Search Results (26)

In this contribution, three techniques related to modelling and remote sensing were tested to answer questions and satisfy requirements from air quality managers in the mining sector: (1) What are appropriate emission factors for blasting operations in copper mines? (2) How can we know the concentration of particulate matter in the next few hours in advance? (3) How can we generate a heat map of the particulate matter levels over the mine and nearby populations? These techniques were evaluated for one of the most relevant open pit mines in southern Europe, the Riotinto Mine, Huelva (Spain). The results obtained suggest that these techniques can efficiently improve the management of air quality in mining activities. Full article

The formation of hot tearing during direct chill casting of aluminum alloys, specifically AA6111, is a significant challenge in the production of ingots for industrial applications. This study investigates the role of hydrostatic pressure and tensile stress in the formation of hot tearing during direct chill casting of rectangular ingots. Combining experimental results and finite element modeling with ABAQUS/CAE 2022, the mechanical behavior of the semi-solid AA6111 alloy was analyzed under different cooling conditions. “Hot” (low water flow) and “Cold” (high water flow) conditions were the two types of cooling conditions that produced cracked and sound ingots, respectively. The outcomes indicate that high tensile stress and localized negative hydrostatic pressure in the hot condition are the main factors promoting the initiation and propagation of cracks in the mushy zone, whereas the improvement of the cooling conditions reduces these defects. Full article

The characterisation of shear modulus degradation is essential for understanding the dynamic response of geomaterials. This article presents a modified hyperbolic model that evaluates the shear modulus for various angular strains and effective confining stresses. The model has been calibrated and validated using data from 108 resonant-column tests conducted on three different types of tailings from the Riotinto mines in Huelva, Spain. These tests were conducted on saturated samples that were consolidated at effective stresses of 50, 100, 150, 200, 250, and 300 kPa, accompanied by various combinations of torsional excitations to induce distinct angular strains. The results show that the hyperbolic model effectively predicts the shear modulus degradation in unconventional geomaterials, characterising the shear modulus under the testing conditions for the three types of Riotinto tailings. Additionally, the model can identify and confirm both the initial (or maximum) shear modulus and the reference angular strain as functions of the effective confining stress. The findings and model presented in this article contribute to enhancing the stability and resilience of geotechnical structures, including tailings storage facilities, that are subjected to dynamic loading, leading to safer designs and improved infrastructure performance. Full article

Spinal muscular atrophy (SMA) and severe T- and/or B-cell lymphopenias (STBCL) in the form of severe combined immunodeficiencies (SCID) or X-linked agammaglobulinemia (XLA) are rare but potentially fatal pathologies. In January 2021, we initiated the first pilot study in Spain to evaluate the efficacy of a very early detection technique for SMA and SCID. RT–PCR was performed on prospectively collected dried blood spots (DBSs) from newborns in Western Andalusia (Spain). Internal and external controls (SCID, XLA and SMA) were included. The determination of SMA was relative (positive/negative) and that of TRECs and KRECs was quantitative (copies/punch). A total of 14.035 prospective samples were analysed. All controls were correctly identified while no cases of SMA or SCID/XLA were prospectively identified. DBS analysis of infants with suspected SMA or STBCL that presented to our centre showed pathological values in two cases each for SMA and SCID and one for XLA, all of them being subsequently confirmed genetically. In this prospective pilot study, no infants with SMA or STBCL were detected; however, the technique applied here was shown to be reliable and fast, further supporting the benefits and need to include SMA and SCID in national newborn screening (NBS) programs, as it will allow early supportive and curative therapy. Full article

