Search Results (657,190)

Background/Objectives: Branched-chain fatty acids (BCFAs) exhibit a range of biological activities; however, their limited natural abundance and high cost have constrained in vivo research. Lanolin represents a promising source for enriching BCFAs. Nevertheless, the in vivo application, safety, and dose-effect relationship of BCFAs derived from lanolin (BCFAs-DFL) remain unassessed. Methods: In this study, the acute toxicity in C57BL/6J mice was first evaluated for 7 days by a single oral administration of 5000 mg/kg BW of BCFAs-DFL. Subsequently, 40 mice were divided into four groups (control group, low dose of 100 mg/kg BW, medium dose of 300 mg/kg BW, and high dose of 600 mg/kg BW) and were continuously administered by gavage for 28 days to study the effects of BCFAs-DFL on the growth, blood biochemistry, intestinal morphology, and intestinal flora of the mice. Results: In the acute toxicity test, BCFAs-DFL exhibited no lethality or abnormalities in mice, indicating its non-toxic nature. Throughout the 28-day trial, mice in the medium- and high-dose groups experienced a notable decrease in average daily feed intake (p < 0.05), yet their weight gain remained unaffected (p > 0.05). Hemoglobin and hematocrit levels declined in the high-dose group (p < 0.05). Conversely, serum aspartate aminotransferase and total bilirubin levels escalated in the medium- and high-dose groups, while triglycerides and urea nitrogen levels decreased (p < 0.05). The serum’s total antioxidant capacity and immunoglobulin levels (IgA, IgG) rose in proportion to the dosage (p < 0.05). BCFAs-DFL notably enhanced the villus height of the jejunum and ileum in mice (p < 0.05). Gut microbiota analysis indicated no significant impact on overall α and β diversity. Conclusions: The 28-day intervention revealed that BCFAs-DFL can modulate feeding behavior, TG, T-AOC, and immunoglobulin levels in mice. Additionally, it promotes the development of intestinal villi. Based on various indicators, a dosage of 100 mg/kg BW effectively induces beneficial metabolic regulation, such as the reduction of triglycerides, without causing a burden on liver metabolism. This dosage may represent a more suitable application for potential use. Full article

To meet the requirements of non-mechanical beam scanning and acquisition in space laser communication, this study proposes a two-dimensional scanning and acquisition method based on a silicon-based optical phased array (OPA). The OPA utilizes thermo-optic phase modulation to achieve horizontal beam pointing, while vertical beam pointing is controlled by wavelength tuning. By combining the OPA with a rectangular spiral scanning strategy, non-mechanical scanning is realized and beam acquisition experiments are carried out. Experimental results demonstrate that for an 8° step signal, the horizontal and vertical rise times are 156.8 μs and 214.76 ms, respectively. A full scan of 440 points covering a ±4° field of view is completed in 8.119 s. Acquisition experiments were conducted assuming a Gaussian-distributed uncertainty region (standard deviation σ = 1°). Out of 106 independent trials, a success rate of 97.17% was achieved with an average acquisition time of 0.41 s. This work experimentally applies a rectangular spiral scanning strategy to an OPA-based acquisition system, addressing a capability that has been largely missing in previous studies. These results verify that the OPA technology has good scanning efficiency and acquisition robustness in space laser communication applications. Full article

