Search Results (3,430)

Pulse-like ground motions can cause severe damage to buried cast iron (CI) pipelines, which necessitates the selection of optimal seismic intensity measures (IMs) to estimate pipeline repair rates. Such a selection is essential for mitigating uncertainty in the seismic risk assessment of buried CI pipelines. For the first time, this study systematically screens the optimal scalar and vector IMs for buried cast iron pipelines with lead-caulked joints under pulse-like ground motions by a symmetrical evaluation based on the criteria of efficiency, sufficiency, and proficiency, providing a new method for reducing uncertainty in pipeline seismic risk assessment. We initiate the study by selecting 124 pulse-like ground motions from the NGA-West2 database and identifying 19 scalar and 171 vector IMs as potential candidates. A two-dimensional soil–pipe model is introduced, incorporating variability in the sealing capacity of lead-caulked joints along the axial direction. CI pipeline repair rates are calculated across various scaling factors and apparent wave velocities, yielding 1116 datasets pertinent to CI pipeline damage. The repair rate is adopted as the engineering demand parameter (EDP) to evaluate the efficiency, sufficiency, and proficiency of candidate IMs. Through comprehensive analysis, peak ground velocity (PGV) and the combination of PGV and the time interval between 5% and 75% of normalized Arias intensity ([PGV, Ds_5–75]) are determined as the optimal scalar- and vector-IMs, respectively, for assessing the repair rate of buried CI pipelines under pulse-like ground motions. Full article

Down Syndrome (DS) is the most common chromosomal abnormality characterized by neurodevelopmental impairment. Apart from maternal age, its risk factors remain poorly understood. This prospective case-control study aimed to evaluate the role of maternal anti-zona pellucida (ZP) antibodies (Ab) and anti-thyroid-Ab in predicting DS. Correlations of anti-ZP-Ab and anti-thyroid-Ab with maternal age were also assessed. Anti-ZP-Ab were measured after childbirth using ELISA. Anti-thyroid peroxidase (aTPO) and anti-thyroglobulin (aTgII) antibodies were also analysed with the Allelica IM platform. Statistical analyses included receiver operating characteristic curve assessment, expressed as area under the curve (AUC) and linear regression modeling. Between September 2020 and October 2022, 58 women were enrolled. Anti-ZP-Ab levels were significantly higher in women with DS pregnancy with an odds ratio adjusted for maternal age of 71.52 (95% CI: 7.05–725.18) and an excellent predictive performance (AUC = 0.94; 95% CI: 0.88–1.00). For optical density levels > 1, the accuracy was 89.7% (95% CI: 78.2–100.0). No statistically significant differences were observed for aTPO and aTgII. Neither Anti-ZP-Ab nor anti-thyroid antibodies increased with age. These findings suggest that Anti-ZP-Ab are strongly associated with DS risk, suggesting a potential age-independent autoimmune contribution to trisomy 21. Their evaluation may support preconception counseling, especially for women aged > 35 years. Future studies could clarify causality and define the role of maternal autoimmunity in DS etiology. Full article

Using additive manufacturing for the design of inserts in injection moulding (IM) offers advantages in product development and customization. However, challenges related to operating temperature and mechanical resistance remain. This article presents a systematic screening methodology to evaluate the suitability of materials for specific applications. Ten commercial Material Extrusion (MEX) filaments were selected to produce test samples. Moldex3D simulation software was employed to model the IM process using two thermoplastics and to determine the temperature and pressure conditions that the printed inserts must withstand. Simulation results were critically interpreted and cross-referenced with the experimental material characterisations to evaluate material suitability. Nine of the ten MEX materials were suitable for IM with LDPE, and five with PP. Dimensional assessments revealed that six insert solutions required further post-processing for assembly, while three did not. All of the selected materials successfully survived 10 injection cycles without encountering any significant issues. The simulation results were validated by comparing temperature data from a thermal imaging camera during IM, revealing only minor deviations. The study concludes that combining targeted material characterization with CAE simulation provides an effective and low-cost strategy for selecting MEX filaments for injection moulding inserts, supporting rapid tooling applications in niche production. Full article