Grade control refers to the procedure to differentiate ore from waste in a mine. It is usually not easy to make such differentiation, especially in metallic mines where grades are very low, and miners have no visual or texture reference to distinguish the rock. This paper gives details of the grade control process that has been in operation during the last 10 years in the Corta Atalaya open pit, Riotinto, Huelva, Spain. The spacing of the blast boreholes, the sampling procedure, the laboratory analysis, and the software used to interpolate the data are discussed in detail. The amount of data generated is huge, as more than 120,000 boreholes are drilled each year, generating a high workload, as each borehole has to be sampled, each sample analyzed, and the results included in Recmin databases. These data are used to generate separation zones for waste and ore that are marked by topographers. This process is a key part of the mining sequence, directly impacting the economic results of the mine as better leverage of the deposit is obtained. Full article

Copper anode slime (CAS) contains high concentrations of precious metals, particularly gold, which can reach up to 11 wt%. During copper anode electrorefining, 5–10 kg of CAS is generated per ton of copper cathode. Processing CAS is crucial for economic reasons, as gold significantly contributes to revenue for both miners and custom copper smelters. This paper provides a comprehensive review of industrial processes and technologies for CAS treatment, with a focus on gold recovery, covering studies from the early 1930s to the present. It documents traditional and recent trends and analyzes the advantages and disadvantages of existing methods. Key factors affecting revenue, such as gold production lead time, in-process inventory, and first-pass recovery rate, are discussed to mitigate losses in fluctuating gold markets. CAS processing routes are categorized into two main groups: traditional hybrid routes (involving hydrometallurgy, pyrometallurgy, and electrorefining/electrowinning) and rather recent purely hydrometallurgical routes. Traditional methods can take up to 45 days, with gold recovery occurring late in the process and losses arising in the anode, cathode, electrolyte, or slag. In contrast, purely hydrometallurgical routes have total processing times of 7–8 days, achieve early gold recovery, and can attain first-pass recovery rates as high as 99%. Additionally, the hydrometallurgical routes are more environmentally friendly, with lower pollution levels and reduced energy consumption compared to hybrid routes. These findings indicate that purely hydrometallurgical routes outperform traditional hybrid methods. This paper aims to serve as a guideline for industrial CAS processing, assisting custom copper smelters in navigating challenging market conditions marked by low treatment and refining charges, with an emphasis on enhancing gold recovery to promote sustainability. Full article

Background/objectives: Fostamatinib is a spleen tyrosine kinase (SYK) inhibitor approved for the treatment of adult patients with chronic immune thrombocytopenia (ITP). There is little information about dose tapering and sustained remission after discontinuation in ITP. In this retrospective multicenter study, we evaluated efficacy and safety of fostamatinib in adult patients with ITP before, during, and after tapering/discontinuation (T/D). Methods: T/D was performed on subjects who achieved complete platelet response (CR) with progressive, conditional dose reduction every four weeks. Results: Sixty-one patients were included from 14 reference centers between October 2021 and May 2023. In subjects that completed T/D (n = 9), the median time from treatment initiation to response was 21 days (IQR: 7.5–42), median time from treatment initiation to CR was 28 days (IQR: 28–42), median time from treatment initiation to the start of tapering was 116 days (IQR: 42–140), and duration of tapering was 112.5 days (IQR: 94.5–191). The median platelet count was 232 × 10⁹/L (IQR: 152–345 × 10⁹/L) at tapering and 190 × 10⁹/L (IQR: 142.5–316.5 × 10⁹/L) at discontinuation. With a median follow-up since discontinuation of 263 days (IQR: 247–313 days), only two patients have relapsed (at 63 and 73 days). Fostamatinib was restarted, achieving a new CR. Platelet counts higher than 100 × 10⁹/L in week 12 were the only positive predictive factors for successful tapering and discontinuation. Conclusions: Sustained response in patient with ITP treated with fostamatinib could be developed. The prognostic factors and recommended scheme of tapering still have to be evaluated. Full article

