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25 pages, 2100 KiB  
Article
Flexible Demand Side Management in Smart Cities: Integrating Diverse User Profiles and Multiple Objectives
by Nuno Souza e Silva and Paulo Ferrão
Energies 2025, 18(15), 4107; https://doi.org/10.3390/en18154107 (registering DOI) - 2 Aug 2025
Abstract
Demand Side Management (DSM) plays a crucial role in modern energy systems, enabling more efficient use of energy resources and contributing to the sustainability of the power grid. This study examines DSM strategies within a multi-environment context encompassing residential, commercial, and industrial sectors, [...] Read more.
Demand Side Management (DSM) plays a crucial role in modern energy systems, enabling more efficient use of energy resources and contributing to the sustainability of the power grid. This study examines DSM strategies within a multi-environment context encompassing residential, commercial, and industrial sectors, with a focus on diverse appliance types that exhibit distinct operational characteristics and user preferences. Initially, a single-objective optimization approach using Genetic Algorithms (GAs) is employed to minimize the total energy cost under a real Time-of-Use (ToU) pricing scheme. This heuristic method allows for the effective scheduling of appliance operations while factoring in their unique characteristics such as power consumption, usage duration, and user-defined operational flexibility. This study extends the optimization problem to a multi-objective framework that incorporates the minimization of CO2 emissions under a real annual energy mix while also accounting for user discomfort. The Non-dominated Sorting Genetic Algorithm II (NSGA-II) is utilized for this purpose, providing a Pareto-optimal set of solutions that balances these competing objectives. The inclusion of multiple objectives ensures a comprehensive assessment of DSM strategies, aiming to reduce environmental impact and enhance user satisfaction. Additionally, this study monitors the Peak-to-Average Ratio (PAR) to evaluate the impact of DSM strategies on load balancing and grid stability. It also analyzes the impact of considering different periods of the year with the associated ToU hourly schedule and CO2 emissions hourly profile. A key innovation of this research is the integration of detailed, category-specific metrics that enable the disaggregation of costs, emissions, and user discomfort across residential, commercial, and industrial appliances. This granularity enables stakeholders to implement tailored strategies that align with specific operational goals and regulatory compliance. Also, the emphasis on a user discomfort indicator allows us to explore the flexibility available in such DSM mechanisms. The results demonstrate the effectiveness of the proposed multi-objective optimization approach in achieving significant cost savings that may reach 20% for industrial applications, while the order of magnitude of the trade-offs involved in terms of emissions reduction, improvement in discomfort, and PAR reduction is quantified for different frameworks. The outcomes not only underscore the efficacy of applying advanced optimization frameworks to real-world problems but also point to pathways for future research in smart energy management. This comprehensive analysis highlights the potential of advanced DSM techniques to enhance the sustainability and resilience of energy systems while also offering valuable policy implications. Full article
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25 pages, 1138 KiB  
Article
Quality over Quantity: An Effective Large-Scale Data Reduction Strategy Based on Pointwise V-Information
by Fei Chen and Wenchi Zhou
Electronics 2025, 14(15), 3092; https://doi.org/10.3390/electronics14153092 (registering DOI) - 1 Aug 2025
Abstract
In order to increase the effectiveness of model training, data reduction is essential to data-centric Artificial Intelligence (AI). It achieves this by locating the most instructive examples in massive datasets. To increase data quality and training efficiency, the main difficulty is choosing the [...] Read more.