Background: The introduction of tyrosine kinase inhibitors has revolutionised the treatment of gastrointestinal stromal tumours (GISTs), yet the role of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) in peritoneal GISTosis remains controversial. Methods: A retrospective analysis was conducted on patients with peritoneal GISTosis who underwent CRS plus HIPEC in an 18-year period. We analysed the clinicopathological characteristics and evaluated the perioperative and long-term outcomes based on the extent of disease (peritoneal cancer index, PCI), the resection (completeness of cytoreduction score) and the IM-administration. The survival factors were also analysed and the Kaplan–Meier estimator to model and estimate overall (OS) and progression-free survival (PFS). The median follow-up period was 72 months (range, 12–146). Results: A total of 25 patients (M:F = 15:10) with a median age of 57 years (range, 32–69) underwent CRS with HIPEC for peritoneal GIST metastases, detected either synchronously (n = 11) or metachronously (n = 14). The media PCI score was 9 (range, 4–20) and complete cytoreduction was achieved in 80%. Grade III complications were observed in two patients, whereas there was no postoperative mortality. Neoadjuvant imatinib-mesylate (IM) therapy was administered in 60% of patients who detected with metachronous metastases (n = 8/14), whereas adjuvant IM therapy was administered in 19 of 25 patients. Median OS was 62 months (95% CI = 22.8–101.2). Median OS and DFS for patients with PCI scores ≤ 10 were significantly longer compared to those with PCI scores > 10 (p = 0.009 and p = 0.024, respectively). Patients with CC scores of 0–1 had a significantly longer OS compared to those with CC scores of 2 (p = 0.005) and 3 (p = 0.002) and longer PFS compared to those with CC scores of 3 (p = 0.005). The need for imatinib did not significantly impact OS (p = 0.240) or PFS (p = 0.243). Conclusions: CRS combined with HIPEC shows promising results in peritoneal GISTosis, especially in patients with lower PCI and CC scores. Until larger studies validate its safety and efficacy, it should be primarily performed in expert hands in specialised peritoneal surface oncology centres. Full article

This article presents the Intelligent Monitoring System (IMS), an AI-assisted, low-latency surveillance platform designed for defense environments. The study addresses the need for real-time autonomous situational awareness by integrating high-speed video transmission with advanced computer vision analytics in constrained network settings. The IMS employs a hybrid transmission architecture based on RTSP for ingestion and WHEP/WebRTC for distribution, orchestrated via MediaMTX, with the objective of achieving end-to-end latencies below one second. The methodology includes a comparative evaluation of video streaming protocols (JPEG-over-WebSocket, HLS, WebRTC, etc.) and AI frameworks, alongside the modular architectural design and prolonged experimental validation. The detection module integrates YOLOv11 models fine-tuned on the VisDrone dataset to optimize performance for small objects, aerial views, and dense scenes. Experimental results, obtained through over 300 h of operational tests using IP cameras and aerial platforms, confirmed the stability and performance of the chosen architecture, maintaining latencies close to 500 ms. The YOLOv11 family was adopted as the primary detection framework, providing an effective trade-off between accuracy and inference performance in real-time scenarios. The YOLOv11n model was trained and validated on a Tesla T4 GPU, and YOLOv11m will be validated on the target platform in subsequent experiments. The findings demonstrate the technical viability and operational relevance of the IMS as a core component for autonomous surveillance systems in defense, satisfying strict requirements for speed, stability, and robust detection of vehicles and pedestrians. Full article