Since the middle of the 20th century, the crisis of industrial mining activities in Western Europe has caused the cessation of mining, triggering a structural crisis. The necessity to look for alternatives has been widely discussed; among these alternatives, tourist activities based on mining heritage stand out. However, it is essential to address the study of those unattractive peripheral spaces in which new activities encounter obstacles to their development and face post-industrial and rural crises. The Riotinto Mining Basin (Huelva, Andalusia) represents an example of such rural spaces; it has an enormous cultural heritage, and the mine has recently been reactivated. The objective of this research is to analyze the contribution of mining tourism to sustainable rural development. The applied methodology was mixed and was based on interviews and secondary data. The results are (a) the achievement of the tourism value of the mining heritage; (b) the difficulties tourism faces in overcoming its peripheral condition; (c) the relative contribution of tourism to the improvement of the territorial image; (d) the lack of coordination among stakeholders; and (e) the limited contribution of tourism to sustainable rural development and its movement to a secondary economic role after the reopening of the mine. Full article

Objective: We aimed to evaluate the use of CDK4/6 inhibitors as a risk factor for medication-related osteonecrosis of the jaw (MRONJ) in a cohort of patients with metastatic breast cancer treated with denosumab. Methods: This was a multicentre, retrospective, observational study. All patients with breast cancer treated with denosumab (January 2011–December 2022) were included. The relationship between CDK4/6 inhibitors and MRONJ was analysed. Results: A total of 243 patients were included, ninety-five (44.2%) of whom used a CDK4/6 inhibitor. There were 21 patients with MRONJ. In patients treated with denosumab without CDK4/6 inhibitors, the incidence of MRONJ and mean time to the occurrence of MRONJ were 6.6% (8/120) and 16.8 months (SD 7.8), respectively; in patients treated with denosumab and CDK4/6 inhibitor, these values were 13.7% (13/95) and 15.4 months (SD 8.7), respectively. The difference in the incidence was not significant (p = 0.085). Among the 19 patients who used abemaciclib, the probability of MRONJ occurrence was significantly higher compared to patients not using CDK4/6 inhibitors (p = 0.0178). Conclusions: These results suggest that the incidence of MRONJ in patients with metastatic breast cancer treated with denosumab is higher, and the onset of MRONJ occurs earlier in the presence of CDK4/6 inhibitors. The differences were statistically significant in the patients who used abemaciclib. Given that the use of this combination is very common in routine clinical practice, it would be advisable to carry out larger prospective studies to clarify the risk of this association. Full article

This study examines some relevant limnological and hydrogeochemical characteristics of the most emblematic pit lake of the Iberian Pyrite Belt (IPB). Corta Atalaya (CA) open pit mine is known for its large size and for being one of the most important exploitations of copper in Europe. Despite its historical importance, little is known about the lake formed in this open pit. During this study, the pit lake presented a surface area of 16 ha, a maximum depth of 106 m, and a 5.8 hm³ volume of acid and metal-enriched water. CA pit lake shows permanent chemical stratification (meromictic lake), where three layers with different density and chemical composition can be differentiated: (i) a superficial layer of 5 ± 2 m water depth, with electric conductivity (EC) between 5.4–6.64 mS/cm, and oxygenated and Fe(III)-rich mixolimnion; (ii) an intermediate layer (between 5–30 m, chemocline), exhibiting strong vertical changes in parameters such as temperature (T) and EC, which show an increase with depth; and (iii) a thick bottom layer from 30 m to 106 m depth, with anoxic, elevated EC (47 mS/cm) and T (32 °C) values, and a concentration of Fe as Fe(II) (monimolimnion).The characterization of the water column is essential to know the potential sources of strategic and critical raw materials, and to evaluate their possible recuperation, thereby activating a circular economy. Full article

