Search Results (183)

Ras El-Bar, a premier historic coastal resort on Egypt’s Nile Delta, has experienced a marked increase in drowning incidents in recent years, despite the presence of extensive coastal protection structures. While these measures, particularly detached breakwaters (DBWs), groins, and port jetties, were originally implemented to mitigate shoreline erosion, their influence on nearshore hydrodynamics and swimmer safety remains insufficiently understood. In this context, the present study integrates high-resolution bathymetric data, remote sensing observations, and coupled numerical modeling (CMS-Wave and CMS-Flow) to examine how these interventions have altered wave–current interactions. The results indicate that the modified coastal setting produces distinct flow regimes, ranging from weak offshore currents (<0.1 m/s) to moderate rip currents (≈0.25 m/s) within DBW shadow zones, and locally intensified flows exceeding 0.7 m/s in shallow nearshore areas. These conditions facilitate the development of vortices and persistent rip currents, particularly within inter-DBW embayments. A simulation-based swimming risk map was developed by integrating water depth and simulated current characteristics, classifying the coastline into safe, moderate-risk, and high-risk zones. High-risk zones, concentrated within inter-DBW embayments at depths exceeding 2 m, show broad spatial agreement with available drowning and rescue incident records, subject to the limitations of the informal dataset, while the shallow accretional shadow zones landward of the DBWs exhibit comparatively lower hydrodynamic energy and safer conditions. Overall, the study demonstrates that coastal protection structures, although effective in controlling erosion, may unintentionally increase human risk when safety considerations are not incorporated into their design and management. Accordingly, a set of integrated, sustainability-oriented measures is proposed, including enhanced real-time monitoring, regulated beach access, adaptive sand nourishment, and targeted public awareness, with the aim of achieving a more balanced and resilient approach to coastal zone management. Full article

The Burullus–Baltim coastal zone of Egypt’s Nile Delta represents a critical geoheritage sand-dune system functioning as the primary natural defense line against inundation of the central Nile Delta. This ecosystem is increasingly threatened by intensive black sand mining, raising concerns regarding long-term coastal sustainability. Black sand extraction disrupts dune integrity by reducing sediment density and heavy mineral content, thereby lowering resistance to wind forcing and accelerating aeolian transport. This study assesses historical dune migration and extraction-driven changes in aeolian dynamics using high-resolution satellite imagery, ERA5 wind reanalysis (1975–2024), and integrated analytical–numerical modeling, with implications for sustainable coastal management. A dominant northwesterly wind regime drives eastward and southward dune migration of 3.22 m/yr and 1.7 m/yr, respectively (2010–2025). Black sand mining since 2022 has measurably reduced heavy mineral content and bulk density, altering grain-size distribution and making dunes significantly more susceptible to wind entrainment. Coupled Bagnold and AeoLiS modeling predicts an 8.21% rise in mass transport rates and a corresponding acceleration in dune migration following extraction. These findings demonstrate that black sand mining amplifies aeolian transport and increases sand encroachment risks to nearby settlements, infrastructure, and agricultural lands. The results highlight the trade-offs between resource extraction and coastal dune ecosystem services, particularly flood protection and land stability, emphasizing the need for regulated mining, bioengineered dune stabilization, and predictive modeling to enhance the Nile Delta’s long-term resilience. Full article

Soil organic carbon (SOC) is a major component of the global carbon cycle. This study aimed to: (i) monitor five decades’ land use/land cover (LULC) changes in the northern Nile delta using Landsat imagery; (ii) quantify baseline SOC stocks (SOCs) in 2021; (iii) project SOCs and potential SOC sequestration (PSOCS) to 2100 under four SSP2-4.5 climate scenarios using RothC model; and (iv) evaluate uncertainty in SOCs and PSOCS projections using the Monte Carlo approach. Sixty soil samples were collected during the winter and summer seasons of 2018/2019 (30 per season). Agricultural land expanded from 12% in 1972 to 35% in 2021, while fish farms, established in the 1990s, accounted for 24% of the area by 2021. SOCs varied across LULC types and seasons. Between 13 and 28% of agricultural land exceeding 7 Mg C ha⁻¹ in summer and winter, respectively. Barren land and sabkha were characterized by low SOCs (<3 Mg C ha⁻¹). Model predictions indicate that mean SOCs will increase from 5.83 (2021) to 6.16 (mid-century), followed by a decline to 5.96 Mg C ha⁻¹ by 2100. Estimated PSOCS range from 0.13 to 0.32 Mg C ha⁻¹. Monte Carlo uncertainty analysis yielded median SOCs between 6.01 and 6.27 Mg C ha⁻¹ and median PSOCS between 0.18 and 0.44 Mg C ha⁻¹, reflecting moderate projection uncertainty. Full article

