Search Results (487)

Cyclin-Dependent Kinase-Like 5 (CDKL5) Deficient Disorder (CDD) is a rare X-linked developmental and epileptic encephalopathy characterized by early-onset refractory epilepsy, severe neurodevelopmental impairment, and lifelong disability. Although more than thirty anti-seizure medications are available, most CDD patients remain pharmaco-resistant. Gene-based therapies are emerging, but therapeutic development is hindered by marked clinical heterogeneity, small patient populations, and the lack of robust, translatable brain-based biomarkers for clinical trials. Genetically engineered Cdkl5 mouse models recapitulate many cognitive, behavioral, and molecular features of CDD, yet their utility is limited by the absence of overt seizures, precluding seizure-based outcome measures. Here, we establish high-definition brain network (HDBN) biomarkers using advanced diffusion MRI tractography combined with graph-theoretical analysis to quantify whole-brain network organization in Cdkl5 knockout mice. Diffusion MRI enables non-invasive mapping of axonal connectivity by leveraging anisotropic water diffusion, while high-angular-resolution acquisition overcomes key limitations of conventional diffusion tensor imaging in regions with complex fiber architecture. We demonstrate that Cdkl5 knockout mice exhibit reproducible and region-specific disruptions in brain network organization, prominently affecting the somatosensory and somatomotor cortex, hippocampus, hypothalamus, amygdala, and superior colliculus—regions implicated in cognition, learning and memory, homeostasis, anxiety, and visual–motor function. In contrast, networks within the entorhinal cortex remain largely preserved. These findings identify HDBN metrics as sensitive, non-invasive biomarkers that capture clinically relevant circuit-level abnormalities in CDD. Because diffusion MRI–based network analyses are directly translatable across species, HDBN biomarkers provide a unified framework for therapeutic evaluation in mouse models, large animals, and human clinical trials, enabling longitudinal monitoring of disease progression and treatment response. Full article

Triaxial induction logging is particularly outstanding in identifying reservoir parameters including anisotropic strata, inclined boreholes and horizontal wells. However, the coplanar systems follow the traditional induction method of using a shielding coil to offset the direct coupling. This method results in severe horns in the coplanar coil response, which makes it more difficult to evaluate the water (oil) saturation of the reservoir. In this study, we used an analytic method to derive the magnetic field in a finite-thickness anisotropic medium by applying tangential continuity of the electric and magnetic field strengths, introducing the magnetic vector potential and Bessel functions. The response model influenced by different parameters was established. Under the same environmental parameters, the measurement range of the vertical and horizontal conductivities was larger than that of the traditional coplanar system. The apparent conductivity of the target layer was closer to the true value of the vertical conductivity in the layered strata, with an accuracy improvement of 78.9%. Furthermore, the improved coplanar system mechanism was revealed by analyzing the spatial distributions of eddy currents and the magnitudes of the magnetic fields generated. Finally, we designed an experimental device for a coplanar sensing system. Under the same parameters, the received signals of the improved coplanar system were greater than those of the traditional coplanar system in the air, which laid a foundation for the quantitative evaluation of stratigraphic anisotropy response characterization and inversion. Full article

Cancer remains a primary global health challenge, accounting for millions of new cases and significant mortality annually. Although doxorubicin (DOX) is a fundamental anthracycline used for various malignancies, its therapeutic index is severely limited by poor selectivity, systemic toxicity, and dose-dependent cardiotoxicity. To address these issues, Janus nanoparticles (JNPs) have emerged as a promising bifunctional platform characterized by a structural asymmetry that allows for the independent functionalization of each hemisphere. This review examines primary fabrication routes—such as masking, microfluidics, self-assembly, and phase separation—and their specific applications in DOX delivery. The anisotropic architecture of JNPs enables a “separate rooms” concept, allowing for the co-delivery of incompatible drugs while facilitating multi-stimuli-responsive release mechanisms triggered by pH, enzymes, or NIR light. Furthermore, JNPs have demonstrated enhanced tumor accumulation and reduced systemic toxicity compared to conventional isotropic carriers. Recent developments even highlight the use of autonomous nanomotors to improve therapeutic delivery while minimizing premature leakage. However, clinical translation is currently hindered by manufacturing complexity, high equipment costs, scalability issues, and a lack of standardized reporting in the literature. Ultimately, JNPs represent a sophisticated frontier in precision oncology, though robust manufacturing processes and characterization protocols are required for future medical adoption. Full article