Global situations such as economic recovery after a pandemic, geopolitical instability, and future digital and energy transition are some of the drivers for the European Union (EU) to explore new and existing sources of raw materials. The Iberian Pyrite Belt in the southwest of the Iberian Peninsula (Spain and Portugal) hosts a great number of tailing deposits from centuries of mining operations. A unique tailings deposit has been studied and characterized. The similarities with other tailing deposits deeply studied suggested the presence of critical raw materials. Furthermore, a very gross reserves estimation was made. The characterization and reserves estimations were compared with the bibliography from mining companies who operated in the area decades ago and from the bibliography available at Fundación Riotinto. The presence of critical raw materials was confirmed, some of them in high concentrations. Moreover, a singular difference was found compared with other similar tailings stored within the Iberian Pyrite Belt. The main valuable metals identified were Au (2.25 ppm), Ag (215 ppm), Co (131 ppm) and Cu (0.29%). The reserves estimation showed that this deposit potentially hosts 1.86 t of Au, 177 t of Ag, 108 t of Co or 2358 t of Cu; in other words, with a copper average price of 8366 US$/t in December 2022, the tailings deposit contains a potential value of more than 19 million USD. Full article

Electromagnetic (EM) methods belong to the main geophysical techniques used in the mineral exploration of massive sulphides. For selecting EM anomalies as possible massive sulphide targets, it is important to combine the geophysical results with other geological and/or geochemical techniques. In 2015, Atalaya Mining started a new mineral exploration project in the Touro Cu deposit, combining geological, geochemical (ore over 0.2% Cu), and geophysical techniques. The geophysical survey consisted of helicopter-borne EM using the versatile time-domain electromagnetic (VTEM™) max system operated by Geotech Ltd. with full-waveform processing. In total, 509 line-km of geophysical data were acquired during the survey that was completed in 2018. The results showed the massive sulphide Touro ore to be typically of the order of 0.25 ohm·m (4S/m conductivity) and host rock in the range of 1000–30,000 ohm·m, measured directly on the drill core. This modelling agreed well with the sub-horizontal dips observed for the known Touro ore bodies. The conductance modelled by the plate estimation of the VTEM data were also in good agreement with those provided by Geotech Ltd. and the resistivity/conductivity measurements we made on the massive sulphide samples from several Touro ore bodies. The combination of flat dips, good conductance, shallow depth, and, lastly, lack of conductive overburden or noneconomic conductive stratigraphy, i.e., graphitic shales and sulphide iron formation make the Touro project an ideal target for airborne electromagnetic prospecting. This paper presents the excellent correlation observed between the EM airborne anomalies and the massive sulphide blocks of the Touro copper deposit. Favourable factors contributing to the success of the survey were the high contrast in resistivity/conductivity between the massive sulphide Touro ore and the amphibolite host rock and minimal interference from “nuisance” conductors, such as graphitic shales. Full article

Introduction: There are studies that evaluate the association between chronic obstructive pulmonary disease (COPD) and heart failure (HF) but there is little evidence regarding the prognosis of this comorbidity in older patients admitted for acute HF. In addition, little attention has been given to the extracardiac and extrapulmonary symptoms presented by patients with HF and COPD in more advanced stages. The aim of this study was to evaluate the prognostic impact of COPD on mortality in elderly patients with acute and advanced HF and the clinical manifestations and management from a palliative point of view. Methods: The EPICTER study (“Epidemiological survey of advanced heart failure”) is a cross-sectional, multicenter project that consecutively collected patients admitted for HF in 74 Spanish hospitals. Demographic, clinical, treatment, organ-dependent terminal criteria (NYHA III-IV, LVEF <20%, intractable angina, HF despite optimal treatment), and general terminal criteria (estimated survival <6 months, patient/family acceptance of palliative approach, and one of the following: evidence of HF progression, multiple Emergency Room visits or admissions in the last six months, 10% weight loss in the last six months, and functional impairment) were collected. Terminal HF was considered if the patient met at least one organ-dependent criterion and all the general criteria. Both groups (HF with COPD and without COPD) were compared. A Kaplan–Meier survival analysis was performed to evaluate the presence of COPD on the vital prognosis of patients with HF. Results: A total of 3100 patients were included of which 812 had COPD. In the COPD group, dyspnea and anxiety were more frequently observed (86.2% vs. 75.3%, p = 0.001 and 35.4% vs. 31.2%, p = 0.043, respectively). In patients with a history of COPD, presentation of HF was in the form of acute pulmonary edema (21% vs. 14.4% in patients without COPD, p = 0.0001). Patients with COPD more frequently suffered from advanced HF (28.9% vs. 19.4%; p < 0.001). Consultation with the hospital palliative care service during admission was more frequent when patients with HF presented with associated COPD (94% vs. 6.8%; p = 0.036). In-hospital and six-month follow-up mortality was 36.5% in patients with COPD vs. 30.7% in patients without COPD, p = 0.005. The mean number of hospital admissions during follow-up was higher in patients with HF and COPD than in those with isolated HF (0.63 ± 0.98 vs. 0.51 ± 0.84; p < 0.002). Survival analysis showed that patients with a history of COPD had fewer survival days during follow-up than those without COPD (log Rank chi-squared 4.895 and p = 0.027). Conclusions: patients with HF and COPD had more severe symptoms (dyspnea and anxiety) and also a worse prognosis than patients without COPD. However, the prognosis of patients admitted to our setting is poor and many patients with HF and COPD may not receive the assessment and palliative care support they need. Palliative care is necessary in chronic non-oncologic diseases, especially in multipathologic and symptom-intensive patients. This is a clinical care aspect to be improved and evaluated in future research studies. Full article

