilitates comprehensive analysis of multiscale brain anatomy, thereby offering insights into fundamental principles of function and addressing neurological disorders. This review summarizes technological advances in fluorescent labeling methods in the field of neuroscience, and their applications in neural circuit analysis, cerebrovascular imaging, neuronal activity monitoring, and fluorescence-guided treatment of brain tumors. A challenging trend in integrating smart fluorescent labeling with tissue clearing, wide-field 3D imaging, artificial intelligence-assisted data processing/reconstruction, and multimodal information fusion is highlighted and discussed. The future direction of combining high-resolution, low-damage, dynamic imaging with big data analysis is envisioned, providing tools for understanding brain structure and function and their roles in disease. Full article

This study presents a systematic review of the role of key technologies in advancing sustainable logistics and supply chain management. Specifically, it explores the integration of Industry 4.0 (I4.0), logistics 4.0, and digital supply chains, focusing on technologies such as artificial intelligence (AI), augmented reality (AR), big data analytics (BDA), blockchain, cloud computing (CC), industrial internet of things (IIoT), machine learning (ML), robotics, virtual reality (VR), and internet of things (IoT). The aim is to examine how these technologies contribute to green logistics (GL), green supply chain management, sustainability, and the circular economy (CE). Data were collected from the Scopus database, covering studies published between 2019 and 2024. A total of 1471 publications were initially identified, and 39 studies met the selection criteria. The PRISMA approach was employed for the systematic review, revealing that leading research on I4.0 is concentrated in top-tier journals, with a significant number of publications from Italy focusing on digitalization in the agriculture and food sectors. Systematic literature reviews and resource-based theory are predominant, yet there is a notable gap in aligning research with the United Nations Agenda 2030 Sustainable Development Goals (SDGs). This paper provides insights into technological adoption trends and offers recommendations for industry leaders seeking to enhance sustainability, eco-friendliness, and alignment with the SDGs within their supply chains. Full article