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27 Results Found

  • Article
  • Open Access
9 Citations
9,571 Views
5 Pages

Cu2+ and butylic ester of 2,4-Dichlorophenoxyacetic acid as Esternon Ultra (2,4-D) toxicity on Bufo arenarum embryos were evaluated by means of a short-term chronic toxicity test (AMPHITOX). The NOEC values for Cu and 2,4-D were 0.02 mg/L and 2 mg/L...

  • Article
  • Open Access
4 Citations
9,519 Views
5 Pages

The exposure of Bufo arenarum embryos to 300-310 nm UV-B at a dose of 4,104 Joule/m2 resulted in 100% lethality within 24 hr while 820 Joule/m2 was the NOEC value for short-term chronic (10 days) exposure. The dose response curves show that lethal ef...

  • Article
  • Open Access
14 Citations
10,239 Views
7 Pages

The acclimation possibilities to copper in Bufo arenarum embryos was evaluated by means of three different low level copper exposure conditions during 14 days. By the end of the acclimation period the copper content in control embryos was 1.04 ± 0.09...

  • Article
  • Open Access
2 Citations
1,875 Views
16 Pages

20 March 2024

In recent years, nitrate (NO3-N) pollution in water bodies has been increasing due to the excessive use of nitrogen-based fertilizers. Exposure to NO3-N during the development of amphibian embryos may have lasting effects on the growth and developmen...

  • Review
  • Open Access
5 Citations
5,661 Views
18 Pages

23 October 2021

This paper reviews current research on the microbial life that surrounds vertebrate embryos. Several clades are believed to develop inside sterile—or near-sterile—embryonic microhabitats, while others thrive within a veritable zoo of microbial life....

  • Review
  • Open Access
2,015 Views
26 Pages

Methodological and Ethical Considerations in the Use of Chordate Embryos in Biomedical Research

  • Laura Maria Mendes Campitelli,
  • Karina Pereira Lopes,
  • Isabela Lemos de Lima,
  • Flávia Batista Ferreira,
  • Nayara Delfim Isidoro,
  • Giovana Magalhães Ferreira,
  • Maria Clara Fioravanti Ponce,
  • Milene Caroline de Oliveira Ferreira,
  • Ludmilla Silva Mendes and
  • Pedro Henrique Ribeiro Marcelino
  • + 5 authors

Animal embryos are vital tools in scientific research, providing insights into biological processes and disease mechanisms. This paper explores their historical and contemporary significance, highlighting the shift towards the refinement of in vitro...

  • Review
  • Open Access
50 Citations
10,027 Views
20 Pages

16 March 2010

In this review, we focus on processes, organs and systems targeted by the marine toxins yessotoxin (YTX), okadaic acid (OA) and palytoxin (PTX). The effects of YTX and their basis are analyzed from data collected in the mollusc Mytilus galloprovincia...

  • Feature Paper
  • Article
  • Open Access
4 Citations
2,190 Views
17 Pages

Adverse Effect of Metallic Gold and Silver Nanoparticles on Xenopus laevis Embryogenesis

  • Rosa Carotenuto,
  • Margherita Tussellino,
  • Sabato Fusco,
  • Giovanna Benvenuto,
  • Fabio Formiggini,
  • Bice Avallone,
  • Chiara Maria Motta,
  • Chiara Fogliano and
  • Paolo Antonio Netti

4 September 2023

Exposure to metal nanoparticles is potentially harmful, particularly when occurring during embryogenesis. In this study, we tested the effects of commercial AuNPs and AgNPs, widely used in many fields for their features, on the early development of X...

  • Article
  • Open Access
1,036 Views
17 Pages

Amphibian Egg Jelly as a Biocompatible Material: Physicochemical Characterization and Selective Cytotoxicity Against Melanoma Cells

  • Behlul Koc-Bilican,
  • Tugce Karaduman-Yesildal,
  • Selay Tornaci,
  • Demet Cansaran-Duman,
  • Ebru Toksoy Oner,
  • Serkan Gül and
  • Murat Kaya

27 July 2025

Extensive research on amphibians has focused on areas such as morphological and molecular taxonomy, ecology, embryology, and molecular phylogeny. However, the structure and biotechnological potential of egg jelly—which plays a protective and nu...