This study examines the socio-demographic characteristics, rice production practices, and breeding preferences of farmers across three major rice-growing regions of Vietnam: the Mekong Delta, Central Vietnam, and North Vietnam. A survey of 109 rice farmers captured information on cultivation status, livelihood activities, and preferred breeding traits for rice improvement. The results reveal clear regional differentiation in farm structure, production objectives, and varietal preferences. Rice farming in the Mekong Delta is predominantly commercially oriented, characterized by larger landholdings and greater male participation, whereas rice production in Central and Northern Vietnam is more subsistence-oriented, with higher female involvement. Farmers across regions consistently valued locally adapted rice varieties, but articulated region-specific trait priorities shaped by agro-ecological conditions. In the Mekong Delta, preferences emphasized soft grain quality and salinity tolerance, reflecting coastal production constraints. In Central Vietnam, farmers prioritized heat tolerance and resistance to pests and diseases, while in Northern Vietnam, cold tolerance and grain quality attributes, including aroma and harder texture, were most important. Major biotic stresses, particularly blast and bacterial blight, also showed significant regional variation in reported incidence. By linking these region-specific preferences to clearly defined Target Populations of Environments (TPEs), this study provides a practical framework for aligning breeding targets with real-world production conditions. The findings offer actionable guidance for participatory breeding and decentralized varietal evaluation under the Biodiversity for Opportunities, Livelihoods, and Development (BOLD) initiative, as well as other rice improvement programs. To our knowledge, this represents the first multi-region evidence from Vietnam that systematically integrates agro-ecological variation with a TPE-based breeding approach, supporting the development of climate-resilient, farmer-preferred rice varieties and more sustainable rice production systems. Full article

The development of large-scale cascade hydropower complexes has improved the navigation conditions of mountainous rivers but creates unique “continuous dam zones,” presenting complex challenges for port site selection due to hydrological variability and geological risks. To address the lack of specialized evaluation tools for this specific context, this paper constructs a comprehensive evaluation indicator system tailored for mountainous reservoir areas. The proposed system explicitly integrates critical engineering and physical constraints—specifically fluctuating backwater zones, geological hazards, and dam-bypass mileage—alongside ecological and social requirements. The Analytic Hierarchy Process (AHP) and Entropy Weight Method (EWM) are integrated using a Game Theory model to determine combined weights, and the Evaluation based on Distance from Average Solution (EDAS) model is applied to rank the alternatives. An empirical analysis of the Xiluodu Reservoir area on the Jinsha River demonstrates that operational efficiency, geological safety, and environmental feasibility constitute the critical decision-making factors. The results indicate that Option C (Majiaheba site) offers the optimal solution (ASi = 0.9695), effectively balancing engineering utility with environmental protection. Sensitivity analysis further validates the consistency and stability of this ranking under different decision-making scenarios. The findings provide quantitative decision support for project implementation and offer a replicable reference for infrastructure planning in similar complex mountainous river basins. Full article

The 3D reconstruction of vessel hulls is crucial for enhancing safety, efficiency, and knowledge in the maritime industry. Neural Radiance Fields (NeRFs) are an alternative to 3D reconstruction and rendering from multi-view images; particularly, tensor-based methods have proven effective in improving efficiency. However, existing tensor-based methods typically suffer from a lack of spatial coherence, resulting in gaps in the reconstruction of fine-grained geometric structures. This paper proposes a spatial multi-scale weighted NeRF (MDW-NeRF) for accurate and efficient surface reconstruction of vessel hulls. The proposed method develops a novel multi-scale feature decomposition mechanism that models 3D space by leveraging multi-resolution features, facilitating the integration of high-resolution details with low-resolution regional information. We designed separate color and density weighting, using a coarse-to-fine strategy, for density and a weighted matrix for color to decouple feature vectors from appearance attributes. To boost the efficiency of 3D reconstruction and rendering, we implement a hybrid sampling point strategy for volume rendering, selecting sample points based on volumetric density. Extensive experiments on the SVH dataset confirm MDW-NeRF’s superiority: quantitatively, it outperforms TensoRF by 1.5 dB in PSNR and 6.1% in CD, and shrinks the model size by 9%, with comparable training times; qualitatively, it resolves tensor-based methods’ inherent spatial incoherence and fine-grained gaps, enabling accurate restoration of hull cavities and realistic surface texture rendering. These results validate our method’s effectiveness in achieving excellent rendering quality, high reconstruction accuracy, and timeliness. Full article