Soil instability is a major hazard facing the mining industry in its role of supplying the indispensable mineral resources that our societal challenges require. Aiming to demonstrate the monitoring potential of radar satellites in the mining sector, we analyze the deformation field in the Riotinto mine, Spain. We propose a new method for combining ascending and descending results into a common dataset that provides better resolution. We project the LOS measurements resulting from both geometries to a common reference system without applying any type of geometric restriction. As a projection system, we use the vertical direction in flat areas and the slope in steep topographies. We then identify and remove outliers and artifacts from the joint dataset to finally obtain a deformation map that combines the two acquisition perspectives. The results in the Atalaya pit are consistent with GNSS measurements. The movements observed in the rock dumps were unknown before this study. We demonstrate the great potential of the Sentinel-1 satellite as a complementary tool for monitoring systems in mining environments and we call for its use to be standardized to guarantee a safe and sustainable supply of mineral resources necessary for a just technological transition. Full article

Introduction: Heart failure (HF) and cancer are currently the leading causes of death worldwide, with an increasing incidence with age. Little is known about the treatment received and the prognosis of patients with acute HF and a prior cancer diagnosis. Objective: to determine the clinical characteristics, palliative treatment received, and prognostic impact of patients with acute HF and a history of solid tumor. Methods: The EPICTER study (“Epidemiological survey of advanced heart failure”) is a cross-sectional, multicenter project that consecutively collected patients admitted for acute HF in 74 Spanish hospitals. Patients were classified into two groups according to whether they met criteria for acute HF with and without solid cancer, and the groups were subsequently compared. A multivariable logistic regression analysis was conducted, using the forward stepwise method. A Kaplan–Meier survival analysis was performed to evaluate the impact of solid tumor on prognosis in patients with acute HF. Results: A total of 3127 patients were included, of which 394 patients (13%) had a prior diagnosis of some type of solid cancer. Patients with a history of cancer presented a greater frequency of weight loss at admission: 18% vs. 12% (p = 0.030). In the cancer group, functional impairment was noted more frequently: 43% vs. 35%, p = 0.039). Patients with a history of solid cancer more frequently presented with acute HF with preserved ejection fraction (65% vs. 58%, p = 0.048) than reduced or mildly reduced. In-hospital and 6-month follow-up mortality was 31% (110/357) in patients with solid cancer vs. 26% (637/2466), p = 0.046. Conclusion: Our investigation demonstrates that in-hospital mortality and mortality during 6-month follow-up in patients with acute HF were higher in those subjects with a history of concomitant solid tumor cancer diagnosis. Full article