  • Review
  • Open Access
16 Citations
4,854 Views
18 Pages

Gravitational Experimental Platform for Animal Models, a New Platform at ESA’s Terrestrial Facilities to Study the Effects of Micro- and Hypergravity on Aquatic and Rodent Animal Models

  • Julie Bonnefoy,
  • Stéphanie Ghislin,
  • Jérôme Beyrend,
  • Florence Coste,
  • Gaetano Calcagno,
  • Isabelle Lartaud,
  • Guillemette Gauquelin-Koch,
  • Sylvain Poussier and
  • Jean-Pol Frippiat

Using rotors to expose animals to different levels of hypergravity is an efficient means of understanding how altered gravity affects physiological functions, interactions between physiological systems and animal development. Furthermore, rotors can...

  • Review
  • Open Access
1,984 Views
55 Pages

The retinal pigment epithelium (RPE) is a cellular source of retinal regeneration in lower vertebrates and a cellular source of retinal diseases in mammals, including humans. Both processes are based on a genetic program for the conversion of RPE cel...

  • Article
  • Open Access
12 Citations
4,911 Views
18 Pages

Comparative Toxicological Evaluation of Tattoo Inks on Two Model Organisms

  • Rosa Carotenuto,
  • Chiara Fogliano,
  • Mariangela Rienzi,
  • Antonietta Siciliano,
  • Maria Michela Salvatore,
  • Gaetano De Tommaso,
  • Giovanna Benvenuto,
  • Emilia Galdiero and
  • Marco Guida

9 December 2021

Tattooing is a technique that introduces colored substances under the skin in order to color it permanently. Decomposition products of tattoo pigments produce numerous damages for the skin and other organs. We studied the effects of a commercial red...

  • Review
  • Open Access
3 Citations
6,019 Views
14 Pages

6 November 2019

During vertebrate embryogenesis, precise regulation of gene expression is crucial for proper cell fate determination. Much of what we know about vertebrate development has been gleaned from experiments performed on embryos of the amphibian Xenopus la...

  • Review
  • Open Access
5 Citations
2,549 Views
13 Pages

Research Trends in C-Terminal Domain Nuclear Envelope Phosphatase 1

  • Harikrishna Reddy Rallabandi,
  • Haewon Choi,
  • Hyunseung Cha and
  • Young Jun Kim

7 June 2023

C-terminal domain nuclear envelope phosphatase 1 (CTDNEP1, formerly Dullard) is a member of the newly emerging protein phosphatases and has been recognized in neuronal cell tissues in amphibians. It contains the phosphatase domain in the C-terminal,...

  • Article
  • Open Access
1 Citations
2,105 Views
12 Pages

The Molecular Mechanism of Body Axis Induction in Lampreys May Differ from That in Amphibians

  • Galina V. Ermakova,
  • Aleksandr V. Kucheryavyy,
  • Andrey G. Zaraisky and
  • Andrey V. Bayramov

19 February 2024

Lamprey homologues of the classic embryonic inducer Noggin are similar in expression pattern and functional properties to Noggin homologues of jawed vertebrates. All noggin genes of vertebrates apparently originated from a single ancestral gene as a...

  • Article
  • Open Access
31 Citations
5,053 Views
23 Pages

Pesticides and Parabens Contaminating Aquatic Environment: Acute and Sub-Chronic Toxicity towards Early-Life Stages of Freshwater Fish and Amphibians

  • Denisa Medkova,
  • Aneta Hollerova,
  • Barbora Riesova,
  • Jana Blahova,
  • Nikola Hodkovicova,
  • Petr Marsalek,
  • Veronika Doubkova,
  • Zuzana Weiserova,
  • Jan Mares and
  • Martin Faldyna
  • + 3 authors

31 March 2023

Pesticides and personal care products are two very important groups of contaminants posing a threat to the aquatic environment and the organisms living in it.. Therefore, this study aimed to describe the effects of widely used pesticides and parabens...

  • Article
  • Open Access
1 Citations
1,886 Views
17 Pages

17 October 2024

Hynobius amjiensis, also known as the Anji salamander, is an amphibian species currently categorized as endangered due to its limited geographical distribution, primarily in China. To address the critical conservation status of this species, artifici...

  • Review
  • Open Access
14 Citations
9,829 Views
26 Pages

Reproduction and the Early Development of Vertebrates in Space: Problems, Results, Opportunities

  • Alexandra Proshchina,
  • Victoria Gulimova,
  • Anastasia Kharlamova,
  • Yuliya Krivova,
  • Nadezhda Besova,
  • Rustam Berdiev and
  • Sergey Saveliev

31 January 2021

Humans and animals adapt to space flight conditions. However, the adaptive changes of fully formed organisms differ radically from the responses of vertebrate embryos, foetuses, and larvae to space flight. Development is associated with active cell p...