With the increasing integration of renewable energy into power grids, voltage source converter-based high-voltage direct current (VSC-HVDC) stations often adopt hybrid grid-following (GFL) and grid-forming (GFM) control strategies to improve adaptability to varying grid strengths. In many existing schemes, the hybrid coefficient changes abruptly, which may produce large transient current overshoots and compromise the safe and stable operation of converters. An adaptive hybrid GFL-GFM control framework equipped with a hybrid coefficient transition regulation is proposed. Small-signal state–space models are established and eigenvalue analysis confirms stability over the considered short-circuit ratio (SCR) range. The regulating method is activated only during coefficient transitions and is inactive in steady-state, thereby preserving the operating-point eigenvalue properties. Dynamic equations of the converter current change rate are derived to reveal the key role of the hybrid-coefficient change rate in driving transient current overshoots, based on which a real-time hybrid coefficient regulating method is developed to shape coefficient transitions. Simulations on a 500 kV/2100 MW VSC-HVDC project demonstrate reduced transient current overshoot and power oscillations during SCR variations, with robustness under moderate parameter deviations as well as representative SCR assessment error and update delay. Full article

The present study reports the design and physicochemical characterization of a hybrid nanoparticle system for the potential intranasal delivery of galantamine (GAL), aimed at improving its bioavailability. Carbon dots (CDs) were used to load GAL, enhancing its dissolution and stability, and were subsequently incorporated into a poly(lactic-co-glycolic acid)–curcumin (PLGA–Cur) conjugate matrix. The successful formation of the PLGA-Cur conjugate was verified via ¹H-NMR and FTIR spectroscopy, while the loading of GAL and its physical state in the CDs was assessed via FTIR and pXRD, respectively. The resulting GAL-CD/PLGA–Cur nanoparticles were spherical, with particle sizes varying from 153.7 nm to 256.3 nm, a uniform morphology and a narrow size distribution. In vitro release studies demonstrated a multi-phase sustained release pattern extending up to 12 days. Spectroscopic and thermal analyses confirmed successful conjugation and molecular interactions between GAL and the carrier matrix. This proof-of-concept hybrid system demonstrates promising controlled, multi-phase sustained galantamine release in vitro, highlighting the role of curcumin conjugation in modulating polymer structure and release kinetics and providing a foundation for future biological evaluation. Full article

Chromium (Cr) is a highly toxic heavy metal, yet its effects on soil invertebrates—particularly Caenorhabditis elegans (C. elegans)—remain insufficiently understood, especially regarding how soil properties and Cr speciation change regulate its bioavailability and toxicity. In this study, the toxicity of Cr(VI) to the growth, fertility, and reproduction of C. elegans was assessed in six representative agricultural soils following 7, 60, and 120 days of spiked soil aging, following ISO 10872 guidelines. Substantial differences in toxicity were observed among soils after 7 days of aging, with toxicity ranking from low to high as black soil < yellowish-red soil < red soil < yellow–brown soil < fluvo-aquic soil < purple soil. After 60 days of aging, Cr(VI) toxicity decreased markedly, with EC₅₀ values for growth, fertility, and reproduction increasing by 1.04–2.32, 1.04–2.34, and 1.40–2.20 times, respectively. Organic matter (OM) and amorphous aluminum oxides (Al_AO) were identified as the principal soil properties that were significantly correlated with Cr(VI) toxicity and were useful for explaining and estimating toxicity thresholds within the range of soils examined in this study. In addition, the magnitude of the aging effect showed significant positive correlations with both amorphous aluminum oxides (Al_AO) and total aluminum (Al_total), suggesting that Al-bearing minerals may contribute to the time-dependent immobilization of Cr(VI) under the experimental conditions of this study. These findings expand the ecotoxicological database for chromium, improve the prediction of toxicity thresholds under diverse soil conditions, and provide a scientific basis for refining soil environmental quality standards and developing targeted management strategies for Cr-contaminated agricultural soils. Full article