In order to increase the effectiveness of model training, data reduction is essential to data-centric Artificial Intelligence (AI). It achieves this by locating the most instructive examples in massive datasets. To increase data quality and training efficiency, the main difficulty is choosing the best examples rather than the complete datasets. In this paper, we propose an effective data reduction strategy based on Pointwise 𝒱-Information (PVI). To enable a static method, we first use PVI to quantify instance difficulty and remove instances with low difficulty. Experiments show that classifier performance is maintained with only a 0.0001% to 0.76% decline in accuracy when 10–30% of the data is removed. Second, we train the classifiers using a progressive learning strategy on examples sorted by increasing PVI, accelerating convergence and achieving a 0.8% accuracy gain over conventional training. Our findings imply that training a classifier on the chosen optimal subset may improve model performance and increase training efficiency when combined with an efficient data reduction strategy. Furthermore, we have adapted the PVI framework, which was previously limited to English datasets, to a variety of Chinese Natural Language Processing (NLP) tasks and base models, yielding insightful results for faster training and cross-lingual data reduction. Full article
(This article belongs to the Special Issue Data Retrieval and Data Mining)
23 pages, 4356 KiB  
Article
Quantifying Cotton Content in Post-Consumer Polyester/Cotton Blend Textiles via NIR Spectroscopy: Current Attainable Outcomes and Challenges in Practice
by Hana Stipanovic, Gerald Koinig, Thomas Fink, Christian B. Schimper, David Lilek, Jeannie Egan and Alexia Tischberger-Aldrian
Recycling 2025, 10(4), 152; https://doi.org/10.3390/recycling10040152 - 1 Aug 2025
Viewed by 101
Abstract
Rising volumes of textile waste necessitate the development of more efficient recycling systems, with a primary focus on the optimization of sorting technologies. Near-infrared (NIR) spectroscopy is a state-of-the-art method for fiber identification; however, its accuracy in quantifying textile blends, particularly common polyester/cotton [...] Read more.
Rising volumes of textile waste necessitate the development of more efficient recycling systems, with a primary focus on the optimization of sorting technologies. Near-infrared (NIR) spectroscopy is a state-of-the-art method for fiber identification; however, its accuracy in quantifying textile blends, particularly common polyester/cotton blend textiles, still requires refinement. This study explores the potential and limitations of NIR spectroscopy for quantifying cotton content in post-consumer textiles. A lab-scale NIR sorter and a handheld NIR spectrometer in complementary wavelength ranges were applied to a diverse range of post-consumer textile samples to test model accuracies. Results show that the commonly assumed 10% accuracy threshold in industrial sorting can be exceeded, especially when excluding textiles with <35% cotton content. Identifying and excluding the range of non-linearity significantly improved the model’s performance. The final models achieved an RMSEP of 6.6% and bias of −0.9% for the NIR sorter and an RMSEP of 3.1% and bias of −0.6% for the handheld NIR spectrometer. This study also assessed how textile characteristics—such as color, structure, product type, and alkaline treatment—affect spectral behavior and model accuracy, highlighting their importance for refining quantification when high-purity inputs are needed. By identifying current limitations and potential sources of errors, this study provides a foundation for improving NIR-based models. Full article
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13 pages, 1189 KiB  
Article
Positive Effects of Reduced Tillage Practices on Earthworm Population Detected in the Early Transition Period
by Irena Bertoncelj, Anže Rovanšek and Robert Leskovšek
Agriculture 2025, 15(15), 1658; https://doi.org/10.3390/agriculture15151658 - 1 Aug 2025
Viewed by 128
Abstract
Tillage is a major factor influencing soil biological communities, particularly earthworms, which play a key role in soil structure and nutrient cycling. To address soil degradation, less-intensive tillage practices are increasingly being adopted globally and have shown positive effects on earthworm populations when [...] Read more.
