Search Results (112)

In the context of global warming, polar tourism is developing rapidly, and the demand for polar cruise travel in the Northwest Passage continues to increase, while sea ice has long been a key factor limiting the development of polar cruise tourism. This study focuses on the operational risk of sea ice on cruise ships in the Northwest Passage (NWP), aiming to provide a scientific basis for ensuring the safety of cruise ship navigation and promoting the sustainable development of polar tourism. Based on ice data from 2015 to 2024, this study used the Polar Operational Limit Assessment Risk Indexing System (POLARIS) methodology recommended by the International Maritime Organization (IMO) to establish three scenarios for the route of ice class IC cruise ships: light ice, normal ice, and heavy ice. The navigable windows were systematically analyzed and critical waters along the route were identified. The results indicate that the navigable windows for IC ice-class cruise ships under light ice conditions are from mid-July to early December, while the navigable period under normal ice conditions is only from mid- to late September, and navigation is not possible under heavy ice conditions. The study identified Larsen Sound, Barrow Strait, Bellot Strait and Eastern Beaufort Sea as critical waters on the NWP cruise route. Among them, Larsen Sound and Eastern Beaufort Sea have a more prominent impact on voyage scheduling because their navigation weeks overlap less with other waters. This study provides a new idea for the risk assessment of polar cruise ships in ice regions. The research results can provide an important reference for the safe operation of polar cruise ships in the NWP and the decision-making of relevant parties. Full article

Nature-based solutions (NBS) have attracted increasing attention in local air quality and climate change adaptation plans as suitable measures to reduce health risks. Although several studies have reported health benefits from short-term urban cooling effects of NBS, medium- to long-term health benefits are still poorly understood. In this study, we assess the changes in long-term mortality related to temperature fluctuations induced by city-scale vegetation actuations in three Southern European cities. We performed two annual high-resolution simulations with the Weather Research and Forecasting model to anticipate the impact of future revegetation strategies on temperature in these urban areas. Further, we assessed the impact of temperature changes on health using a country-specific minimum mortality temperature (MMT) reported in scientific literature. It was found that NBS could provide non-negligible reductions of long-term mortality related to temperature regulation (central estimate of 4.1, 1.2, and 3.4 cases avoided per year in Madrid, Milano, and Bologna, respectively). The effect of vegetation is site-dependent, and the cooling effect explains most of the benefits, especially in densely built-up areas of the cities analyzed. Future research should combine short/long-term temperature effects with other indirect implications (air quality, mental health) in the context of climate change. Full article

At present, sea ice remains a critical factor affecting the safety of vessel operations along the Northern Sea Route (NSR). However, inconsistencies between the navigability outcomes derived from the criteria for the admission of ships in the area of the Northern Sea Route (NSR criteria) and the polar operational limit assessment risk indexing system (POLARIS) methodology present challenges for navigational decision-making. This study aims to conduct a systematic comparison of the POLARIS methodology and the NSR criteria in evaluating the navigability of independently operating vessels classified as Arc4 to Arc9. Through comparative calculations of navigability and the navigability rates for six ice-class vessels across 27 districts using the two methods, this study reveals the consistencies and discrepancies in their navigability outcomes. Firstly, using the POLARIS methodology, the risk index outcome (RIO) is calculated for six ice-class vessels across 27 districts. For these districts, the navigability threshold is defined when 95% or more of the area exhibits an RIO greater than or equal to zero. Secondly, using the NSR criteria, navigability ratios for six ice-class vessels under varying ice conditions are evaluated. A navigability threshold is defined when 95% or more of the ice conditions in a district are classified as navigable. Finally, a quantitative comparison of the weekly navigability ratios obtained by the two methods is conducted to reveal the consistencies and discrepancies in the navigability outcomes of each ice-class vessel across different NSR districts. The results indicate that the consistency between the navigability outcomes of the two methods decreases with lower vessel ice classes, particularly in September and March. In general, the consistency of performance between the two methods in terms of navigability outcomes deteriorates as the vessel ice class decreases and ice conditions become more complex. This study provides a scientific foundation and data-based support for route planning and real-time decision-making in polar waters. Full article