The mechanization of wheat harvesting in Egypt is a critical step towards enhancing food security. This study evaluated the operational performance, grain loss, and economic viability of four wheat harvesting systems for the ‘Sakha 95’ variety in the Nile Delta. To evaluate and rank the different systems based on multiple criteria, the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) was employed. A Randomized Complete Block Design (RCBD) with three replicates was used to test three self-propelled combine harvesters (Claas [4.2 m], Field-King [2.0 m], Daedong [1.4 m]) alongside one semi-mechanized system (reaper–binder + stationary thresher). The TOPSIS analysis identified the Field King combine as the most recommended system (Rank 1), providing the optimal balance between operational efficiency and cost. It achieved the lowest direct harvesting cost (3386.66 EGP ha⁻¹) with a minimal grain loss of only 0.05%. The Claas combine secured Rank 2. While it reached the highest effective field capacity (1.18 ha h⁻¹) and near-total grain recovery (0.005% loss), its ranking was influenced by its high initial purchase price and fuel consumption. The reaper–binder system (Rank 3) and Daedong combine (Rank 4) followed. Despite having the highest operational cost (7371.42 EGP ha⁻¹) and higher grain losses (0.72%), the reaper–binder remains a scientifically justified choice for integrated crop-livestock systems, as its ability to produce ready-to-use “soft straw” provides a net economic advantage for smallholders. The study concludes that while large combines are ideal for the “New Lands,” mid-sized units like the Field King are best suited for scaling through cooperatives in fragmented landscapes. Full article

The Damietta–Port Said coast, Nile Delta, has experienced extreme morphological change over the past four decades due to sediment reduction due to Aswan High Dam and continued anthropogenic pressures. Using multi-temporal Landsat (1985–2025) and high-resolution RapidEye and PlanetScope imagery with 50 m-spaced transects, the study documents major shoreline shifts: the Damietta sand spit retreated by >1 km at its proximal apex while its distal tip advanced by ≈3.1 km southeastward under persistent longshore drift. Sectoral analyses reveal typical structure-induced patterns of updrift accretion (+180 to +210 m) and downdrift erosion (−50 to −330 m). To improve predictive capability beyond linear DSAS extrapolation, Nonlinear Autoregressive Exogenous (NARX) and Bidirectional Long Short-Term Memory (BiLSTM) neural networks were applied to forecast the 2050 shoreline. BiLSTM demonstrated superior stability, capturing nonlinear sediment transport patterns where NARX produced unstable over-predictions. Furthermore, coupled wave–flow modeling validates a sustainable management strategy employing successive short groins (45–50 m length, 150 m spacing). Simulations indicate that this configuration reduces longshore current velocities by 40–60% and suppresses rip-current eddies, offering a sediment-compatible alternative to conventional breakwaters and seawalls. This integrated remote sensing, hydrodynamic, and AI-based framework provides a robust scientific basis for adaptive, sediment-compatible shoreline management, supporting the long-term resilience of one of Egypt’s most vulnerable deltaic coasts under accelerating climatic and anthropogenic pressures. Full article

