Search Results (32)

The COVID-19 pandemic prompted widespread adoption of intensified hand hygiene practices, raising concerns about their medium-term impact on the skin microbiome. This study investigates alterations in the hand microbiome of healthy adults during the pandemic compared to pre-pandemic periods in Majorca, Spain. A total of 30 volunteers (16 women, 14 men; mean age 44.1 ± 8.8 years) were sampled between 2014 and 2021. Palm swabs were collected following WHO guidelines, alongside measurements of skin pH, temperature, and handwashing frequency. Bacterial DNA was extracted and analyzed via 16S rRNA (V3-V4) metagenomic sequencing to assess microbial diversity and composition. Results revealed a significant decline in microbial diversity during the COVID-19 period, accompanied by a marked shift in the community structure. The Firmicutes phylum dominated, with Bacillales increasing from 30.7% to 84.1%, primarily driven by a surge in Staphylococcus species (e.g., S. pasteuri). Conversely, S. hominis and Actinomycetales nearly disappeared. No significant associations were observed with gender or handwashing frequency. The skin temperature increased during the pandemic, while the pH remained stable. The Staphylococcus/Bacillus ratio shifted significantly, favoring Staphylococcus dominance. These findings, derived from a geographically limited population in Majorca, Spain, demonstrate that stringent hygiene measures during COVID-19 reduced microbial diversity and restructured hand microbiome composition. The study underscores the necessity for balanced hygiene strategies that mitigate pathogen transmission while preserving beneficial microbial communities critical to skin health. Full article

Carob pulp powder (CPP), a by-product of Ceratonia siliqua L., is rich in bioactive compounds with potential for functional foods. This study evaluated how genetic variability among cultivars affects the nutritional composition and functional quality of CPP. Nineteen cultivars from Majorca (13), Ibiza (4), and two open-flowering selections were grown under identical conditions in Majorca, Spain. CPP samples showed high dietary fibre (22.6–47.4 g/100 g dry matter), total sugars (22.5–62.5 g/100 g dm), and antioxidant activity (11.1–78.4 µmol TE/g dm, CUPRAC method). Significant differences among cultivars were observed in protein and fructose content, fatty acid profiles, antioxidant activity, colour, acidity, and functional properties like water- and oil-holding capacities. Principal component analysis distinguished the Ibiza cultivars by higher soluble solids, fructose, and stearic acid content but lower antioxidant activity. Open-flowering selections exhibited the highest antioxidant and water retention capacities. These results confirm that genetic origin strongly influences CPP’s nutritional and functional traits, endorsing its use as a natural, health-promoting ingredient for functional food development. Full article

Pernambuco, a northeastern Brazilian state, suffered significantly during the COVID-19 pandemic. The incidence, mortality, and fatality rates were incredibly high; these outcomes were a direct failure of the public health system to manage the COVID-19 pandemic. We developed an efficient method to analyze the trends in incidence, mortality, and lethality indicators of COVID-19 and the dynamics of their main determinants in the state of Pernambuco from March 2020 to March 2022. This was a time series ecological study. We calculated the lethality, mortality, and incidence rates with official and public data from the Health Department of this state. The effective reproduction number (Rt) was estimated, and then the periods were delimited, thus creating the efficiency model. Differences were considered significant when p < 0.05. We found 585,551 cases and 18,233 deaths from COVID-19. January 2022 was the month with the highest number of cases (6312) and, in May 2020, we recorded the highest number of deaths (149). Our method was efficient in analyzing periods of COVID-19, noting a contrast between the early and most recent periods, with the latter showing a stable number of new cases and patient deaths. Full article