Tillage is a major factor influencing soil biological communities, particularly earthworms, which play a key role in soil structure and nutrient cycling. To address soil degradation, less-intensive tillage practices are increasingly being adopted globally and have shown positive effects on earthworm populations when applied consistently over extended periods. However, understanding of the earthworm population dynamics in the period following the implementation of changes in tillage practices remains limited. This three-year field study (2021–2023) investigates earthworm populations during the early transition phase (4–6 years) following the conversion from conventional ploughing to conservation (<8 cm depth, with residue retention) and no-tillage systems in a temperate arable system in central Slovenia. Earthworms were sampled annually in early October from three adjacent fields, each following the same three-year crop rotation (maize—winter cereal + cover crop—soybeans), using a combination of hand-sorting and allyl isothiocyanate (AITC) extraction. Results showed that reduced tillage practices significantly increased both earthworm biomass and abundance compared to conventional ploughing. However, a significant interaction between tillage and year was observed, with a sharp decline in earthworm abundance and mass in 2022, likely driven by a combination of 2022 summer tillage prior to cover crop sowing and extreme drought conditions. Juvenile earthworms were especially affected, with their proportion decreasing from 62% to 34% in ploughed plots and from 63% to 26% in conservation tillage plots. Despite interannual fluctuations, no-till showed the lowest variability in earthworm population. Long-term monitoring is essential to disentangle management and environmental effects and to inform resilient soil management strategies. Full article
(This article belongs to the Section Agricultural Soils)
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12 pages, 1392 KiB  
Brief Report
Soft Fillets in a Sustainable Seafood Era: Assessing Texture, Yield Loss and Valorization Potential of ‘Mushy’ Greenland Halibut Fillets
by Natacha L. Severin and Kurt Buchmann
Fishes 2025, 10(8), 367; https://doi.org/10.3390/fishes10080367 (registering DOI) - 1 Aug 2025
Viewed by 128
Abstract
‘Mushy halibut syndrome’ (MHS) is associated with inferior fillet quality in Greenland halibut and is reported to occur in commercial catches across the North Atlantic. MHS constitutes a quality issue in fisheries and leads to economic losses and food wastage. Despite the known [...] Read more.
‘Mushy halibut syndrome’ (MHS) is associated with inferior fillet quality in Greenland halibut and is reported to occur in commercial catches across the North Atlantic. MHS constitutes a quality issue in fisheries and leads to economic losses and food wastage. Despite the known challenges associated with MHS, quantitative data on product properties are lacking, and yet they are crucial to assess actual losses and value-adding processing potential. As part of a larger effort to document and characterize MHS in Greenland halibut, we investigated how thaw drip loss (TDL), cooked drip loss (CDL), cooked yield, and tissue compressibility and elasticity differ between normal and ‘mushy’ halibut fillets. The fillets were sorted into three categories: normal, intermediate MHS, and severe MHS. The mean TDL and CDL increased more than three-fold in both MHS categories compared to normal fillets, while cooked yield decreased by approximately 20%. Fillets severely affected by MHS demonstrated high tissue compressibility (56%) and poor elasticity (46%), while the elasticity of the fillets belonging to the intermediate MHS category did not differ significantly from that of normal ones. These findings provide new insights into the product attributes of fillets affected by MHS, which are important for developing utilization and valorization strategies. Full article
(This article belongs to the Section Processing and Comprehensive Utilization of Fishery Products)
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21 pages, 1192 KiB  
Article
Net and Configurational Effects of Determinants on Managers’ Construction and Demolition Waste Sorting Intention in China Using Partial Least Squares Structural Equation Modeling and the Fuzzy-Set Qualitative Comparative Analysis
by Guanfeng Yan, Yuhang Tian and Tianhai Zhang
Sustainability 2025, 17(15), 6984; https://doi.org/10.3390/su17156984 (registering DOI) - 31 Jul 2025
Viewed by 192
Abstract
Construction and demolition waste (C&D waste) contains various types of substances, which require different processing methods to maximize benefits and minimize harm to realize the goal of the circular economy. Therefore, it is urgent to promote the on-site sorting of C&D waste and [...] Read more.
