Search Results (642)

The fifth annual pan-tumour Early Age Onset Cancer (EAOC) Symposium, held in November 2025 and organized by the Colorectal Cancer Resource & Action Network (CCRAN), convened clinicians, researchers, policymakers, patients, and caregivers to address the rising incidence of cancers in individuals under 50 years. In addition to discussions around diagnostic and therapeutic advances for patients with late-stage disease, content centered on addressing critical gaps along the EAOC care continuum, including (i) diagnostic delays related to limited awareness and suboptimal primary care pathways, (ii) screening eligibility criteria for colorectal cancer (CRC) that no longer reflect current disease epidemiology, and (iii) insufficient age-appropriate infrastructure to meet the EAOC population’s unique unmet needs with respect to psychosocial support, fertility counseling, financial navigation, and survivorship planning. The symposium generated consensus recommendations such as the embedding of EAOC education into medical training curricula to increase the index of suspicion of EAOC in primary care, lowering the CRC screening age to 45 years to match this population’s rising disease incidence, and expanding multidisciplinary adolescent and young adult (AYA) and EAOC programs—including through the use of virtual models—to ensure that patients receive coordinated, comprehensive, equitable and age-appropriate care across the country. Full article

Cancer incidence among adolescents is increasing, yet cancer risk reduction education remains largely absent from school-based curricula. This pilot study assessed whether a small-scale early, developmentally appropriate intervention could improve cancer literacy to support long-term risk reduction. This pilot study used a convergent parallel mixed-methods pre–post design to evaluate two separate, 45 min, school-based cancer education interventions delivered to 24 middle-school students in Pennsylvania. The intervention delivered developmentally appropriate content on cancer biology, modifiable risk factors, genetics, HPV vaccination, and self-advocacy using a low-resource, low-investment model easy for schools to implement. Pre- and post-intervention surveys assessed student knowledge, awareness, and health-related perceptions. Survey data were analyzed both descriptively using frequencies and percentages and thematically. Post-intervention results demonstrated substantial improvements across all domains. Correct definition of cancer increased from 16% to 100%. Awareness of modifiable risk factors increased to 96%, sunscreen knowledge to 90%, genetic testing awareness to 83%, and HPV vaccine understanding from 21% to 57%. Students also reported increased confidence in recognizing symptoms and engaging in health-seeking behaviors. Findings suggest that small-scale, school-based cancer education interventions are feasible and effective in improving adolescent cancer literacy. These results support the need for larger, controlled studies to evaluate long-term knowledge retention and behavioral outcomes. Full article

Rural adolescents face persistent health inequities driven by limited access to preventive health education, intergenerational engagement, and resources that support lifelong wellness. This study evaluated the effectiveness of Active Aging for L.I.F.E., a school-based intergenerational health literacy program, in improving adolescents’ attitudes toward aging and health. The four-session program, delivered through a train-the-trainer model involving older adults and undergraduate students, was implemented in three rural schools during the 2024–2025 academic year. A total of 86 junior high and high school students participated, with 77 completing pre- and post-program surveys assessing attitudes toward aging, health consciousness, and intergenerational engagement. Paired t-tests and multiple regression analyses examined overall program effects and differences by sex/gender and age group. Students demonstrated significant improvements in aging attitudes, perceived relevance of aging topics, enjoyment of intergenerational interaction, and awareness of health-promoting behaviors across the lifespan. Several baseline sex/gender and age-based gaps in health-related perceptions were reduced following participation, with stronger future-oriented attitude shifts observed among younger adolescents. These findings suggest that brief, scalable intergenerational interventions embedded in rural school settings can support early prevention, health literacy, and community capacity building, offering a promising strategy for advancing rural public health outcomes across the life course. Full article