Obesity is among the top contributing factors for non-communicable chronic disease development and has attained menacing global proportions, affecting approximately one of eight adults. Phytochemicals that support energy metabolism and prevent obesity development have been the subject of intense research endeavors over the past several decades. Cycloastragenol is a natural triterpenoid compound and aglycon of astragaloside IV, known for activating telomerase and mitigating cellular aging. Here, we aim to characterize the effect of cycloastragenol on lipid metabolism in a glucose-induced obesity model in Caenorhabditis elegans. We assessed the changes in the body length, width, and area in C. elegans maintained under elevated glucose through automated WormLab system. Lipid accumulation in the presence of either cycloastragenol (100 μM) or orlistat (12 μM), used as a positive anti-obesity control drug, was quantified through Nile Red fluorescent staining. Furthermore, we evaluated the changes in key energy metabolism molecular players in GFP-reporter transgenic strains. Our results revealed that cycloastragenol treatment decreased mean body area and reduced lipid accumulation in the C. elegans glucose-induced model. The mechanistic data indicated that cycloastragenol suppresses the nuclear hormone receptor family member NHR-49 and the delta(9)-fatty-acid desaturase 7 (FAT-7) enzyme, and activates the 5′-AMP-activated protein kinase catalytic subunit alpha-2 (AAK-2) and the protein skinhead 1 (SKN-1) signaling. Collectively, our findings highlight that cycloastragenol reprograms lipid metabolism by down-regulating the insulin-like receptor (daf-2)/phosphatidylinositol 3-kinase (age-1)/NHR-49 signaling while simultaneously enhancing the activity of the AAK-2/NAD-dependent protein deacetylase (SIR-2.1) pathway. The anti-obesogenic potential of cycloastragenol rationalizes further validation in the context of metabolic diseases and obesity management. Full article

Background and Rationale: Tinospora crispa (L.) Hook.f. & Thomson (T. crispa) is a climbing medicinal plant with long-standing ethnopharmacological use, particularly in inflammatory and hepatic disorders and cancer-related conditions. There is a knowledge gap regarding how wild versus cultivated ecotypes differ in chemotype, bioactivity, and safety, and how this might support or refine traditional use. Study Objectives: This study aimed to compare wild and cultivated ecotypes of T. crispa from the Nile Delta (Egypt) in terms of quantitative and qualitative phytochemical profiles; selected in vitro biological activities (especially antioxidant and cytotoxic actions); genetic markers potentially associated with metabolic variation; and short-term oral safety in an animal model. Core Methodology: Standardized extraction of plant material from wild and cultivated ecotypes. Determination of total phenolics, total flavonoids, and major phytochemical classes (alkaloids, tannins, terpenoids). Metabolomic characterization using UHPLC-ESI-QTOF-MS, supported by NMR, to confirm key compounds such as berberine, palmatine, chlorogenic acid, rutin, and borapetoside C. In vitro bioassays including: Antioxidant activity (e.g., radical-scavenging assay with EC₅₀ determination). Cytotoxicity against human cancer cell lines, with emphasis on HepG2 hepatoma cells and calculation of IC₅₀ values. Targeted genetic analysis to detect single-nucleotide polymorphisms (SNPs) in the gen1 locus that differentiate ecotypes. A 14-day oral toxicity study in rats, assessing liver and kidney function markers and performing histopathology of liver and kidney tissues. Principal Results: The wild ecotype showed a 43–65% increase in total flavonoid and polyphenol content compared with the cultivated ecotype, as well as substantially higher levels of key alkaloids, particularly berberine (around 12.5 ± 0.8 mg/g), along with elevated chlorogenic acid and borapetoside C. UHPLC-MS and NMR analyses confirmed the identity of the main bioactive constituents and defined a distinct chemical fingerprint for the wild chemotype. Bioassays demonstrated stronger antioxidant activity of the wild extract than the cultivated one and selective cytotoxicity of the wild extract against HepG2 cells (IC₅₀ ≈ 85 µg/mL), being clearly more potent than extracts from cultivated plants. Genetic profiling detected a C → T SNP within the gen1 region that differentiates the wild ecotype and may be linked to altered biosynthetic regulation. The 14-day oral toxicity study (up to 600 mg/kg) revealed no evidence of hepatic or renal toxicity, with biochemical markers remaining within physiological limits and normal liver and kidney histology. Conclusions and Future Perspectives: The wild Nile-Delta ecotype of T. crispa appears to be a stress-adapted chemotype characterized by enriched levels of multiple bioactive metabolites, superior in vitro bioactivity, and an encouraging preliminary safety margin. These findings support further evaluation of wild T. crispa as a candidate source for standardized botanical preparations targeting oxidative stress-related and hepatic pathologies, while emphasizing the need for: More comprehensive in vivo efficacy studies. Cultivation strategies that deliberately maintain or mimic beneficial stress conditions to preserve phytochemical richness. Broader geographical and genetic sampling to assess how generalizable the present chemotypic and bioactivity patterns are across the species. Full article

