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Article

16 Citations

4,471 Views

17 Pages

Discovery of a Nitric Oxide-Responsive Protein in Arabidopsis thaliana

Randa Zarban,
Malvina Vogler,
Aloysius Wong,
Joerg Eppinger,
Salim Al-Babili and
Chris Gehring

Molecules2019, 24(15), 2691;https://doi.org/10.3390/molecules24152691

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24 July 2019

In plants, much like in animals, nitric oxide (NO) has been established as an important gaseous signaling molecule. However, contrary to animal systems, NO-sensitive or NO-responsive proteins that bind NO in the form of a sensor or participating in r...

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Article

6 Citations

4,867 Views

15 Pages

Dynamic Characterization of the Human Heme Nitric Oxide/Oxygen (HNOX) Domain under the Influence of Diatomic Gaseous Ligands

Rana Rehan Khalid,
Abdul Rauf Siddiqi,
Efstratios Mylonas,
Arooma Maryam and
Michael Kokkinidis

Int. J. Mol. Sci.2019, 20(3), 698;https://doi.org/10.3390/ijms20030698

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6 February 2019

Soluble guanylate cyclase (sGC) regulates numerous physiological processes. The β subunit Heme Nitric Oxide/Oxygen (HNOX) domain makes this protein sensitive to small gaseous ligands. The structural basis of the activation mechanism of sGC under...

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Article

19 Citations

5,584 Views

15 Pages

Comparative Studies of the Dynamics Effects of BAY60-2770 and BAY58-2667 Binding with Human and Bacterial H-NOX Domains

Rana Rehan Khalid,
Muhammad Tahir ul Qamar,
Arooma Maryam,
Ayesha Ashique,
Farooq Anwar,
Mohammed H. Geesi and
Abdul Rauf Siddiqi

Molecules2018, 23(9), 2141;https://doi.org/10.3390/molecules23092141

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25 August 2018

Soluble guanylate cyclase (sGC) is a key enzyme implicated in various physiological processes such as vasodilation, thrombosis and platelet aggregation. The enzyme’s Heme-Nitric oxide/Oxygen (H-NOX) binding domain is the only sensor of nitric o...

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