Construction and demolition waste (C&D waste) contains various types of substances, which require different processing methods to maximize benefits and minimize harm to realize the goal of the circular economy. Therefore, it is urgent to promote the on-site sorting of C&D waste and explore the determinants of managers’ waste sorting intention. Based on a comprehensive literature review of C&D waste management, seven determinants are identified to explore how antecedent factors influence waste sorting intention by symmetric and asymmetric techniques. Firstly, the partial least squares structural equation modeling (PLS-SEM) was adopted to analyze the data collected from 489 managers to assess the net impact of each determinant on their intentions. Then, the fuzzy-set qualitative comparative analysis (fsQCA) provided another perspective by determining the configurations of the causal conditions that lead to higher or lower levels of intention. The PLS-SEM results reveal that all determinants show a significant positive relationship with the intention except for the perceived risks, which are negatively correlated with managers’ attitudes and intentions regarding C&D waste sorting. Moreover, top management support and subjective norms from other project participants and the public exhibit a huge impact, while the influence of perceived behavioral control (PBC) and policies is moderate. Meanwhile, fsQCA provides a complementary analysis of the complex causality that PLS-SEM fails to capture. That is, fsQCA identified six and five configurations resulting in high and low levels of intention to sort the C&D waste, respectively, and highlighted the crucial role of core conditions. The results provide theoretical and practical insights regarding proper C&D waste management and enhancing sustainable development. Full article
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35 pages, 3218 KiB  
Article
Integrated GBR–NSGA-II Optimization Framework for Sustainable Utilization of Steel Slag in Road Base Layers
by Merve Akbas
Appl. Sci. 2025, 15(15), 8516; https://doi.org/10.3390/app15158516 (registering DOI) - 31 Jul 2025
Viewed by 98
Abstract
This study proposes an integrated, machine learning-based multi-objective optimization framework to evaluate and optimize the utilization of steel slag in road base layers, simultaneously addressing economic costs and environmental impacts. A comprehensive dataset of 482 scenarios was engineered based on literature-informed parameters, encompassing [...] Read more.
This study proposes an integrated, machine learning-based multi-objective optimization framework to evaluate and optimize the utilization of steel slag in road base layers, simultaneously addressing economic costs and environmental impacts. A comprehensive dataset of 482 scenarios was engineered based on literature-informed parameters, encompassing transport distance, processing energy intensity, initial moisture content, gradation adjustments, and regional electricity emission factors. Four advanced tree-based ensemble regression algorithms—Random Forest Regressor (RFR), Extremely Randomized Trees (ERTs), Gradient Boosted Regressor (GBR), and Extreme Gradient Boosting Regressor (XGBR)—were rigorously evaluated. Among these, GBR demonstrated superior predictive performance (R2 > 0.95, RMSE < 7.5), effectively capturing complex nonlinear interactions inherent in slag processing and logistics operations. Feature importance analysis via SHapley Additive exPlanations (SHAP) provided interpretative insights, highlighting transport distance and energy intensity as dominant factors affecting unit cost, while moisture content and grid emission factor predominantly influenced CO2 emissions. Subsequently, the Gradient Boosted Regressor model was integrated into a Non-Dominated Sorting Genetic Algorithm II (NSGA-II) framework to explore optimal trade-offs between cost and emissions. The resulting Pareto front revealed a diverse solution space, with significant nonlinear trade-offs between economic efficiency and environmental performance, clearly identifying strategic inflection points. To facilitate actionable decision-making, the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) method was applied, identifying an optimal balanced solution characterized by a transport distance of 47 km, energy intensity of 1.21 kWh/ton, moisture content of 6.2%, moderate gradation adjustment, and a grid CO2 factor of 0.47 kg CO2/kWh. This scenario offered a substantial reduction (45%) in CO2 emissions relative to cost-minimized solutions, with a moderate increase (33%) in total cost, presenting a realistic and balanced pathway for sustainable infrastructure practices. Overall, this study introduces a robust, scalable, and interpretable optimization framework, providing valuable methodological advancements for sustainable decision making in infrastructure planning and circular economy initiatives. Full article
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23 pages, 1830 KiB  
Article
Fuzzy Multi-Objective Optimization Model for Resilient Supply Chain Financing Based on Blockchain and IoT
by Hamed Nozari, Shereen Nassar and Agnieszka Szmelter-Jarosz
Digital 2025, 5(3), 32; https://doi.org/10.3390/digital5030032 (registering DOI) - 31 Jul 2025
Viewed by 190
Abstract
Managing finances in a supply chain today is not as straightforward as it once was. The world is constantly shifting—markets fluctuate, risks emerge unexpectedly—and companies are continually trying to stay one step ahead. In all this, financial resilience has become more than just [...] Read more.