Hawk tea (Litsea coreana Levl. var. lanuginosa), a naturally caffeine-free herbal beverage widely consumed in Southwest China, is characterized by a pronounced camphoraceous note that often deters first-time consumers. In this study, hawk tea leaves were subjected to solid-state fermentation with four microbial strains—Monascus purpureus, Aspergillus cristatus, Bacillus subtilis, and Blastobotrys adeninivorans. The volatile compounds of unfermented and fermented hawk teas were identified by ultra-fast gas chromatography electronic nose (ultra-fast GC e-nose), gas chromatography–mass spectrometry (GC-MS) and gas chromatography–ion mobility spectrometry (GC-IMS) analyses, respectively. Furthermore, the calculation of odor activity values (OAVs) and relative odor activity value (ROAV) revealed that 6 and 25 volatile chemicals, including perillaldehyde (OAV 3.692) and linalool (ROAV 100), were the main contributors to the floral, fruity, and woody aroma of fermented hawk tea. Sensory evaluation confirmed that fermentation generally enhanced woody notes while significantly reducing the characteristic camphoraceous and oil oxidation odors. Notably, the Blastobotrys adeninivorans-fermented sample exhibited the most pronounced floral and fruity nuances, accompanied by significantly elevated aroma complexity and acceptability. Consequently, Blastobotrys adeninivorans represents a promising starter culture for the improvement of hawk tea flavor. Full article

This paper addresses the signal detection problem in orthogonal frequency division multiplexing with index modulation (OFDM-IM) systems using deep learning (DL) techniques. In particular, a DL-based detector termed FullTrans-IM is proposed, which integrates the Transformer architecture with long short-term memory (LSTM) networks. Unlike conventional methods that treat signal detection as a classification task, the proposed approach reformulates it as a sequence prediction problem by exploiting the sequence modeling capability of the Transformer’s decoder rather than relying solely on the encoder. This formulation enables the detector to effectively learn channel characteristics and modulation patterns, thereby improving detection accuracy and robustness. Simulation results demonstrate that the proposed FullTrans-IM detector achieves superior bit error rate (BER) performance compared with conventional methods such as zero-forcing (ZF) and existing DL-based detectors under Rayleigh fading channels. Full article

Background and Objectives: Corpus atrophic gastritis (CAG) is associated with vitamin B₁₂ deficiency due to impaired gastric acid and intrinsic factor secretion. Untreated vitamin B₁₂ deficiency can lead to pernicious anemia, severe neurological consequences, and acute cardiocerebral-vascular events. Timely vitamin B₁₂ supplementation is relevant; however, the dosage of intramuscular (IM) vitamin B₁₂ supplementation has not been standardized to date. The objective was to assess the efficacy of a 1st and 2nd treatment schedule of IM-cyanocobalamin treatment in CAG patients with vitamin B₁₂ deficiency at long-term follow-up and to identify the predictors of increased cyanocobalamin requirement. Methods: This monocentric real-life cohort study included 213 CAG patients with vitamin B₁₂ deficiency. Inclusion criteria were adult age, histological diagnosis of CAG with vitamin B₁₂ deficiency (<220 pg/mL), and follow-up of more than 12 months. The 1st-treatment-schedule (TxA) was 5000 µg IM cyanocobalamin every 5 days for 3 times, followed by 5000 µg IM cyanocobalamin every 3 mos (20,000 µg/yr); the 2nd-treatment-schedule (TxB) was 5000 µg IM cyanocobalamin every 5 days for 3 times, followed by 5000 µg IM cyanocobalamin every 2 mos (30,000 µg/yr). The treatment endpoint was serum vitamin B₁₂ normalization. Clinical-biochemical follow-up was scheduled every 12 ± 6 mos: patients who satisfied the endpoint maintained the TxA, otherwise, TxB was prescribed. Results: Of the 213 CAG patients with vitamin B₁₂ deficiency, 48.3% had anemia, and 26.3% macrocytosis without anemia. TxA efficaciously corrected vitamin B₁₂ deficiency in 146 (68.5%) patients, maintaining efficacy until the longest available follow-up (42.2 ± 2.6 months). The remaining 67 patients (31.5%) were switched to TxB due to persistent vitamin B₁₂ deficiency observed at 12 (6–36) months and were maintained until the longest available follow-up (50.2 ± 4.1 months). At the longest available follow-up, a significant increase in Hb (TxA: 11.9 ± 0.2 to 13.1 ± 0.1 g/dL, p < 0.001; TxB: 12.2 ± 0.3 to 13.6 ± 0.2 g/dL, p = 0.003) and serum vitamin B₁₂ (TxA: 168 ± 7 to 402 ± 19 pg/mL, p < 0.0001; TxB: 157 ± 12 to 340 ± 24 pg/mL, p < 0.0001) was shown in both schedules. A significant decrease in MCV was shown in TxB only (p = 0.0003). In logistic regression, switching to TxB was significantly associated with severe corpus intestinal metaplasia (OR 11.0, 95% CI 2.8–43.7), macrocytosis at CAG diagnosis (OR 2.7, 95% CI 1.2–6.3), and male sex (OR 2.4, 95% CI 1.1–5.2). Conclusions: In this real-world setting, at long-term follow-up, nearly 70% of CAG patients with vitamin B₁₂ deficiency restored their vitamin B₁₂ levels with 20,000 µg/yr of cyanocobalamin, while the remaining 30% required 30,000 µg/yr. Male vitamin B₁₂-deficient CAG patients with advanced gastric damage and severe macrocytosis required higher dosages of cyanocobalamin. They should be carefully monitored to avoid suboptimal supplementation and potentially dangerous consequences of vitamin B₁₂ deficiency. Full article