Background: Nutritional management has become an integral part of Inflammatory Bowel Disease (IBD) care, with growing evidence supporting specific dietary interventions alongside pharmacologic therapy. However, clinical guidance remains fragmented due to heterogeneous study designs and variable endpoints. Objectives: This review critically examines the current evidence on dietary strategies and oral nutritional supplementation (ONS) in both Crohn’s Disease (CD) and Ulcerative Colitis (UC), highlighting their clinical applications, mechanisms of action, and limitations. Methods: A comprehensive literature search was conducted using PubMed, Scopus, and Web of Science databases, analyzing studies on various dietary approaches and ONS in IBD. Results: Exclusive Enteral Nutrition (EEN) is a first-line therapy in pediatric CD, while partial enteral nutrition (PEN) and the Crohn’s Disease Exclusion Diet (CDED) show promising efficacy and better adherence in both children and adults. Whole-food-based interventions, including the Mediterranean Diet, Specific Carbohydrate Diet, plant-based diets, and emerging strategies such as CD-TREAT and the Tasty & Healthy diet, have demonstrated varying levels of benefit in disease maintenance and symptom control. Targeted exclusion diets—such as low-FODMAP, low-emulsifier, and low-sulfur diets—may relieve functional symptoms and influence inflammatory activity, although evidence remains preliminary. ONS plays a pivotal role in addressing malnutrition and improving outcomes in perioperative and hospitalized patients. Conclusions: Dietary interventions and ONS represent valuable therapeutic tools in IBD management. Future research should prioritize standardized, well-powered clinical trials and personalized nutritional approaches to better define their role within integrated care pathways. Full article

E-leadership has become particularly prominent in the public sector over the last five years. The urgent shift requires more remote work and management via information and communication technologies. In recognition of its ever-growing popularity, the objective of this article is to provide a systematic review of the existing literature on e-leadership within public sector organisations and identify key research approaches and outcomes. The analysis provides a framework of research on e-leadership in public sector entities, by focusing on various theoretical, methodological, empirical and contextual perspectives, specifically tailored to public sector organisations. The detailed framework, presented here, incorporates dimensions, approaches, clusters and findings of previous research (articles, published in the period 2013–2022), aiding a deeper understanding of the phenomenon and its practical implementation. The study complies with PRISMA 2020 requirements. As it shall be demonstrated, interest in the phenomenon surged during the pandemic, particularly within educational and management disciplines. The findings highlight a predominant focus on leadership within educational institutions, whilst areas such as healthcare and public governance remain under-researched. The most common theoretical approach adopted is associated with the transformational leadership theory and encompasses three main interpretations. Specifically, it evaluates e-leadership as a strategic approach, a leadership process and a leadership transformation. Qualitative methodology predominates in e-leadership research within the public sector, with quantitative and mixed-method approaches being less frequent. Addressing the challenges identified by previous research, such as competency and infrastructure deficiencies, is crucial for advancing knowledge of e-leadership in the public sector and improving sustainable performance. Full article

Bio-based nanomaterials (B-NMs), such as silica oxide (SiO₂)- and lignin (Lig)- based nanoparticles (NPs) derived from biomass waste, have gained attention in the last few years in the view of promoting the sustainability principles in several applications. However, scarce data are available about their safety. Thus, a hazard-testing strategy was designed considering as a reference the safe-and-sustainable-by-design (SSbD) framework for chemicals and materials, prioritizing the use of new approach methodologies (NAMs), such as in vitro and adverse outcome pathways (AOPs) approaches, for generating data about the potential hazard of B-NMs. Literature research was performed to identify the adverse outcomes (AOs) related to the selected B-NMs. All the AOPs investigated shared at least oxidative stress, inflammation and cytotoxicity as key events (KEs) that were investigated in lung and immune cells. The tested B-NMs resulted either non-toxic or moderately toxic towards human cells, validating their biocompatibility when compared to reference NMs of similar composition, but not of bio-origin. However, attention should be given to possible AOs deriving after specific functionalization of the B-NMs. Considering the lack of knowledge in this field, the studies performed represent a step forward in the state of the art of the safety assessment of B-NMs. Full article