Silicon carbide (SiC) has emerged as a highly attractive material for microelectromechanical systems (MEMS) operating in harsh environments, owing to its outstanding mechanical, thermal, and chemical properties. This review provides a comprehensive overview of the advantages and limitations of SiC-based MEMS, with particular emphasis on the strong interdependence between material structure, mechanical properties, and epitaxial growth processes. The role of defects, residual stress, and crystal quality is discussed in relation to device performance and reliability. Special attention is devoted to cubic SiC grown on silicon substrates, highlighting how growth-induced features influence the mechanical response of micromachined structures. Furthermore, a detailed analysis of the quality factor (Q-factor) is presented for 3C-SiC (111)/Si resonators, including the development of analytical models and their validation through numerical simulations performed using COMSOL Multiphysics (Version 6.1). The necessity of incorporating anisotropic loss factors in numerical modeling is demonstrated to be essential for accurately describing the experimentally observed behavior. This review aims to provide design guidelines and modeling strategies for the optimization of SiC MEMS, supporting their further development for high-performance and extreme-environment applications, including pressure sensors, mechanical resonators and high-stress-tolerant sensors. Full article

Deep shale of the Lower Cambrian Qiongzhusi Formation in the Sichuan Basin represents a critical frontier for shale gas exploration in China. However, systematic understanding of the multi-scale links among lamination type, mechanical anisotropy, and fracture complexity remains limited. Based on lamination characteristics and total organic carbon (TOC) content, core samples were classified into four types. Using a multi-scale approach (uniaxial compression, Brazilian splitting, in situ CT scanning, QEMSCAN, and SEM), this study elucidates how lamination structure controls mechanical anisotropy, failure modes, and fracture mechanisms. The novelties of this work are threefold: (1) quantitatively linking specific lamination types (ORM, OPM, PAFC, PAF) to anisotropic mechanical responses; (2) introducing 3D fractal dimensions to evaluate fracture network complexity; and (3) integrating micro- (SEM) and macro-scale tests to reveal the coupled control of weak planes and brittle minerals on fracture propagation. Results indicate that laminated shales exhibit pronounced mechanical anisotropy. Loading parallel to laminations induces tensile splitting along weak planes, significantly reducing strength. Conversely, perpendicular loading generates complex fracture networks of horizontal secondary fractures along laminae and vertical main fractures through the matrix. Furthermore, 3D fractal dimension analysis quantifies fracture network complexity as follows: organic-poor clay-feldspar laminated shale > organic-poor clay-feldspar-calcareous laminated shale > organic-rich massive shale. Microscopic observations confirm that fracture propagation is jointly governed by weak plane systems and brittle mineral content, which collectively determine macroscopic failure patterns. These findings clarify how lamination type controls the laboratory mechanical response and fracture morphology of deep shale and provide a laboratory-scale framework for comparing lamination-related differences in mechanical anisotropy and fracture complexity in the Qiongzhusi Formation. Full article

This study proposes an innovative structural wall system and evaluates its compressive performance. The wall consists of GLPB manufactured using laminated bonding (along the grain direction) and assembled using a staggered interlocking masonry method. Two key geometric parameters controlling the mechanical response of the GLPB wall—the slenderness ratio (β) and the eccentricity (e)—were selected as the primary design variables. Using a combined experimental and numerical approach, the study systematically investigated the compressive mechanical behavior and performance evolution of the wall, including compressive strength and deformation behavior. Through axial and eccentric compression tests, six sets of specimens with varying geometric parameters β and e were analyzed, yielding relevant data and characteristics regarding failure modes, ultimate load-carrying capacity, load–displacement response, crack resistance, and wall deformation. To further characterize the compressive mechanical performance of GLPB walls, a refined nonlinear finite element model was developed in ABAQUS (version 2020). This model incorporates the anisotropic constitutive behavior of wood, the Hill yield criterion, and the mechanical interactions at the interlocking and bonding interfaces. The study indicates that the average compressive strength of GLPB walls is 2.63 MPa, with a crack-to-failure load ratio ranging from 0.68 to 0.83. GLPB walls demonstrate comparable load-bearing capacity. The total axial vertical strain ranges from 0.033 to 0.041, indicating that the walls possess good deformation capacity. Based on Chinese masonry design standards and experimental evidence, a preliminary predictive formula for the load-bearing capacity of this wall was derived. A comparison of the aforementioned experimental measurements with simulation results showed errors of less than 10%, verifying the model’s validity and accuracy. Numerical simulation can, to a certain extent, compensate for the limitations of experimental methods in capturing internal mechanical states. Full article