Hydraulic manipulators are vital for heavy-duty applications such as rescue robotics due to their high power density, yet these scenarios increasingly demand safe and compliant physical interaction. Impedance control is a key enabling technology for such capabilities. However, a significant challenge arises when implementing impedance control on Independent Metering Systems (IMS), which are widely adopted for their energy efficiency. The inherent multi-mode operation of IMS relies on discrete switching logic. Crucially, when mode switching occurs during physical interaction with the environment, the unpredictable external forces can trigger frequent and abrupt switching between operating modes (e.g., resistive and overrunning), leading to severe chattering. This phenomenon not only undermines the smooth interaction that impedance control aims to achieve but also jeopardizes overall system stability. To address this critical issue, this paper proposes a seamless control framework based on a Takagi–Sugeno (T-S) fuzzy model. Two premise variables based on the physical characteristics of the system are innovatively designed to make the rule division highly consistent with the dynamic nature of the system. Asymmetric membership functions are introduced to handle direction-dependent switching, with orthogonal functions ensuring logical exclusivity between extension and retraction, and smooth complementary functions enabling seamless transitions between resistance and overrunning modes. Experimental validation on a small hydraulic manipulator validates the effectiveness of the proposed method. The controller eliminates switching-induced instability and smooths velocity transitions, even under dynamic external force disturbances. This work provides a crucial solution for high-performance, stable hydraulic interaction control, paving the way for the application of hydraulic robots in complex and dynamic environments. Full article

Mycoplasma ovipneumoniae poses a major threat to sheep respiratory health, contributing to significant economic losses in farming communities. In this study, we isolated a novel strain, IM-DMQ, from a Hu sheep in Inner Mongolia that exhibited pulmonary adenomatous-like lesions, which is an uncommon pathological manifestation for this pathogen. The complete genome was sequenced using a hybrid Nanopore and Illumina approach, revealing a 1,039,804 bp circular chromosome with a GC content of 29.15%, encoding 1529 genes. Functional annotation highlighted genes involved in essential metabolic processes and potential virulence mechanisms. Comparative genomic analysis demonstrated that IM-DMQ shares the closest ancestry (ANI: 98.3%) with the Chinese strain NXNK2203, while structural variations and 14 unique genes distinguished it from other global strains. Furthermore, microbial community profiling of the original lung tissue revealed a co-infection background involving multiple bacterial pathogens, offering an etiological context for the severe disease presentation. These results provide the first complete genomic resource for an M. ovipneumoniae strain from Inner Mongolia associated with unusual pulmonary pathology, offering insights into its genetic diversity and supporting the future development of targeted diagnostics and vaccines for regional disease control. Full article

