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Article

7 Citations

4,240 Views

38 Pages

Repurposing Multiple-Molecule Drugs for COVID-19-Associated Acute Respiratory Distress Syndrome and Non-Viral Acute Respiratory Distress Syndrome via a Systems Biology Approach and a DNN-DTI Model Based on Five Drug Design Specifications

Ching-Tse Ting and
Bor-Sen Chen

Int. J. Mol. Sci.2022, 23(7), 3649;https://doi.org/10.3390/ijms23073649

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26 March 2022

The coronavirus disease 2019 (COVID-19) epidemic is currently raging around the world at a rapid speed. Among COVID-19 patients, SARS-CoV-2-associated acute respiratory distress syndrome (ARDS) is the main contribution to the high ratio of morbidity...

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Article

3 Citations

2,404 Views

26 Pages

Genetic and Epigenetic Host–Virus Network to Investigate Pathogenesis and Identify Biomarkers for Drug Repurposing of Human Respiratory Syncytial Virus via Real-World Two-Side RNA-Seq Data: Systems Biology and Deep-Learning Approach

Bo-Wei Hsu and
Bor-Sen Chen

Biomedicines2023, 11(6), 1531;https://doi.org/10.3390/biomedicines11061531

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25 May 2023

Human respiratory syncytial virus (hRSV) affects more than 33 million people each year, but there are currently no effective drugs or vaccines approved. In this study, we first constructed a candidate host–pathogen interspecies genome-wide gene...

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Article

5 Citations

2,448 Views

32 Pages

Multiple-Molecule Drug Repositioning for Disrupting Progression of SARS-CoV-2 Infection by Utilizing the Systems Biology Method through Host-Pathogen-Interactive Time Profile Data and DNN-Based DTI Model with Drug Design Specifications

Cheng-Gang Wang and
Bor-Sen Chen

Stresses2022, 2(4), 405-436;https://doi.org/10.3390/stresses2040029

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3 November 2022

The coronavirus disease 2019 (COVID-19) pandemic has claimed many lives since it was first reported in late December 2019. However, there is still no drug proven to be effective against the virus. In this study, a candidate host–pathogen–...

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