Almond cultivation has a long-standing tradition on the island of Majorca, traditionally practiced under rainfed conditions. Currently, new plantations are established with irrigation; however, due to present conditions and the impacts of climate change, water availability is limited. The Government of the Balearic Islands permits a maximum water supply of 3000 m³ ha⁻¹ per year for almond cultivation. In this study, a 6-year field trial was conducted to investigate the adaptation of fourteen almond cultivars obtained from different research centers under deficit irrigation practices in the soil and climatic conditions of Majorca Island. The cultivars had a significant effect on trunk cross-sectional area TCSA, cumulative almond in-shell yield, cumulative kernel yield, yield efficiency, and shelling percentage. The ‘Marta’ and ‘Tarraco’ cultivars exhibited the highest TCSA values. Regarding cumulative almond in-shell yield, ‘Glorieta’ and ‘Constantí’ produced the highest yields, whereas the lowest yields were observed in ‘Mardía’ and ‘Tarraco’. In terms of shelling percentage, ‘Ferragnès’ exhibited the highest value. Kernel quality parameters were cultivar-specific. Additionally, oleic acid content was strongly negatively correlated with linoleic acid content. All cultivars exhibited an unsaturated fatty acid content exceeding 90%, with ‘Masbovera’ showing the highest value. Full article

The production of backyard chickens is an activity of great importance in the economy of rural families in Paraguay. The Rustipollos population was created through directed crosses between a commercial meat line and a local population belonging to non-specific breeds but phenotypically assimilated to Creole breeds. The aim of this study was to evaluate the genetic diversity, relationship, and structure of Rustipollos using 29 microsatellite markers. Analysis was performed on 50 Rustipollos animals and 926 other individuals as reference breeds/populations from Europe, Africa, South, and North America. A total of 318 alleles were detected, with a mean of 10.97 per locus. The polymorphic information content indicated that 80% of all loci were highly to moderately informative. Only two breeds/populations showed loci that did not deviate from the Hardy–Weinberg equilibrium. The results of genetic diversity indexes suggested moderate levels of genetic variability in Rustipollos population and low inbreeding level. The genetic differentiation index indicates a high genetic differentiation between populations. The results of the Neighbor-Net tree and STRUCTURE analyses indicate the existence of distinct gene pools, with some genetic relationships between Rustipollos, the commercial chicken strain, and south Spanish breeds. The Discriminant Analysis of Principal Components confirmed the observed genetic distances between breeds/populations. The results will be useful for sustainable use and official recognition of this population. Full article

This study delves into the complex relationships between indigenous dog breeds in the Balearic Isles and their human counterparts, specifically breeders and owners. Using Canonical Correlation Analysis, the research examines variables such as breed registries and the number of breeders/owners, uncovering significant correlations within registries. For example, an increase in female auxiliary registrations corresponds to a decline in foundational registrations, indicating shifts in breed documentation dynamics. Similarly, a rise in definitive female registrations coincides with a decrease in foundational female registrations, suggesting increased pedigree awareness across generations. Beyond registries, the study explores the correlation between breeders/owners and various initial records, highlighting that a notable increase in breeders positively influences initial registrations, definitive totals, and overall counts, underscoring their crucial role in early breed stages. Gender preferences in registrations are noted, with a historical bias towards female entries during foundational stages gradually shifting in favor of males in definitive registrations. In conclusion, the research underscores the interconnected roles of breeders, owners, and comprehensive registries in preserving genetic diversity among Balearic dog breeds, emphasizing the need for ongoing efforts to address gaps in genealogical data for a more accurate understanding of breed dynamics. Full article

The hyperinflammatory response caused by SARS-CoV-2 infection contributes to its severity, and many critically ill patients show features of cytokine storm (CS) syndrome. We investigated, by next-generation sequencing, 24 causative genes of primary immunodeficiencies whose defect predisposes to CS. We studied two cohorts with extreme phenotypes of SARS-CoV-2 infection: critical/severe hyperinflammatory patients (H-P) and asymptomatic patients (AM-risk-P) with a high risk (older age) to severe COVID-19. To explore inborn errors of the immunity, we investigated the presence of pathogenic or rare variants, and to identify COVID-19 severity-associated markers, we compared the allele frequencies of common genetic polymorphisms between our two cohorts. We found: 1 H-P carries the likely pathogenic variant c.887-2 A>C in the IRF7 gene and 5 H-P carries variants in the MEFV gene, whose role in the pathogenicity of the familial Mediterranean fever (FMF) disease is controversial. The common polymorphism analysis showed three potential risk biomarkers for developing the hyperinflammatory response: the homozygous haplotype rs1231123A/A-rs1231122A/A in MEFV gene, the IFNAR2 p.Phe8Ser variant, and the CARMIL2 p.Val181Met variant. The combined analysis showed an increased risk of developing severe COVID-19 in patients that had at least one of our genetic risk markers (odds ratio (OR) = 6.2 (95% CI) (2.430–16.20)). Full article