Managing finances in a supply chain today is not as straightforward as it once was. The world is constantly shifting—markets fluctuate, risks emerge unexpectedly—and companies are continually trying to stay one step ahead. In all this, financial resilience has become more than just a strategy. It is a survival skill. In our research, we examined how newer technologies (such as blockchain and the Internet of Things) can make a difference. The idea was not to reinvent the wheel but to see if these tools could actually make financing more transparent, reduce some of the friction, and maybe even help companies breathe a little easier when it comes to liquidity. We employed two optimization methods (Non-dominated Sorting Genetic Algorithm II (NSGA-II) and Multi-Objective Particle Swarm Optimization (MOPSO)) to achieve a balanced outcome. The goal was lower financing costs, better liquidity, and stronger resilience. Blockchain did not just record transactions—it seemed to build trust. Meanwhile, the Internet of Things (IoT) provided companies with a clearer picture of what is happening in real-time, making financial outcomes a bit less of a guessing game. However, it gives financial managers a better chance at planning and not getting caught off guard when the economy takes a turn. Full article
(This article belongs to the Topic Sustainable Supply Chain Practices in A Digital Age)
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26 pages, 2059 KiB  
Article
Integration and Development Path of Smart Grid Technology: Technology-Driven, Policy Framework and Application Challenges
by Tao Wei, Haixia Li and Junfeng Miao
Processes 2025, 13(8), 2428; https://doi.org/10.3390/pr13082428 - 31 Jul 2025
Viewed by 270
Abstract
As a key enabling technology for energy transition, the smart grid is propelling the global power system to evolve toward greater efficiency, reliability, and sustainability. Based on the three-dimensional analysis framework of “technology–policy–application”, this study systematically sorts out the technical architecture, regional development [...] Read more.
As a key enabling technology for energy transition, the smart grid is propelling the global power system to evolve toward greater efficiency, reliability, and sustainability. Based on the three-dimensional analysis framework of “technology–policy–application”, this study systematically sorts out the technical architecture, regional development mode, and typical application scenarios of the smart grid, revealing the multi-dimensional challenges that it faces. By using the methods of literature review, cross-national case comparison, and technology–policy collaborative analysis, the differentiated paths of China, the United States, and Europe in the development of smart grids are compared, aiming to promote the integration and development of smart grid technologies. From a technical perspective, this paper proposes a collaborative framework comprising the perception layer, network layer, and decision-making layer. Additionally, it analyzes the integration pathways of critical technologies, including sensors, communication protocols, and artificial intelligence. At the policy level, by comparing the differentiated characteristics in policy orientation and market mechanisms among China, the United States, and Europe, the complementarity between government-led and market-driven approaches is pointed out. At the application level, this study validates the practical value of smart grids in optimizing energy management, enhancing power supply reliability, and promoting renewable energy consumption through case analyses in urban smart energy systems, rural electrification, and industrial sectors. Further research indicates that insufficient technical standardization, data security risks, and the lack of policy coordination are the core bottlenecks restricting the large-scale development of smart grids. This paper proposes that a new type of intelligent and resilient power system needs to be constructed through technological innovation, policy coordination, and international cooperation, providing theoretical references and practical paths for energy transition. Full article
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19 pages, 1072 KiB  
Article
Efficient and Reliable Identification of Probabilistic Cloning Attacks in Large-Scale RFID Systems
by Chu Chu, Rui Wang, Nanbing Deng and Gang Li
Micromachines 2025, 16(8), 894; https://doi.org/10.3390/mi16080894 (registering DOI) - 31 Jul 2025
Viewed by 122
Abstract
Radio Frequency Identification (RFID) technology is widely applied in various scenarios, including logistics tracking, supply chain management, and target monitoring. In these contexts, the malicious cloning of legitimate tag information can lead to sensitive data leakage and disrupt the normal acquisition of tag [...] Read more.