Background/Objectives: While tick-borne encephalitis virus (TBEV) is genetically relatively conserved, the significant antigenic divergence between its main circulating subtypes hinders the development of broadly effective antiviral treatments and vaccines. Current inactivated TBEV vaccines offer limited cross-protection against heterologous strains, as evidenced by cases among vaccinated individuals in endemic regions. The aim of this study was to design a candidate mRNA vaccine and evaluate the breadth of protective immunity it elicits. Methods: Ten candidate mRNA-PrM/E-LNP vaccines were comparatively evaluated for immunogenicity and protective efficacy in BALB/c mice. Immunogenicity was assessed by measuring antigen-specific IgG titers via ELISA and neutralizing antibody titers against a panel of TBEV strains using a virus-neutralization test. Protective efficiency was determined in a lethal challenge model, where immunized mice were challenged with one of seven distinct TBEV strains. Results: Vaccination with all tested mRNA-PrM/E-LNP candidates conferred 100% survival in mice following a lethal challenge with each of the seven TBEV strains (100 LD₅₀). The construct mRNA-PrM/E—Krasny Yar-8 demonstrated the highest immunogenicity, inducing antigen-specific antibodies with a geometric mean titer (GMT) of 1:6625, as well as the broadest virus-neutralizing activity against both homologous and heterologous TBEV strains in vitro. Conclusions: The mRNA platform represents a promising strategy for developing TBEV vaccines, demonstrating high immunogenicity and cross-protective efficacy against diverse viral strains. Full article

Aiming at the wind-blown snow disasters plaguing tunnel portals along the China-Tajikistan Highway Phase II Project, this study optimizes the protective parameters of wind deflectors through numerical simulation to improve the disaster prevention efficiency of tunnel portals in alpine mountainous areas. Three core control parameters of wind deflectors, namely horizontal distance from the tunnel portal (L), plate inclination angle (β), and top installation height (h), were selected as the research objects. Single-factor numerical simulation scenarios were designed for each parameter, and an L9(3³) orthogonal test was further adopted to formulate 9 groups of multi-parameter combination scenarios, with the snow phase volume fraction at 35 m on the leeward side of the tunnel portal set as the core evaluation index. A computational fluid dynamics (CFD) model was established to systematically investigate the influence laws of each parameter on the wind field structure and snow drift deposition characteristics at tunnel portals and clarify the flow field response rules under different parameter configurations. Single-factor simulation results show that the wind deflector exerts distinct regulatory effects on the wind-snow flow field with different parameter settings: when L = 6 m, the disturbance zone of the wind deflector precisely covers the main wind flow development area in front of the tunnel portal, which effectively lifts the main incoming flow path, compresses the recirculation zone (length reduced from 45.8 m to 22.3 m), and reduces the settlement of snow particles, achieving the optimal comprehensive prevention effect; when β = 60°, the leeward wind speed at the tunnel portal is significantly increased to 10–12 m/s (from below 10 m/s), which effectively promotes the transport of snow particles and mitigates the accumulation risk, being the optimal inclination angle; when h = 2 m, the wind speed on both the windward and leeward sides of the tunnel portal is significantly improved, and the snow accumulation risk at the portal reaches the minimum. Orthogonal test results further quantify the influence degree of each parameter on the snow prevention effect, revealing that the horizontal distance from the tunnel portal is the most significant influencing factor. The optimal parameter combination of the wind deflector is determined as L = 6 m, β = 60°, and h = 2 m. Under this optimal combination, the snow phase volume fraction at 35 m on the leeward side of the tunnel portal is 0.0505, a 12.3% reduction compared with the non-deflector condition; the high-concentration snow accumulation zone is shifted 25 m leeward, and the high-value snow phase volume fraction area (>0.06) disappears completely, which can effectively alleviate the adverse impact of wind-blown snow disasters on the normal operation of tunnel portals. The research results reveal the regulation mechanism of wind deflector parameters on the wind-snow flow field at alpine tunnel portals and determine the optimal protective parameter combination, which can provide important theoretical reference and technical support for the prevention and control of wind-blown snow disasters at tunnel portals in similar alpine mountainous areas. Full article