Background/Objectives: Emotion processing has increasingly been conceptualized as a transdiagnostic mechanism underlying psychological adaptation and psychopathology. From an attachment perspective, individual differences in emotion perception may be rooted in internal working models shaped by early relationships. This systematic review synthesized the literature on the relationship between adult attachment representations and intrapersonal emotion perception (Impathy) and interpersonal emotion perception (Empathy). Methods: The review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A systematic search was conducted on 9 February 2026, in PsycINFO, PsycArticles, and PubMed. Studies were included if they investigated adolescents or adults, assessed attachment representations using narrative-based measures (Adult Attachment Interview (AAI) or Adult Attachment Projective Picture System (AAP)), and examined intrapersonal and/or interpersonal emotion perception. Findings were synthesized narratively, and a random-effects meta-analysis examined the association between attachment security and reflective functioning. Results: Thirty-eight studies, including 2736 participants, met the inclusion criteria. Across studies, attachment representations were systematically associated with intrapersonal and interpersonal emotion perception. The strongest evidence emerged for reflective functioning, the Impathy dimensions Perceiving and Understanding, and cognitive-empathic processes. Secure attachment representations were consistently associated with higher reflective functioning and more adaptive emotion perception, whereas insecure and especially unresolved attachment representations were linked to impairments in emotional self-awareness, alexithymia-related processes, differentiated emotional understanding, and cognitive-empathic processing. The meta-analysis showed a large positive association between secure attachment representations and reflective functioning (k = 8; r = 0.64, 95% CI [0.50, 0.74]). Conclusions: Attachment representations appear systematically associated with the perceptual foundations of emotion processing. Intrapersonal and interpersonal emotion perception may therefore represent attachment-sensitive processes relevant to psychological adaptation, psychopathology, caregiving, and therapeutic change. Full article

Background and objectives: Social media use has become pervasive among the general population, with growing concern regarding its potential effects on mental health and sleep. While existing studies report associations between social media engagement and psychological outcomes, limited attention has been given to users’ self-perceived impact. To assess the self-perceived impact of social media use on mental health and sleep-related outcomes among healthy adolescents and adults aged 16–50 years old, and to identify associated demographic and behavioral factors. Methods: A cross-sectional survey was conducted among residents of Jeddah, Saudi Arabia, aged 16–50 years without a history of psychiatric or chronic sleep disorders, using a structured online questionnaire. Perceived mental health impact was assessed using a six-item study-specific questionnaire evaluating participants’ subjective perceptions regarding emotional and psychological responses to social media exposure. Higher perceived impact was defined as a composite score of 12–24 points on the study-specific scale. Data included sociodemographic characteristics, patterns of social media use, perceived mental health impact assessed through a 6-item Likert scale, and sleep-related outcomes. Associations were evaluated using chi-square tests and logistic regression analysis. Results: Most participants reported daily social media use exceeding 3 h, with 44.9% engaging in late-night use and 87.6% using devices within 30 min before sleep. Overall, 18.6% exhibited higher perceived mental health impact. Higher odds were observed among younger participants, students, and single individuals. Snapchat and YouTube use, and late-night engagement were independently associated with increased perceived impact. Approximately one-third reported insomnia after social media use, and 44.3% perceived improved sleep with reduced usage. Conclusions: Social media use is widely prevalent and commonly perceived to negatively affect mental well-being and sleep, particularly with intensive and late-night use. Self-awareness of these effects may represent a valuable leverage point for prevention, supporting the need for targeted digital wellness strategies and public health interventions. Full article

Background/Objectives: Advanced technologies in type 1 diabetes mellitus (T1DM) management have reshaped the strategies used to achieve optimal glucose control. Continuous subcutaneous insulin infusion (CSII) and automated insulin delivery (AID) systems are effective alternatives to multiple daily injections (MDI). This study aims to evaluate glycemic regulation in children and adolescents transitioning from MDI to insulin pumps and to raise awareness among patients and their families regarding the benefits of these systems. Methods: 50 pediatric patients with T1DM (24 males, 26 females; mean age 10.76 ± 3.2 years) were evaluated. Cycle 1 established MDI metrics 3 months pre-transition. In cycle 2, patients transitioned either to an AID system (Medtronic MiniMed 780G, (Northridge, CA, USA), 78%), or a non-automated system (Omnipod DASH, 22%). Data were assessed at 3 and 6 months post-initiation. Parameters assessed were glycosylated hemoglobin (HbA1c), time in range (TIR), time above range (TAR), time below range (TBR), glucose management indicator (GMI) and coefficient of variation (CV). Results: The cohort exhibited a statistically significant increase in TIR (p = 0.0038) with mean values of 70.9% at 3 months and 73.2% at 6 months. TAR significantly reduced (p = 0.033) to 26.5% and 24.3% at 3 and 6 months, respectively. Sub-analysis in the AID group revealed a marked increase in TIR (p = 0.0001) alongside significant reductions in TAR (p = 0.0009) and GMI (p = 0.03). Conclusions: Transitioning from MDI to insulin pump therapy, particularly AID systems, leads to modest but significant improvements in specific sensor metrics (TIR, TAR) in real-world clinical practice. The consistency of these results across age groups indicates that AID systems can successfully overcome pediatric and adolescent diabetes management challenges. Full article