Radio Frequency Identification (RFID) technology is widely applied in various scenarios, including logistics tracking, supply chain management, and target monitoring. In these contexts, the malicious cloning of legitimate tag information can lead to sensitive data leakage and disrupt the normal acquisition of tag information by readers, thereby threatening personal privacy and corporate security and incurring significant economic losses. Although some efforts have been made to detect cloning attacks, the presence of missing tags in RFID systems can obscure cloned ones, resulting in a significant reduction in identification efficiency and accuracy. To address these problems, we propose the block-based cloned tag identification (BCTI) protocol for identifying cloning attacks in the presence of missing tags. First, we introduce a block indicator to sort all tags systematically and design a block mechanism that enables tags to respond repeatedly within a block with minimal time overhead. Then, we design a superposition strategy to further reduce the number of verification times, thereby decreasing the execution overhead. Through an in-depth analysis of potential tag response patterns, we develop a precise method to identify cloning attacks and mitigate interference from missing tags in probabilistic cloning attack scenarios. Moreover, we perform parameter optimization of the BCTI protocol and validate its performance across diverse operational scenarios. Extensive simulation results demonstrate that the BCTI protocol meets the required identification reliability threshold and achieves an average improvement of 24.01% in identification efficiency compared to state-of-the-art solutions. Full article
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17 pages, 1204 KiB  
Article
The Great Wanderer: The Phylogeographic History of the Bicolor Pyramid Ant (Dorymyrmex bicolor Wheeler, 1906) in Central Veracruz, Mexico
by Maria Gómez-Lazaga and Alejandro Espinosa de los Monteros
Insects 2025, 16(8), 785; https://doi.org/10.3390/insects16080785 (registering DOI) - 31 Jul 2025
Viewed by 184
Abstract
The goal of phylogeography is to explain how microevolutionary forces shape the gene pool of a lineage into the geography. In this study we have evaluated the amount of genetic variation in 13 populations of Dorymyrmex bicolor distributed in a mountainous region in [...] Read more.
The goal of phylogeography is to explain how microevolutionary forces shape the gene pool of a lineage into the geography. In this study we have evaluated the amount of genetic variation in 13 populations of Dorymyrmex bicolor distributed in a mountainous region in Central Veracruz, Mexico. To do so, we sequenced fragments from the mitochondrial COI, COII, and nuclear LWRh genes. Segregated sites were found only at the mitochondrial markers, recovering a total of 21 different haplotypes. The nucleotide diversity ranged from 0 to 0.5% at the different sampling sites. Phylogenetic and spatial analyses of molecular variance revealed a weak but significant phylogeographic structure associated with lowland and mountainous zones. Molecular clock analysis suggests that radiation in the mountain area started 7500 years ago, whereas lineage radiation in the lowland started more recently, around 2700 years ago. The phylogeographic structure is incipient, with nests from lowlands more closely related to mountain nests than to other lowland nests, and vice versa. This seems to be consistent with a model of incomplete lineage sorting. The obtained patterns appear to be the result of restricted gene flow mediated by a complex topographic landscape that has been shaped by a dynamic geologic history. Full article
(This article belongs to the Special Issue Ant Population Genetics, Phylogeography and Phylogeny)
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22 pages, 6820 KiB  
Article
Bathymetric Profile and Sediment Composition of a Dynamic Subtidal Bedform Habitat for Pacific Sand Lance
by Matthew R. Baker, H. G. Greene, John Aschoff, Michelle Hoge, Elisa Aitoro, Shaila Childers, Junzhe Liu and Jan A. Newton
J. Mar. Sci. Eng. 2025, 13(8), 1469; https://doi.org/10.3390/jmse13081469 - 31 Jul 2025
Viewed by 269
Abstract
The eastern North Pacific Ocean coastline (from the Salish Sea to the western Aleutian Islands) is highly glaciated with relic sediment deposits scattered throughout a highly contoured and variable bathymetry. Oceanographic conditions feature strong currents and tidal exchange. Sand wave fields are prominent [...] Read more.