The accuracy of soil databases is essential in hydrological modeling, yet limited studies have evaluated the implications of using emerging soil datasets like POLARIS compared to traditional ones such as SSURGO. This study evaluates the performance of POLARIS soil data for simulating the streamflow and sediment yield at both the sub-basin and field scales within the Big Muddy Watershed (BMW), Illinois, U.S.A., using a soft-calibrated SWAT+ model. The field-scale analysis focused on cropland-dominated HRUs from two sub-basins with contrasting POLARIS-SSURGO similarities at the sub-basin scale, optimizing computational efficiency. POLARIS results were compared to those derived from the widely used SSURGO soil database using a soft-calibrated SWAT+ model. At the sub-basin scale, the two datasets showed strong overall agreement for the streamflow and sediment yield over the 81 BMW sub-basins, with minor discrepancies, especially in sediment yield predictions, which exhibited more variability. At the field scale, the agreement between POLARIS and SSURGO was good for both variables, streamflow and sediment yield, though the sediment yield showed greater variability as shown at the sub-basin level. At both scales, the POLARIS and SSURGO outcomes for the streamflow and sediment yield did not always follow the same trend, with discrepancies observed in some sub-basins and HRUs. This suggested that while POLARIS can replicate SSURGO’s streamflow outcomes, this similarity does not always extend to sediment yield predictions and vice versa. At the sub-basin scale, the POLARIS and SSURGO outcomes showed strong alignment (88.9% in “very good” agreement). However, at the field scale, this alignment decreased to 42.9% and 33.3% in specific sub-basins. This indicates that sub-basin aggregation reduces local variability, while finer scales reveal greater sensitivity to soil and hydrological differences. This study highlights POLARIS as a robust alternative to SSURGO for hydrological modeling. Future research should explore its broader application across diverse conditions. Full article

This paper presents the highlights of boiling water reactor (BWR) core physics studies performed at Oak Ridge National Laboratory as part of a series of studies conducted to compare low-enriched uranium (LEU) with LEU+ fuel. The studies analyzed isotopic fuel content, lattice parameters (Phase 1), and core physics (Phase 2) to identify challenges in operation, storage, and transportation for BWRs and pressurized water reactors (PWRs). Because of a lack of publicly available lattice and core designs for modern BWR fuel assemblies and reactor cores, several optimized lattice designs were generated, and different core loading strategies were investigated. Twelve optimized lattice designs with ²³⁵U enrichments ranging from 1.6% to 9% and gadolinia loadings ranging from 3 to 8 wt% were used to model axial enrichment and geometry variations in fuel assemblies for core designs. Each core shares a common set of approximations in design and analysis to allow for consistent comparisons between LEU and LEU+ fuel. The objective is to highlight anticipated changes in core behavior with respect to the reference LEU core. The results of this study show that the differences in LEU and LEU+ core reactor physics characteristics are less significant than the differences in lattice physics characteristics reported in the Phase 1 studies. Full article

