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Review

27 Citations

4,744 Views

21 Pages

The IGF-II–Insulin Receptor Isoform-A Autocrine Signal in Cancer: Actionable Perspectives

Pierluigi Scalia,
Antonio Giordano and
Stephen J. Williams

Cancers2020, 12(2), 366;https://doi.org/10.3390/cancers12020366

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5 February 2020

Insulin receptor overexpression is a common event in human cancer. Its overexpression is associated with a relative increase in the expression of its isoform A (IRA), a shorter variant lacking 11 aa in the extracellular domain, conferring high affini...

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Article

24 Citations

3,555 Views

18 Pages

Implication of miR-155-5p and miR-143-3p in the Vascular Insulin Resistance and Instability of Human and Experimental Atherosclerotic Plaque

Paula González-López,
Carla Ares-Carral,
Andrea R. López-Pastor,
Jorge Infante-Menéndez,
Tamara González Illaness,
Melina Vega de Ceniga,
Leticia Esparza,
Nuria Beneit,
José Luis Martín-Ventura and
Almudena Gómez-Hernández
+ 1 author

Int. J. Mol. Sci.2022, 23(18), 10253;https://doi.org/10.3390/ijms231810253

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6 September 2022

(1) Background: Cardiovascular diseases (CVDs) are the main cause of death in developed countries, being atherosclerosis, a recurring process underlying their apparition. MicroRNAs (miRNAs) modulate the expression of their targets and have emerged as...

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Article

26 Citations

5,953 Views

12 Pages

Genome-Wide Scan Identifies Selection Signatures in Chinese Wagyu Cattle Using a High-Density SNP Array

Zezhao Wang,
Haoran Ma,
Lei Xu,
Bo Zhu,
Ying Liu,
Farhad Bordbar,
Yan Chen,
Lupei Zhang,
Xue Gao and
Junya Li
+ 3 authors

Animals2019, 9(6), 296;https://doi.org/10.3390/ani9060296

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30 May 2019

Selective breeding can lead to genetic diversity and diverse phenotypes in farm animals. Analysis of the genomic regions under selection can provide important insights into the genetic basis of complex traits. In this study, a high-density SNP array...

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