The eastern North Pacific Ocean coastline (from the Salish Sea to the western Aleutian Islands) is highly glaciated with relic sediment deposits scattered throughout a highly contoured and variable bathymetry. Oceanographic conditions feature strong currents and tidal exchange. Sand wave fields are prominent features within these glaciated shorelines and provide critical habitat to sand lance (Ammodytes spp.). Despite an awareness of the importance of these benthic habitats, attributes related to their structure and characteristics remain undocumented. We explored the micro-bathymetric morphology of a subtidal sand wave field known to be a consistent habitat for sand lance. We calculated geomorphic attributes of the bedform habitat, analyzed sediment composition, and measured oceanographic properties of the associated water column. This feature has a streamlined teardrop form, tapered in the direction of the predominant tidal current. Consistent flow paths along the long axis contribute to well-defined and maintained bedform morphology and margin. Distinct patterns in amplitude and period of sand waves were documented. Strong tidal exchange has resulted in well-sorted medium-to-coarse-grained sediments with coarser sediments, including gravel and cobble, within wave troughs. Extensive mixing related to tidal currents results in a highly oxygenated water column, even to depths of 80 m. Our analysis provides unique insights into the physical characteristics that define high-quality habitat for these fish. Further work is needed to identify, enumerate, and map the presence and relative quality of these benthic habitats and to characterize the oceanographic properties that maintain these benthic habitats over time. Full article
(This article belongs to the Special Issue Dynamics of Marine Sedimentary Basin)
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21 pages, 6921 KiB  
Article
Transcriptomic Analysis Identifies Oxidative Stress-Related Hub Genes and Key Pathways in Sperm Maturation
by Ali Shakeri Abroudi, Hossein Azizi, Vyan A. Qadir, Melika Djamali, Marwa Fadhil Alsaffar and Thomas Skutella
Antioxidants 2025, 14(8), 936; https://doi.org/10.3390/antiox14080936 - 30 Jul 2025
Viewed by 293
Abstract
Background: Oxidative stress is a critical factor contributing to male infertility, impairing spermatogonial stem cells (SSCs) and disrupting normal spermatogenesis. This study aimed to isolate and characterize human SSCs and to investigate oxidative stress-related gene expression, protein interaction networks, and developmental trajectories involved [...] Read more.
Background: Oxidative stress is a critical factor contributing to male infertility, impairing spermatogonial stem cells (SSCs) and disrupting normal spermatogenesis. This study aimed to isolate and characterize human SSCs and to investigate oxidative stress-related gene expression, protein interaction networks, and developmental trajectories involved in SSC function. Methods: SSCs were enriched from human orchiectomy samples using CD49f-based magnetic-activated cell sorting (MACS) and laminin-binding matrix selection. Enriched cultures were assessed through morphological criteria and immunocytochemistry using VASA and SSEA4. Transcriptomic profiling was performed using microarray and single-cell RNA sequencing (scRNA-seq) to identify oxidative stress-related genes. Bioinformatic analyses included STRING-based protein–protein interaction (PPI) networks, FunRich enrichment, weighted gene co-expression network analysis (WGCNA), and predictive modeling using machine learning algorithms. Results: The enriched SSC populations displayed characteristic morphology, positive germline marker expression, and minimal fibroblast contamination. Microarray analysis revealed six significantly upregulated oxidative stress-related genes in SSCs—including CYB5R3 and NDUFA10—and three downregulated genes, such as TXN and SQLE, compared to fibroblasts. PPI and functional enrichment analyses highlighted tightly clustered gene networks involved in mitochondrial function, redox balance, and spermatogenesis. scRNA-seq data further confirmed stage-specific expression of antioxidant genes during spermatogenic differentiation, particularly in late germ cell stages. Among the machine learning models tested, logistic regression demonstrated the highest predictive accuracy for antioxidant gene expression, with an area under the curve (AUC) of 0.741. Protein oxidation was implicated as a major mechanism of oxidative damage, affecting sperm motility, metabolism, and acrosome integrity. Conclusion: This study identifies key oxidative stress-related genes and pathways in human SSCs that may regulate spermatogenesis and impact sperm function. These findings offer potential targets for future functional validation and therapeutic interventions, including antioxidant-based strategies to improve male fertility outcomes. Full article
(This article belongs to the Special Issue Oxidative Stress and Male Reproductive Health)
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23 pages, 783 KiB  
Article
An Effective QoS-Aware Hybrid Optimization Approach for Workflow Scheduling in Cloud Computing
by Min Cui and Yipeng Wang
Sensors 2025, 25(15), 4705; https://doi.org/10.3390/s25154705 (registering DOI) - 30 Jul 2025
Viewed by 142
Abstract
Workflow scheduling in cloud computing is attracting increasing attention. Cloud computing can assign tasks to available virtual machine resources in cloud data centers according to scheduling strategies, providing a powerful computing platform for the execution of workflow tasks. However, developing effective workflow scheduling [...] Read more.