Background/Objectives: DNAJC3-related syndromic monogenic diabetes is a rare autosomal recessive disorder that presents as juvenile-onset non-autoimmune diabetes; it has been associated with sensorineural hearing loss, hypothyroidism, short stature, and variable degrees of neurological manifestations. A delayed diagnosis occurs frequently because of fragmented subspecialty care and lack of awareness of syndromic monogenic diabetes. Methods: We report a 34-year-old Saudi male from a consanguineous family with insulin-treated diabetes diagnosed during adolescence. He had long-standing sensorineural hearing loss, hypothyroidism, and short stature, which were managed separately. Results: Genetic analysis using whole-exome sequencing identified a homozygous likely pathogenic DNAJC3 variant, c.1177C>T p.(Arg393*), confirming the diagnosis of DNAJC3-related syndromic monogenic diabetes. In addition, he demonstrated no clinically evident neurological manifestations at the time of evaluation, including ataxia, despite reaching adulthood, highlighting the phenotypic variability associated with DNAJC3-related disease. Conclusions: This case adds to the growing evidence supporting phenotypic variability in DNAJC3-related syndromic monogenic diabetes by describing an adult presentation without clinically evident neurological manifestations at the time of evaluation. It highlights how systemic manifestations may remain unrecognized when managed separately across different specialties. In individuals with atypical diabetes accompanied by multisystem involvement, particularly in the setting of consanguinity, early consideration of monogenic diabetes and timely genetic testing may facilitate accurate diagnosis and molecular classification. Establishing a specific genetic diagnosis supports appropriate genetic counseling, informs reproductive decision-making, and may help reduce prolonged diagnostic uncertainty. Full article

Background/Objectives: Adolescence is a crucial stage of development, in which life skills are essential for promoting psychological well-being. Social and Emotional Learning (SEL) interventions aim to develop social–emotional and relational skills that foster resilience and adaptation. Short-term effects may be nonlinear and influenced by gender differences, with possible fluctuations in self-assessments due to increased social–emotional awareness (response shift). Methods: This action research study involved 179 preteens (ages 11–17) from educational settings in Aosta Valley. The SEL program consisted of three experiential sessions on key life skills, led by psychologists and psychiatrists and including group activities and role-playing. Quality of life was assessed before and after the intervention using the Q-LES-Q, which measures satisfaction and well-being in the areas of social relationships, physical health, academic performance, leisure activities, and subjective feelings. Subscale scores were calculated as the mean of the corresponding items. Results: The results revealed nonlinear patterns: a decline in satisfaction with social relationships, which may reflect a response shift. Males reported higher initial levels and greater perceived positive effects, while females reported lower post-intervention scores, likely due to greater self-reflection and self-criticism. Conclusions: The data highlight the complexity of the short-term effects of SEL interventions and the importance of considering developmental trajectories and gender differences when evaluating their effectiveness. Full article

Gait symmetry in healthy children is frequently interpreted as a marker of biomechanical balance; however, its developmental trajectory and measurement stability remain incompletely defined. This systematic review with structured quantitative synthesis aimed to evaluate (i) the reliability of instrumented symmetry measures and (ii) the magnitude of physiological asymmetry across childhood. Following PRISMA guidelines, 500 records were identified, of which 297 met inclusion criteria for qualitative synthesis. Forty-six studies provided extractable numerical data for quantitative integration, representing approximately 9420 participants. Reliability aggregation demonstrated strong repeatability of plantar pressure symmetry measures (ICC = 0.88), whereas stabilometric indices showed lower consistency (ICC = 0.54), highlighting the importance of instrument-aware interpretation. Quantitative synthesis revealed small but consistent asymmetry in healthy children (Hedges’ g = 0.31 for plantar pressure; g = 0.18 for temporal–spatial parameters), with the magnitude decreasing progressively from early childhood to adolescence. These findings indicate that complete bilateral equivalence is not a normative standard in pediatric gait. Instead, symmetry represents a development-dependent continuum shaped by neuromotor maturation and measurement context. Age-specific reference ranges and standardized asymmetry indices are essential for clinical interpretation and future methodological harmonization. Full article