Effective fisheries management relies on accurate stock assessments to ensure sustainable exploitation and long-term ecosystem stability. Fisheries from the Nile Delta lakes of Egypt—comprising Manzala, Burullus, Edku, and Mariout—are economically critical, collectively contributing about 40% of the nation’s total capture fisheries and are facing severe anthropogenic challenges. This study assessed the stock status of 10 key fish species and two crustacean species from these four Nile Delta lakes by determining their life history parameters and exploitation levels. The analysis included estimation of the Length–Weight Relationship (LWR), von Bertalanffy Growth Function (VBGF) parameters, instantaneous mortality coefficients (Z, M, F), and the exploitation ratio (E). Asymptotic total length (L∞) varied widely, ranging from 10.47 cm for Portunus pelagicus to 86.78 cm for Clarias gariepinus (in Lake Manzala). The growth coefficient (K) spanned from 0.31 yr⁻¹ (C. gariepinus) to 1.79 yr⁻¹ (Metapenaeus stebbingi), reflecting diverse life history strategies. The key finding, based on the Gulland criterion, is that all commercial stocks examined in the Nile Delta lakes are currently subjected to severe overexploitation, with the exploitation ratio (E) consistently exceeding the optimal threshold of 0.5. These results underscore the urgent need for adaptive management strategies, including stricter gear regulations and improved fisheries monitoring, to ensure the sustainability of these vital resources. Full article

On 1 April 2471 b.C., an impressive, unpredictable phenomenon occurred over the Delta of the Nile: a total solar eclipse, with the totality band almost centred on the sacred city of Buto, and the “capital” Memphis on the verge of the totality. This date is compatible with existing chronologies for the reign of Pharaoh Shepseskaf, who adopted a clamorous symbolic break with respect to the tradition of “solarized” kings started by Khufu. Indeed, his tomb was not built in view from Heliopolis and was not a pyramid, but a kind of unique monument resembling the symbolic shrine at Buto. The aim of the present paper is to investigate in a systematic way the possibility that the origin of this historical and architectural passage, which marks the end of the Fourth Dynasty, can be identified precisely in the 2471 b.C. eclipse, therefore furnishing a new astronomical anchor for the chronology of the Old Kingdom. Full article

Egypt has the highest global prevalence of hepatitis C virus (HCV), with genotype 4 (G4) in over 94% of cases. Direct-acting antivirals (DAAs) yield sustained virologic response (SVR) rates above 95%. Second-generation DAAs are recommended for patients with virological failure, achieving over 90% eradication. This study aimed to classify and evaluate the pattern of HCV resistance-associated substitutions (RASs) in patients who failed DAA treatment in Egypt. A total of 1778 chronically infected HCV patients from Egypt’s Nile Delta were enrolled (2016–2018). Among them, 37 relapsed, and high-quality serum samples from 22 patients were available, including 6 cases with pre- and post-treatment samples. Next-generation sequencing (NGS) was performed for HCV subtyping and RAS identification. Among the 22 analyzed cases, 21 (95.4%) were G4: 11 were classified as subtype G4a, seven G4o, and three G4m. One patient (4.5%) was identified as G1g. One case shifted from G4a pre- to G4o post-treatment, suggesting reinfection. The RAS pattern in rare G4 subtypes (G4m/G4o) differs from the G4a subtype. The combination of L28M/L30S mutations was detected in 8/11 G4a samples; in contrast, RASs in G4o were characterized by T30S or Y93C/H/N/S substitutions. Notably, some substitutions identified as RASs may represent fixed polymorphisms in regional viral populations, such as those in Egypt’s Nile Delta. HCV subtypes significantly influence the RAS pattern, particularly within the NS5A region, after DAA-treatment failure. The RAS pattern differs among G4 subtypes, particularly in rare ones, predisposing patients to resistance and underscoring the importance of NGS in regional populations to optimize treatment strategies. Full article