Numerical predictions of the wrinkling behavior of biaxially fiber-reinforced elastomer sheets are carried out under consideration of finite deformations. The Holzapfel–Gasser–Ogden material model is used to account for the anisotropic hyperelastic material behavior of the sheets, where material parameters are identified based on experimental data of tensile tests from literature. A Finite Element Method-based simulation strategy is presented to extract critical loading conditions and to access the postbuckling response using geometrical imperfections. Depending on the layup and aspect ratio of the sheets, wrinkling onset was predicted for global stretches between 10% and 25%. For sheets with fiber orientations [±45°] wrinkling is predicted at larger global stretches than for sheets with fiber orientations of $[+{30}^{\circ }/-{60}^{\circ }]$ for the same aspect ratio. Furthermore, it is shown that short sheets have a tendency towards symmetric wrinkling patterns whereas for long sheets asymmetric wrinkles are more likely to occur. Comparison of the numerical predictions with experiments from the literature shows that the geometrical characteristics of the wrinkles, such as wavelengths and amplitudes, can be well predicted. Far into the postbuckling regime, the deviations of the predicted wrinkling amplitudes and their experimental counterparts are around 30% or less. Full article

Current strategies for treating organic dye wastewater are shifting from single-function removal processes and catalytic degradation methods toward more integrated treatment approaches. This study proposes a multifunctional composite integrating adsorption–photodegradation–intelligent recovery for photodegradation and recovery of methylene blue-contaminated wastewater. By optimizing the preparation process to precisely control the pore size and arrangement of the aerogel, a hierarchical porous framework with a high specific surface area is formed, featuring efficient mass transfer and ultra-multiple loading sites. The graphene framework enhances visible-light absorption by optimizing TiO₂ loading, agglomeration behavior and addressing detachable defects through a metal–polyphenol network. After 60 min of illumination, the degradation efficiency exceeds 99.5%, demonstrating superior cycling stability. After 100 cycles, the photocatalytic efficiency remains above 97%, showcasing excellent durability. Furthermore, the in situ polymerized thermoresponsive poly (N-isopropylacrylamide) (PNIPAm) composite exhibits smart responsiveness, enabling reversible temperature-responsive adsorption–desorption behavior within PNIPAm’s LCST range. with an adsorption capacity of 28,000 mg/g at LCST. Heating above LCST desorbs 90.2% of the wastewater, and adsorption stability remains above 98% after 100 thermal cycles, resolving operational challenges in mechanical wastewater recovery. The synergistic integration of an anisotropic porous structure, stable TiO₂ loading, and thermal responsiveness provides an efficient platform for integrated adsorption and recovery. Full article

Satellite remote sensing plays an essential role in wildfire monitoring due to its large-scale observation capability. However, fire targets in satellite imagery are typically extremely small, sparsely distributed, and embedded in complex backgrounds, making accurate segmentation highly challenging for existing methods. To address these challenges, this paper proposes a multi-scale Mamba-based network for tiny fire segmentation, named FireMambaNet. The network adopts a nested U-shaped encoder-decoder architecture, primarily consisting of three modules: the Cross-layer Gated Residual U-shaped module (CG-RSU), the Fire-aware Directional Context Modulation module (FDCM), and the Multi-scale Mamba Attention Module (M2AM). The CG-RSU, as the core building block, adaptively suppresses background redundancy and enhances weak fire responses by extracting multi-scale features through cross-layer gating. The FDCM explicitly enhances the network’s ability to perceive anisotropic expansion features of fire points, such as those along the wind direction and terrain orientation, by modeling multi-directional context. The M2AM model employs a Mamba state-space model to suppress background interference through global context modeling during cross-scale feature fusion, while enhancing consistency among sparsely distributed tiny fire targets. In addition, experimental validation is conducted using two subsets from the Active Fire dataset, which have significant pixel-level sparse features: Oceania and Asia4. The results show that the proposed method significantly outperforms various mainstream CNN, Transformer, and Mamba baseline models on both datasets. It achieves an IoU of 88.51% and F1 score of 93.76% on the Oceania dataset, and an IoU of 85.65% and F1 score of 92.26% on the Asia4 dataset. Compared to the best-performing CNN baseline model, the IoU is improved by 1.81% and 2.07%, respectively. Overall, the FireMambaNet demonstrates significant advantages in detecting tiny fire points in complex backgrounds. Full article