Background/Objectives: Adolescence is a critical period for the adoption of health-risk behaviors and the development of non-communicable diseases (NCDs). Schools represent a strategic setting for health promotion interventions; however, Italian studies simultaneously assessing NCD-prevention knowledge and lifestyle behaviors in the same adolescent population remain scarce. The study aimed to evaluate improvements in knowledge regarding nutrition and other lifestyle-related behaviors among Italian adolescents following a school-based educational intervention. Secondary objectives included describing lifestyle behaviors within the study population and exploring participants’ evaluation of the intervention. Methods: A quasi-experimental pre-post study was conducted between March and May 2025 in five lower secondary schools. A total of 410 adolescents aged 11–16 years were enrolled through a two-stage cluster sampling procedure. The intervention, lasting approximately two hours, was delivered by a trained nurse-researcher and addressed four health domains: nutrition, physical activity, screen exposure, and substance use. Results: Following the intervention, a measurable increase in overall knowledge scores (mean increase: +3.9 points) was observed, with 88.9% of participants showing improvement. The largest improvements were observed in nutrition-related knowledge and awareness of passive smoking harms. Despite these gains, unhealthy behaviors remained prevalent, including low adherence to physical activity recommendations (36.1%), suboptimal dietary quality (39.9%), and high screen exposure. A linear regression model identified five independent determinants of higher knowledge improvement: older age, female gender, higher screen exposure, having at least one employed parent, and lower pre-intervention test scores. The intervention was positively evaluated, with high levels of satisfaction, clarity, and perceived usefulness. Conclusions: Nevertheless, the persistent gap between knowledge and behavior underscores the need to integrate motivational and environmental components, gender-sensitive approaches, and longitudinal evaluations to foster sustainable, healthy choices and contribute to NCD prevention. Full article

Background: The use of sports supplements among adolescents is rising globally, driven by fitness trends and social media influence, yet knowledge gaps persist. This study aimed to assess supplement usage patterns, knowledge, attitudes, information sources, and the impact of a social media educational intervention among Serbian secondary school students. Methods: A single-group pre–post educational intervention study was conducted in secondary school students (aged 14–18) in Vojvodina, Serbia. A 21-question anonymous questionnaire was distributed to 1000 students along with parental informed consent forms. Pre-intervention survey assessed sociodemographics, physical activity and social media habits, supplement use information sources, and awareness of risks and banned substances. Based on the initial findings, an educational campaign delivered 56 short videos (≈70 s each) on Instagram and TikTok covering most frequently used supplements (e.g., creatine, proteins, caffeine, energy drinks). After, the intervention survey was repeated. The data were analyzed using the McNemar–Bowker test of symmetry. Results: In this study, 65% of Serbian secondary school adolescents reported being physically active, engaging predominantly in gym workouts and team sports. The majority of participants initiate dietary supplement use independently, without consulting healthcare professionals or adults. The most commonly used supplements were vitamins and minerals, while energy drinks ranked notably high. Social media intervention had a limited impact due to its short duration; however, certain changes were detected. Conclusions: Serbian adolescents frequently use sports supplements without adequate professional guidance. Long-term TikTok/Instagram interventions could be used in the future in order to influence behaviors and improve knowledge about sport supplement use. Full article

In contemporary society, dominated by visual communication and the intensive use of social media, educating learners to interpret images critically has become an essential task for all educational contexts. New generations live immersed in digital environments where images, often decontextualized or manipulated, contribute to shaping identities, relationships, and perceptions of reality. Within this scenario, image education should be understood not merely as technical literacy but as a critical and formative practice aimed at developing awareness, autonomous judgement, and analytical competence. The present contribution proposes a pedagogical reflection on the urgent need to integrate structured pathways of visual media literacy within school curricula, with particular attention to the role of schools as educational bastions in preventing phenomena such as the erosion of critical thinking or the diffusion of distorted and unrealistic visual models. This work situates itself within the interdisciplinary debate on Visual Education, highlighting the need to train teachers and educators capable of guiding children and adolescents in decoding visual messages and developing reflective thinking. Full article