  • Article
  • Open Access
2 Citations
2,353 Views
12 Pages

Engraftment of Allotransplanted Tumor Cells in Adult rag2 Mutant Xenopus tropicalis

  • Dieter Tulkens,
  • Dionysia Dimitrakopoulou,
  • Marthe Boelens,
  • Tom Van Nieuwenhuysen,
  • Suzan Demuynck,
  • Wendy Toussaint,
  • David Creytens,
  • Pieter Van Vlierberghe and
  • Kris Vleminckx

20 September 2022

Modeling human genetic diseases and cancer in lab animals has been greatly aided by the emergence of genetic engineering tools such as TALENs and CRISPR/Cas9. We have previously demonstrated the ease with which genetically engineered Xenopus models (...

  • Review
  • Open Access
17 Citations
11,620 Views
22 Pages

Xenopus laevis (Daudin, 1802) as a Model Organism for Bioscience: A Historic Review and Perspective

  • Rosa Carotenuto,
  • Maria Michela Pallotta,
  • Margherita Tussellino and
  • Chiara Fogliano

20 June 2023

In vitro systems have been mainly promoted by authorities to sustain research by following the 3Rs principle, but continuously increasing amounts of evidence point out that in vivo experimentation is also of extreme relevance. Xenopus laevis, an anur...

  • Article
  • Open Access
6 Citations
3,254 Views
12 Pages

Developing Tadpole Xenopus laevis as a Comparative Animal Model to Study Mycobacterium abscessus Pathogenicity

  • Arianna Lopez,
  • Carolyn Shoen,
  • Michael Cynamon,
  • Dionysia Dimitrakopoulou,
  • Matthieu Paiola,
  • Martin S. Pavelka and
  • Jacques Robert

Mycobacterium abscessus (Mab) is an emerging, nontuberculosis mycobacterium (NTM) that infects humans. Mab has two morphotypes, smooth (S) and rough (R), related to the production of glycopeptidolipid (GPL), that differ in pathogenesis. To further un...

  • Feature Paper
  • Review
  • Open Access
5 Citations
6,303 Views
17 Pages

That form and function are related is a maxim of anatomy and physiology. Yet, form-function relations can be difficult to prove. Human subjects with excessive trabeculated myocardium in the left ventricle, for example, are diagnosed with non-compacti...

  • Article
  • Open Access
38 Citations
8,614 Views
14 Pages

Proteomics Analysis of Early Developmental Stages of Zebrafish Embryos

  • Kathiresan Purushothaman,
  • Prem Prakash Das,
  • Christopher Presslauer,
  • Teck Kwang Lim,
  • Steinar D. Johansen,
  • Qingsong Lin and
  • Igor Babiak

17 December 2019

Zebrafish is a well-recognized organism for investigating vertebrate development and human diseases. However, the data on zebrafish proteome are scarce, particularly during embryogenesis. This is mostly due to the overwhelming abundance of egg yolk p...

  • Article
  • Open Access
10 Citations
4,052 Views
21 Pages

Acute Ecotoxicity Potential of Untreated Tannery Wastewater Release in Arequipa, Southern Peru

  • Kevin Tejada-Meza,
  • Armando Arenazas-Rodríguez,
  • Pablo A. Garcia-Chevesich,
  • Carmen Flores-Farfan,
  • Lino Morales-Paredes,
  • Giuliana Romero-Mariscal,
  • Juana Ticona-Quea,
  • Gary Vanzin and
  • Jonathan O. Sharp

25 October 2023

The centralized Rio Seco Industrial Park (RSIP) tannery collective in the Southern Peruvian city of Arequipa releases untreated tannery wastewater into a proximal creek that is a tributary of the Chili River. As industrial leather tanning wastewater...

  • Review
  • Open Access
30 Citations
12,709 Views
33 Pages

3 July 2021

After its publication in 1999 as a DNA-binding and SMAD-binding transcription factor (TF) that co-determines cell fate in amphibian embryos, ZEB2 was from 2003 studied by embryologists mainly by documenting the consequences of conditional, cell-type...

  • Review
  • Open Access
28 Citations
6,191 Views
23 Pages

21 May 2021

(1) Background: in order to propagate wildlife species (covering the whole spectrum from species suitable for aquaculture to endangered species), it is important to have a good understanding of the quality of their sperm, oocytes and embryos. While s...