We report the use of σ-alkynyl d⁶ electron-rich transition metal complexes as electron-releasing end-groups in octupolar molecules designed for nonlinear optical (NLO) applications, specifically, N,N′,N″-triarylisocyanurates (5,7,8,10,12) and 1,3,5-triarylbenzenes (6,9,11) functionalized by Fe(II) and Ru(II) organometallic moieties, and their NLO properties, as assessed by hyper-Rayleigh scattering (HRS) and Z-scan. The redox properties are briefly investigated through isolation of the corresponding Fe(III) trications 5[PF₆]₃ and 6[PF₆]₃. The second-harmonic generation (SHG) or two-photon absorption (2PA) performance of the Fe(II) and Ru(II) parents is compared with the help of TD-DFT calculations performed on models. Comparison with tris-ferrocenyl isocyanurate 4 reveals that the σ-connection of the metallic centers to the π-manifold is superior to the η⁵-connection for enhancing NLO properties. The positive effect of organometallic end-groups on NLO properties relative to purely organic electron-releasing substituents is established. The mechanism by which NLO enhancement occurs is complex and possibly connected to the polarizable π-electrons in the ligands surrounding the metal alkynyl units, but in most cases, the observed NLO enhancement must arise from the transition metal centers interacting with the central π-manifold. Full article

The Global Navigation Satellite System-Scattering (GNSS-S) radar has a wide coverage and strong concealment, enabling large-scale and long-term monitoring of sea surface targets. However, its signal power is extremely low and susceptible to sea clutter interference. To address the challenge of detecting and tracking moving targets in complex maritime environments using low-resolution radar, this paper proposes a method for extracting moving target trajectories from GNSS-S radar under low signal-to-noise ratio (SNR) conditions. The method constructs a feature plane consisting of statistical and polarization characteristics, based on the unique distribution of different motion targets in this plane, the distinction between sea clutter and multi-motion targets is carried out using machine learning algorithms, and finally the trajectory association of the targets is achieved by the Kalman filter, and the tracking correctness can reach more than 93.89%. Compared with the tracking method based on high-resolution imaging targets, this technique does not require complex imaging operations, and only requires certain processing on the radar echo, which has the advantages of easy operation and high reliability. Full article

Waterlogging stress severely limits crop photosynthesis and energy supplies, resulting in significant yield reductions. However, the critical duration of waterlogging stress during the maize jointing stage remains unclear, and the physiological and molecular mechanisms underlying its effects on photosynthetic efficiency and energy synthesis in maize require further investigation. In this study, we systematically analyzed the responses of physiological traits, transcriptomic profiles, and the yield formation in maize (Zea mays L.) to varying waterlogging durations imposed during the jointing stage, including 0 days (CK), 2 days (F2), 4 days (F4), 6 days (F6), 8 days (F8), and 10 days (F10). Our results indicate that the (1) grain weight (GW) showed no significant difference between F2 and CK. However, the GW in F4, F6, F8, and F10 decreased significantly by 17.49%, 26.45%, 60.24%, and 100.00%, respectively, compared to the CK. (2) Compared with the CK, the malondialdehyde content progressively increased from F4 to F10, while antioxidant enzyme activity gradually decreased. The chlorophyll content declined by 29.93% to 57.38%, and net photosynthetic efficiency decreased by 13.82% to 38.93%. Although the leaf sucrose content in from F4 to F10 gradually decreased, the leaf starch content remained stable in F4 and F6. In contrast, the starch content in F8 and F10 leaves was significantly reduced by 37.55% and 47.60%, respectively, compared with CK. (3) A transcriptomic analysis revealed that during from F2 to F4, genes encoding photosystem I subunit protein, such as PSAD, and the cytochrome b6f complex proteingene PETC were downregulated. At F6, these key genes encoding photosynthetic proteins were upregulated. However, at F8 and F10, their expression was significantly downregulated. Concurrently, genes related to ATP synthesis (e.g., ATPD) as well as starch and sucrose metabolism (e.g., SPP2, SS1) were also downregulated. In summary, when waterlogging stress persists for no longer than 6 days, plants can maintain their starch content to supply energy for growth, thereby ensuring basic developmental needs. When waterlogging persists for more than 6 days, energy synthesis is impaired, and the nutrient transport to the grains is significantly inhibited, ultimately resulting in a substantial reduction in yield. Therefore, 6 days of waterlogging can be considered the critical threshold for significant yield loss in maize during the jointing stage. Full article