Carbon nanotube yarns (CNTYs) have received more consideration recently due to their excellent specific mechanical, electrical and thermal properties, making them promising materials for different applications. Until now, the axial properties of the yarn have been thoroughly investigated; however, the transverse or radial properties, orthogonal to the fiber axis, remain relatively unknown due to the challenges associated with their measurement. In this study, the transverse or radial response of the CNTY including its elastic modulus was determined using Atomic Force Microscopy (AFM) and Raman Spectroscopy. Determining transverse properties in fibrous materials presents challenges owing to their geometry, inherent anisotropy, whereby mechanical characteristics exhibit directional disparities; i.e., the properties in the transverse direction may be several orders of magnitude smaller than those in the axial direction. To overcome these difficulties, AFM was utilized to perform nanoindentation experiments, where a tipless flexible cantilever probe was used to apply a controlled force to the CNTY surface. The resulting indentation depth was then analyzed to determine the transversal elastic modulus. Preliminary findings indicate that the transverse elastic modulus of the CNTYs ranges from 10–54 kPa for strain levels below 3%. Complementary Raman spectroscopy provided insight into the bulk-scale mechanical behavior of CNTYs. Incremental compressive loading between microscope slides induced nonlinear upshifts in the 2D Raman band (from ~2686.6 to 2691.4 cm⁻¹), indicating nanoscale tube realignment, inter-tube densification, and compaction. From lateral diameter measurements under load, a stress–strain curve was constructed, revealing three distinct regimes: one with an initial elastic modulus of 3.12 MPa (0.3–11.2% strain), another one with an elastic modulus increasing to 8.46 MPa (11.2–14.4%), and finally one with an elastic modulus peaking at 16.86 MPa beyond 14.4% strain. Together, these methods delineate the hierarchical and anisotropic nature of CNTYs, validating the importance of multiscale mechanical characterization for their deployment in piezoresistive sensors and multifunctional composites. This study establishes a robust framework for quantifying the transverse mechanical response of CNTYs. Full article

Mechanochromism is a phenomenon in which mechanical stimuli change the optical properties of a material, such as its color and emission properties. Various materials exhibiting this behavior have been intensively studied. Mechanochromic materials that exploit liquid crystals have been previously reported. Using liquid crystals, properties different from those of conventional materials, such as anisotropic response and multicolored luminescence due to intermediate aggregation phase stabilization, can be expected. Recently, we reported the preparation and evaluation of the optical properties of liquid-crystalline mechanochromic dyes with cholesterol terminals. The dyes formed gels in some solvents, changed their emission color, and exhibited a friable response without reaching a crystalline state. In addition, film-forming properties, processability, and responsiveness were improved in thin films mixed with polymers. However, the mechanical and thermal stabilities of the gels were low. In this study, a compound similar to the polymerizable unit was synthesized to produce tougher gels. In addition, triblock polymers with a mechanoresponsive dye in the hard segment were synthesized. The xerogel film prepared from the monomer showed an irreversible blue shift in photoluminescent color by mechanical grinding and also exhibited linearly polarized photoluminescence by uniaxial grinding due to force-induced alignment. On the other hand, the xerogel film prepared from the triblock copolymer showed a blue shift in photoluminescent color that can approximately revert to the initial state by thermal annealing, though it showed no anisotropy by uniaxial grinding, indicating that polymerization partially preserves mechanical responsiveness. Full article

Interlayer-sliding ferroelectricity in van der Waals bilayers enables ultralow-power switching, but practical devices are often limited by contact/interface scattering and weak coupling between polarization and transport. We propose homophase lateral architectures based on bilayer Janus MoSSe: a 1T/2H/1T ferroelectric tunnel homojunction and an H-phase lateral p–i–n photodetector (artificially doped electrode). Metallic 1T electrodes largely eliminate contact barriers and maximize polarization-driven tunneling modulation. Using non-equilibrium Green’s function–density functional theory (Perdew–Burke–Ernzerhof approximation, without explicit spin–orbit coupling), we find that AB to BA sliding reduces the current from the nA range to the pA range, with the minimum current of|I_OFF|_min = 2.83 pA, yielding giant tunneling electroresistance up to 5.3 × 10⁴%. Projected local density of states reveals a non-rigid long-range potential redistribution that reshapes the tunneling barrier and opens high-transmission channels. In the p–i–n photodetector, the response is strongly anisotropic and stacking-dependent: AB reaches photocurrent density J_ph ≈ 7.2 µA·mm⁻² at 2.6 eV for in-plane light versus ≈ 2.9 µA·mm⁻² at 3.5 eV for out-of-plane, and exceeds BA by 1.5–1.8 times due to density of states advantages and Mo-d orbital selection rules. Bilayer Janus MoSSe therefore provides a reconfigurable platform for high-contrast memory and polarization-sensitive photodetection. Full article