Background: New-onset postoperative atrial fibrillation (POAF) is the most common complication after cardiac surgery, occurring approximately in one-third of the patients. This study considered all-comer patients who underwent cardiac surgery to build a predictive model for POAF. Methods: A total of 3467 (Center 1) consecutive patients were used as a derivation cohort to build the model. The POLARIS score was then derived proportionally from the odds ratios obtained following multivariable logistic regression (MLR). The Brier Score, the area under the receiver operating characteristic curve, and the Hosmer–Lemeshow goodness-of-fit test were used to validate the model. Then, 2272 (Center 2) consecutive patients were used as an external validation cohort. Results: In the overall population (n = 5739), POAF occurred in 32.7% of patients. MLR performed in the derivation cohort showed that age, obesity, chronic renal failure, pulmonary hypertension, minimally invasive surgery, and aortic and mitral valve surgery were predictors of POAF. The derived POLARIS score was used to further stratify the population into four risk clusters: low (1.5–3), intermediate (3.5–5), high (5.5–7), and very high (7.5–9), each progressively showing an increase in POAF incidence. This was confirmed in a correlation analysis (Spearman’s rho: 0.636). Conclusions: The POLARIS score is a simple-to-use tool to stratify patients at higher risk of POAF. Precise identification of such patients might be used to implement clinical practice with the introduction of preoperative antiarrhythmic prophylaxis, further reducing the incidence of POAF and, potentially, its clinical sequelae, despite further investigations being warranted to test this model in prospective studies. Full article

Free-electron lasers (FELs) operating in the extreme ultraviolet (XUV) and X-ray regions deliver ultrashort pulses with unprecedented intensity, enabling groundbreaking research across various scientific disciplines. A potential chirp (frequency change within the pulse) of these pulses influences their spectral properties, directly impacting the experimental outcomes and FEL performance. The accurate characterization of the chirp is, therefore, important for optimizing FEL operation and interpreting experimental results. This study presents a comprehensive comparison of two techniques determining the chirp of the XUV pulses at FLASH by directly measuring the XUV pulses with THz streaking and by detecting the chirp of the electron bunches by a Transverse Deflection Structure (PolariX TDS) to infer the XUV chirp. We conducted simultaneous measurements using both techniques at FLASH2 while tuning the FEL to produce various energy chirps on the electron bunch. Full article

As Arctic sea ice continues to melt and global demand for clean energy rises, Russia’s Liquefied Natural Gas (LNG) exports via the Northern Sea Route (NSR) are rapidly increasing. To ensure the operational safety of LNG carriers and safeguard the economic interests of stakeholders, including shipowners, a thorough assessment of the navigability of various ice-class LNG carriers along this route is essential. This study collected Arctic ice condition data from 2014 to 2023 and applied the Polar Operational Limit Assessment Risk Indexing System (POLARIS) methodology to calculate the Risk Index Outcome (RIO) for LNG carriers with No Ice Class, Arc4, and Arc7 ice classifications in Arctic waters. A navigability threshold of 95% RIO ≥ 0 was established to define navigable windows, and critical waters were identified where sections of the route remain in hazardous or risky conditions year-round. The results indicate that for No Ice Class vessels, Arc4 vessels, and Arc7 vessels, the navigable windows for westbound Route 1 and Route 2 under light, normal, and heavy ice conditions range from 70 to 133 days, 70 to 365 days, and 70 to 365 days, respectively, while for eastbound Route 3, the navigable windows range from 0 to 84 days, 0 to 238 days, and 7 to 365 days, respectively. The critical waters affecting the navigability of No Ice Class vessels, Arc4 vessels, and Arc7 vessels are primarily located in the Kara Sea, Laptev Sea and East Siberian Sea. This study, using the POLARIS methodology, provides valuable insights into the navigability of LNG carriers with different ice classes along the NSR, supporting the development and utilization of Arctic energy and shipping routes while offering decision-making support for stakeholders involved in Arctic maritime operations. Full article

Non-melanoma skin cancers (NMSCs), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are highly prevalent and a significant cause of morbidity. Image-guided superficial radiation therapy (IGSRT) uses integrated high-resolution dermal ultrasound to improve lesion visualization, but it is unknown whether efficacy varies by histology. This large retrospective cohort study was conducted to determine the effect of tumor histology on freedom from recurrence in 20,069 biopsy-proven NMSC lesions treated with IGSRT, including 9928 BCCs (49.5%), 5294 SCCs (26.4%), 4648 SCCIS cases (23.2%), and 199 lesions with ≥2 NMSCs (1.0%). Freedom from recurrence at 2, 4, and 6 years was 99.60%, 99.45%, and 99.45% in BCC; 99.58%, 99.49%, and 99.49% in SCC; and 99.96%, 99.80%, and 99.80% in SCCIS. Freedom from recurrence at 2, 4, and 6 years following IGSRT did not differ significantly comparing BCC vs. non-BCC or SCC vs. non-SCC but were slightly lower among SCCIS vs. non-SCCIS (p = 0.002). There were no significant differences in freedom from recurrence when stratifying lesions by histologic subtype. This study demonstrates that there is no significant effect of histology on freedom from recurrence in IGSRT-treated NMSC except in SCCIS. These findings support IGSRT as a first-line therapeutic option for NMSC regardless of histology. Full article