The Nile, Indus, and Yellow River deltas are historically significant and have experienced extensive shoreline changes over the past 50 years, yet the roles of human interventions and natural events remain unclear. In this study, the Net Shoreline Movement and End Point Rate (EPR) were calculated to quantify the erosion and accretion of the shoreline, respectively. Subsequently, linear trend analysis was employed to identify potential directional shifts in shoreline behavior. These measures are combined with segment-scale cumulative area and the EPR trend to reveal where erosion or accretion intensifies, weakens, or reverses through time. Results show distinct, system-specific trajectories, the Nile lost ~27 km² from 1972 to1997 as a result of the dam construction and sediment reduction, and lost only ~3 km² more from 1997 to 2022, with local stabilization. The Indus switched from intermittent gains before 1990s to sustained loss after that, totaling ~300 km² of cumulative land loss mainly due to upstream dam constructions and storm events. The Yellow River gained ~500 km² from 1973 to 1996 then lost ~200 km² after main-channel relocation and reduced sediment supply despite active-mouth management. These outcomes indicate that deltas are very vulnerable to system wide human activities and natural events. Combined, satellite-derived metrics can help prioritize locations, guide feasible interventions, establish annual monitoring and trigger action. A major caveat of this study is that yearly shoreline rates and 5–10-yearaverages can mask short-lived or very local shifts. Targeted field surveys and finer-scale modeling (hydrodynamics, subsidence monitoring, bathymetry) are therefore needed to refine the design and inform better policy choices. Full article

The present study provides a comprehensive characterization of soil elemental composition in the Nile Delta, Egypt. The soil samples were analyzed using Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES), highly appropriative for the major element determination and Inductively Coupled Plasma Mass Spectrometry (ICP–MS), outstanding for the trace element analysis. A total of 55 elements were measured across 53 soil samples. A variety of statistical and analytical techniques, including both descriptive and inferential methods, were employed to assess the elemental composition of the soil. Bivariate and multivariate statistical analyses, discriminative ternary diagrams, ratio biplots, and unsupervised machine learning algorithms—such as Principal Component Analysis (PCA), t-Distributed Stochastic Neighbour Embedding (t-SNE), and Hierarchical Agglomerative Clustering (HAC)—were utilized to explore the geochemical similarities between elements in the soil. The application of t-SNE for soil geochemistry is still emerging and is characterized by the fact that it preserves the local distribution of elements and reveals non-linear relationships in geochemical research compared to PCA. Geochemical background levels were estimated using Bayesian inference, and the impact of outliers was analyzed. Pollution indices were subsequently calculated to assess potential contamination. The findings suggest that the studied areas do not exhibit significant pollution. Variations in background levels were primarily attributed to the presence of outliers. The clustering results from PCA and t-SNE were consistent in terms of accuracy and the number of identified groups. Four distinct groups were identified, with soil samples in each group sharing similar geochemical properties. While PCA is effective for linear data, t-SNE proved more suitable for nonlinear dimensionality reduction. These results provide valuable baseline data for future research on the studied areas and for evaluating their environmental situation. Full article

This study examined long-term trends (1991–2019) in landings and fish community structure in the four Egyptian Nile Delta lakes. Using fisheries data, we explored trends in the catch per unit effort (CPUE) and temporal dynamics of landings and fishing effort. Non-metric Multidimensional Scaling (nMDS) and Similarity Percentage Analysis (SIMPER) were employed to assess long-term changes in fish community structure. The results revealed variable productivity across the lakes. Lake Manzala often exhibited higher yields between 1991 and 2004, and notably in 2013 (e.g., 62,372 tons), while Lake Burullus peaked at 81,399 tons in 2019. A reciprocal trend was often observed in their total yields. Lake Burullus catches were dominated by Tilapia and Mullets, while Edku and Mariout showed lower productivity. CPUE patterns varied, with Lake Manzala showing a notable increase, peaking at approximately 52 tons per boat per year in 2013, and Lake Burullus experienced a sharp increase to about 29 tons per boat per year in 2019. A shift towards amateur fishing was observed predominantly in Lake Manzala, alongside a decline in traditional licensing. An increase in fishers operating without boats was also noted across all the Northern Lakes, with contributions from Lake Edko and Lake Manzala. nMDS and SIMPER analyses revealed distinct temporal groupings of years within each lake, indicating significant shifts in fish community structure, likely in response to invasive species, pollution, and habitat degradation. These findings underscore the need for lake-specific management and long-term monitoring to address unsustainable fishing and ecological changes, ensuring biodiversity conservation and fisheries sustainability in the region. Full article