Cancer arises from the complex interplay of various factors. Traditionally, the identification of driver genes focuses primarily on the analysis of somatic mutations. We describe a new method for the detection of driver gene pairs based on an epistasis analysis that considers both germline and somatic variations. Specifically, the identification of significantly mutated gene pairs entails the calculation of a contingency table, wherein one of the co-mutated genes can exhibit a germline variant. By adopting this approach, it is possible to select gene pairs in which the individual genes do not exhibit significant associations with cancer. Finally, a survival analysis is used to select clinically relevant gene pairs. To test the efficacy of the new algorithm, we analyzed the colon adenocarcinoma (COAD) and lung adenocarcinoma (LUAD) samples available at The Cancer Genome Atlas (TCGA). In the analysis of the COAD and LUAD samples, we identify epistatic gene pairs significantly mutated in tumor tissue with respect to normal tissue. We believe that further analysis of the gene pairs detected by our method will unveil new biological insights, enhancing a better description of the cancer mechanism. Full article

Leishmaniasis is an infectious zoonotic disease caused by protozoan parasites of the genus Leishmania. In the Mediterranean basin, leishmaniasis is caused by Leishmania infantum and transmitted by bites of sandflies of the genus Phlebotomus, with the dog as the main reservoir host. The most common form is cutaneous leishmaniasis (CL), although visceral cases also occur. The aim of this study was to assess the underestimation of CL in an endemic Mediterranean region. Thus, a retrospective study was performed on all CL cases diagnosed and treated in the Dermatology Service of Manacor Hospital (Majorca, Balearic Islands), and the data obtained were compared with those of local government epidemiological bulletins for the same period. The different clinical presentations were compiled, and data related to sex, age, and lesion type and number were analyzed. The results reveal a clear sub-notification, which indicates that the real incidence of human CL in this area is unknown. Full article

Water quality and pollution is the main environmental concern for ports and adjacent coastal waters. Therefore, the development of Port Environmental Management systems often relies on water pollution monitoring. Computer vision is a powerful and versatile tool for an exhaustive and systematic monitoring task. An investigation has been conducted at the Port of Palma de Mallorca (Spain) to assess the feasibility and evaluate the main opportunities and difficulties of the implementation of water pollution monitoring based on computer vision. Experiments on surface slicks and marine litter identification based on random image sets have been conducted. The reliability and development requirements of the method have been evaluated, concluding that computer vision is suitable for these monitoring tasks. Several computer vision techniques based on convolutional neural networks were assessed, finding that Image Classification is the most adequate for marine pollution monitoring tasks due to its high accuracy rates and low training requirements. Image set size for initial training and the possibility to improve accuracy through retraining with increased image sets were considered due to the difficulty in obtaining port spill images. Thus, we have found that progressive implementation can not only offer functional monitoring systems in a shorter time frame but also reduce the total development cost for a system with the same accuracy level. Full article

The Anthropocene era demands a future alternative to the current state of play. The aim of this study is to analyze spatial and climate governance and policy through a critical geographical study of the island of Mallorca (Spain), an example of the model of urban development and tourism growth that has generated acute environmental impacts. Beginning with the European Union and Spain, the work then narrows its focus to the case study of Mallorca. The study is based on a review of the academic literature, statistical sources, and an analysis of the content of spatial and climate policy in Spain and the Balearic Islands. The work reflects on the flawed spatial planning responses to climate change and outlines strategies to adopt more radical measures for effective climate action. The work identifies six main shortcomings and makes proposals to tackle the challenges of the Anthropocene in Mallorca, responding to each of the deficiencies detected. The article seeks to encourage reflection and proposes key strategies for spatial governance and climate policy to lend coherence to the fight against climate change. Full article