Dangerous emerging water micropollutants like Diclofenac are harming ecosystems all over the planet, and immediate action is needed. The large bandgap photocatalysts conventionally used to degrade them need to be more efficient. Cu₂ZnSnS₄, a well-known light absorber in photovoltaics with a bandgap of 1.5 eV, can efficiently harvest an abundant portion of the solar spectrum. However, its photocatalytic activity has so far only been reported in relation to the degradation of organic dyes, and it is usually used as a benchmark to assess the activity of a photocatalyst without testing its actual potential on a hazardous water micropollutant conventionally encountered in primary and secondary waters. Here, we report the promising photocatalytic activity of Cu₂ZnSnS₄ nanoparticles in the degradation of Diclofenac, chosen as a benchmark for dangerous emerging water micropollutants. Full article

The SCALE/Polaris–PARCS code procedure has been used in the confirmatory analysis for boiling water reactors by the US Nuclear Regulatory Commission. In this study, the SCALE/Polaris v6.3.0–PARCS v3.4.2 code procedure with the Evaluated Nuclear Data File (ENDF)/B-VII.1 AMPX 56-group library was validated by comparing the simulated results with the measured data for operating boiling water reactors, including Peach Bottom Unit 2 cycles 1–3, Hatch Unit 1 cycles 1–3, and Quad Cities Unit 1 cycles 1–3. The uncertainties and biases of the SCALE/Polaris–PARCS code package for boiling water reactor physics analysis were evaluated in the validation for key nuclear parameters such as reactivity and traversing in-core probe data. Full article

The overlap between the geographic distribution of COVID-19 outbreaks and pollution levels confirmed a correlation between exposure to atmospheric particulate matter (PM) and the SARS-CoV-2 pandemic. The RAS system is essential in the pathogenesis of inflammatory diseases caused by pollution: the ACE/AngII/AT1 axis activates a pro-inflammatory pathway, which is counteracted by the ACE2/Ang(1-7)/MAS axis, which activates an anti-inflammatory and protective pathway. However, ACE2 is also known to act as a receptor through which SARS-CoV-2 enters host cells to replicate. Furthermore, in vivo systems have demonstrated that exposure to PM increases ACE2 expression. In this study, the effects of acute and sub-acute exposure to ultrafine particles (UFP), originating from different anthropogenic sources (DEP and BB), on the levels of ACE2, ACE, COX-2, HO-1, and iNOS in the lungs and other organs implicated in the pathogenesis of COVID-19 were analyzed in the in vivo BALB/c male mice model. Exposure to UFP alters the levels of ACE2 and/or ACE in all examined organs, and exposure to sub-acute DEP also results in the release of s-ACE2. Furthermore, as evidenced in this and our previous works, COX-2, HO-1, and iNOS levels also demonstrated organ-specific alterations. These proteins play a pivotal role in the UFP-induced inflammatory and oxidative stress responses, and their dysregulation is linked to the development of severe symptoms in individuals infected with SARS-CoV-2, suggesting a heightened vulnerability or a more severe clinical course of the disease. UFP and SARS-CoV-2 share common pathways; therefore, in a “risk stratification” concept, daily exposure to air pollution may significantly increase the likelihood of developing a severe form of COVID-19, explaining, at least in part, the greater lethality of the virus observed in highly polluted areas. Full article