Accurate prediction of failure in industrial machinery and engines is critical for minimizing unexpected downtimes and enabling cost-effective maintenance. Existing predictive models often struggle to generalize across diverse datasets and require extensive hyperparameter tuning, while conventional optimization methods are prone to local optima, limiting predictive performance. To address these limitations, this study proposes a hybrid optimization framework combining Harris Hawks Optimization (HHO) and Wild Horse Optimization (WHO) to fine-tune the hyperparameters of ResNet, Bi-LSTM, Bi-GRU, CNN, DNN, VAE, and Transformer-GRU models. The framework leverages HHO’s global exploration and WHO’s local exploitation to overcome local optima and optimize predictive performance. Following hybrid optimization, the Transformer-GRU model consistently outperformed all other models across four benchmark datasets, including time-to-failure (TTF), intelligent maintenance system (IMS), C-MAPSS FD001, and FD003. On the TTF dataset, mean absolute error (MAE) decreased from 0.72 to 0.15, and root mean square error (RMSE) from 1.31 to 0.23. On the IMS dataset, MAE decreased from 0.04 to 0.01, and RMSE from 0.06 to 0.02. On C-MAPSS FD001, MAE decreased from 11.45 to 9.97, RMSE from 16.02 to 13.56, and score from 410.1 to 254.3. On C-MAPSS FD003, MAE decreased from 11.28 to 9.98, RMSE from 15.33 to 14.57, and score from 352.3 to 320.8. These results confirm that the hybrid HHO–WHO optimized Transformer-GRU framework significantly improves prediction performance, robustness, stability, and generalization, providing a reliable solution for predictive maintenance. Full article

Background: Nipah virus (NiV), a zoonotic paramyxovirus with high case fatality and pandemic potential, remains without a licensed vaccine for humans to date. Although there has been progress in vaccine development, it remains limited, and peptide vaccines have rarely been validated in vivo. Methods: Here, we report the rational antigen selection, synthesis, and preliminary immunogenicity evaluation of NiV fusion glycoprotein (NiV-F)-derived linear peptides as vaccine candidates. Candidate epitopes were identified by in silico, and a total of 18 B- and T-cell epitope-derived peptides were shortlisted for synthesis and antigenicity validation by ELISA. Results: Antigenicity evaluation showed that 9 of the synthesized peptides have A_450nm of over 1 (8 from the F11 group, A_450nm: 1.13–3.6; 1 from the F18 group, A_450nm: 1.51), with the peptide constructs F11-3 (A_450nm: 3.5) and F11-4 (A_450nm: 3.6) showing the highest antigenicity. Interestingly, peptides from F11 with amidation increased antibody binding (F11-4-NH2, A_450nm: 3.05; F11-4-9mer-1-NH2, A_450nm: 0.87). The lead peptide candidates, F11-3 and F11-4, were subsequently used for the immunization experiment, and mouse sera were assessed against their homologous peptide antigens or recombinant NiV-F protein. ELISA result showed detectable antibody reactivity against their homologous antigen for the intramuscular (IM) F11-3 vaccinated group (A_450nm: 0.30 ± 0.35), whereas increased binding was observed for both IM-administered F11-3 (A_450nm: 1.62 ± 0.97) and F11-4 (A_450nm: 2.0 ± 0.77) against NiV-F protein, albeit without statistical significance compared to the negative control (NC, p > 0.05), and were markedly lower compared to mice immunized with NiV-F recombinant protein (PC, p < 0.01), underscoring the need for further optimization procedures. Conclusions: Collectively, these results support an exploratory antigen discovery and prioritization framework for NiV-F-derived peptide candidates and provide a foundation for future studies aimed at optimizing immunogenicity and evaluating protective relevance in appropriate preclinical models. Full article