Research is required to determine whether the coinfections by Fasciola spp. and other parasite species result from poor rural hygiene or reflect underlying epidemiological patterns and causes. Therefore, the role of fascioliasis is analyzed concerning coinfection complexity, risk of multiparasitism, parasite associations, pathogenic implications and their multifactorial causes. Helminth and protozoan coinfections are studied in 2575 previously untreated individuals from four rural hyperendemic areas (Northern Bolivian Altiplano, Peruvian Altiplano and Cajamarca valley, and the Egyptian Nile Delta). This cross-sectional study was conducted from January 2011 to December 2023. Coinfections were coprologically assessed by the merthiolate–iodine–formalin and formol–ether concentration techniques. Infection intensity was measured as eggs/gram of feces (epg) with the Kato–Katz technique. Parasite and coinfection prevalences were stratified by age, sex and geographical location. High mixed infections, fascioliasis prevalences and very low non-coinfected Fasciola-infected subjects were associated with the following regions: Bolivian Altiplano, 96.5%, 16.8% and 3.5%; Peruvian Altiplano, 100%, 24.6% and 0%; Cajamarca valley, 98.7%, 21.4% and 1.8%; Nile Delta, 84.1%, 13.0% and 15.9%. Transmission routes and human infection sources underlie fascioliasis associations with protozoan and other helminth infections. Prevalence pattern of protozoan–helminth coinfections differed between Fasciola-infected individuals and individuals not infected with Fasciola, presenting higher prevalences in individuals with fascioliasis. Multiparasitism diagnosed in Fasciola-infected subjects included coinfections by up to nine parasite species, eight protozoan species, and five helminth species. The most prevalent pathogenic protozoan was Giardia intestinalis. The most prevalent helminth species differ according to environmental conditions. Several parasites indicate fecal environmental contamination. When the fascioliasis burden increases, the total number of parasite species also increases. The fascioliasis risk increases when the total helminth species number/host increases. Fasciola-infected subjects may present a modification in the clinical phenotypes of coinfecting parasitic diseases. Fascioliasis coinfection factors include transmission ways and immunological, environmental and social aspects. Coinfections must be considered when assessing the health impact of fascioliasis, including the analysis of the fascioliasis effects on malnutrition and physical/intellectual child development. Fascioliasis-control schemes should, therefore, integrate control measures mainly against other helminthiases. Full article

This study presents an integrated approach combining molecular, phytochemical, and biological analyses to characterize a newly discovered Zizania specimen from the northern Nile Delta, Egypt. Genetic fingerprinting using RAPD and ISSR markers revealed 85% band-sharing similarity with Zizania texana (Z. texana), though distinct morphological and genetic traits suggested potential intraspecific variation. Phytochemical profiling identified high concentrations of bioactive compounds, including quercetin (42.1 µg/mL), β-caryophyllene (11.21%), and gallic acid (23.4 µg/mL), which are pertinent and correlated with robust biological activities. The ethanolic leaf extract exhibited significant antioxidant capacity (IC₅₀ = 38.6 µg/mL in DPPH assay), potent antimicrobial effects against Candida albicans (C. albicans) (IC₅₀ = 4.9 ± 0.6 µg/mL), and dose-dependent cytotoxicity against cancer cell lines. MCF-7 has the lowest IC₅₀ (28.3 ± 1.5 µg/mL), indicating the highest potency among the tested cell lines. In contrast, HepG2 demonstrates moderate sensitivity (IC₅₀ = 31.4 ± 1.8 µg/mL), while A549 shows the highest IC₅₀ value (36.9 ± 2.0 µg/mL), indicating greater resistance. These findings underscore the taxonomic novelty of the specimen and its potential as a source of natural antioxidants, antimicrobials, and anticancer agents. The study highlights the importance of interdisciplinary approaches in resolving taxonomic uncertainties and unlocking the medicinal value of understudied aquatic plants. Full article