Sensitive and on-site detection of pesticide residues remains a critical challenge for food safety, particularly in developing regions where rapid screening tools are urgently needed. Herein, we report a flexible surface-enhanced Raman scattering (SERS) platform based on triangular silver nanoplates (TSNPs) integrated onto a polydimethylsiloxane (PDMS) substrate, enabling sensitive and conformal detection of paraquat residues on agricultural surfaces. TSNPs were synthesized via a seed-mediated photochemical growth method and formulated into a TSNP ink, which was directly deposited onto oxygen-plasma-treated and thiol-functionalized PDMS substrates. Owing to the highly anisotropic geometry and sharp edges of TSNPs, the flexible SERS substrate exhibits strong localized surface plasmon resonance (LSPR) enhancement and mechanically stable electromagnetic hot spots. Systematic optimization of TSNP optical absorbance revealed that uniform nanoplate distribution and optimal hotspot density were achieved at an absorbance of 2.0. The SERS performance was evaluated using rhodamine 6G under front-side and back-side illumination configurations, demonstrating good signal reproducibility and a detection limit of approximately 10⁻⁵ M. Notably, back-side illumination through the PDMS layer provided superior SERS responses due to improved optical transmission and light–matter interaction. The practical applicability was further demonstrated through back-side SERS detection of paraquat on aluminum foil as a model surface, achieving a lowest detectable concentration of 5 × 10⁻⁶ M, followed by damage-free detection on Chinese pear peels. This work highlights a reliable and nondestructive flexible SERS platform for on-site pesticide residue monitoring. Full article

Various types of turbine engines have been chosen as the primary power source of the long-endurance unmanned aerial vehicles (UAVs) because of their high propulsive efficiency and low specific fuel consumption. To ensure the healthy operation of UAV turbine engines, rotor unbalance should be monitored and constrained to a preset limit. This paper proposes an efficient and physically interpretable method to achieve rotor unbalance monitoring. This method enables the frequency response function (FRF) to inform the neural network design, bringing the physics-informed convolutional neural network (PICNN). Firstly, the FRF gives a qualitative judgment of the axial positions of dominant faulty parts. Then, the following subnet proceeds to achieve quantitative identification. This method is demonstrated on a series of numerical cases and on a twin-disk rotor-bearing-casing experimental setup with anisotropic supporting stiffness. This setup is representative of engine installation status on the UAV platform. The results show that the PICNN can achieve higher precision compared to pure data-driven or model-based benchmarks. The PI layer does not require a high-fidelity model that generates responses identical to the actual ones. The robustness against modeling errors in stiffness and damping ratios is demonstrated. The achieved relative errors are less than 1.5% under various experimental datasets. Full article

Protein crystals are intrinsically hydrated systems, and their structural integrity is strongly influenced by environmental humidity. Understanding the effects of relative humidity (RH) variation on crystal stability is therefore essential for both fundamental research and applied studies. In this work, the structural response of tetragonal hen egg-white lysozyme (HEWL) to controlled RH variation was investigated using in situ X-ray powder diffraction (XRPD). Polycrystalline HEWL samples were subjected to systematic gradual dehydration and rehydration cycles, as well as to non-gradual RH variation protocols. Pawley analysis of the XRPD data enabled monitoring of the evolution of unit cell parameters and unit cell volume as a function of RH. Under all experimental conditions, the tetragonal polymorph (space group P4₃2₁2; a = 79.105 (4) Å, c = 38.231 (2) Å) was preserved. RH variation induced smooth, continuous and anisotropic lattice changes, characterized by a decrease in the a (=b)-axis and a concomitant increase in the c-axis upon dehydration, while rehydration resulted in the opposite behavior. The overall magnitude of lattice variation remained limited (within ±2%), indicating a high degree of structural stability. Partial degradation of crystallinity was observed only after prolonged exposure to low RH levels. These findings demonstrate the remarkable structural resilience of tetragonal HEWL and highlight the effectiveness of in situ XRPD as a powerful tool for probing hydration-driven lattice responses in protein crystals under realistic environmental conditions. Full article