This study investigated the effect of superheated steam (SS) assisted glycosylation modification on the flavor profile of oyster peptides (OP), and explored the correlation between key flavor compounds and glycosylation degree using Gas Chromatography–Ion Mobility Spectrometry (GC-IMS) and nano-scale Liquid Chromatography coupled with High-Resolution Mass Spectrometry (nano-LC/HRMS). The results indicated that SS treatment accelerated the glycosylation process, reduced free amino groups level, and distinguished their unique flavor through E-nose. GC-IMS analysis detected 64 signal peaks including 13 aldehydes, 6 ketones, 7 esters, 6 alcohols, 2 acids, 2 furans and 5 other substances. And it was revealed that SS-mediated glycosylation treatment reduced the levels of fishy odorants like Heptanal and Nonanal, while promoting the pleasant-smelling alcohols and esters. In addition, Pearson correlation showed a positive correlation between excessive glycation and the increase in aldehydes, which might cause the recurrence of undesirable fishy notes. Further nano-LC/HRMS analysis revealed that arginine and lysine acted as the main sites for glycosylation modification. Notably, glycosylated peptides such as KAFGHENEALVRK, DSRAATSPGELGVTIEGPKE, generated by mild SS treatment could convert into ketones and pyrazines in subsequent reactions, thereby contributing to overall sensory enhancement. In conclusion, SS treatment at 110 °C for 1 min significantly improved the flavor quality of OP and sustains improvement in subsequent stages, providing theoretical support for flavor optimization of oyster peptides. Full article

Microbial fermentation is an important means to enhance the nutrition and functionality of food, and soybean fermentation has a long history and a wide variety of products. This study systematically compared the effects of fermentation and post-ripening processes of Bacillus subtilis natto JLCC513 on the nutritional components, active substances, and sensory characteristics of soybeans. The experimental results showed that, in terms of basic nutrition, fermentation led to a significant decrease in fat and reducing sugar content, followed by an initial increase and then a decrease in total protein content. In contrast, water-soluble protein continued to increase, and the total amount of free amino acids surged. The active nutritional indicators before and after soybean fermentation showed that nattokinase activity continued to increase during fermentation and post-ripening. At the same time, the number of viable bacteria decreased slightly during post-ripening. The increase in the proportion of easily absorbed aglycone-type isoflavones before and after soybean fermentation is accompanied by a sustained increase in vitamin K2 and gamma aminobutyric acid (GABA) content. In terms of sensory quality, color-difference analysis shows a decrease in brightness (L value) and an increase in redness (a value), resulting in the characteristic yellow-brown color of natto. In terms of texture characteristics, the hardness decreases, while the viscosity and elasticity are significantly enhanced. Through GC-IMS analysis of volatile aromas during soybean fermentation and post-ripening, it was found that esters (such as ethyl acetate) and pyrazines (such as 2,3-dimethylpyrazine) increased, and the product flavor shifted from grassy to fruity and nutty. In summary, natto bacteria enhance the digestibility, nutritional value, and sensory acceptance of soybeans through enzymatic hydrolysis and metabolic transformation. The post-ripening stage plays a key role in flavor maturation and further accumulation of active ingredients. Full article

The paper provides a comprehensive overview of stray losses in conductive structural parts of power transformers, addressing the effects of stray magnetic fields on simple conductive plates, the distribution of additional losses across structural components and measures for their reduction. It examines the (im)possibility of directly measuring stray losses and presents methods for their indirect measurement, highlighting the generation of fault gases due to thermal faults and the importance of understanding multiphysical (electromagnetic–thermal) coupling in calculating stray losses. A problem rarely mentioned in the literature but confirmed here by measurements, is the excessive heating of the connecting elements of the clamping system caused by circulating currents. Full article