Background: Recent studies have shown that the lifetime prevalence of low back pain (LBP) in schoolchildren aged 10–12 years is 73.6%, and that it appears to have an impact on people’s quality of life. A wide range of risk factors associated with LBP have been studied. However, inconsistent results have been reported. In recent decades, the physical fitness level of children and adolescents has worsened, and the current data on the relationship between muscular fitness and musculoskeletal pain are ambiguous. The purpose of the present study was to analyze the relationship between physical fitness and the occurrence and intensity of LBP. Methods: This cross-sectional study assessed 849 students, aged 10–12 years, from 10 primary schools (fifth and sixth grades) from Majorca (Spain). It was based on two different structured and self-administered questionnaires and a fitness test battery validated for child populations. Results: The results showed that higher levels of VO2Max correspond to less LBP intensity. Additionally, LBP was less prevalent among participants who self-reported more physical activity, and higher VO2Max and higher levels of flexibility were associated with the absence of LBP in bed. Conclusion: These results are of particular importance, as cardiorespiratory fitness is the parameter most closely related to health, and it seems to also be related to LBP-prevention. Full article

In recent years, there has been a big shift in analyses of historic centres, with the spotlight turning from the issue of urban degradation and the ageing population to studies of the risks associated with touristification and gentrification. The island of Ibiza is one of the Mediterranean’s leading tourist destinations, and its capital is one of the fifteen Spanish cities declared as World Heritage Sites (UNESCO). This study aimed to explore the touristification of Ibiza’s historic centre (a World Heritage Site). To do so, it explored three interrelated variables, the historic centre’s demographic dynamics, tourist accommodations, and heritage, through an analysis of heritage interventions derived from the UNESCO declaration. The methodology was based on the statistical use of demographic and tourism accommodation data on an inter-urban scale by mapping the main results, as well as on a study of the heritage data from the municipal catalogue. We concluded that the old city is in a state of change, both socially (with a demographic decline and drop in the native population) and culturally. All this reinforces its role as a supplier of complementary tourism services and as a museumized space for sun and sand resorts in the rest of the city and throughout the island. Full article

From 1338 onwards, the inhabitants of late-medieval Valencia celebrated a feast every 9 October commemorating the entrance into the city of King James I’s forces on that day in 1238. It has been argued that this was essentially a spiritual display from its establishment in 1338 until the beginning of the fifteenth century. The present study delves deeper into the religious and political aims of the feast from its origins, framing the celebration within a broader Mediterranean context. The first part analyses the 9 October feast in relation to two medieval liturgies that also commemorated crusading victories against Islam: the “Feast of the Liberation of Jerusalem” and the “Feast of the Banner of Majorca”. The second part focuses on the combination of performance and images during the ceremony, leading to the conclusion that the 9 October procession had similar goals to those in Jerusalem and Majorca. Indeed, the ceremony intended to convey an interpretation of the conquest as the continuation of Biblical history because it visibly and orally aligned the capture of Valencia with divine will and the sacred Scriptures. Full article

Low back pain (LBP) is a prevalent musculoskeletal disease that affects a large percentage of the working population, including teachers. The World Health Organization has identified the school as an effective environment for improving child health. For this reason, the figure of the teacher is a fundamental piece in the process of knowledge acquisition about postural education and prevention of LBP among schoolchildren. The present study aims to determine the knowledge of postural education and back pain prevention among primary school teachers. This cross-sectional study evaluated 85 primary school teachers from Majorca (Spain), of whom 17.6% were physical education teachers and 82.4% were classroom teachers. The study was based on two different structured and self-administered questionnaires to investigate into specific knowledge about LBP: Low Back Pain Knowledge Questionnaire (LKQ) and COSACUES-AEF Questionnaire. The results demonstrated a lifetime prevalence of LBP of 96.5% with significant differences determined by sex. The knowledge of participants about LBP was 17.3 in LKQ (range scale 0–24) and 4.3 in COSACUES (range scale 1–10). In conclusion, the teachers knowledge is insufficient to carry out an efficient and useful health promotion program among schoolchildren to prevent LBP. Full article