Workflow scheduling in cloud computing is attracting increasing attention. Cloud computing can assign tasks to available virtual machine resources in cloud data centers according to scheduling strategies, providing a powerful computing platform for the execution of workflow tasks. However, developing effective workflow scheduling algorithms to find optimal or near-optimal task-to-VM allocation solutions that meet users’ specific QoS requirements still remains an open area of research. In this paper, we propose a hybrid QoS-aware workflow scheduling algorithm named HLWOA to address the problem of simultaneously minimizing the completion time and execution cost of workflow scheduling in cloud computing. First, the workflow scheduling problem in cloud computing is modeled as a multi-objective optimization problem. Then, based on the heterogeneous earliest finish time (HEFT) heuristic optimization algorithm, tasks are reverse topologically sorted and assigned to virtual machines with the earliest finish time to construct an initial workflow task scheduling sequence. Furthermore, an improved Whale Optimization Algorithm (WOA) based on Lévy flight is proposed. The output solution of HEFT is used as one of the initial population solutions in WOA to accelerate the convergence speed of the algorithm. Subsequently, a Lévy flight search strategy is introduced in the iterative optimization phase to avoid the algorithm falling into local optimal solutions. The proposed HLWOA is evaluated on the WorkflowSim platform using real-world scientific workflows (Cybershake and Montage) with different task scales (100 and 1000). Experimental results demonstrate that HLWOA outperforms HEFT, HEPGA, and standard WOA in both makespan and cost, with normalized fitness values consistently ranking first. Full article
(This article belongs to the Section Internet of Things)
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33 pages, 11892 KiB  
Article
Experimental Study on Mechanical Properties of Waste Steel Fiber Polypropylene (EPP) Concrete
by Yanyan Zhao, Xiaopeng Ren, Yongtao Gao, Youzhi Li and Mingshuai Li
Buildings 2025, 15(15), 2680; https://doi.org/10.3390/buildings15152680 - 29 Jul 2025
Viewed by 140
Abstract
Polypropylene (EPP) concrete offers advantages such as low density and good thermal insulation properties, but its relatively low strength limits its engineering applications. Waste steel fibers (WSFs) obtained during the sorting and processing of machining residues can be incorporated into EPP concrete (EC) [...] Read more.
Polypropylene (EPP) concrete offers advantages such as low density and good thermal insulation properties, but its relatively low strength limits its engineering applications. Waste steel fibers (WSFs) obtained during the sorting and processing of machining residues can be incorporated into EPP concrete (EC) to enhance its strength and toughness. Using the volume fractions of EPP and WSF as variables, specimens of EPP concrete (EC) and waste steel fiber-reinforced EPP concrete (WSFREC) were prepared and subjected to cube compressive strength tests, splitting tensile strength tests, and four-point flexural strength tests. The results indicate that EPP particles significantly improve the toughness of concrete but inevitably lead to a considerable reduction in strength. The incorporation of WSF substantially enhanced the splitting tensile strength and flexural strength of EC, with increases of at least 37.7% and 34.5%, respectively, while the improvement in cube compressive strength was relatively lower at only 23.6%. Scanning electron microscopy (SEM) observations of the interfacial transition zone (ITZ) and WSF surface morphology in WSFREC revealed that the addition of EPP particles introduces more defects in the concrete matrix. However, the inclusion of WSF promotes the formation of abundant hydration products on the fiber surface, mitigating matrix defects, improving the bond between WSF and the concrete matrix, effectively inhibiting crack propagation, and enhancing both the strength and toughness of the concrete. Full article
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