Pachydermodactyly (PDD) is a benign, non-inflammatory, non-erosive digital fibromatosis characterized by progressive, asymptomatic, periarticular soft tissue thickening predominantly affecting the proximal interphalangeal (PIP) joints. Additional localizations, including the palm and the distal interphalangeal (DIP) or metacarpophalangeal (MCP) joints, have also been reported. The etiology of PDD is multifactorial, encompassing idiopathic, trauma-induced, genetic, and behavioral factors. Objective: The aim of this report is to describe the clinical, imaging, and laboratory features of pachydermodactyly in two male adolescents initially referred to a pediatric rheumatology service for suspected juvenile idiopathic arthritis (JIA), highlighting the diagnostic pitfalls and differentiation criteria from inflammatory arthritis. In addition, a narrative review of cases published from 1975 to 2025 is presented to contextualize our findings within the broader literature. Results: Two male adolescents (aged 13 years and 5 months and 16 years) presented with progressive, painless periarticular soft tissue swelling of the PIP joints, initially raising suspicion for JIA. Comprehensive evaluation identified characteristic features of PDD in both patients, with complete absence of inflammatory markers, synovitis, or osseous changes. Case 1 was classified as mono-PDD and Case 2 as classic, trauma-associated PDD with atypical perilesional hypopigmentation, requiring MRI for definitive exclusion of infiltrative pathology. A narrative review of 15 representative published cases from 2014 to 2025 is presented, demonstrating persistent underdiagnosis and consistent misclassification as JIA across multiple clinical settings and geographic regions. Conclusions: PDD should be considered in the differential diagnosis of any adolescent presenting with painless digital swelling. Its recognition as a benign, non-inflammatory entity is essential to prevent unnecessary diagnostic procedures and immunosuppressive therapy. Clinical awareness and multidisciplinary assessment remain the cornerstones of accurate diagnosis and appropriate management. Full article

Background: The global shortage of healthcare workers continues to grow each year. In particular, low nurse staffing levels are known to be associated with adverse patient outcomes. Helping adolescents understand the nursing profession beyond stereotypical societal perceptions—and recognize its full range of roles—may make nursing a more attractive career option. However, little is known about the perceptions of adolescents who are in the process of making career choices. Objective: This study aims to determine the perceptions of high school adolescents in Türkiye regarding the image of the nursing profession. Method: The sample of this cross-sectional study consisted of 581 high school adolescents in Türkiye. Data were collected using the Descriptive Characteristics Form and the Adolescents’ Perceptions of the Image of Nursing Scale (APNIS). In addition to descriptive statistics, independent-samples t-tests, one-way ANOVA, and Chi-Square analyses were performed. Results: The findings indicated that adolescents generally hold a positive perception of the nursing profession, with higher scores in the professional image, perception, and care and therapeutic role subscales, and lower scores in the communication, informative role, and healing environment subscales. A total of 65.7% of the adolescents reported that they did not intend to choose nursing as a career. The intention to choose nursing as a career was higher among adolescents who did not have a nurse in their family (p < 0.05). Conclusions: The results indicate that positive perceptions of the nursing image alone may not be sufficient in adolescents’ career decision-making and underscore the importance of presenting the profession’s roles in a comprehensive and realistic manner. While adolescents with a nurse in the family demonstrated more positive perceptions of the nursing profession (higher APNIS scores), their intention to choose nursing as a career was lower compared to those without a nurse in the family. These findings suggest that familiarity with the profession may positively influence professional image while simultaneously reducing career intention, possibly due to greater awareness of occupational challenges. The findings provide important insights into how adolescents form their perceptions of the image of nursing and may contribute to future research and educational initiatives aimed at increasing interest in the nursing profession. Full article

Currently, identity formation is undertaken in hyper-individualized virtual microsystems, such as TikTok. Here, content creators set the boundaries of adolescents’ identity exploration and construction. However, few studies have engaged with the content adolescents actively choose to follow to understand the behaviors and messages that are circulated and modeled by TikTok creators. To bridge this gap, 127 TikTok videos from accounts that a sample of 328 Romanian adolescents (M_age = 16.99, SD_age = 0.78; 60.4% male) reported following were thematically analyzed. This resulted in a novel codebook that went beyond surface-level content typologies to reveal exposure to positive content, such as awareness raising, family values, and motivational videos, as well as negative content, such as age-inappropriate behaviors, materialistic values, and gender stereotypes. Results suggest that master and alternative narratives are portrayed by TikTok creators, generating tensions between conforming to norms that might be potentially harmful and following less common identity scripts. Full article