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Article

1 Citations

1,887 Views

16 Pages

Rapid Syndromic Testing: A Key Strategy for Antibiotic Stewardship in ICU Patients with Pneumonia

Silvana Vulpie,
Monica Licker,
Oana Izmendi,
Delia Muntean,
Diana Lungeanu,
Beatrice Sarah Zembrod,
Iasmina Maria Hancu,
Ovidiu Bedreag,
Dorel Sandesc and
Luminita Mirela Baditoiu
+ 1 author

Antibiotics2025, 14(5), 426;https://doi.org/10.3390/antibiotics14050426

23 April 2025

Background/Objectives: According to the European Centre for Disease Prevention and Control, improved antimicrobial stewardship programs (ASPs) combined with rapid diagnostic tests could potentially prevent thousands of deaths caused by multidrug-resi...

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Review

832 Views

25 Pages

Rapid Molecular Diagnostics for MDR Nosocomial Infections in ICUs: Integration with Prevention, Stewardship, and Novel Therapies

Karina Cristina Marin,
Stelian Adrian Ritiu,
Adelina Băloi,
Claudiu Rafael Barsac,
Dorel Sandesc,
Marius Papurica,
Alexandru Florin Rogobete,
Daiana Toma,
Mirela Tamara Porosnicu and
Ovidiu Horea Bedreag
+ 2 authors

Diagnostics2025, 15(23), 3060;https://doi.org/10.3390/diagnostics15233060

30 November 2025

Background/Objectives: Multidrug-resistant (MDR) nosocomial infections remain a major challenge in intensive care units (ICUs), where delays in diagnosis and suboptimal antimicrobial therapy significantly impact outcomes. This narrative review synthe...

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Article

842 Views

13 Pages

Multiplex PCR for Microbiological Testing in Patients with Peritoneal Dialysis- and Liver Cirrhosis-Related Peritonitis: Faster, but Less Sensitive

Sebastian Schwab,
Daniel Pörner,
Dominik Boes,
Achim Hoerauf,
Jacob Nattermann,
Christian Strassburg,
Gunnar T. R. Hischebeth and
Philipp Lutz

J. Clin. Med.2025, 14(8), 2641;https://doi.org/10.3390/jcm14082641

11 April 2025

Background: We analyzed the performance of a multiplex PCR application (Unyvero IAI) in comparison to culture in a cohort of peritonitis patients undergoing peritoneal dialysis or with liver cirrhosis. Methods: We performed a single-center study of 4...

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Review

25 Citations

7,454 Views

13 Pages

Impact of Multiplex PCR in the Therapeutic Management of Severe Bacterial Pneumonia

Julien Dessajan and
Jean-François Timsit

Antibiotics2024, 13(1), 95;https://doi.org/10.3390/antibiotics13010095

18 January 2024

Pneumonia is a common and severe illness that requires prompt and effective management. Advanced, rapid, and accurate tools are needed to diagnose patients with severe bacterial pneumonia, and to rapidly select appropriate antimicrobial therapy, whic...

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Review

17 Citations

9,804 Views

29 Pages

Getting Up to Speed: Rapid Pathogen and Antimicrobial Resistance Diagnostics in Sepsis

Mariana P. Liborio,
Patrick N. A. Harris,
Chitra Ravi and
Adam D. Irwin

Microorganisms2024, 12(9), 1824;https://doi.org/10.3390/microorganisms12091824

3 September 2024

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Time to receive effective therapy is a primary determinant of mortality in patients with sepsis. Blood culture is the reference standard for the micro...

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